ZA200707855B - Anti-cancer and antimicrobial oxazolidinones and analogues - Google Patents
Anti-cancer and antimicrobial oxazolidinones and analoguesInfo
- Publication number
- ZA200707855B ZA200707855B ZA200707855A ZA200707855A ZA200707855B ZA 200707855 B ZA200707855 B ZA 200707855B ZA 200707855 A ZA200707855 A ZA 200707855A ZA 200707855 A ZA200707855 A ZA 200707855A ZA 200707855 B ZA200707855 B ZA 200707855B
- Authority
- ZA
- South Africa
- Prior art keywords
- cancer
- oxazolidinones
- analogues
- antimicrobial
- analogs
- Prior art date
Links
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical class O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 title abstract 2
- 230000001093 anti-cancer Effects 0.000 title abstract 2
- 230000000845 anti-microbial effect Effects 0.000 title abstract 2
- PXHFLWCSJYTAFU-UHFFFAOYSA-N 1,3-oxazolidin-4-one Chemical class O=C1COCN1 PXHFLWCSJYTAFU-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- YAMHXTCMCPHKLN-UHFFFAOYSA-N imidazolidin-2-one Chemical compound O=C1NCCN1 YAMHXTCMCPHKLN-UHFFFAOYSA-N 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/36—One oxygen atom
- C07D263/40—One oxygen atom attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/04—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines without replacement of the other oxygen atom of the carboxyl group, e.g. imino-ethers
- C07C257/06—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines without replacement of the other oxygen atom of the carboxyl group, e.g. imino-ethers having carbon atoms of imino-carboxyl groups bound to hydrogen atoms, to acyclic carbon atoms, or to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/14—Nitrogen or oxygen as hetero atom and at least one other diverse hetero ring atom in the same ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Public Health (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65560505P | 2005-02-22 | 2005-02-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200707855B true ZA200707855B (en) | 2008-09-25 |
Family
ID=36580024
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200707855A ZA200707855B (en) | 2005-02-22 | 2007-09-14 | Anti-cancer and antimicrobial oxazolidinones and analogues |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US7378530B2 (https=) |
| EP (1) | EP1856066B1 (https=) |
| JP (1) | JP2008531573A (https=) |
| KR (1) | KR20070106578A (https=) |
| CN (1) | CN101160294A (https=) |
| AT (1) | ATE503748T1 (https=) |
| AU (1) | AU2006216708A1 (https=) |
| BR (1) | BRPI0607974A2 (https=) |
| CA (1) | CA2597667A1 (https=) |
| DE (1) | DE602006020992D1 (https=) |
| IL (1) | IL185266A0 (https=) |
| MX (1) | MX2007009990A (https=) |
| WO (1) | WO2006091669A1 (https=) |
| ZA (1) | ZA200707855B (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7378530B2 (en) * | 2005-02-22 | 2008-05-27 | Nereus Pharmaceuticals, Inc. | Anti-cancer and anti-microbial 5-membered heterocyclic compounds |
| US20110118274A1 (en) * | 2007-08-23 | 2011-05-19 | Cornell Research Foundation, Inc. | Proteasome inhibitors and their use in treating pathogen infection and cancer |
| FR2948940B1 (fr) * | 2009-08-04 | 2011-07-22 | Servier Lab | Nouveaux derives dihydroindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| MX2015002399A (es) * | 2012-10-29 | 2015-06-10 | Hoffmann La Roche | Derivados de oxazolidinona 3,4-disustituidos y su uso como inhibidores del canal de potasio activado con calcio. |
| US10556874B2 (en) * | 2015-07-03 | 2020-02-11 | Bayer Cropscience Aktiengesellschaft | N-(1,3,4-oxadiazol-2-yl)aryl carboxamide derivatives with herbicidal action |
| AU2016290425A1 (en) * | 2015-07-03 | 2018-01-18 | Bayer Cropscience Aktiengesellschaft | N-(tetrazole-5-yl)- and N-(triazole-5-yl)aryl carboxamide derivatives with herbicidal action |
| US10822315B2 (en) | 2016-08-22 | 2020-11-03 | North Carolina State University | 5-benzylidene-4-oxazolidinones |
| WO2018039242A1 (en) | 2016-08-22 | 2018-03-01 | North Carolina State University | 4-oxazolidinone antimicrobial agents |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2915527A (en) * | 1959-12-01 | Oxazolidone compounds and means for | ||
| US2971958A (en) * | 1959-03-17 | 1961-02-14 | Union Carbide Corp | Cyanoethylated oxalactams |
| US3129222A (en) * | 1960-12-01 | 1964-04-14 | Merck & Co Inc | 2, 2, 5-trisubstituted-4-oxazolidinone compounds |
| US3182063A (en) * | 1961-03-06 | 1965-05-04 | Warner Lambert Pharmaceutical | Substituted 4-thiazolidinones and process therefor |
| DE1917615U (de) | 1963-02-15 | 1965-06-10 | Kloeckner Humboldt Deutz Ag | Rotationskolbenmaschine. |
| DE1916715A1 (de) | 1969-04-01 | 1970-10-08 | Goedecke Ag | Verfahren zur Herstellung von Oxazolidon-(4)-Derivaten |
| US4049816A (en) * | 1975-03-24 | 1977-09-20 | Beecham Group Limited | Antiviral 2-amino-5-[1-(indol-3-yl)alkyl]-2-thiazolin-4-ones |
| US4584385A (en) * | 1984-03-22 | 1986-04-22 | Pfizer Inc. | Antibacterial 2-amino-oxazolinones and process therefor |
| US4769232A (en) * | 1984-03-22 | 1988-09-06 | Pfizer Inc. | Parenteral formulations of indolmycin |
| US4650512A (en) * | 1984-09-27 | 1987-03-17 | Stauffer Chemical Company | Oxazolidone herbicides and methods of use |
| US4629794A (en) * | 1985-02-04 | 1986-12-16 | Pfizer Inc. | Antibacterial 2-amino-oxazolinones and process therefor |
| US5677463A (en) | 1996-11-20 | 1997-10-14 | Abbott Laboratories | Process for the preparation of 2-imino-5-phenyl-4 oxazolidinone and its intermediates |
| EP1103600A4 (en) * | 1998-07-30 | 2002-11-06 | Takeda Chemical Industries Ltd | PROCESS FOR PRODUCING INDOLEMYCIN |
| US7378530B2 (en) * | 2005-02-22 | 2008-05-27 | Nereus Pharmaceuticals, Inc. | Anti-cancer and anti-microbial 5-membered heterocyclic compounds |
-
2006
- 2006-02-21 US US11/358,961 patent/US7378530B2/en not_active Expired - Fee Related
- 2006-02-22 EP EP06735789A patent/EP1856066B1/en not_active Expired - Lifetime
- 2006-02-22 DE DE602006020992T patent/DE602006020992D1/de not_active Expired - Lifetime
- 2006-02-22 WO PCT/US2006/006278 patent/WO2006091669A1/en not_active Ceased
- 2006-02-22 BR BRPI0607974-1A patent/BRPI0607974A2/pt not_active IP Right Cessation
- 2006-02-22 MX MX2007009990A patent/MX2007009990A/es active IP Right Grant
- 2006-02-22 CN CNA2006800120083A patent/CN101160294A/zh active Pending
- 2006-02-22 JP JP2007557124A patent/JP2008531573A/ja not_active Withdrawn
- 2006-02-22 AT AT06735789T patent/ATE503748T1/de not_active IP Right Cessation
- 2006-02-22 AU AU2006216708A patent/AU2006216708A1/en not_active Abandoned
- 2006-02-22 CA CA002597667A patent/CA2597667A1/en not_active Abandoned
- 2006-02-22 KR KR1020077021734A patent/KR20070106578A/ko not_active Ceased
-
2007
- 2007-08-14 IL IL185266A patent/IL185266A0/en unknown
- 2007-09-14 ZA ZA200707855A patent/ZA200707855B/xx unknown
-
2008
- 2008-05-21 US US12/124,896 patent/US20080221182A1/en not_active Abandoned
- 2008-05-21 US US12/124,909 patent/US7879892B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1856066A1 (en) | 2007-11-21 |
| US20080221183A1 (en) | 2008-09-11 |
| KR20070106578A (ko) | 2007-11-01 |
| JP2008531573A (ja) | 2008-08-14 |
| ATE503748T1 (de) | 2011-04-15 |
| BRPI0607974A2 (pt) | 2010-08-17 |
| AU2006216708A1 (en) | 2006-08-31 |
| IL185266A0 (en) | 2008-02-09 |
| CN101160294A (zh) | 2008-04-09 |
| US20080221182A1 (en) | 2008-09-11 |
| WO2006091669A1 (en) | 2006-08-31 |
| EP1856066B1 (en) | 2011-03-30 |
| US20060205799A1 (en) | 2006-09-14 |
| US7879892B2 (en) | 2011-02-01 |
| MX2007009990A (es) | 2007-09-26 |
| US7378530B2 (en) | 2008-05-27 |
| CA2597667A1 (en) | 2006-08-31 |
| DE602006020992D1 (de) | 2011-05-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA200707855B (en) | Anti-cancer and antimicrobial oxazolidinones and analogues | |
| GEP20156309B (en) | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 | |
| CY1106958T1 (el) | Ν-αλκυλο-4-μεθυλεναμινο-3-υδροξυ-2-πυριδονες ως αντιμικροβιακα | |
| MX2010008921A (es) | Derivados de oxazolidinona. | |
| MX2009010642A (es) | Antibioticos de oxazolidinona. | |
| NZ593111A (en) | Antibacterial compounds | |
| EA200601896A1 (ru) | Производные пролина и их применение в качестве ингибиторов дипептидилпептидазы iv | |
| JOP20200130A1 (ar) | مركبات كرومان مونوباكتام لعلاج العدوى البكتيرية | |
| BRPI0717266A2 (pt) | Derivados de oxindol | |
| TW200740435A (en) | Therapeutic agent for diabetes | |
| WO2007023507A3 (en) | Oxazolidinones bearing antimicrobial activity composition and methods of preparation | |
| BRPI0414694A (pt) | pró-fármaco(s) aciloximetilcarbamato de oxazolidinonas | |
| NO20081005L (no) | 8-methoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents | |
| NZ598165A (en) | Nitroimidazooxazine and nitroimidazooxazole analogues and their uses | |
| NZ594675A (en) | Actagardine derivatives | |
| SG151309A1 (en) | Novel use of peptide compounds for treating pain in painful diabetic neuropathy | |
| MX2007007598A (es) | Macrolidos. | |
| NZ596628A (en) | Ketolide compounds having antimicrobial activity | |
| EA200800302A1 (ru) | Применение производных и аналогов тиазола при лечении рака | |
| ATE516022T1 (de) | Antimikrobielle zusammensetzungen und anwendungsverfahren dafür | |
| WO2008014108A3 (en) | Antimicrobial oxazolidinone prodrugs | |
| WO2005054234A8 (en) | Substituted piperidino phenyloxazolidinones having antimicriobial activity with improved in vivo efficacy | |
| BRPI0519355A2 (pt) | compostos para tratamento contra flaviviridae | |
| ATE372986T1 (de) | N-sulfonyl-4-methyleneamino-3-hydroxy-2-pyridon s als antimikrobielle mittel | |
| TW200740800A (en) | Oxazolidinone compounds, and compositions and methods related thereto |