ZA200706353B - Pyrazolo-pyrimidine derivatives as mGluR2 antagonists - Google Patents
Pyrazolo-pyrimidine derivatives as mGluR2 antagonistsInfo
- Publication number
- ZA200706353B ZA200706353B ZA200706353A ZA200706353A ZA200706353B ZA 200706353 B ZA200706353 B ZA 200706353B ZA 200706353 A ZA200706353 A ZA 200706353A ZA 200706353 A ZA200706353 A ZA 200706353A ZA 200706353 B ZA200706353 B ZA 200706353B
- Authority
- ZA
- South Africa
- Prior art keywords
- pyrazolo
- pyrimidine derivatives
- mglur2 antagonists
- mglur2
- antagonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05101027 | 2005-02-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200706353B true ZA200706353B (en) | 2009-09-30 |
Family
ID=36090752
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200706353A ZA200706353B (en) | 2005-02-11 | 2007-07-31 | Pyrazolo-pyrimidine derivatives as mGluR2 antagonists |
Country Status (18)
Country | Link |
---|---|
US (1) | US7361659B2 (xx) |
EP (1) | EP1851225B1 (xx) |
JP (1) | JP4708438B2 (xx) |
KR (1) | KR100968291B1 (xx) |
CN (1) | CN101115755B (xx) |
AR (1) | AR052568A1 (xx) |
AT (1) | ATE512966T1 (xx) |
AU (1) | AU2006212457B2 (xx) |
BR (1) | BRPI0607927A2 (xx) |
CA (1) | CA2597608C (xx) |
ES (1) | ES2365406T3 (xx) |
IL (1) | IL184712A (xx) |
MX (1) | MX2007009106A (xx) |
NO (1) | NO20073876L (xx) |
RU (1) | RU2402553C2 (xx) |
TW (1) | TW200716120A (xx) |
WO (1) | WO2006084634A1 (xx) |
ZA (1) | ZA200706353B (xx) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2085398A1 (en) * | 2008-02-01 | 2009-08-05 | Merz Pharma GmbH & Co. KGaA | Pyrazolopyrimidines, a process for their preparation and their use as medicine |
WO2009110901A1 (en) * | 2008-03-06 | 2009-09-11 | Sanofi-Aventis | Substituted dihydro, trihydro and tetrahydro cycloalkyloxazolopyrimidinones, preparation and use thereof as allosteric modulators of mglur |
US8207181B2 (en) | 2008-03-06 | 2012-06-26 | Sanofi | Substituted dihydro, trihydro and tetrahydro cycloalkyloxazolopyrimidinones, preparation and use thereof |
WO2012020820A1 (ja) | 2010-08-11 | 2012-02-16 | 大正製薬株式会社 | ヘテロアリール-ピラゾール誘導体 |
US9447099B2 (en) * | 2011-10-04 | 2016-09-20 | Hoffmann-La Roche Inc. | Methods for the preparation of 5-[2-[7 (trifluoromethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo [1,5-A]pyrimidin-3-yl[ethynyl]-2-pyridinamine |
US9957271B2 (en) | 2011-10-20 | 2018-05-01 | Glaxosmithkline Llc | Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators |
EP2666775A1 (en) | 2012-05-21 | 2013-11-27 | Domain Therapeutics | Substituted pyrazoloquinazolinones and pyrroloquinazolinones as allosteric modulators of group II metabotropic glutamate receptors |
JP2015534993A (ja) | 2012-10-23 | 2015-12-07 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffma | 自閉症性障害の処置のためのmGlu2/3アンタゴニスト |
EP3134089A2 (en) | 2014-04-23 | 2017-03-01 | F. Hoffmann-La Roche AG | Mglu2/3 antagonists for the treatment of intellectual disabilities |
JOP20150179B1 (ar) | 2014-08-01 | 2021-08-17 | Janssen Pharmaceutica Nv | مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2 |
EP3000814A1 (en) | 2014-09-26 | 2016-03-30 | Domain Therapeutics | Substituted pyrazoloquinazolinones and pyrroloquinazolinones as allosteric modulators of group II metabotropic glutamate receptors |
AU2015342883B2 (en) | 2014-11-06 | 2020-07-02 | Bial - R&D Investments, S.A. | Substituted pyrrolo(1,2-a)pyrimidines and their use in the treatment of medical disorders |
EP3215511B1 (en) | 2014-11-06 | 2024-04-17 | Bial-R&D Investments, S.A. | Substituted pyrazolo(1,5-a)pyrimidines and their use in the treatment of medical disorders |
ES2958391T3 (es) | 2014-11-06 | 2024-02-08 | Bial R&D Invest S A | Imidazo[1,5-a]pirimidinas sustituidas y su uso en el tratamiento de trastornos médicos |
ES2727158T3 (es) | 2014-12-03 | 2019-10-14 | Janssen Pharmaceutica Nv | Ligandos para PET de mGluR2 radiomarcados |
PL236355B1 (pl) * | 2015-04-02 | 2021-01-11 | Celon Pharma Spolka Akcyjna | Pochodne 7-(morfolin-4-ylo)pirazolo[1,5-α]pirymidyny jako inhibitory kinazy PI3 |
SI3389727T1 (sl) | 2015-12-18 | 2020-10-30 | Janssen Pharmaceutica Nv | Radioaktivno označeni ligandi PET MGLUR2/3 |
US11045562B2 (en) | 2015-12-18 | 2021-06-29 | Janssen Pharmaceutica Nv | Radiolabelled mGluR2/3 PET ligands |
EP3440080A4 (en) | 2016-04-06 | 2020-01-22 | Lysosomal Therapeutics Inc. | PYRAZOLO [1,5-A] PYRIMIDINYL CARBOXAMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS |
US11124516B2 (en) | 2016-04-06 | 2021-09-21 | BIAL-BioTech Investments, Inc. | Pyrrolo[1,2-A]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders |
MX2018012208A (es) | 2016-04-06 | 2019-03-28 | Lysosomal Therapeutics Inc | Compuestos a base de imidazo [1,5-a] pirimidinil carboxamida y su uso en el tratamiento de trastornos médicos. |
US11345698B2 (en) | 2016-05-05 | 2022-05-31 | Bial—R&D Investments, S.A. | Substituted imidazo[1,2-a]pyridines, substituted imidazo[1,2-a]pyrazines, related compounds, and their use in the treatment of medical disorders |
US11168087B2 (en) | 2016-05-05 | 2021-11-09 | Bial—R&D Investments, S.A. | Substituted imidazo[1,2-b]pyridazines, substituted imidazo[1,5-b]pyridazines, related compounds, and their use in the treatment of medical disorders |
CN110225781B (zh) * | 2017-01-09 | 2022-05-17 | 辉诺生物医药科技(杭州)有限公司 | 噻唑衍生物及其应用 |
CN111601811B (zh) | 2017-11-24 | 2023-05-05 | 住友制药株式会社 | 6,7-二氢吡唑并[1,5-a]吡嗪酮衍生物和其医药用途 |
KR102535452B1 (ko) * | 2018-07-06 | 2023-05-26 | 파에노 테라퓨틱스 씨오., 엘티디. | 티아졸 화합물의 결정형 및 이의 응용 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TR199800792T2 (xx) | 1996-02-07 | 1998-07-21 | Janssen Pharmaceutica N.V. | CRF resept�r antagonistleri olarak pirazolopirimidinler. |
SI0891978T1 (en) | 1997-07-18 | 2002-06-30 | F. Hoffmann-La Roche Ag | 5H-Thiazolo (3,2-a) pyrimidine derivatives |
AU4203500A (en) | 1999-04-06 | 2000-10-23 | Du Pont Pharmaceuticals Company | Pyrazolopyrimidines as crf antagonists |
DK1379511T3 (da) * | 2001-04-12 | 2005-11-07 | Hoffmann La Roche | Dihydro-benzo[b][1,4]diazepin-2-on-derivater som mGLuR2-antagonister II |
ATE387435T1 (de) * | 2003-04-15 | 2008-03-15 | Astrazeneca Ab | Substituirte benzosulfonamide als potenzierungsmittel von glutamatrezeptoren |
US7329662B2 (en) * | 2003-10-03 | 2008-02-12 | Hoffmann-La Roche Inc. | Pyrazolo-pyridine |
JP4608542B2 (ja) * | 2004-06-21 | 2011-01-12 | エフ.ホフマン−ラ ロシュ アーゲー | ピラゾロピリミジン誘導体 |
-
2006
- 2006-02-03 EP EP06706609A patent/EP1851225B1/en not_active Not-in-force
- 2006-02-03 CA CA2597608A patent/CA2597608C/en not_active Expired - Fee Related
- 2006-02-03 JP JP2007554484A patent/JP4708438B2/ja not_active Expired - Fee Related
- 2006-02-03 KR KR1020077018345A patent/KR100968291B1/ko not_active IP Right Cessation
- 2006-02-03 WO PCT/EP2006/000940 patent/WO2006084634A1/en active Application Filing
- 2006-02-03 ES ES06706609T patent/ES2365406T3/es active Active
- 2006-02-03 BR BRPI0607927-0A patent/BRPI0607927A2/pt not_active IP Right Cessation
- 2006-02-03 AU AU2006212457A patent/AU2006212457B2/en not_active Ceased
- 2006-02-03 RU RU2007128624/04A patent/RU2402553C2/ru not_active IP Right Cessation
- 2006-02-03 MX MX2007009106A patent/MX2007009106A/es active IP Right Grant
- 2006-02-03 CN CN2006800046579A patent/CN101115755B/zh not_active Expired - Fee Related
- 2006-02-03 AT AT06706609T patent/ATE512966T1/de active
- 2006-02-06 AR ARP060100412A patent/AR052568A1/es not_active Application Discontinuation
- 2006-02-06 US US11/348,105 patent/US7361659B2/en not_active Expired - Fee Related
- 2006-02-08 TW TW095104260A patent/TW200716120A/zh unknown
-
2007
- 2007-07-19 IL IL184712A patent/IL184712A/en not_active IP Right Cessation
- 2007-07-24 NO NO20073876A patent/NO20073876L/no not_active Application Discontinuation
- 2007-07-31 ZA ZA200706353A patent/ZA200706353B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
IL184712A (en) | 2013-05-30 |
CA2597608A1 (en) | 2006-08-17 |
MX2007009106A (es) | 2007-09-11 |
US7361659B2 (en) | 2008-04-22 |
KR100968291B1 (ko) | 2010-07-07 |
IL184712A0 (en) | 2007-12-03 |
NO20073876L (no) | 2007-09-10 |
US20060183756A1 (en) | 2006-08-17 |
JP2008530042A (ja) | 2008-08-07 |
CN101115755B (zh) | 2013-01-16 |
KR20070104592A (ko) | 2007-10-26 |
TW200716120A (en) | 2007-05-01 |
JP4708438B2 (ja) | 2011-06-22 |
RU2007128624A (ru) | 2009-03-20 |
BRPI0607927A2 (pt) | 2009-10-20 |
CA2597608C (en) | 2013-12-24 |
AU2006212457B2 (en) | 2011-04-14 |
AU2006212457A1 (en) | 2006-08-17 |
WO2006084634A1 (en) | 2006-08-17 |
RU2402553C2 (ru) | 2010-10-27 |
EP1851225A1 (en) | 2007-11-07 |
EP1851225B1 (en) | 2011-06-15 |
ES2365406T3 (es) | 2011-10-04 |
ATE512966T1 (de) | 2011-07-15 |
AR052568A1 (es) | 2007-03-21 |
CN101115755A (zh) | 2008-01-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA200706353B (en) | Pyrazolo-pyrimidine derivatives as mGluR2 antagonists | |
IL185692A0 (en) | Acetylenyl-pyrazolo-pyrimidine derivatives as mglur2 antagonists | |
ZA200803811B (en) | Neuropolin antagonists | |
EP1928237A4 (en) | NEW HETEROCYCLES BASED ON IMIDAZO | |
IL189856A0 (en) | New formulation | |
HK1129305A1 (zh) | 取代的 -氨基-吡咯並三嗪衍生物 | |
PL1879451T3 (pl) | Innowacyjna formulacja | |
TWI370115B (en) | New formulation | |
HK1120269A1 (en) | Pyrimidine derivatives | |
AP2007004047A0 (en) | Substituted triazole derivatives as oxtocin antagonists | |
GB0525080D0 (en) | Pyrimidine derivatives | |
GB0525083D0 (en) | Pyrimidine derivatives | |
IL185326A0 (en) | PYRIDINE-2-CARBOXAMIDE DERIVATIVES AS mGluR5 ANTAGONISTS | |
PL1954674T3 (pl) | Nowe pochodne N-fenetylokarboksyamidu | |
ZA200804335B (en) | Substituted bicyclic pyrimidone derivatives | |
GB0525081D0 (en) | Pyrimidine derivatives | |
GB0526419D0 (en) | Formulation | |
IL184841A0 (en) | Substituted aminoalkyl-and amidoalkyl-benzopyran derivatives | |
GB0517673D0 (en) | Formulation | |
EP1854446A4 (en) | ANTIALLERGIC COMPOSITION | |
IL192308A0 (en) | Oxazoloisoquinoline derivatives as thrombin receptor antagonists | |
GB0501030D0 (en) | Formulation | |
LT1928232T (lt) | Kieta kompozicija | |
GB0508681D0 (en) | Antagonist | |
GB0514579D0 (en) | Substituted benzyloxy-phenylmethylamide derivatives |