ZA200705190B - Novel efficient production process for capsular polysaccharides of pathogenic Gram-positive bacteria by heterologous expression and secretion of complex polysaccharides in non-pathogenic, non-invasive Gram-positive bacteria - Google Patents
Novel efficient production process for capsular polysaccharides of pathogenic Gram-positive bacteria by heterologous expression and secretion of complex polysaccharides in non-pathogenic, non-invasive Gram-positive bacteriaInfo
- Publication number
- ZA200705190B ZA200705190B ZA200705190A ZA200705190A ZA200705190B ZA 200705190 B ZA200705190 B ZA 200705190B ZA 200705190 A ZA200705190 A ZA 200705190A ZA 200705190 A ZA200705190 A ZA 200705190A ZA 200705190 B ZA200705190 B ZA 200705190B
- Authority
- ZA
- South Africa
- Prior art keywords
- pathogenic
- positive bacteria
- gram
- polysaccharides
- secretion
- Prior art date
Links
- 241000192125 Firmicutes Species 0.000 title 2
- 150000004676 glycans Chemical class 0.000 title 2
- 230000001717 pathogenic effect Effects 0.000 title 2
- 229920001282 polysaccharide Polymers 0.000 title 2
- 239000005017 polysaccharide Substances 0.000 title 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 230000028327 secretion Effects 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
- C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/07—Bacillus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/085—Staphylococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04078418 | 2004-12-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200705190B true ZA200705190B (en) | 2008-09-25 |
Family
ID=34928745
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200705190A ZA200705190B (en) | 2004-12-16 | 2007-06-27 | Novel efficient production process for capsular polysaccharides of pathogenic Gram-positive bacteria by heterologous expression and secretion of complex polysaccharides in non-pathogenic, non-invasive Gram-positive bacteria |
Country Status (11)
Country | Link |
---|---|
US (1) | US20080219960A1 (fr) |
EP (1) | EP1828230A2 (fr) |
JP (1) | JP2008523804A (fr) |
KR (1) | KR20070091333A (fr) |
CN (1) | CN101120013A (fr) |
AU (1) | AU2005317302A1 (fr) |
BR (1) | BRPI0519086A2 (fr) |
CA (1) | CA2591421A1 (fr) |
MX (1) | MX2007007291A (fr) |
WO (1) | WO2006065137A2 (fr) |
ZA (1) | ZA200705190B (fr) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2075332B1 (fr) * | 2006-10-27 | 2014-04-16 | Kabushiki Kaisha Yakult Honsha | Gène régulateur de la production de cytokines et utilisation de celui-ci |
CN102869782B (zh) * | 2010-03-01 | 2015-11-25 | 生化学工业株式会社 | 细菌产生软骨素的组合物和方法 |
CN102559705A (zh) * | 2010-10-28 | 2012-07-11 | 内蒙古蒙牛乳业(集团)股份有限公司 | 一种EPS基因簇EpsA、EpsB、EpsC、EpsD |
US10046013B2 (en) | 2011-03-08 | 2018-08-14 | The Trustees Of The University Of Pennsylvania | Engineered bacteria for oral delivery of glucoregulatory proteins |
WO2014013375A1 (fr) | 2012-07-16 | 2014-01-23 | Pfizer Inc. | Saccharides et leurs utilisations |
US10375972B2 (en) * | 2012-08-22 | 2019-08-13 | Kraft Foods Group Brands Llc | Processed cheese with cultured dairy components and method of manufacturing |
GB201222183D0 (en) * | 2012-12-10 | 2013-01-23 | Univ Manchester | Polysaccharides |
EP3011009A4 (fr) * | 2013-06-18 | 2016-11-23 | Novozymes As | Mutants bactériens présentant une efficacité de transformation améliorée |
EP2942396A1 (fr) * | 2014-05-07 | 2015-11-11 | Novartis AG | Polysaccharides produits par mutants CPSC |
BE1022780B1 (fr) * | 2014-05-07 | 2016-09-02 | Glaxosmithkline Biologicals S.A. | Purification des polysaccharides secretes par s. agalactiae |
US9107906B1 (en) | 2014-10-28 | 2015-08-18 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
WO2018152148A1 (fr) * | 2017-02-15 | 2018-08-23 | The Medical College Of Wisconsin, Inc. | Souche bactérienne modifiée réduisant la colonisation à entérocoques résistants aux antibiotiques dans le tractus gastro-intestinal |
US10259865B2 (en) | 2017-03-15 | 2019-04-16 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
KR20200051005A (ko) | 2017-09-07 | 2020-05-12 | 머크 샤프 앤드 돔 코포레이션 | 폐렴구균 폴리사카라이드 및 면역원성 폴리사카라이드-담체 단백질 접합체에서의 그의 용도 |
CN107653260B (zh) * | 2017-11-08 | 2020-11-17 | 中国水产科学研究院珠江水产研究所 | 一种重组乳酸乳球菌的制备方法及应用 |
EA202091382A1 (ru) | 2017-12-06 | 2021-01-15 | Мерк Шарп И Доум Корп. | Композиции, содержащие конъюгаты полисахарид streptococcus pneumoniae с белком, и способы их применения |
CN109182186B (zh) * | 2018-09-19 | 2022-02-01 | 内蒙古大学 | 一种乳酸菌胞外多糖及免疫佐剂 |
TWI788610B (zh) | 2018-12-19 | 2023-01-01 | 美商默沙東有限責任公司 | 包含肺炎鏈球菌多醣-蛋白質結合物之組合物及其使用方法 |
CN109735556A (zh) * | 2019-02-22 | 2019-05-10 | 昆明理工大学 | 引导糖基转移酶基因的用途 |
CN112280795A (zh) * | 2020-11-17 | 2021-01-29 | 昆明理工大学 | 糖基转移酶基因的用途 |
CN112946297A (zh) * | 2021-01-29 | 2021-06-11 | 中南大学湘雅三医院 | 一种解脲支原体感染的诊断标物及其对应的检测试剂盒的制备方法与应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995031548A1 (fr) * | 1994-05-16 | 1995-11-23 | The Uab Research Foundation | Genes de polysaccharide capsulaire de streptococcus pneumoniaeet leurs regions d'encadrement |
GB9700939D0 (en) * | 1997-01-17 | 1997-03-05 | Microbial Technics Limited | Therapy |
-
2005
- 2005-12-16 US US11/722,062 patent/US20080219960A1/en not_active Abandoned
- 2005-12-16 MX MX2007007291A patent/MX2007007291A/es not_active Application Discontinuation
- 2005-12-16 JP JP2007546588A patent/JP2008523804A/ja active Pending
- 2005-12-16 CN CNA2005800481246A patent/CN101120013A/zh active Pending
- 2005-12-16 KR KR1020077016172A patent/KR20070091333A/ko not_active Application Discontinuation
- 2005-12-16 BR BRPI0519086-0A patent/BRPI0519086A2/pt not_active IP Right Cessation
- 2005-12-16 EP EP05851064A patent/EP1828230A2/fr not_active Withdrawn
- 2005-12-16 AU AU2005317302A patent/AU2005317302A1/en not_active Abandoned
- 2005-12-16 WO PCT/NL2005/050079 patent/WO2006065137A2/fr active Application Filing
- 2005-12-16 CA CA002591421A patent/CA2591421A1/fr not_active Abandoned
-
2007
- 2007-06-27 ZA ZA200705190A patent/ZA200705190B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
US20080219960A1 (en) | 2008-09-11 |
WO2006065137A3 (fr) | 2006-10-12 |
AU2005317302A1 (en) | 2006-06-22 |
BRPI0519086A2 (pt) | 2008-12-23 |
KR20070091333A (ko) | 2007-09-10 |
EP1828230A2 (fr) | 2007-09-05 |
CA2591421A1 (fr) | 2006-06-22 |
WO2006065137A2 (fr) | 2006-06-22 |
MX2007007291A (es) | 2007-08-22 |
JP2008523804A (ja) | 2008-07-10 |
CN101120013A (zh) | 2008-02-06 |
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