ZA200705190B - Novel efficient production process for capsular polysaccharides of pathogenic Gram-positive bacteria by heterologous expression and secretion of complex polysaccharides in non-pathogenic, non-invasive Gram-positive bacteria - Google Patents

Novel efficient production process for capsular polysaccharides of pathogenic Gram-positive bacteria by heterologous expression and secretion of complex polysaccharides in non-pathogenic, non-invasive Gram-positive bacteria

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Publication number
ZA200705190B
ZA200705190B ZA200705190A ZA200705190A ZA200705190B ZA 200705190 B ZA200705190 B ZA 200705190B ZA 200705190 A ZA200705190 A ZA 200705190A ZA 200705190 A ZA200705190 A ZA 200705190A ZA 200705190 B ZA200705190 B ZA 200705190B
Authority
ZA
South Africa
Prior art keywords
pathogenic
positive bacteria
gram
polysaccharides
secretion
Prior art date
Application number
ZA200705190A
Other languages
English (en)
Inventor
Nierop Groot Masja Nathalie
Kleerebezem Michiel
De Vos Willem Meindert
Original Assignee
Stichting Top Inst Food And Nu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stichting Top Inst Food And Nu filed Critical Stichting Top Inst Food And Nu
Publication of ZA200705190B publication Critical patent/ZA200705190B/xx

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/07—Bacillus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/085—Staphylococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
ZA200705190A 2004-12-16 2007-06-27 Novel efficient production process for capsular polysaccharides of pathogenic Gram-positive bacteria by heterologous expression and secretion of complex polysaccharides in non-pathogenic, non-invasive Gram-positive bacteria ZA200705190B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04078418 2004-12-16

Publications (1)

Publication Number Publication Date
ZA200705190B true ZA200705190B (en) 2008-09-25

Family

ID=34928745

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200705190A ZA200705190B (en) 2004-12-16 2007-06-27 Novel efficient production process for capsular polysaccharides of pathogenic Gram-positive bacteria by heterologous expression and secretion of complex polysaccharides in non-pathogenic, non-invasive Gram-positive bacteria

Country Status (11)

Country Link
US (1) US20080219960A1 (fr)
EP (1) EP1828230A2 (fr)
JP (1) JP2008523804A (fr)
KR (1) KR20070091333A (fr)
CN (1) CN101120013A (fr)
AU (1) AU2005317302A1 (fr)
BR (1) BRPI0519086A2 (fr)
CA (1) CA2591421A1 (fr)
MX (1) MX2007007291A (fr)
WO (1) WO2006065137A2 (fr)
ZA (1) ZA200705190B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2075332B1 (fr) * 2006-10-27 2014-04-16 Kabushiki Kaisha Yakult Honsha Gène régulateur de la production de cytokines et utilisation de celui-ci
CN102869782B (zh) * 2010-03-01 2015-11-25 生化学工业株式会社 细菌产生软骨素的组合物和方法
CN102559705A (zh) * 2010-10-28 2012-07-11 内蒙古蒙牛乳业（集团）股份有限公司 一种EPS基因簇EpsA、EpsB、EpsC、EpsD
US10046013B2 (en) 2011-03-08 2018-08-14 The Trustees Of The University Of Pennsylvania Engineered bacteria for oral delivery of glucoregulatory proteins
WO2014013375A1 (fr) 2012-07-16 2014-01-23 Pfizer Inc. Saccharides et leurs utilisations
US10375972B2 (en) * 2012-08-22 2019-08-13 Kraft Foods Group Brands Llc Processed cheese with cultured dairy components and method of manufacturing
GB201222183D0 (en) * 2012-12-10 2013-01-23 Univ Manchester Polysaccharides
EP3011009A4 (fr) * 2013-06-18 2016-11-23 Novozymes As Mutants bactériens présentant une efficacité de transformation améliorée
EP2942396A1 (fr) * 2014-05-07 2015-11-11 Novartis AG Polysaccharides produits par mutants CPSC
BE1022780B1 (fr) * 2014-05-07 2016-09-02 Glaxosmithkline Biologicals S.A. Purification des polysaccharides secretes par s. agalactiae
US9107906B1 (en) 2014-10-28 2015-08-18 Adma Biologics, Inc. Compositions and methods for the treatment of immunodeficiency
WO2018152148A1 (fr) * 2017-02-15 2018-08-23 The Medical College Of Wisconsin, Inc. Souche bactérienne modifiée réduisant la colonisation à entérocoques résistants aux antibiotiques dans le tractus gastro-intestinal
US10259865B2 (en) 2017-03-15 2019-04-16 Adma Biologics, Inc. Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection
KR20200051005A (ko) 2017-09-07 2020-05-12 머크 샤프 앤드 돔 코포레이션 폐렴구균 폴리사카라이드 및 면역원성 폴리사카라이드-담체 단백질 접합체에서의 그의 용도
CN107653260B (zh) * 2017-11-08 2020-11-17 中国水产科学研究院珠江水产研究所 一种重组乳酸乳球菌的制备方法及应用
EA202091382A1 (ru) 2017-12-06 2021-01-15 Мерк Шарп И Доум Корп. Композиции, содержащие конъюгаты полисахарид streptococcus pneumoniae с белком, и способы их применения
CN109182186B (zh) * 2018-09-19 2022-02-01 内蒙古大学 一种乳酸菌胞外多糖及免疫佐剂
TWI788610B (zh) 2018-12-19 2023-01-01 美商默沙東有限責任公司 包含肺炎鏈球菌多醣-蛋白質結合物之組合物及其使用方法
CN109735556A (zh) * 2019-02-22 2019-05-10 昆明理工大学 引导糖基转移酶基因的用途
CN112280795A (zh) * 2020-11-17 2021-01-29 昆明理工大学 糖基转移酶基因的用途
CN112946297A (zh) * 2021-01-29 2021-06-11 中南大学湘雅三医院 一种解脲支原体感染的诊断标物及其对应的检测试剂盒的制备方法与应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995031548A1 (fr) * 1994-05-16 1995-11-23 The Uab Research Foundation Genes de polysaccharide capsulaire de streptococcus pneumoniaeet leurs regions d'encadrement
GB9700939D0 (en) * 1997-01-17 1997-03-05 Microbial Technics Limited Therapy

Also Published As

Publication number Publication date
US20080219960A1 (en) 2008-09-11
WO2006065137A3 (fr) 2006-10-12
AU2005317302A1 (en) 2006-06-22
BRPI0519086A2 (pt) 2008-12-23
KR20070091333A (ko) 2007-09-10
EP1828230A2 (fr) 2007-09-05
CA2591421A1 (fr) 2006-06-22
WO2006065137A2 (fr) 2006-06-22
MX2007007291A (es) 2007-08-22
JP2008523804A (ja) 2008-07-10
CN101120013A (zh) 2008-02-06

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