ZA200703981B - Method of determining the concentration of an analyte in a body fluid and system therefor - Google Patents
Method of determining the concentration of an analyte in a body fluid and system therefor Download PDFInfo
- Publication number
- ZA200703981B ZA200703981B ZA200703981A ZA200703981A ZA200703981B ZA 200703981 B ZA200703981 B ZA 200703981B ZA 200703981 A ZA200703981 A ZA 200703981A ZA 200703981 A ZA200703981 A ZA 200703981A ZA 200703981 B ZA200703981 B ZA 200703981B
- Authority
- ZA
- South Africa
- Prior art keywords
- mediation
- layer
- pressure member
- skin
- multilayer film
- Prior art date
Links
- 210000001124 body fluid Anatomy 0.000 title claims description 85
- 239000010839 body fluid Substances 0.000 title claims description 85
- 239000012491 analyte Substances 0.000 title claims description 39
- 238000000034 method Methods 0.000 title description 140
- 239000000463 material Substances 0.000 claims description 105
- 108010010803 Gelatin Proteins 0.000 claims description 44
- 239000008273 gelatin Substances 0.000 claims description 44
- 229920000159 gelatin Polymers 0.000 claims description 44
- 235000019322 gelatine Nutrition 0.000 claims description 44
- 235000011852 gelatine desserts Nutrition 0.000 claims description 44
- 239000003153 chemical reaction reagent Substances 0.000 claims description 23
- 238000003825 pressing Methods 0.000 claims description 22
- 239000006229 carbon black Substances 0.000 claims description 14
- 238000002360 preparation method Methods 0.000 claims description 14
- 239000002250 absorbent Substances 0.000 claims description 13
- 230000002745 absorbent Effects 0.000 claims description 13
- 239000012858 resilient material Substances 0.000 claims description 13
- 210000003491 skin Anatomy 0.000 description 108
- 230000008569 process Effects 0.000 description 74
- 210000003722 extracellular fluid Anatomy 0.000 description 14
- 239000008103 glucose Substances 0.000 description 13
- 239000012530 fluid Substances 0.000 description 12
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 11
- 239000008280 blood Substances 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 8
- 230000005670 electromagnetic radiation Effects 0.000 description 8
- 210000002615 epidermis Anatomy 0.000 description 8
- 238000010438 heat treatment Methods 0.000 description 8
- 238000012544 monitoring process Methods 0.000 description 7
- 210000004207 dermis Anatomy 0.000 description 6
- 230000003287 optical effect Effects 0.000 description 4
- 238000010183 spectrum analysis Methods 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 238000002679 ablation Methods 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 210000000245 forearm Anatomy 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- -1 polyethylene Polymers 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 239000004800 polyvinyl chloride Substances 0.000 description 2
- 238000011002 quantification Methods 0.000 description 2
- 229910052709 silver Inorganic materials 0.000 description 2
- 239000004332 silver Substances 0.000 description 2
- 210000000434 stratum corneum Anatomy 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 229910000530 Gallium indium arsenide Inorganic materials 0.000 description 1
- 208000002705 Glucose Intolerance Diseases 0.000 description 1
- 206010018429 Glucose tolerance impaired Diseases 0.000 description 1
- 208000034693 Laceration Diseases 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000013013 elastic material Substances 0.000 description 1
- 238000000835 electrochemical detection Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000004544 sputter deposition Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15134—Bladeless capillary blood sampling devices, i.e. devices for perforating the skin in order to obtain a blood sample but not using a blade, needle, canula, or lancet, e.g. by laser perforation, suction or pressurized fluids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/14—Devices for taking samples of blood ; Measuring characteristics of blood in vivo, e.g. gas concentration within the blood, pH-value of blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150015—Source of blood
- A61B5/150022—Source of blood for capillary blood or interstitial fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
- A61B5/150061—Means for enhancing collection
- A61B5/150068—Means for enhancing collection by tissue compression, e.g. with specially designed surface of device contacting the skin area to be pierced
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
- A61B5/150106—Means for reducing pain or discomfort applied before puncturing; desensitising the skin at the location where body is to be pierced
- A61B5/150114—Means for reducing pain or discomfort applied before puncturing; desensitising the skin at the location where body is to be pierced by tissue compression, e.g. with specially designed surface of device contacting the skin area to be pierced
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150358—Strips for collecting blood, e.g. absorbent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150755—Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15134—Bladeless capillary blood sampling devices, i.e. devices for perforating the skin in order to obtain a blood sample but not using a blade, needle, canula, or lancet, e.g. by laser perforation, suction or pressurized fluids
- A61B5/15136—Bladeless capillary blood sampling devices, i.e. devices for perforating the skin in order to obtain a blood sample but not using a blade, needle, canula, or lancet, e.g. by laser perforation, suction or pressurized fluids by use of radiation, e.g. laser
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62083504P | 2004-10-21 | 2004-10-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200703981B true ZA200703981B (en) | 2008-08-27 |
Family
ID=35912173
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200703981A ZA200703981B (en) | 2004-10-21 | 2007-05-17 | Method of determining the concentration of an analyte in a body fluid and system therefor |
Country Status (14)
Country | Link |
---|---|
US (1) | US7896819B2 (fr) |
EP (1) | EP1848337A2 (fr) |
JP (1) | JP2008517658A (fr) |
KR (1) | KR20070073918A (fr) |
CN (1) | CN101080200A (fr) |
AU (1) | AU2005299759A1 (fr) |
BR (1) | BRPI0516978A (fr) |
CA (1) | CA2584800A1 (fr) |
MX (1) | MX2007004757A (fr) |
NO (1) | NO20072566L (fr) |
RU (1) | RU2007118684A (fr) |
TW (1) | TW200630070A (fr) |
WO (1) | WO2006047290A2 (fr) |
ZA (1) | ZA200703981B (fr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009042810A2 (fr) * | 2007-09-25 | 2009-04-02 | Isense Corporation | Procédé et appareil pour un traitement cutané avant l'insertion de biocapteur |
JP5178272B2 (ja) * | 2008-03-24 | 2013-04-10 | パナソニック株式会社 | マイクロデバイス |
MX2010006393A (es) * | 2007-12-10 | 2010-06-25 | Bayer Healthcare Llc | Amperimetria regulada de lectura rapida. |
JP2010266203A (ja) * | 2008-05-20 | 2010-11-25 | Sony Corp | 生体情報取得方法及び生体情報取得装置、並びに生理活性物質測定方法及び生理活性物質測定装置 |
JP5816080B2 (ja) * | 2008-05-30 | 2015-11-17 | インテュイティ メディカル インコーポレイテッド | 体液採取装置及び採取部位インターフェイス |
US10549218B2 (en) | 2011-06-27 | 2020-02-04 | Emd Millipore Corporation | Method and apparatus for filtering a liquid sample |
MX369763B (es) | 2014-03-07 | 2019-11-21 | Ascensia Diabetes Care Holdings Ag | Sistemas y metodos de codificacion para la calibracion de biosensores. |
KR101535216B1 (ko) * | 2015-04-02 | 2015-07-09 | (주) 비비비 | 유체 장치 및 이를 포함하는 체액 분석 장치 |
KR101822417B1 (ko) | 2017-06-14 | 2018-01-29 | 주식회사 청도제약 | 인간의 체액에서 산화 스트레스를 측정하기 위한 방법 |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1139896A (en) * | 1963-12-05 | 1969-01-15 | Gevaert Photo Prod Nv | Light- and heat-sensitive recording materials and information recording processes using such materials |
US4959305A (en) * | 1986-06-18 | 1990-09-25 | Miles Inc. | Reversible immobilization of assay reagents in a multizone test device |
US5161532A (en) | 1990-04-19 | 1992-11-10 | Teknekron Sensor Development Corporation | Integral interstitial fluid sensor |
WO1993017719A1 (fr) | 1992-03-13 | 1993-09-16 | Diatech, Inc. | PEPTIDES MARQUES AU TECHNETIUM-99m POUR LA MISE EN IMAGE D'UNE INFLAMMATION |
US6251100B1 (en) | 1993-09-24 | 2001-06-26 | Transmedica International, Inc. | Laser assisted topical anesthetic permeation |
US5582184A (en) | 1993-10-13 | 1996-12-10 | Integ Incorporated | Interstitial fluid collection and constituent measurement |
US20020169394A1 (en) * | 1993-11-15 | 2002-11-14 | Eppstein Jonathan A. | Integrated tissue poration, fluid harvesting and analysis device, and method therefor |
US5885211A (en) | 1993-11-15 | 1999-03-23 | Spectrix, Inc. | Microporation of human skin for monitoring the concentration of an analyte |
JP3328061B2 (ja) | 1994-04-15 | 2002-09-24 | 富士写真フイルム株式会社 | 乾式分析フイルム用カートリッジ |
WO1996007908A1 (fr) * | 1994-09-08 | 1996-03-14 | Lifescan, Inc. | Bandelette a lecture optique et etalon incorpore pour la detection d'un analyte |
ATE237265T1 (de) | 1995-08-29 | 2003-05-15 | Philippe Holder | Stützelement und vorrichtung zum aufhängen und positionieren von gemälden oder dergleichen |
PT1563788E (pt) | 1995-08-29 | 2015-06-02 | Nitto Denko Corp | Microporação de pele humana para distribuição de fármaco e aplicações de monitorização |
US5879367A (en) | 1995-09-08 | 1999-03-09 | Integ, Inc. | Enhanced interstitial fluid collection |
AU7015096A (en) | 1995-09-08 | 1997-04-09 | Integ, Inc. | Body fluid sampler |
US5682233A (en) | 1995-09-08 | 1997-10-28 | Integ, Inc. | Interstitial fluid sampler |
IL120587A (en) * | 1996-04-04 | 2000-10-31 | Lifescan Inc | Reagent test strip for determination of blood glucose |
US5879311A (en) | 1996-05-17 | 1999-03-09 | Mercury Diagnostics, Inc. | Body fluid sampling device and methods of use |
DK0921840T3 (da) | 1996-07-03 | 2003-09-22 | Altea Therapeutics Corp | Multipel mekanisk mikroperforering af hud eller slimhinde |
US6027459A (en) * | 1996-12-06 | 2000-02-22 | Abbott Laboratories | Method and apparatus for obtaining blood for diagnostic tests |
US5913833A (en) | 1997-02-07 | 1999-06-22 | Abbott Laboratories | Method and apparatus for obtaining biological fluids |
US6027496A (en) | 1997-03-25 | 2000-02-22 | Abbott Laboratories | Removal of stratum corneum by means of light |
JP3097600B2 (ja) | 1997-05-30 | 2000-10-10 | 日本電気株式会社 | 角質層穿刺装置 |
US5964718A (en) | 1997-11-21 | 1999-10-12 | Mercury Diagnostics, Inc. | Body fluid sampling device |
US6155992A (en) * | 1997-12-02 | 2000-12-05 | Abbott Laboratories | Method and apparatus for obtaining interstitial fluid for diagnostic tests |
CA2319388C (fr) * | 1998-02-17 | 2007-12-04 | Abbott Laboratories | Dispositif de collecte et de controle de liquide interstitiel |
ATE375752T1 (de) | 1998-03-06 | 2007-11-15 | Spectrx Inc | Integrierte gewebeporations-, flüssigkeitsammel- und analysevorrichtung |
US6022316A (en) * | 1998-03-06 | 2000-02-08 | Spectrx, Inc. | Apparatus and method for electroporation of microporated tissue for enhancing flux rates for monitoring and delivery applications |
US6091975A (en) | 1998-04-01 | 2000-07-18 | Alza Corporation | Minimally invasive detecting device |
US7384396B2 (en) | 1998-07-21 | 2008-06-10 | Spectrx Inc. | System and method for continuous analyte monitoring |
US6132449A (en) * | 1999-03-08 | 2000-10-17 | Agilent Technologies, Inc. | Extraction and transportation of blood for analysis |
US6306152B1 (en) * | 1999-03-08 | 2001-10-23 | Agilent Technologies, Inc. | Lancet device with skin movement control and ballistic preload |
CA2369336A1 (fr) * | 1999-04-22 | 2000-11-02 | Cygnus, Inc. | Hydrogel dans un dispositif iontophoretique pour mesurer le glucose |
DE10030410C1 (de) * | 2000-06-21 | 2002-01-24 | Roche Diagnostics Gmbh | Blutlanzettenvorrichtung zur Entnahme von Blut für Diagnosezwecke |
US6558528B1 (en) * | 2000-12-20 | 2003-05-06 | Lifescan, Inc. | Electrochemical test strip cards that include an integral dessicant |
US20030143113A2 (en) * | 2002-05-09 | 2003-07-31 | Lifescan, Inc. | Physiological sample collection devices and methods of using the same |
US20060184189A1 (en) * | 2002-11-15 | 2006-08-17 | Lorin Olson | Cap for a dermal tissue lancing device |
US20040127818A1 (en) * | 2002-12-27 | 2004-07-01 | Roe Steven N. | Precision depth control lancing tip |
-
2005
- 2005-10-20 RU RU2007118684/14A patent/RU2007118684A/ru not_active Application Discontinuation
- 2005-10-20 AU AU2005299759A patent/AU2005299759A1/en not_active Abandoned
- 2005-10-20 CA CA002584800A patent/CA2584800A1/fr not_active Abandoned
- 2005-10-20 WO PCT/US2005/037901 patent/WO2006047290A2/fr active Application Filing
- 2005-10-20 JP JP2007538065A patent/JP2008517658A/ja not_active Withdrawn
- 2005-10-20 MX MX2007004757A patent/MX2007004757A/es unknown
- 2005-10-20 EP EP05816007A patent/EP1848337A2/fr not_active Withdrawn
- 2005-10-20 US US11/665,118 patent/US7896819B2/en active Active
- 2005-10-20 KR KR1020077011344A patent/KR20070073918A/ko not_active Application Discontinuation
- 2005-10-20 BR BRPI0516978-0A patent/BRPI0516978A/pt not_active IP Right Cessation
- 2005-10-20 CN CNA2005800435286A patent/CN101080200A/zh active Pending
- 2005-10-21 TW TW094137055A patent/TW200630070A/zh unknown
-
2007
- 2007-05-17 ZA ZA200703981A patent/ZA200703981B/en unknown
- 2007-05-21 NO NO20072566A patent/NO20072566L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US20080097240A1 (en) | 2008-04-24 |
WO2006047290A2 (fr) | 2006-05-04 |
CN101080200A (zh) | 2007-11-28 |
CA2584800A1 (fr) | 2006-05-04 |
NO20072566L (no) | 2007-07-17 |
BRPI0516978A (pt) | 2008-09-30 |
RU2007118684A (ru) | 2008-11-27 |
KR20070073918A (ko) | 2007-07-10 |
EP1848337A2 (fr) | 2007-10-31 |
TW200630070A (en) | 2006-09-01 |
JP2008517658A (ja) | 2008-05-29 |
MX2007004757A (es) | 2007-06-25 |
WO2006047290A3 (fr) | 2006-09-21 |
US7896819B2 (en) | 2011-03-01 |
AU2005299759A1 (en) | 2006-05-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US7896819B2 (en) | Method of determining the concentration of an analyte in a body fluid and system in therefor | |
US7374949B2 (en) | Diagnostic test strip for collecting and detecting an analyte in a fluid sample | |
US7264627B2 (en) | Wicking methods and structures for use in sampling bodily fluids | |
US7625457B2 (en) | Dual blade lancing test strip | |
US7476202B2 (en) | Sampling devices and methods utilizing a horizontal capillary test strip | |
US6721586B2 (en) | Percutaneous biological fluid sampling and analyte measurement devices and methods | |
US9022952B2 (en) | Body fluid sampling device | |
JP4365116B2 (ja) | 穿刺針一体型最小観血的光学フォーマット | |
US20030212344A1 (en) | Physiological sample collection devices and methods of using the same | |
JP2001515377A (ja) | 診断テスト用血液の採取方法及び装置 | |
EP1399066B1 (fr) | Dispositifs d'expression de fluides corporels provenant d'une incision | |
JP3853789B2 (ja) | サンプリング装置および段状毛管路を使用する方法 | |
JPH11155844A (ja) | 生体接触面積を一定にした生体計測装置 | |
JPH09117437A (ja) | 無侵襲生化学センサ |