ZA200701881B - Novel heterocyclic NF-KB inhibitors - Google Patents
Novel heterocyclic NF-KB inhibitors Download PDFInfo
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- ZA200701881B ZA200701881B ZA200701881A ZA200701881A ZA200701881B ZA 200701881 B ZA200701881 B ZA 200701881B ZA 200701881 A ZA200701881 A ZA 200701881A ZA 200701881 A ZA200701881 A ZA 200701881A ZA 200701881 B ZA200701881 B ZA 200701881B
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- South Africa
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- alkyl
- aryl
- haloalkyl
- carbonyl
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
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| EP04022363A EP1637529A1 (en) | 2004-09-20 | 2004-09-20 | Novel piperidin-4-yl-thiazole-carboxamide analogues as inhibitors of T-cell proliferation and uses thereof |
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| US7601745B2 (en) | 2004-09-27 | 2009-10-13 | 4Sc Ag | Heterocyclic NF-kB inhibitors |
| CA2589271A1 (en) * | 2004-12-07 | 2006-06-15 | Locus Pharmaceuticals, Inc. | Urea inhibitors of map kinases |
| CA2589274A1 (en) * | 2004-12-07 | 2006-06-15 | Locus Pharmaceuticals, Inc. | Inhibitors of protein kinases |
| DE102005033103A1 (de) * | 2005-07-15 | 2007-01-25 | Bayer Healthcare Ag | Heterocyclylamid-substituierte Thiazole, Pyrrole und Thiophene |
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| WO2007081690A2 (en) * | 2006-01-04 | 2007-07-19 | Locus Pharmaceuticals, Inc. | Inhibitors of protein kinases |
| EP1834954A1 (en) * | 2006-03-15 | 2007-09-19 | 4Sc Ag | Thiazoles as NF-kB Inhibitors (proteasome inhibitors) |
| WO2007115805A2 (en) * | 2006-04-05 | 2007-10-18 | European Molecular Biology Laboratory (Embl) | Aurora kinase inhibitors |
| US20110117121A1 (en) * | 2006-10-27 | 2011-05-19 | James Dao | Compositions for treatment and inhibition of pain |
| CN101573345A (zh) * | 2006-10-31 | 2009-11-04 | 先灵公司 | 作为蛋白激酶抑制剂的2-氨基噻唑-4-甲酰胺 |
| CN101622245B (zh) * | 2007-01-25 | 2014-09-10 | 纳幕尔杜邦公司 | 杀真菌酰胺 |
| EP1977759A1 (en) * | 2007-03-27 | 2008-10-08 | 4Sc Ag | Pharmaceutical composition comprising a cytokine |
| US20080241100A1 (en) * | 2007-03-27 | 2008-10-02 | Stefan Strobl | Pharmaceutical composition comprising a cytokine |
| JP2010522724A (ja) * | 2007-03-27 | 2010-07-08 | ４エスツェー アクチェンゲゼルシャフト | サイトカインを含有する医薬組成物 |
| DE102007047735A1 (de) * | 2007-10-05 | 2009-04-09 | Merck Patent Gmbh | Thiazolderivate |
| PL2206707T3 (pl) * | 2007-10-24 | 2015-01-30 | Astellas Pharma Inc | Związek azolokarboksamidowy lub jego sól |
| KR101058136B1 (ko) * | 2007-11-09 | 2011-08-24 | 신동헌 | 캡시에이트 또는 디하이드로캡시에이트의 신규한 용도 |
| JP2011518109A (ja) * | 2007-11-30 | 2011-06-23 | ビオタ サイエンティフィック マネージメント ピーティーワイ リミテッド | 抗菌剤としてのテトラヒドロ−イソキノリンｐｐａｔ阻害剤 |
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| US8546575B2 (en) * | 2008-05-05 | 2013-10-01 | Merck Patent Gmbh | NIP thiazole derivatives as inhibitors of 11-beta-hydroxysteroid dehydroge-nase-1 |
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| RU2514427C2 (ru) | 2008-06-16 | 2014-04-27 | Юниверсити Оф Теннесси Рисёч Фаундейшн | Соединения для лечения рака |
| US9029408B2 (en) | 2008-06-16 | 2015-05-12 | Gtx, Inc. | Compounds for treatment of cancer |
| US9447049B2 (en) | 2010-03-01 | 2016-09-20 | University Of Tennessee Research Foundation | Compounds for treatment of cancer |
| WO2010001366A1 (en) * | 2008-07-04 | 2010-01-07 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Piperazines derivatives as proteasome modulators |
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| US20110014121A1 (en) * | 2008-11-04 | 2011-01-20 | Chemocentryx, Inc. | Modulators of cxcr7 |
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| AU1930900A (en) | 1998-12-04 | 2000-06-26 | University Of Maryland Biotechnology Institute | Use of protease inhibitors to modulate cellular pathways, immunity and therapiesassociated therewith |
| CN100357267C (zh) * | 1999-04-27 | 2007-12-26 | 诺瓦提斯公司 | 2,4－二氨基－3－羟基羧酸衍生物在制备作为蛋白酶体抑制剂的药物中的用途 |
| DE19921971A1 (de) | 1999-05-12 | 2000-11-16 | Volkswagen Ag | Abgasreinigungsvorrichtung mit NO¶x¶-Speicherkatalysator und Vorkatalysator |
| CA2389685C (fr) * | 1999-11-05 | 2011-07-12 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R) | Nouveaux composes heterocycliques et leur application a titre de medicaments |
| WO2001068648A1 (en) | 2000-03-15 | 2001-09-20 | Aventis Pharma Deutschland Gmbh | Substituted beta-carbolines with ikb-kinase inhibiting activity |
| BR0115454A (pt) * | 2000-11-16 | 2003-09-23 | Sankyo Co | Composto de 1-metilcarbapenem ou um sal ou derivado de éster deste farmaceuticamente aceitável, composição farmacêutica, e, uso de um composto ou de um sal ou derivado de éster deste farmaceuticamente aceitável |
| KR20090090406A (ko) * | 2000-12-18 | 2009-08-25 | 가부시키가이샤 이야쿠 분지 셋케이 겐쿠쇼 | 염증성 사이토카인 생산 유리 억제제 |
| AU2002248432A1 (en) * | 2001-02-14 | 2002-08-28 | Sankyo Company, Limited | Oxazole derivatives, their preparation and their use as cytokine inhibitors |
| DE10208256A1 (de) | 2002-02-26 | 2003-09-04 | Bayer Ag | Piperidinouracile |
| US7345078B2 (en) | 2002-05-31 | 2008-03-18 | The Board Of Trustees Of Michigan State University | NF-κB inhibitors and uses thereof |
| AU2003255240A1 (en) * | 2002-08-09 | 2004-02-25 | Axys Pharmaceuticals | Proteasome inhibitors : peptide derivatives having c-terminal heteroaryl groups |
| AU2003257637A1 (en) | 2002-08-23 | 2004-03-11 | Dainippon Pharmaceutical Co., Ltd. | Proline derivatives |
| DE10252102A1 (de) * | 2002-11-08 | 2004-05-27 | Merck Patent Gmbh | Indolderivate |
| GB0230162D0 (en) * | 2002-12-24 | 2003-02-05 | Metris Therapeutics Ltd | Compounds useful in inhibiting angiogenesis |
| FR2856685B1 (fr) * | 2003-06-25 | 2005-09-23 | Merck Sante Sas | Derives de thiazolylpiperidine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
| CN100509808C (zh) * | 2003-12-08 | 2009-07-08 | 霍夫曼-拉罗奇有限公司 | 新型噻唑衍生物 |
| DE102004006808A1 (de) | 2004-02-11 | 2005-09-01 | Grünenthal GmbH | Substituierte 4,5,6,7-Tetrahydro-benzothiazol-2-ylamin-Verbindungen |
| EP1637529A1 (en) * | 2004-09-20 | 2006-03-22 | 4Sc Ag | Novel piperidin-4-yl-thiazole-carboxamide analogues as inhibitors of T-cell proliferation and uses thereof |
| CN101031567B (zh) * | 2004-09-20 | 2011-12-21 | 4Sc股份有限公司 | 新型杂环NF-κB抑制剂 |
| US7601745B2 (en) * | 2004-09-27 | 2009-10-13 | 4Sc Ag | Heterocyclic NF-kB inhibitors |
| EP1834954A1 (en) * | 2006-03-15 | 2007-09-19 | 4Sc Ag | Thiazoles as NF-kB Inhibitors (proteasome inhibitors) |
-
2004
- 2004-09-20 EP EP04022363A patent/EP1637529A1/en not_active Withdrawn
-
2005
- 2005-07-29 CN CN2010102433714A patent/CN101987847B/zh not_active Expired - Fee Related
- 2005-07-29 NZ NZ588143A patent/NZ588143A/en not_active IP Right Cessation
- 2005-07-29 US US11/192,009 patent/US7812041B2/en not_active Expired - Fee Related
- 2005-07-29 EP EP10193705A patent/EP2343293A1/en not_active Withdrawn
- 2005-07-29 EA EA200900934A patent/EA200900934A1/ru unknown
-
2007
- 2007-03-02 ZA ZA200701881A patent/ZA200701881B/en unknown
-
2009
- 2009-08-24 US US12/546,505 patent/US20100048583A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EA200900934A1 (ru) | 2009-12-30 |
| US7812041B2 (en) | 2010-10-12 |
| EP1637529A1 (en) | 2006-03-22 |
| US20100048583A1 (en) | 2010-02-25 |
| CN101987847A (zh) | 2011-03-23 |
| EP2343293A1 (en) | 2011-07-13 |
| CN101987847B (zh) | 2012-10-10 |
| NZ588143A (en) | 2012-04-27 |
| US20060069102A1 (en) | 2006-03-30 |
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