ZA200701612B - Cyclopropyl piperidine glycine transporter inhibitors - Google Patents
Cyclopropyl piperidine glycine transporter inhibitorsInfo
- Publication number
- ZA200701612B ZA200701612B ZA200701612A ZA200701612A ZA200701612B ZA 200701612 B ZA200701612 B ZA 200701612B ZA 200701612 A ZA200701612 A ZA 200701612A ZA 200701612 A ZA200701612 A ZA 200701612A ZA 200701612 B ZA200701612 B ZA 200701612B
- Authority
- ZA
- South Africa
- Prior art keywords
- glycine transporter
- cyclopropyl piperidine
- transporter inhibitors
- piperidine glycine
- cyclopropyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61494204P | 2004-09-30 | 2004-09-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200701612B true ZA200701612B (en) | 2009-05-27 |
Family
ID=36142986
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200701612A ZA200701612B (en) | 2004-09-30 | 2007-02-23 | Cyclopropyl piperidine glycine transporter inhibitors |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7776886B2 (xx) |
| EP (1) | EP1797035B1 (xx) |
| JP (1) | JP4646984B2 (xx) |
| KR (1) | KR20070058565A (xx) |
| CN (1) | CN101031547A (xx) |
| AT (1) | ATE488501T1 (xx) |
| AU (1) | AU2005292323B2 (xx) |
| BR (1) | BRPI0515954A (xx) |
| CA (1) | CA2581582C (xx) |
| DE (1) | DE602005024838D1 (xx) |
| IL (1) | IL182253A0 (xx) |
| MX (1) | MX2007003816A (xx) |
| NO (1) | NO20072208L (xx) |
| RU (1) | RU2387644C2 (xx) |
| WO (1) | WO2006039221A2 (xx) |
| ZA (1) | ZA200701612B (xx) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2544981A1 (en) * | 2003-11-12 | 2005-05-26 | Merck & Co., Inc. | 4-phenyl piperidine sulfonyl glycine transporter inhibitors |
| JP4756031B2 (ja) * | 2004-03-24 | 2011-08-24 | メルク・シャープ・エンド・ドーム・コーポレイション | ヘテロアリールピペリジングリシン輸送体インヒビター |
| JP2007535538A (ja) * | 2004-04-29 | 2007-12-06 | メルク エンド カムパニー インコーポレーテッド | アゼチジングリシン輸送体インヒビター |
| WO2005107469A2 (en) * | 2004-05-05 | 2005-11-17 | Merck & Co., Inc. | Morpholinyl piperidine glycine transporter inhibitors |
| WO2006067529A1 (en) * | 2004-12-21 | 2006-06-29 | Merck Sharp & Dohme Limited | Piperidine and azetidine derivatives as glyt1 inhibitors |
| WO2006131711A1 (en) * | 2005-06-06 | 2006-12-14 | Merck Sharp & Dohme Limited | Cyclohexanesulfonyl derivatives as glyt1 inhibitors to treat schizophrenia |
| WO2006134341A1 (en) | 2005-06-13 | 2006-12-21 | Merck Sharp & Dohme Limited | Therapeutic agents |
| WO2007053400A2 (en) | 2005-10-28 | 2007-05-10 | Merck & Co., Inc. | Piperidine glycine transporter inhibitors |
| EP2403337A4 (en) * | 2009-03-03 | 2012-08-15 | Univ Vanderbilt | ALKYLSULFONYL-2,3-DIHYDROSPIRO [INDEN-1,4'-PIPERIDIN] ANALOGUE AS A GLYT1 INHIBITOR, METHOD FOR THE PRODUCTION THEREOF, AND ITS USE IN THE TREATMENT OF PSYCHIATRIC ILLNESSES |
| EP3134406A1 (en) | 2014-04-24 | 2017-03-01 | Dart Neuroscience (Cayman) Ltd | Substituted 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole and 4,5,6,7-tetrahydro-2h-pyrazolo [4,3-c]pyridine compounds as glyt1 inhibitors |
| EP3215500A1 (en) | 2014-11-05 | 2017-09-13 | Dart NeuroScience (Cayman) Ltd. | Substituted azetidinyl compounds as glyt1 inhibitors |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5532237A (en) | 1995-02-15 | 1996-07-02 | Merck Frosst Canada, Inc. | Indole derivatives with affinity for the cannabinoid receptor |
| US6303637B1 (en) * | 1998-10-30 | 2001-10-16 | Merck & Co., Inc. | Heterocyclic potassium channel inhibitors |
| US6458790B2 (en) * | 2000-03-23 | 2002-10-01 | Merck & Co., Inc. | Substituted piperidines as melanocortin receptor agonists |
| US7507767B2 (en) | 2001-02-08 | 2009-03-24 | Schering Corporation | Cannabinoid receptor ligands |
| EP1444203A1 (en) * | 2001-11-14 | 2004-08-11 | Schering Corporation | Cannabinoid receptor ligands |
| GB0130696D0 (en) | 2001-12-21 | 2002-02-06 | Smithkline Beecham Plc | Chemical Compounds |
| TW200403058A (en) | 2002-04-19 | 2004-03-01 | Bristol Myers Squibb Co | Heterocyclo inhibitors of potassium channel function |
| CA2544981A1 (en) * | 2003-11-12 | 2005-05-26 | Merck & Co., Inc. | 4-phenyl piperidine sulfonyl glycine transporter inhibitors |
| JP4756031B2 (ja) * | 2004-03-24 | 2011-08-24 | メルク・シャープ・エンド・ドーム・コーポレイション | ヘテロアリールピペリジングリシン輸送体インヒビター |
| JP2007535538A (ja) * | 2004-04-29 | 2007-12-06 | メルク エンド カムパニー インコーポレーテッド | アゼチジングリシン輸送体インヒビター |
| WO2005107469A2 (en) | 2004-05-05 | 2005-11-17 | Merck & Co., Inc. | Morpholinyl piperidine glycine transporter inhibitors |
| WO2006067529A1 (en) | 2004-12-21 | 2006-06-29 | Merck Sharp & Dohme Limited | Piperidine and azetidine derivatives as glyt1 inhibitors |
| WO2006131711A1 (en) * | 2005-06-06 | 2006-12-14 | Merck Sharp & Dohme Limited | Cyclohexanesulfonyl derivatives as glyt1 inhibitors to treat schizophrenia |
| EP1942733B1 (en) | 2005-09-29 | 2012-03-21 | Merck Sharp & Dohme Corp. | Radiolabeled glycine transporter inhibitors |
| WO2007053400A2 (en) | 2005-10-28 | 2007-05-10 | Merck & Co., Inc. | Piperidine glycine transporter inhibitors |
-
2005
- 2005-09-26 WO PCT/US2005/034301 patent/WO2006039221A2/en active Application Filing
- 2005-09-26 US US11/664,190 patent/US7776886B2/en active Active
- 2005-09-26 RU RU2007116165/04A patent/RU2387644C2/ru not_active IP Right Cessation
- 2005-09-26 JP JP2007534679A patent/JP4646984B2/ja not_active Expired - Fee Related
- 2005-09-26 BR BRPI0515954-7A patent/BRPI0515954A/pt not_active IP Right Cessation
- 2005-09-26 MX MX2007003816A patent/MX2007003816A/es active IP Right Grant
- 2005-09-26 AU AU2005292323A patent/AU2005292323B2/en not_active Ceased
- 2005-09-26 AT AT05801197T patent/ATE488501T1/de not_active IP Right Cessation
- 2005-09-26 EP EP05801197A patent/EP1797035B1/en active Active
- 2005-09-26 KR KR1020077007362A patent/KR20070058565A/ko not_active Application Discontinuation
- 2005-09-26 CN CNA2005800331179A patent/CN101031547A/zh active Pending
- 2005-09-26 DE DE602005024838T patent/DE602005024838D1/de active Active
- 2005-09-26 CA CA2581582A patent/CA2581582C/en active Active
-
2007
- 2007-02-23 ZA ZA200701612A patent/ZA200701612B/xx unknown
- 2007-03-27 IL IL182253A patent/IL182253A0/en unknown
- 2007-04-27 NO NO20072208A patent/NO20072208L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US20080108663A1 (en) | 2008-05-08 |
| KR20070058565A (ko) | 2007-06-08 |
| MX2007003816A (es) | 2007-04-24 |
| IL182253A0 (en) | 2007-09-20 |
| CA2581582A1 (en) | 2006-04-13 |
| AU2005292323A1 (en) | 2006-04-13 |
| EP1797035A2 (en) | 2007-06-20 |
| ATE488501T1 (de) | 2010-12-15 |
| US7776886B2 (en) | 2010-08-17 |
| JP2008514705A (ja) | 2008-05-08 |
| DE602005024838D1 (en) | 2010-12-30 |
| JP4646984B2 (ja) | 2011-03-09 |
| RU2387644C2 (ru) | 2010-04-27 |
| NO20072208L (no) | 2007-04-27 |
| EP1797035B1 (en) | 2010-11-17 |
| WO2006039221A2 (en) | 2006-04-13 |
| CN101031547A (zh) | 2007-09-05 |
| BRPI0515954A (pt) | 2008-08-12 |
| CA2581582C (en) | 2010-07-20 |
| RU2007116165A (ru) | 2008-11-10 |
| AU2005292323B2 (en) | 2011-06-09 |
| EP1797035A4 (en) | 2009-08-05 |
| WO2006039221A3 (en) | 2006-09-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL182253A0 (en) | Cyclopropyl piperidine glycine transporter inhibitors | |
| WO2005046601A3 (en) | 4-phenyl piperdine sulfonyl glycine transporter inhibitors | |
| WO2005094514A3 (en) | Heteroaryl piperidine glycine transporter inhibitors | |
| WO2007053400A3 (en) | Piperidine glycine transporter inhibitors | |
| HUS2100051I1 (hu) | Kompozíciók és eljárások sejtproliferációs rendellenességek kezelésére | |
| WO2005107469A3 (en) | Morpholinyl piperidine glycine transporter inhibitors | |
| TW200602052A (en) | Azaindoles useful as inhibitors of JAK and other protein kinases | |
| DE602005025941D1 (de) | Alpha-Aminoamid-Derivate zur Behandlung von Suchtstörungen | |
| WO2007020103A3 (en) | Novel use of peptide compounds for treating muscle pain | |
| TW200800976A (en) | New compounds for the treatment of neurological, psychiatric or pain disorders | |
| SG151327A1 (en) | Deazapurines useful as inhibitors of janus kinases | |
| HK1116349A1 (en) | Pyrrolopyrimidines useful as inhibitors of protein kinase | |
| TW200630090A (en) | Triazoles useful as inhibitors of protein kinases | |
| WO2005120539A3 (en) | Novel use of peptide compounds for treating pain in trigeminal neuralgia | |
| WO2007025069A3 (en) | Diazaspirodecane orexin receptor antagonists | |
| TW200621716A (en) | Novel compounds | |
| TW200724140A (en) | Hydantoin compounds | |
| WO2005117939A3 (en) | Use of GPCR54 ligands for the treatment of infertility | |
| TW200611701A (en) | Novel compounds | |
| EP1814535A4 (en) | NITROSED AND NITROSYLATED COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING EYE DISEASES | |
| MY146238A (en) | Prodrugs of excitatory amino acids | |
| UA85471C2 (ru) | Применение оксикодона для лечения висцеральной боли | |
| HK1121378A1 (en) | Compositions and methods for the treatment of addiction and other neuropsychiatric disorders | |
| IL184355A0 (en) | Sulfanyl substituted phenyl methanones as glycine transporter 1 (glyt-1) inhibitors for the treatment of neurological and neuropsychiatric disorders | |
| WO2007076318A3 (en) | Camphor-derived cxcr3 antagonists |