NO20072208L - Syklopropylpiperidinglysintransportorinhibitorer. - Google Patents

Syklopropylpiperidinglysintransportorinhibitorer.

Info

Publication number
NO20072208L
NO20072208L NO20072208A NO20072208A NO20072208L NO 20072208 L NO20072208 L NO 20072208L NO 20072208 A NO20072208 A NO 20072208A NO 20072208 A NO20072208 A NO 20072208A NO 20072208 L NO20072208 L NO 20072208L
Authority
NO
Norway
Prior art keywords
glycine transporter
transporter glyt1
syklopropylpiperidinglysintransportorinhibitorer
glycinergic
glutamatergic
Prior art date
Application number
NO20072208A
Other languages
English (en)
Inventor
Craig W Lindsley
David D Wisnoski
Scott E Wolkenberg
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of NO20072208L publication Critical patent/NO20072208L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Den foreliggende oppfinnelse er rettet mot syklopropylpiperidinfiorbindelser som inhiberer glysintransportøren GlyTl, og som er anvendbare ved behandlingen av nevrologiske og psykiatriske fiorstyrrelser fiorbundet med glysinerg eller glutamaterg nevrotiansmisjons-dysfimksjon, og sykdommer hvor glysintransportøren GlyTl er involvert.
NO20072208A 2004-09-30 2007-04-27 Syklopropylpiperidinglysintransportorinhibitorer. NO20072208L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61494204P 2004-09-30 2004-09-30
PCT/US2005/034301 WO2006039221A2 (en) 2004-09-30 2005-09-26 Cyclopropyl piperidine glycine transporter inhibitors

Publications (1)

Publication Number Publication Date
NO20072208L true NO20072208L (no) 2007-04-27

Family

ID=36142986

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20072208A NO20072208L (no) 2004-09-30 2007-04-27 Syklopropylpiperidinglysintransportorinhibitorer.

Country Status (16)

Country Link
US (1) US7776886B2 (no)
EP (1) EP1797035B1 (no)
JP (1) JP4646984B2 (no)
KR (1) KR20070058565A (no)
CN (1) CN101031547A (no)
AT (1) ATE488501T1 (no)
AU (1) AU2005292323B2 (no)
BR (1) BRPI0515954A (no)
CA (1) CA2581582C (no)
DE (1) DE602005024838D1 (no)
IL (1) IL182253A0 (no)
MX (1) MX2007003816A (no)
NO (1) NO20072208L (no)
RU (1) RU2387644C2 (no)
WO (1) WO2006039221A2 (no)
ZA (1) ZA200701612B (no)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070105902A1 (en) * 2003-11-12 2007-05-10 Lindsley Craig W 4-Phenyl piperdine sulfonyl glycine transporter inhibitors
CN1933836B (zh) * 2004-03-24 2011-08-17 默沙东公司 杂芳基哌啶甘氨酸转运蛋白抑制剂
JP2007535538A (ja) * 2004-04-29 2007-12-06 メルク　エンド　カムパニー　インコーポレーテッド アゼチジングリシン輸送体インヒビター
US7576083B2 (en) * 2004-05-05 2009-08-18 Merck & Co., Inc. Morpholinyl piperidine glycine transporter inhibitors
DE602005022764D1 (de) * 2004-12-21 2010-09-16 Merck Sharp & Dohme Piperidin- und azetidinderivate als glyt1-inhibitoren
EP1893566B1 (en) * 2005-06-06 2013-02-13 Merck Sharp & Dohme Ltd. Cyclohexanesulfonyl derivatives as glyt1 inhibitors to treat schizophrenia
CA2611376C (en) 2005-06-13 2013-09-10 Merck Sharp & Dohme Limited Therapeutic agents
AU2006309050B2 (en) 2005-10-28 2012-08-16 Merck Sharp & Dohme Corp. Piperidine glycine transporter inhibitors
US8431700B2 (en) 2009-03-03 2013-04-30 Vanderbilt University Alkylsulfonyl-2,3-dihydrospiro[indene-1,4′-piperidine] analogs as GlyT1 inhibitors, methods for making same, and use of same in treating psychiatric disorders
WO2015164520A1 (en) 2014-04-24 2015-10-29 Dart Neuroscience, Llc Substituted 2,4,5,6-tetrahydropyrrolo[3,4-c] pyrazole and 4,5,6,7-tetrahydro-2h-pyrazolo [4,3-c] pyridine compounds as glyt1 inhibitors
EP3215500A1 (en) 2014-11-05 2017-09-13 Dart NeuroScience (Cayman) Ltd. Substituted azetidinyl compounds as glyt1 inhibitors

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5532237A (en) 1995-02-15 1996-07-02 Merck Frosst Canada, Inc. Indole derivatives with affinity for the cannabinoid receptor
US6303637B1 (en) * 1998-10-30 2001-10-16 Merck & Co., Inc. Heterocyclic potassium channel inhibitors
JP2003528088A (ja) * 2000-03-23 2003-09-24 メルク エンド カムパニー インコーポレーテッド メラノコルチン受容体作働薬としての置換ピペリジン類
US7507767B2 (en) 2001-02-08 2009-03-24 Schering Corporation Cannabinoid receptor ligands
NZ532291A (en) * 2001-11-14 2005-11-25 Schering Corp Cannabinoid receptor ligands
GB0130696D0 (en) 2001-12-21 2002-02-06 Smithkline Beecham Plc Chemical Compounds
TW200403058A (en) 2002-04-19 2004-03-01 Bristol Myers Squibb Co Heterocyclo inhibitors of potassium channel function
US20070105902A1 (en) * 2003-11-12 2007-05-10 Lindsley Craig W 4-Phenyl piperdine sulfonyl glycine transporter inhibitors
CN1933836B (zh) 2004-03-24 2011-08-17 默沙东公司 杂芳基哌啶甘氨酸转运蛋白抑制剂
JP2007535538A (ja) * 2004-04-29 2007-12-06 メルク　エンド　カムパニー　インコーポレーテッド アゼチジングリシン輸送体インヒビター
US7576083B2 (en) * 2004-05-05 2009-08-18 Merck & Co., Inc. Morpholinyl piperidine glycine transporter inhibitors
DE602005022764D1 (de) * 2004-12-21 2010-09-16 Merck Sharp & Dohme Piperidin- und azetidinderivate als glyt1-inhibitoren
EP1893566B1 (en) * 2005-06-06 2013-02-13 Merck Sharp & Dohme Ltd. Cyclohexanesulfonyl derivatives as glyt1 inhibitors to treat schizophrenia
EP1942733B1 (en) 2005-09-29 2012-03-21 Merck Sharp & Dohme Corp. Radiolabeled glycine transporter inhibitors
AU2006309050B2 (en) 2005-10-28 2012-08-16 Merck Sharp & Dohme Corp. Piperidine glycine transporter inhibitors

Also Published As

Publication number Publication date
DE602005024838D1 (en) 2010-12-30
US20080108663A1 (en) 2008-05-08
WO2006039221A3 (en) 2006-09-08
IL182253A0 (en) 2007-09-20
ZA200701612B (en) 2009-05-27
JP2008514705A (ja) 2008-05-08
EP1797035B1 (en) 2010-11-17
JP4646984B2 (ja) 2011-03-09
CA2581582A1 (en) 2006-04-13
RU2007116165A (ru) 2008-11-10
EP1797035A4 (en) 2009-08-05
ATE488501T1 (de) 2010-12-15
US7776886B2 (en) 2010-08-17
AU2005292323A1 (en) 2006-04-13
BRPI0515954A (pt) 2008-08-12
CA2581582C (en) 2010-07-20
MX2007003816A (es) 2007-04-24
KR20070058565A (ko) 2007-06-08
WO2006039221A2 (en) 2006-04-13
CN101031547A (zh) 2007-09-05
RU2387644C2 (ru) 2010-04-27
AU2005292323B2 (en) 2011-06-09
EP1797035A2 (en) 2007-06-20

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