ZA200610593B - Diphenylimidazopyrimidine and -imidazole amines as inhibitors of ß-secretase - Google Patents
Diphenylimidazopyrimidine and -imidazole amines as inhibitors of ß-secretaseInfo
- Publication number
- ZA200610593B ZA200610593B ZA200610593A ZA200610593A ZA200610593B ZA 200610593 B ZA200610593 B ZA 200610593B ZA 200610593 A ZA200610593 A ZA 200610593A ZA 200610593 A ZA200610593 A ZA 200610593A ZA 200610593 B ZA200610593 B ZA 200610593B
- Authority
- ZA
- South Africa
- Prior art keywords
- diphenylimidazopyrimidine
- secretase
- inhibitors
- imidazole amines
- imidazole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58018704P | 2004-06-16 | 2004-06-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200610593B true ZA200610593B (en) | 2009-09-30 |
Family
ID=34982285
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200610593A ZA200610593B (en) | 2004-06-16 | 2006-12-15 | Diphenylimidazopyrimidine and -imidazole amines as inhibitors of ß-secretase |
Country Status (24)
Country | Link |
---|---|
US (2) | US7456186B2 (zh) |
EP (1) | EP1758907B1 (zh) |
JP (1) | JP2008503460A (zh) |
KR (1) | KR20070026811A (zh) |
CN (1) | CN1997646A (zh) |
AR (1) | AR049399A1 (zh) |
AT (1) | ATE423121T1 (zh) |
AU (1) | AU2005264917A1 (zh) |
BR (1) | BRPI0512220A (zh) |
CA (1) | CA2578600A1 (zh) |
DE (1) | DE602005012825D1 (zh) |
EC (1) | ECSP067080A (zh) |
ES (1) | ES2321853T3 (zh) |
GT (1) | GT200500157A (zh) |
IL (1) | IL180018A0 (zh) |
MX (1) | MXPA06014792A (zh) |
NO (1) | NO20065847L (zh) |
PA (1) | PA8637201A1 (zh) |
PE (1) | PE20060299A1 (zh) |
RU (1) | RU2006144075A (zh) |
SV (1) | SV2007002146A (zh) |
TW (1) | TW200602048A (zh) |
WO (1) | WO2006009655A1 (zh) |
ZA (1) | ZA200610593B (zh) |
Families Citing this family (77)
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US7700603B2 (en) | 2003-12-15 | 2010-04-20 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
US7592348B2 (en) | 2003-12-15 | 2009-09-22 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
CN1968945A (zh) * | 2004-06-16 | 2007-05-23 | 惠氏公司 | 用于抑制β分泌酶的氨基-5,5-二苯基咪唑酮衍生物 |
CN101027297B (zh) * | 2004-07-28 | 2010-09-08 | 先灵公司 | 大环β-分泌酶抑制剂 |
RU2007126570A (ru) * | 2005-01-14 | 2009-02-20 | Вайет (Us) | Аминоимидазолоны, применяемые для ингибирования бета-секретазы |
WO2006083760A1 (en) * | 2005-02-01 | 2006-08-10 | Wyeth | AMINO-PYRIDINES AS INHIBITORS OF β-SECRETASE |
WO2006088711A1 (en) | 2005-02-14 | 2006-08-24 | Wyeth | AZOLYLACYLGUANIDINES AS β-SECRETASE INHIBITORS |
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AR056865A1 (es) | 2005-06-14 | 2007-10-31 | Schering Corp | Heterociclos nitrogenados y su uso como inhibidores de proteasas, composiciones farmaceuticas |
CN101193859A (zh) * | 2005-06-14 | 2008-06-04 | 先灵公司 | 蛋白酶抑制剂的制备和用途 |
KR20080015861A (ko) | 2005-06-14 | 2008-02-20 | 쉐링 코포레이션 | 아스파르틸 프로테아제 억제제로서의 화합물의 제조방법 및용도 |
SG162790A1 (en) | 2005-06-14 | 2010-07-29 | Schering Corp | Aspartyl protease inhibitors |
ATE482214T1 (de) * | 2005-06-14 | 2010-10-15 | Schering Corp | Aspartylproteasehemmer |
EP1891021B1 (en) * | 2005-06-14 | 2019-01-23 | Merck Sharp & Dohme Corp. | Aspartyl protease inhibitors |
TW200738683A (en) * | 2005-06-30 | 2007-10-16 | Wyeth Corp | Amino-5-(5-membered)heteroarylimidazolone compounds and the use thereof for β-secretase modulation |
CA2613435A1 (en) * | 2005-06-30 | 2007-01-11 | Wyeth | Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for .beta.-secretase modulation |
TW200730523A (en) * | 2005-07-29 | 2007-08-16 | Wyeth Corp | Cycloalkyl amino-hydantoin compounds and use thereof for β-secretase modulation |
JP2009507032A (ja) * | 2005-09-02 | 2009-02-19 | アボット・ラボラトリーズ | 新規なイミダゾ系複素環 |
WO2007038271A1 (en) * | 2005-09-26 | 2007-04-05 | Wyeth | Amino-5- [4- (difluoromethoxy) phenyl] -5-phenylimidazolone compounds as inhibitors of the beta-secretase (bace) |
CN103936690B (zh) | 2005-10-25 | 2016-06-08 | 盐野义制药株式会社 | 氨基二氢噻嗪衍生物 |
WO2007078813A2 (en) * | 2005-12-19 | 2007-07-12 | Wyeth | 2-AMINO-5-PIPERIDINYLIMIDAZOLONE COMPOUNDS AND USE THEREOF FOR β-SECRETASE MODULATION |
WO2007100536A1 (en) * | 2006-02-24 | 2007-09-07 | Wyeth | DIHYDROSPIRO[DIBENZO[A,D][7]ANNULENE-5,4'-IMIDAZOL] COMPOUNDS FOR THE INHIBITION OF β-SECRETASE |
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TW200815449A (en) * | 2006-06-14 | 2008-04-01 | Astrazeneca Ab | Novel compounds II |
TW200815443A (en) * | 2006-06-14 | 2008-04-01 | Astrazeneca Ab | Novel compounds I |
TW200808796A (en) * | 2006-06-14 | 2008-02-16 | Astrazeneca Ab | New compounds III |
TW200815447A (en) * | 2006-06-14 | 2008-04-01 | Astrazeneca Ab | Novel compounds IV |
TW200815349A (en) * | 2006-06-22 | 2008-04-01 | Astrazeneca Ab | New compounds |
US7700606B2 (en) * | 2006-08-17 | 2010-04-20 | Wyeth Llc | Imidazole amines as inhibitors of β-secretase |
TW200817406A (en) * | 2006-08-17 | 2008-04-16 | Wyeth Corp | Imidazole amines as inhibitors of β-secretase |
JP2010504326A (ja) * | 2006-09-21 | 2010-02-12 | ワイス エルエルシー | β−セクレターゼを阻害するためのインドリルアルキルピリジン−2−アミン |
WO2008063114A1 (en) * | 2006-11-20 | 2008-05-29 | Astrazeneca Ab | Amino- imidazolones and their use as medicament for treating cognitive impairment alzheimer disease, neurodegeneration and dementia |
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MX2010013256A (es) | 2008-06-13 | 2010-12-21 | Shionogi & Co | Derivado heterociclico que contiene azufre que tiene actividad inhibitoria de beta-secretasa. |
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JP5417860B2 (ja) * | 2008-08-26 | 2014-02-19 | 住友化学株式会社 | α−ヒドロキシエステル類の製造方法 |
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CA2867891C (en) | 2012-03-19 | 2021-09-14 | Buck Institute For Research On Aging | App specific bace inhibitors (asbis) and uses thereof |
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JP2016501827A (ja) | 2012-10-24 | 2016-01-21 | 塩野義製薬株式会社 | Bace1阻害作用を有するジヒドロオキサジンまたはオキサゼピン誘導体 |
KR102051485B1 (ko) | 2013-02-12 | 2019-12-03 | 버크 인스티튜트 포 리서치 온 에이징 | Bace 매개 app 처리과정을 조절하는 히단토인 |
KR101668857B1 (ko) | 2015-01-08 | 2016-10-24 | 한양대학교 에리카산학협력단 | 이미다졸-1-일 피리미딘 유도체, 또는 이의 약학적으로 허용가능한 염 및 이를 유효성분으로 포함하는 약학적 조성물 |
JP7268049B2 (ja) | 2018-03-08 | 2023-05-02 | インサイト・コーポレイション | PI3K-γ阻害剤としてのアミノピラジンジオール化合物 |
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WO2007100536A1 (en) | 2006-02-24 | 2007-09-07 | Wyeth | DIHYDROSPIRO[DIBENZO[A,D][7]ANNULENE-5,4'-IMIDAZOL] COMPOUNDS FOR THE INHIBITION OF β-SECRETASE |
US7700606B2 (en) | 2006-08-17 | 2010-04-20 | Wyeth Llc | Imidazole amines as inhibitors of β-secretase |
-
2005
- 2005-06-14 JP JP2007516603A patent/JP2008503460A/ja active Pending
- 2005-06-14 AT AT05758187T patent/ATE423121T1/de not_active IP Right Cessation
- 2005-06-14 EP EP05758187A patent/EP1758907B1/en active Active
- 2005-06-14 WO PCT/US2005/020736 patent/WO2006009655A1/en active Application Filing
- 2005-06-14 PE PE2005000678A patent/PE20060299A1/es not_active Application Discontinuation
- 2005-06-14 RU RU2006144075/04A patent/RU2006144075A/ru not_active Application Discontinuation
- 2005-06-14 BR BRPI0512220-1A patent/BRPI0512220A/pt not_active IP Right Cessation
- 2005-06-14 KR KR1020077000970A patent/KR20070026811A/ko not_active Application Discontinuation
- 2005-06-14 CA CA002578600A patent/CA2578600A1/en not_active Abandoned
- 2005-06-14 ES ES05758187T patent/ES2321853T3/es active Active
- 2005-06-14 CN CNA2005800194504A patent/CN1997646A/zh active Pending
- 2005-06-14 AU AU2005264917A patent/AU2005264917A1/en not_active Abandoned
- 2005-06-14 MX MXPA06014792A patent/MXPA06014792A/es active IP Right Grant
- 2005-06-14 DE DE602005012825T patent/DE602005012825D1/de active Active
- 2005-06-14 TW TW094119581A patent/TW200602048A/zh unknown
- 2005-06-15 AR ARP050102450A patent/AR049399A1/es unknown
- 2005-06-15 US US11/152,925 patent/US7456186B2/en not_active Expired - Fee Related
- 2005-06-15 PA PA20058637201A patent/PA8637201A1/es unknown
- 2005-06-16 SV SV2005002146A patent/SV2007002146A/es unknown
- 2005-06-16 GT GT200500157A patent/GT200500157A/es unknown
-
2006
- 2006-12-12 IL IL180018A patent/IL180018A0/en unknown
- 2006-12-13 EC EC2006007080A patent/ECSP067080A/es unknown
- 2006-12-15 ZA ZA200610593A patent/ZA200610593B/xx unknown
- 2006-12-18 NO NO20065847A patent/NO20065847L/no not_active Application Discontinuation
-
2008
- 2008-10-07 US US12/246,790 patent/US20090042912A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ATE423121T1 (de) | 2009-03-15 |
CA2578600A1 (en) | 2006-01-26 |
WO2006009655A1 (en) | 2006-01-26 |
JP2008503460A (ja) | 2008-02-07 |
US20090042912A1 (en) | 2009-02-12 |
PA8637201A1 (es) | 2006-06-02 |
AR049399A1 (es) | 2006-07-26 |
SV2007002146A (es) | 2007-03-20 |
US7456186B2 (en) | 2008-11-25 |
GT200500157A (es) | 2006-11-07 |
BRPI0512220A (pt) | 2008-02-19 |
ES2321853T3 (es) | 2009-06-12 |
AU2005264917A1 (en) | 2006-01-26 |
PE20060299A1 (es) | 2006-05-18 |
EP1758907B1 (en) | 2009-02-18 |
IL180018A0 (en) | 2007-05-15 |
CN1997646A (zh) | 2007-07-11 |
TW200602048A (en) | 2006-01-16 |
EP1758907A1 (en) | 2007-03-07 |
US20050282826A1 (en) | 2005-12-22 |
ECSP067080A (es) | 2007-05-30 |
RU2006144075A (ru) | 2008-07-27 |
DE602005012825D1 (de) | 2009-04-02 |
NO20065847L (no) | 2006-12-18 |
KR20070026811A (ko) | 2007-03-08 |
MXPA06014792A (es) | 2007-02-16 |
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