ZA200610593B - Diphenylimidazopyrimidine and -imidazole amines as inhibitors of ß-secretase - Google Patents

Diphenylimidazopyrimidine and -imidazole amines as inhibitors of ß-secretase

Info

Publication number
ZA200610593B
ZA200610593B ZA200610593A ZA200610593A ZA200610593B ZA 200610593 B ZA200610593 B ZA 200610593B ZA 200610593 A ZA200610593 A ZA 200610593A ZA 200610593 A ZA200610593 A ZA 200610593A ZA 200610593 B ZA200610593 B ZA 200610593B
Authority
ZA
South Africa
Prior art keywords
diphenylimidazopyrimidine
secretase
inhibitors
imidazole amines
imidazole
Prior art date
Application number
ZA200610593A
Other languages
English (en)
Inventor
Malamas Michael Sotirios
Gunawan Iwan Suwandi
Johnson Matthew Robert
Erdei James Joseph
Barnes Keith Douglas
Hui Yu
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of ZA200610593B publication Critical patent/ZA200610593B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA200610593A 2004-06-16 2006-12-15 Diphenylimidazopyrimidine and -imidazole amines as inhibitors of ß-secretase ZA200610593B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US58018704P 2004-06-16 2004-06-16

Publications (1)

Publication Number Publication Date
ZA200610593B true ZA200610593B (en) 2009-09-30

Family

ID=34982285

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200610593A ZA200610593B (en) 2004-06-16 2006-12-15 Diphenylimidazopyrimidine and -imidazole amines as inhibitors of ß-secretase

Country Status (24)

Country Link
US (2) US7456186B2 (zh)
EP (1) EP1758907B1 (zh)
JP (1) JP2008503460A (zh)
KR (1) KR20070026811A (zh)
CN (1) CN1997646A (zh)
AR (1) AR049399A1 (zh)
AT (1) ATE423121T1 (zh)
AU (1) AU2005264917A1 (zh)
BR (1) BRPI0512220A (zh)
CA (1) CA2578600A1 (zh)
DE (1) DE602005012825D1 (zh)
EC (1) ECSP067080A (zh)
ES (1) ES2321853T3 (zh)
GT (1) GT200500157A (zh)
IL (1) IL180018A0 (zh)
MX (1) MXPA06014792A (zh)
NO (1) NO20065847L (zh)
PA (1) PA8637201A1 (zh)
PE (1) PE20060299A1 (zh)
RU (1) RU2006144075A (zh)
SV (1) SV2007002146A (zh)
TW (1) TW200602048A (zh)
WO (1) WO2006009655A1 (zh)
ZA (1) ZA200610593B (zh)

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TW200815443A (en) * 2006-06-14 2008-04-01 Astrazeneca Ab Novel compounds I
TW200808796A (en) * 2006-06-14 2008-02-16 Astrazeneca Ab New compounds III
TW200815447A (en) * 2006-06-14 2008-04-01 Astrazeneca Ab Novel compounds IV
TW200815349A (en) * 2006-06-22 2008-04-01 Astrazeneca Ab New compounds
US7700606B2 (en) * 2006-08-17 2010-04-20 Wyeth Llc Imidazole amines as inhibitors of β-secretase
TW200817406A (en) * 2006-08-17 2008-04-16 Wyeth Corp Imidazole amines as inhibitors of β-secretase
JP2010504326A (ja) * 2006-09-21 2010-02-12 ワイス エルエルシー β−セクレターゼを阻害するためのインドリルアルキルピリジン−２−アミン
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CL2007003410A1 (es) * 2006-11-28 2008-04-11 Wyeth Corp Compuestos derivados de 5-fluoro-8-{4-[4-(6-metoxiquinolin-8-il)piperazin-1-il]piperidin-1-il}quinolina; procedimiento de preparacion; compuestos intermediarios; procedimiento de preparacion; composicion farmaceutica; y uso en el tratamiento de trast
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Also Published As

Publication number Publication date
ATE423121T1 (de) 2009-03-15
CA2578600A1 (en) 2006-01-26
WO2006009655A1 (en) 2006-01-26
JP2008503460A (ja) 2008-02-07
US20090042912A1 (en) 2009-02-12
PA8637201A1 (es) 2006-06-02
AR049399A1 (es) 2006-07-26
SV2007002146A (es) 2007-03-20
US7456186B2 (en) 2008-11-25
GT200500157A (es) 2006-11-07
BRPI0512220A (pt) 2008-02-19
ES2321853T3 (es) 2009-06-12
AU2005264917A1 (en) 2006-01-26
PE20060299A1 (es) 2006-05-18
EP1758907B1 (en) 2009-02-18
IL180018A0 (en) 2007-05-15
CN1997646A (zh) 2007-07-11
TW200602048A (en) 2006-01-16
EP1758907A1 (en) 2007-03-07
US20050282826A1 (en) 2005-12-22
ECSP067080A (es) 2007-05-30
RU2006144075A (ru) 2008-07-27
DE602005012825D1 (de) 2009-04-02
NO20065847L (no) 2006-12-18
KR20070026811A (ko) 2007-03-08
MXPA06014792A (es) 2007-02-16

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