ZA200610102B - Pyrrazolo-pyrimidine derivatives - Google Patents

Pyrrazolo-pyrimidine derivatives

Info

Publication number
ZA200610102B
ZA200610102B ZA200610102A ZA200610102A ZA200610102B ZA 200610102 B ZA200610102 B ZA 200610102B ZA 200610102 A ZA200610102 A ZA 200610102A ZA 200610102 A ZA200610102 A ZA 200610102A ZA 200610102 B ZA200610102 B ZA 200610102B
Authority
ZA
South Africa
Prior art keywords
pyrrazolo
pyrimidine derivatives
pyrimidine
derivatives
Prior art date
Application number
ZA200610102A
Other languages
English (en)
Inventor
Goetschi Erwin
Woltering Thomas Johannes
Wichmann Juergen
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ZA200610102B publication Critical patent/ZA200610102B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA200610102A 2004-06-21 2006-12-01 Pyrrazolo-pyrimidine derivatives ZA200610102B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04102837 2004-06-21

Publications (1)

Publication Number Publication Date
ZA200610102B true ZA200610102B (en) 2008-08-27

Family

ID=34971089

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200610102A ZA200610102B (en) 2004-06-21 2006-12-01 Pyrrazolo-pyrimidine derivatives

Country Status (26)

Country Link
US (1) US7378417B2 (es)
EP (1) EP1761541B1 (es)
JP (1) JP4608542B2 (es)
CN (1) CN100528876C (es)
AR (1) AR049521A1 (es)
AT (1) ATE383361T1 (es)
AU (1) AU2005254657B2 (es)
BR (1) BRPI0512330A (es)
CA (1) CA2571487C (es)
DE (1) DE602005004287T2 (es)
DK (1) DK1761541T3 (es)
ES (1) ES2299044T3 (es)
HK (1) HK1105971A1 (es)
HR (1) HRP20080070T3 (es)
IL (1) IL179736A (es)
MX (1) MXPA06014809A (es)
MY (1) MY143368A (es)
NO (1) NO20070249L (es)
NZ (1) NZ551660A (es)
PL (1) PL1761541T3 (es)
PT (1) PT1761541E (es)
RU (1) RU2378277C2 (es)
SI (1) SI1761541T1 (es)
TW (1) TWI301835B (es)
WO (1) WO2005123738A1 (es)
ZA (1) ZA200610102B (es)

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BRPI0607927A2 (pt) * 2005-02-11 2009-10-20 Hoffmann La Roche derivados de pirazol-pirimidina
BRPI0609719B8 (pt) 2005-03-23 2021-05-25 Hoffmann La Roche derivados de acetilenil-pirazol-pirimidina como antagonistas de mgbur2
BRPI0616571A2 (pt) 2005-09-27 2011-06-21 Hoffmann La Roche oxadiazolil pirazol-piridiminas como antagonistas de mglur2, processo para sua preparação, composição farmacêutica que os contém e uso dos mesmo
WO2007048065A2 (en) * 2005-10-21 2007-04-26 Exelixis, Inc. Pyrimidinones as casein kinase ii (ck2) modulators
WO2009014620A1 (en) * 2007-07-20 2009-01-29 Merck & Co., Inc. Pyrazolo[1,5-a]pyrimidine derivatives
CN102271515B (zh) * 2008-10-31 2014-07-02 健泰科生物技术公司 吡唑并嘧啶jak抑制剂化合物和方法
AR078171A1 (es) 2009-09-15 2011-10-19 Sanofi Aventis Dihidrobenzocicloalquiloximetil-oxazolopirimidinonas sustituidas, preparacion y uso de las mismas
WO2012075393A2 (en) * 2010-12-02 2012-06-07 President And Fellows Of Harvard College Activators of proteasomal degradation and uses thereof
ES2912284T3 (es) * 2010-12-08 2022-05-25 Us Health Pirazolopirimidinas sustituidas como activadoras de la glucocerebrosidasa
WO2012149157A2 (en) 2011-04-26 2012-11-01 Bioenergenix Heterocyclic compounds for the inhibition of pask
JP2015512913A (ja) 2012-03-28 2015-04-30 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ グルコセレブロシダーゼ活性剤として有用なサリチル酸誘導体
CN104736140A (zh) 2012-10-23 2015-06-24 霍夫曼-拉罗奇有限公司 用于治疗自闭症的mGlu2/3拮抗剂
US9278973B2 (en) 2012-10-25 2016-03-08 Bioenergenix Llc Heterocyclic compounds for the inhibition of PASK
WO2014066795A1 (en) 2012-10-25 2014-05-01 Bioenergenix Heterocyclic compounds for the inhibition of pask
EP3134089A2 (en) 2014-04-23 2017-03-01 F. Hoffmann-La Roche AG Mglu2/3 antagonists for the treatment of intellectual disabilities
JOP20150179B1 (ar) 2014-08-01 2021-08-17 Janssen Pharmaceutica Nv مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2
EP3000814A1 (en) 2014-09-26 2016-03-30 Domain Therapeutics Substituted pyrazoloquinazolinones and pyrroloquinazolinones as allosteric modulators of group II metabotropic glutamate receptors
JP6734860B2 (ja) 2014-11-06 2020-08-05 リソソーマル・セラピューティクス・インコーポレイテッドＬｙｓｏｓｏｍａｌ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． 置換ピラゾロ［１，５−ａ］ピリミジンおよび医療疾患の治療におけるその使用
ES2958391T3 (es) 2014-11-06 2024-02-08 Bial R&D Invest S A Imidazo[1,5-a]pirimidinas sustituidas y su uso en el tratamiento de trastornos médicos
US20180185368A1 (en) 2014-11-06 2018-07-05 Lysosomal Therapeutics Inc. Substituted pyrrolo[1,2-a]pyrimidines and their use in the treatment of medical disorders
WO2016087489A1 (en) 2014-12-03 2016-06-09 Janssen Pharmaceutica Nv Radiolabelled mglur2 pet ligands
WO2017066428A1 (en) 2015-10-13 2017-04-20 H. Lee Moffitt Cancer Center & Research Institute, Inc. Brd4-kinase inhibitors as cancer therapeutics
US11045562B2 (en) 2015-12-18 2021-06-29 Janssen Pharmaceutica Nv Radiolabelled mGluR2/3 PET ligands
JP6927974B2 (ja) 2015-12-18 2021-09-01 ヤンセン ファーマシューティカ エヌ．ベー． 放射性標識ｍＧｌｕＲ２／３ＰＥＴリガンド
EP3440083A4 (en) 2016-04-06 2019-09-18 Lysosomal Therapeutics Inc. IMIDAZO [1,5-A] PYRIMIDINYL-CARBOXAMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDER
AU2017246455B2 (en) * 2016-04-06 2021-09-30 Bial - R&D Investments, S.A. Pyrazolo[1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
US11124516B2 (en) 2016-04-06 2021-09-21 BIAL-BioTech Investments, Inc. Pyrrolo[1,2-A]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
SG11201809693SA (en) 2016-05-05 2018-11-29 Lysosomal Therapeutics Inc SUBSTITUTED IMIDAZO[1,2-b]PYRIDAZINES, SUBSTITUTED IMIDAZO[1,5-b]PYRIDAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
WO2017192931A1 (en) 2016-05-05 2017-11-09 Lysosomal Therapeutics Inc. SUBSTITUTED IMDAZO[1,2-α]PYRIDINES, SUBSTITUTED IMIDAZO[1,2-α]PYRAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
US11414431B2 (en) 2018-10-15 2022-08-16 Nimbus Lakshmi, Inc. Substituted pyrazolo[1,5-a]pyrimidines as TYK2 inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5017212A (en) * 1986-03-20 1991-05-21 Takeda Chemical Industries, Ltd. Sulfonylurea compounds and herbicidal use
SI0891978T1 (en) * 1997-07-18 2002-06-30 F. Hoffmann-La Roche Ag 5H-Thiazolo (3,2-a) pyrimidine derivatives
YU23802A (sh) * 1999-09-30 2004-09-03 Neurogen Corporation Određeni alkilen diamin-supstituisani pirazolo/1,5-a/-1,5- piramidini i pirazolo/1,5-a/1,3,5-triazini
IL164187A0 (en) * 2002-03-28 2005-12-18 Eisai Co Ltd 7-Azaindole derivatives and pharmaceutical compositions containing the same
US7329662B2 (en) * 2003-10-03 2008-02-12 Hoffmann-La Roche Inc. Pyrazolo-pyridine

Also Published As

Publication number Publication date
JP4608542B2 (ja) 2011-01-12
WO2005123738A1 (en) 2005-12-29
EP1761541A1 (en) 2007-03-14
CN100528876C (zh) 2009-08-19
CN1964973A (zh) 2007-05-16
US7378417B2 (en) 2008-05-27
MXPA06014809A (es) 2007-02-12
NZ551660A (en) 2009-08-28
ES2299044T3 (es) 2008-05-16
BRPI0512330A (pt) 2008-02-26
JP2008503510A (ja) 2008-02-07
HRP20080070T3 (en) 2008-05-31
CA2571487A1 (en) 2005-12-29
CA2571487C (en) 2013-04-30
PL1761541T3 (pl) 2008-06-30
DE602005004287T2 (de) 2008-12-24
DE602005004287D1 (de) 2008-02-21
ATE383361T1 (de) 2008-01-15
EP1761541B1 (en) 2008-01-09
IL179736A0 (en) 2007-05-15
RU2378277C2 (ru) 2010-01-10
IL179736A (en) 2010-12-30
US20050282827A1 (en) 2005-12-22
SI1761541T1 (sl) 2008-06-30
MY143368A (en) 2011-04-29
NO20070249L (no) 2007-02-15
PT1761541E (pt) 2008-03-13
TWI301835B (en) 2008-10-11
AR049521A1 (es) 2006-08-09
HK1105971A1 (en) 2008-02-29
AU2005254657B2 (en) 2011-03-17
TW200626598A (en) 2006-08-01
DK1761541T3 (da) 2008-04-28
AU2005254657A1 (en) 2005-12-29
RU2006143571A (ru) 2008-07-27

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