ZA200609930B - Macromolecular peg conjucates by four-component condensation - Google Patents

Macromolecular peg conjucates by four-component condensation

Info

Publication number
ZA200609930B
ZA200609930B ZA200609930A ZA200609930A ZA200609930B ZA 200609930 B ZA200609930 B ZA 200609930B ZA 200609930 A ZA200609930 A ZA 200609930A ZA 200609930 A ZA200609930 A ZA 200609930A ZA 200609930 B ZA200609930 B ZA 200609930B
Authority
ZA
South Africa
Prior art keywords
conjucates
component condensation
macromolecular
peg
macromolecular peg
Prior art date
Application number
ZA200609930A
Other languages
English (en)
Inventor
Zalipsky Samuel
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of ZA200609930B publication Critical patent/ZA200609930B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
ZA200609930A 2004-06-08 2005-06-08 Macromolecular peg conjucates by four-component condensation ZA200609930B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57819904P 2004-06-08 2004-06-08

Publications (1)

Publication Number Publication Date
ZA200609930B true ZA200609930B (en) 2009-01-28

Family

ID=35355954

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200609930A ZA200609930B (en) 2004-06-08 2005-06-08 Macromolecular peg conjucates by four-component condensation

Country Status (12)

Country Link
US (1) US7476725B2 (es)
EP (1) EP1761282A2 (es)
JP (1) JP2008502788A (es)
KR (1) KR20070027621A (es)
CN (1) CN1997401A (es)
AU (1) AU2005253979A1 (es)
CA (1) CA2568388A1 (es)
IL (1) IL179303A0 (es)
MX (1) MXPA06014307A (es)
NO (1) NO20070114L (es)
WO (1) WO2005123140A2 (es)
ZA (1) ZA200609930B (es)

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JP2008505853A (ja) 2004-04-13 2008-02-28 クインテセンス バイオサイエンシーズ インコーポレーティッド 細胞傷害性薬剤としての非天然のリボヌクレアーゼ複合体
EP2007538A4 (en) * 2006-03-31 2011-04-20 Centocor Ortho Biotech Inc BINDING PARTNER WITH MODIFIED IMMUNOGLOBULINDOMAS FOR EXTENDED SEMI-VALUE TIME
US20090285780A1 (en) * 2006-05-24 2009-11-19 Chyi Lee Peg linker compounds and biologically active conjugates thereof
EP2044097A4 (en) 2006-06-23 2010-10-06 Quintessence Biosciences Inc MODIFIED RIBONUCLEASES
CN101495155A (zh) 2006-07-07 2009-07-29 诺沃-诺迪斯克保健股份有限公司 新的蛋白结合物及其制备方法
US8298801B2 (en) * 2006-07-17 2012-10-30 Quintessence Biosciences, Inc. Methods and compositions for the treatment of cancer
CA2702043A1 (en) 2007-10-08 2009-04-16 Quintessence Biosciences, Inc. Compositions and methods for ribonuclease-based therapies
KR100967833B1 (ko) * 2008-05-20 2010-07-05 아이디비켐(주) 고순도의 폴리에틸렌글리콜 알데하이드 유도체의 제조방법
US8029782B2 (en) 2008-10-01 2011-10-04 Quintessence Biosciences, Inc. Therapeutic ribonucleases
US8815226B2 (en) 2011-06-10 2014-08-26 Mersana Therapeutics, Inc. Protein-polymer-drug conjugates
WO2012171020A1 (en) * 2011-06-10 2012-12-13 Mersana Therapeutics, Inc. Protein-polymer-drug conjugates
JP5841768B2 (ja) * 2011-08-05 2016-01-13 花王株式会社 脂肪蓄積抑制剤

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US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4766106A (en) 1985-06-26 1988-08-23 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
US4917888A (en) 1985-06-26 1990-04-17 Cetus Corporation Solubilization of immunotoxins for pharmaceutical compositions using polymer conjugation
US5103556A (en) 1988-05-05 1992-04-14 Circon Corporation Method of manufacturing an electrohydraulic probe
US4902502A (en) 1989-01-23 1990-02-20 Cetus Corporation Preparation of a polymer/interleukin-2 conjugate
DE69033192T3 (de) 1989-04-19 2004-05-19 Enzon, Inc. Aktive karbonate von polyalkylenoxyden zur modifizierung von polypeptiden
ATE136315T1 (de) * 1989-05-27 1996-04-15 Sumitomo Pharma Verfahren für die herstellung von polyethylenglykolderivate und modifizierte proteine.
JP3202744B2 (ja) * 1989-05-27 2001-08-27 住友製薬株式会社 ポリエチレングリコール誘導体を含有する蛋白質修飾試薬
US5286637A (en) * 1989-08-07 1994-02-15 Debiopharm, S.A. Biologically active drug polymer derivatives and method for preparing same
CA2101918A1 (en) 1991-03-18 1992-09-19 Samuel Zalipsky Hydrazine containing conjugates of polypeptides and glycopolypeptides with polymers
US5395619A (en) 1993-03-03 1995-03-07 Liposome Technology, Inc. Lipid-polymer conjugates and liposomes
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
SE9503380D0 (sv) * 1995-09-29 1995-09-29 Pharmacia Ab Protein derivatives
IL128229A0 (en) 1996-08-02 1999-11-30 Ortho Mcneil Pharm Inc Polypeptides having a single covalently bound n-terminal water-soluble polymer
DE19636538A1 (de) * 1996-09-09 1998-03-12 Bayer Ag Substituierte Aminosäurederivate
EP0983290B1 (de) * 1997-05-14 2004-03-03 Morphochem AG Verfahren zur herstellung von polymeren, die nucleobasen als seitengruppen aufweisen
US6043221A (en) * 1997-07-30 2000-03-28 Amgen Inc. Method for preventing and treating hearing loss using a neuturin protein product
JP2000146971A (ja) * 1998-11-10 2000-05-26 Nisshinbo Ind Inc 生物学的活性物質の固定化用担体
EP1006767B1 (en) 1998-11-30 2006-06-07 Omron Corporation Electronic component comprising a control unit with a battery holder including a battery reverse insertion prevention means
SE519326C2 (sv) 1999-11-22 2003-02-11 Astrazeneca Ab Funktionaliserade polymera reagens innefattande en syralabil isonitrildel samt förfarande för dess framställning
CN1434726A (zh) * 2000-06-08 2003-08-06 拉卓拉药物公司 包含高分子量聚环氧乙烷的多价平台分子
DE10150077B4 (de) * 2001-10-10 2004-07-29 Morphochem Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung polymergebundener Isonitrile
DE10162134A1 (de) * 2001-12-18 2003-07-10 Morphochem Ag Ag Fuer Kombinat Harzgebundene Isonitrile
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JP2005146068A (ja) * 2003-11-13 2005-06-09 Japan Science & Technology Agency アルコキシアセチル基を構成するカルボン酸修飾されたモノメチルエーテルポリエチレングリコールポリマーの利用、前記ポリマーからの誘導体化合物類

Also Published As

Publication number Publication date
IL179303A0 (en) 2007-03-08
CN1997401A (zh) 2007-07-11
US20050287113A1 (en) 2005-12-29
EP1761282A2 (en) 2007-03-14
US7476725B2 (en) 2009-01-13
CA2568388A1 (en) 2005-12-29
WO2005123140A2 (en) 2005-12-29
KR20070027621A (ko) 2007-03-09
JP2008502788A (ja) 2008-01-31
AU2005253979A1 (en) 2005-12-29
NO20070114L (no) 2007-01-08
MXPA06014307A (es) 2007-03-12
WO2005123140A3 (en) 2006-08-03

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