ZA200609730B - DPP-IV inhibitors - Google Patents
DPP-IV inhibitors Download PDFInfo
- Publication number
- ZA200609730B ZA200609730B ZA200609730A ZA200609730A ZA200609730B ZA 200609730 B ZA200609730 B ZA 200609730B ZA 200609730 A ZA200609730 A ZA 200609730A ZA 200609730 A ZA200609730 A ZA 200609730A ZA 200609730 B ZA200609730 B ZA 200609730B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- group
- cycloalkyl
- heterocycle
- independently selected
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
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| ZA200609730B true ZA200609730B (en) | 2008-01-30 |
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| JP (1) | JP2008501751A (es) |
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| CN (1) | CN101001838A (es) |
| AU (1) | AU2005251910A1 (es) |
| BR (1) | BRPI0510849A (es) |
| CA (1) | CA2569535A1 (es) |
| IL (1) | IL179305A0 (es) |
| MX (1) | MXPA06014324A (es) |
| NO (1) | NO20070089L (es) |
| RU (1) | RU2006140796A (es) |
| WO (1) | WO2005121089A1 (es) |
| ZA (1) | ZA200609730B (es) |
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| PE20071221A1 (es) | 2006-04-11 | 2007-12-14 | Arena Pharm Inc | Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas |
| AU2007236115A1 (en) * | 2006-04-11 | 2007-10-18 | Novartis Ag | Organic compounds |
| BRPI0709984A2 (pt) | 2006-04-12 | 2011-08-02 | Probiodrug Ag | inibidores de enzima |
| EP2089383B1 (en) | 2006-11-09 | 2015-09-16 | Probiodrug AG | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
| US9126987B2 (en) | 2006-11-30 | 2015-09-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| EP2124913A1 (en) * | 2006-12-22 | 2009-12-02 | Novartis AG | 1-aminomethyl- l- phenyl- cyclohexane derivatives as ddp-iv inhibitors |
| US9656991B2 (en) | 2007-04-18 | 2017-05-23 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| WO2009003681A1 (en) * | 2007-07-02 | 2009-01-08 | Santhera Pharmaceuticals (Schweiz) Ag | Dpp-iv inhibitors |
| EP2019099A1 (en) * | 2007-07-02 | 2009-01-28 | Santhera Pharmaceuticals (Schweiz) AG | Dpp-IV inhibitors |
| EP2108960A1 (en) | 2008-04-07 | 2009-10-14 | Arena Pharmaceuticals, Inc. | Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditons modulated by PYY |
| WO2010081172A1 (en) * | 2009-01-12 | 2010-07-15 | Akebia Therapeutics Inc. | Methods for treating vascular leak syndrome |
| PL2475428T3 (pl) | 2009-09-11 | 2015-12-31 | Probiodrug Ag | Pochodne heterocykliczne jako inhibitory cyklazy glutaminowej |
| US9181233B2 (en) | 2010-03-03 | 2015-11-10 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| DK2545047T3 (da) | 2010-03-10 | 2014-07-28 | Probiodrug Ag | Heterocycliske inhibitorer af glutaminylcyclase (QC, EC 2.3.2.5) |
| WO2011131748A2 (en) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
| EP2686313B1 (en) | 2011-03-16 | 2016-02-03 | Probiodrug AG | Benzimidazole derivatives as inhibitors of glutaminyl cyclase |
| WO2012170702A1 (en) | 2011-06-08 | 2012-12-13 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| EP2540649B1 (en) | 2011-06-27 | 2013-12-11 | Metso Paper Inc. | Method and arrangement in connection with an unwinder |
| PL3461819T3 (pl) | 2017-09-29 | 2020-11-30 | Probiodrug Ag | Inhibitory cyklazy glutaminylowej |
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| DE19616486C5 (de) * | 1996-04-25 | 2016-06-30 | Royalty Pharma Collection Trust | Verfahren zur Senkung des Blutglukosespiegels in Säugern |
| TW492957B (en) * | 1996-11-07 | 2002-07-01 | Novartis Ag | N-substituted 2-cyanopyrrolidnes |
| AU2002310465B2 (en) * | 2001-06-20 | 2006-06-15 | Merck & Co., Inc. | Dipeptidyl peptidase inhibitors for the treatment of diabetes |
| EP1406872B1 (en) * | 2001-06-20 | 2007-12-19 | Merck & Co., Inc. | Dipeptidyl peptidase inhibitors for the treatment of diabetes |
| ATE466014T1 (de) * | 2001-12-28 | 2010-05-15 | Acadia Pharm Inc | Spiroazacyclische verbindungen als monoaminrezeptormodulatoren |
| AU2003238046A1 (en) * | 2002-06-27 | 2004-01-19 | Actelion Pharmaceuticals Ltd | Substituted 3- and 4- aminomethylpiperidines for use as beta-secretase in the treatment of alzheimer's disease |
| ATE451369T1 (de) * | 2002-07-15 | 2009-12-15 | Merck & Co Inc | Piperidinopyrimidindipeptidylpeptidaseinhibitor n zur behandlung von diabetes |
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2007
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Also Published As
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| EP1791817A1 (en) | 2007-06-06 |
| EP1604980A8 (en) | 2006-03-15 |
| JP2008501751A (ja) | 2008-01-24 |
| BRPI0510849A (pt) | 2007-11-27 |
| WO2005121089A1 (en) | 2005-12-22 |
| IL179305A0 (en) | 2007-03-08 |
| CA2569535A1 (en) | 2005-12-22 |
| US20070265261A1 (en) | 2007-11-15 |
| AU2005251910A1 (en) | 2005-12-22 |
| CN101001838A (zh) | 2007-07-18 |
| EP1604980A1 (en) | 2005-12-14 |
| RU2006140796A (ru) | 2008-07-20 |
| KR20070026788A (ko) | 2007-03-08 |
| MXPA06014324A (es) | 2007-05-04 |
| NO20070089L (no) | 2007-01-05 |
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