ZA200608496B - Compressed pharmaceutical compositions comprising PEG and electrolytes - Google Patents
Compressed pharmaceutical compositions comprising PEG and electrolytes Download PDFInfo
- Publication number
- ZA200608496B ZA200608496B ZA200608496A ZA200608496A ZA200608496B ZA 200608496 B ZA200608496 B ZA 200608496B ZA 200608496 A ZA200608496 A ZA 200608496A ZA 200608496 A ZA200608496 A ZA 200608496A ZA 200608496 B ZA200608496 B ZA 200608496B
- Authority
- ZA
- South Africa
- Prior art keywords
- pharmaceutical composition
- peg
- composition
- polyethylene glycol
- compressed pharmaceutical
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 30
- 239000003792 electrolyte Substances 0.000 title claims abstract description 17
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 95
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 88
- 239000000203 mixture Substances 0.000 claims abstract description 63
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 26
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 25
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 24
- 210000001072 colon Anatomy 0.000 claims description 21
- 206010010774 Constipation Diseases 0.000 claims description 17
- 238000011282 treatment Methods 0.000 claims description 17
- 239000000796 flavoring agent Substances 0.000 claims description 14
- 239000001103 potassium chloride Substances 0.000 claims description 13
- 235000011164 potassium chloride Nutrition 0.000 claims description 13
- 235000002639 sodium chloride Nutrition 0.000 claims description 13
- 239000011780 sodium chloride Substances 0.000 claims description 12
- 206010056325 Faecaloma Diseases 0.000 claims description 11
- 229910052938 sodium sulfate Inorganic materials 0.000 claims description 11
- 235000011152 sodium sulphate Nutrition 0.000 claims description 11
- 235000003599 food sweetener Nutrition 0.000 claims description 10
- 239000003765 sweetening agent Substances 0.000 claims description 10
- 230000014759 maintenance of location Effects 0.000 claims description 7
- 235000013355 food flavoring agent Nutrition 0.000 claims description 6
- 230000000968 intestinal effect Effects 0.000 claims description 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 6
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 5
- 206010016766 flatulence Diseases 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 230000002746 orthostatic effect Effects 0.000 claims description 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 3
- 239000004615 ingredient Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 235000010323 ascorbic acid Nutrition 0.000 claims description 2
- 239000011668 ascorbic acid Substances 0.000 claims description 2
- 229960005070 ascorbic acid Drugs 0.000 claims description 2
- 125000003289 ascorbyl group Chemical class [H]O[C@@]([H])(C([H])([H])O*)[C@@]1([H])OC(=O)C(O*)=C1O* 0.000 claims description 2
- 239000000843 powder Substances 0.000 abstract description 8
- 239000007788 liquid Substances 0.000 abstract description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 16
- 239000000243 solution Substances 0.000 description 14
- 239000008141 laxative Substances 0.000 description 11
- 238000009472 formulation Methods 0.000 description 8
- 235000017557 sodium bicarbonate Nutrition 0.000 description 8
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 230000002475 laxative effect Effects 0.000 description 7
- 235000019634 flavors Nutrition 0.000 description 6
- 229920002562 Polyethylene Glycol 3350 Polymers 0.000 description 5
- 229940125722 laxative agent Drugs 0.000 description 5
- 210000001035 gastrointestinal tract Anatomy 0.000 description 4
- 229940056944 golytely Drugs 0.000 description 4
- 230000003204 osmotic effect Effects 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 3
- 230000002411 adverse Effects 0.000 description 3
- 239000000825 pharmaceutical preparation Substances 0.000 description 3
- 210000000664 rectum Anatomy 0.000 description 3
- 230000035807 sensation Effects 0.000 description 3
- 235000019615 sensations Nutrition 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- 235000005979 Citrus limon Nutrition 0.000 description 2
- 244000131522 Citrus pyriformis Species 0.000 description 2
- 241000792859 Enema Species 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 229920001030 Polyethylene Glycol 4000 Polymers 0.000 description 2
- WINXNKPZLFISPD-UHFFFAOYSA-M Saccharin sodium Chemical compound [Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 WINXNKPZLFISPD-UHFFFAOYSA-M 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 229940096516 dextrates Drugs 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 239000007920 enema Substances 0.000 description 2
- 229960003511 macrogol Drugs 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 235000010355 mannitol Nutrition 0.000 description 2
- 235000010356 sorbitol Nutrition 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- WSWCOQWTEOXDQX-MQQKCMAXSA-M (E,E)-sorbate Chemical compound C\C=C\C=C\C([O-])=O WSWCOQWTEOXDQX-MQQKCMAXSA-M 0.000 description 1
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 108010011485 Aspartame Proteins 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 206010051244 Dyschezia Diseases 0.000 description 1
- 239000001329 FEMA 3811 Substances 0.000 description 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 235000011941 Tilia x europaea Nutrition 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 235000010358 acesulfame potassium Nutrition 0.000 description 1
- 229960004998 acesulfame potassium Drugs 0.000 description 1
- 239000000619 acesulfame-K Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000000605 aspartame Substances 0.000 description 1
- 235000010357 aspartame Nutrition 0.000 description 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
- 229960003438 aspartame Drugs 0.000 description 1
- 229910052788 barium Inorganic materials 0.000 description 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229940001468 citrate Drugs 0.000 description 1
- 230000000112 colonic effect Effects 0.000 description 1
- 238000002052 colonoscopy Methods 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 239000000625 cyclamic acid and its Na and Ca salt Substances 0.000 description 1
- 230000013872 defecation Effects 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 210000004921 distal colon Anatomy 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000008151 electrolyte solution Substances 0.000 description 1
- 229940095399 enema Drugs 0.000 description 1
- 229940079360 enema for constipation Drugs 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 229940050411 fumarate Drugs 0.000 description 1
- 229940050410 gluconate Drugs 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- -1 granular Substances 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 150000002597 lactoses Chemical class 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 229940049920 malate Drugs 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- ITVGXXMINPYUHD-CUVHLRMHSA-N neohesperidin dihydrochalcone Chemical compound C1=C(O)C(OC)=CC=C1CCC(=O)C(C(=C1)O)=C(O)C=C1O[C@H]1[C@H](O[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 ITVGXXMINPYUHD-CUVHLRMHSA-N 0.000 description 1
- 229940089953 neohesperidin dihydrochalcone Drugs 0.000 description 1
- 235000010434 neohesperidine DC Nutrition 0.000 description 1
- 239000007968 orange flavor Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 229910001414 potassium ion Inorganic materials 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229960001462 sodium cyclamate Drugs 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 229940075554 sorbate Drugs 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 150000003892 tartrate salts Chemical class 0.000 description 1
- 235000010436 thaumatin Nutrition 0.000 description 1
- 239000000892 thaumatin Substances 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
- A61K31/77—Polymers containing oxygen of oxiranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nutrition Science (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0409104.7A GB0409104D0 (en) | 2004-04-23 | 2004-04-23 | Compressed pharmaceutical compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200608496B true ZA200608496B (en) | 2008-07-30 |
Family
ID=32344298
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200608496A ZA200608496B (en) | 2004-04-23 | 2006-10-11 | Compressed pharmaceutical compositions comprising PEG and electrolytes |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20070298100A1 (fr) |
| EP (2) | EP2263680B1 (fr) |
| JP (1) | JP2007533719A (fr) |
| KR (1) | KR20070001280A (fr) |
| CN (1) | CN1950097A (fr) |
| AT (1) | ATE496626T1 (fr) |
| AU (1) | AU2005235345B8 (fr) |
| BR (1) | BRPI0510175A (fr) |
| CA (1) | CA2561649C (fr) |
| DE (1) | DE602005026117D1 (fr) |
| DK (2) | DK2263680T3 (fr) |
| ES (2) | ES2519540T3 (fr) |
| GB (1) | GB0409104D0 (fr) |
| IL (1) | IL178722A0 (fr) |
| MX (1) | MXPA06011906A (fr) |
| NO (1) | NO20064780L (fr) |
| PL (2) | PL2263680T3 (fr) |
| PT (2) | PT1742645E (fr) |
| RU (1) | RU2006137347A (fr) |
| SI (2) | SI1742645T1 (fr) |
| WO (1) | WO2005102364A1 (fr) |
| ZA (1) | ZA200608496B (fr) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006122104A1 (fr) * | 2005-05-06 | 2006-11-16 | Salix Pharmaceuticals, Inc. | Composition purgative au polyethylene glycol pour le colon |
| ES2278537B1 (es) * | 2006-01-30 | 2008-09-16 | Laboratorios Casen-Fleet, S.L. | Procedimiento de fabricacion de una solucion a base de polietilenglicol con electrolitos, producto obtenido y uso. |
| US8784872B2 (en) * | 2007-11-19 | 2014-07-22 | Comgenrx, Inc. | Formulation for decreasing tobacco, alcohol, drug or food consumption |
| US20090130048A1 (en) * | 2007-11-19 | 2009-05-21 | Oronsky Bryan Todd | Topical Composition for Treating Pain |
| WO2009146782A1 (fr) | 2008-06-06 | 2009-12-10 | Roto Frank Ag | Dispositif d’orientation pour une fenêtre, une porte ou similaire |
| WO2009158667A2 (fr) * | 2008-06-27 | 2009-12-30 | Comgenrx, Inc. | Compositions de povidone pour la cicatrisation de plaies |
| LT2421373T (lt) * | 2009-04-21 | 2020-01-10 | Dale R. Bachwich | Gaubtinės žarnos lavažo sistema |
| WO2010141751A1 (fr) * | 2009-06-03 | 2010-12-09 | Axcan Pharma Inc. | Agent de nettoyage du côlon à base de l-sucre et ses utilisations |
| GB0913295D0 (en) | 2009-07-30 | 2009-09-02 | Norgine Bv | Improvements in and relating to pharmaceutical compositions |
| AU2010328366A1 (en) * | 2009-12-07 | 2012-06-21 | Aptalis Pharma Us, Inc | Methods for purifying monosaccharide mixtures containing ionic impurities |
| CN101766648B (zh) * | 2010-03-02 | 2012-01-11 | 舒泰神（北京）生物制药股份有限公司 | 聚乙二醇电解质颗粒制剂及其制造方法 |
| DE202010012256U1 (de) * | 2010-09-07 | 2010-11-11 | Krewel Meuselbach Gmbh | Abführmittel |
| AU2011324995B2 (en) | 2010-11-04 | 2015-12-24 | Norgine Bv | Formulations comprising polyethylene glycol |
| DE202010016235U1 (de) | 2010-12-06 | 2011-05-19 | Norgine B.V. | Formulierungen |
| FR2967069B3 (fr) * | 2010-11-04 | 2012-11-16 | Norgine Bv | Formulations |
| AU2011100528B4 (en) * | 2011-05-10 | 2011-08-25 | Norgine Bv | Formulations |
| CN103391790B (zh) | 2011-01-28 | 2016-06-15 | 布伦特里实验室有限公司 | 用于肠道清洁的方法、组合物以及包装 |
| EA028925B1 (ru) * | 2011-01-31 | 2018-01-31 | Норджин Бв | Способ лечения констипации и/или уплотнения фекальных масс, водный раствор для лечения констипации и/или уплотнения фекальных масс, набор и лекарственное средство (варианты) |
| TWI535461B (zh) | 2011-03-11 | 2016-06-01 | 諾金私人有限公司 | 結腸清潔溶液、用於製備該溶液之組成物、包含該組成物或溶液之套組、與製備該溶液之方法 |
| CN102133225B (zh) * | 2011-03-18 | 2012-11-21 | 海南锦瑞制药股份有限公司 | 一种复方聚乙二醇电解质散剂及其制备方法 |
| JP6240610B2 (ja) * | 2011-10-27 | 2017-11-29 | サリックス ファーマシューティカルズ，インコーポレイテッド | 電解質下剤 |
| CN102600201B (zh) * | 2012-02-07 | 2014-07-16 | 舒泰神（北京）生物制药股份有限公司 | 用于通便和清肠的药物组合物及其制备方法 |
| KR20210063445A (ko) | 2012-09-11 | 2021-06-01 | 노어긴 비.브이. | Peg 및 아스코르베이트를 포함하는 조성물 |
| PT2968174T (pt) * | 2013-03-15 | 2020-01-15 | Braintree Laboratories Inc | Comprimidos de duplo uso oral em composições farmacêuticas de sais de sulfato e seus métodos de utilização |
| US10350165B2 (en) | 2014-12-12 | 2019-07-16 | Ojai Energetics Pbc | Methods and systems for forming stable droplets |
| EA201791299A1 (ru) | 2014-12-12 | 2017-12-29 | ОХАЙ ЭНЕРДЖЕТИКС ПиБиСи | Микроинкапсулированные композиции каннабиноидов |
| FR3056109B1 (fr) * | 2016-09-21 | 2019-10-11 | Pierre Fabre Medicament | Utilisation de formulations solides de polyethylene glycol dans le traitement de la constipation |
| CN107028876B (zh) * | 2016-10-09 | 2020-09-29 | 舒泰神（北京）生物制药股份有限公司 | 聚乙二醇电解质口服液及其制备方法 |
| JP7475270B2 (ja) | 2017-07-20 | 2024-04-26 | ソルヴェイ（ソシエテ アノニム） | 発泡剤としての官能化微粒子重炭酸塩、それを含有する発泡性ポリマー組成物、及び熱可塑性発泡ポリマーの製造でのその使用 |
| KR20190093489A (ko) | 2018-02-01 | 2019-08-09 | 주식회사태준제약 | 장세척 조성물 |
| WO2019151829A1 (fr) * | 2018-02-01 | 2019-08-08 | 주식회사태준제약 | Composition de nettoyage intestinal |
| CN110433174A (zh) * | 2019-07-17 | 2019-11-12 | 华南理工大学 | 一种高依从性的复方聚乙二醇电解质散剂及其制备方法与应用 |
| CN111617102B (zh) * | 2020-05-25 | 2022-05-31 | 南京金凯木纳米材料有限公司 | 一种含聚乙二醇的电解质散剂及其制备方法 |
| EP4232008A4 (fr) * | 2020-10-26 | 2024-07-10 | Braintree Laboratories Inc | Formulations salines de sulfate pour le nettoyage du côlon |
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| US3121663A (en) * | 1956-02-09 | 1964-02-18 | Plough Lab Inc | Carbon dioxide releasing laxative suppository |
| US5229132A (en) * | 1985-02-22 | 1993-07-20 | Grimberg Georges Serge | Non-absorbable gastrointestinal medicament provided for treating the two levels of the digestive tract at the same time |
| EP0231356A1 (fr) * | 1985-08-01 | 1987-08-12 | Braintree Laboratories, Inc. | Laxatif a faible teneur en sodium et compositions de lavage |
| US5273758A (en) * | 1991-03-18 | 1993-12-28 | Sandoz Ltd. | Directly compressible polyethylene oxide vehicle for preparing therapeutic dosage forms |
| US6121663A (en) * | 1997-05-22 | 2000-09-19 | Advanced Micro Devices, Inc. | Local interconnects for improved alignment tolerance and size reduction |
| FR2784897B1 (fr) * | 1998-10-27 | 2002-11-29 | Agronomique Inst Nat Rech | Utilisation d'un laxatif osmotique non fermente dans le traitement et la prevention des cancers colorectaux |
| US6444198B1 (en) * | 1999-02-22 | 2002-09-03 | Smithkline Beecham Corporation | Effervescent laxatives |
| DE19933148A1 (de) * | 1999-07-20 | 2001-01-25 | Boehringer Ingelheim Int | Ambroxolhaltige Lutschtablette |
| WO2005049049A1 (fr) * | 2003-11-17 | 2005-06-02 | Braintree Laboratories, Inc. | Concentre de solution peg therapeutique |
| US7687075B2 (en) * | 2003-11-19 | 2010-03-30 | Salix Pharmaceuticals, Ltd. | Colonic purgative composition with soluble binding agent |
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2004
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2005
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- 2005-04-25 PL PL10177007T patent/PL2263680T3/pl unknown
- 2005-04-25 US US11/587,114 patent/US20070298100A1/en not_active Abandoned
- 2005-04-25 CN CNA2005800127497A patent/CN1950097A/zh active Pending
- 2005-04-25 AT AT05735983T patent/ATE496626T1/de active
- 2005-04-25 ES ES10177007.1T patent/ES2519540T3/es active Active
- 2005-04-25 KR KR1020067024419A patent/KR20070001280A/ko not_active Application Discontinuation
- 2005-04-25 DK DK10177007.1T patent/DK2263680T3/en active
- 2005-04-25 PT PT05735983T patent/PT1742645E/pt unknown
- 2005-04-25 DK DK05735983.8T patent/DK1742645T3/da active
- 2005-04-25 EP EP10177007.1A patent/EP2263680B1/fr active Active
- 2005-04-25 CA CA2561649A patent/CA2561649C/fr not_active Expired - Fee Related
- 2005-04-25 WO PCT/GB2005/001555 patent/WO2005102364A1/fr active Application Filing
- 2005-04-25 PL PL05735983T patent/PL1742645T3/pl unknown
- 2005-04-25 MX MXPA06011906A patent/MXPA06011906A/es active IP Right Grant
- 2005-04-25 BR BRPI0510175-1A patent/BRPI0510175A/pt not_active IP Right Cessation
- 2005-04-25 PT PT101770071T patent/PT2263680E/pt unknown
- 2005-04-25 SI SI200531271T patent/SI1742645T1/sl unknown
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- 2005-04-25 JP JP2007508973A patent/JP2007533719A/ja active Pending
- 2005-04-25 SI SI200531914T patent/SI2263680T1/sl unknown
- 2005-04-25 EP EP05735983A patent/EP1742645B1/fr active Active
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- 2005-04-25 RU RU2006137347/15A patent/RU2006137347A/ru unknown
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2006
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- 2006-10-18 IL IL178722A patent/IL178722A0/en unknown
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| Publication number | Publication date |
|---|---|
| GB0409104D0 (en) | 2004-05-26 |
| PT1742645E (pt) | 2011-04-29 |
| DK2263680T3 (en) | 2014-12-08 |
| MXPA06011906A (es) | 2007-01-25 |
| WO2005102364A1 (fr) | 2005-11-03 |
| PT2263680E (pt) | 2014-11-19 |
| EP1742645A1 (fr) | 2007-01-17 |
| KR20070001280A (ko) | 2007-01-03 |
| DE602005026117D1 (de) | 2011-03-10 |
| RU2006137347A (ru) | 2008-05-27 |
| CA2561649C (fr) | 2014-10-14 |
| PL1742645T3 (pl) | 2011-06-30 |
| CN1950097A (zh) | 2007-04-18 |
| BRPI0510175A (pt) | 2007-10-02 |
| EP2263680B1 (fr) | 2014-08-27 |
| ES2361816T3 (es) | 2011-06-22 |
| SI2263680T1 (sl) | 2015-01-30 |
| SI1742645T1 (sl) | 2011-05-31 |
| ATE496626T1 (de) | 2011-02-15 |
| EP2263680A1 (fr) | 2010-12-22 |
| JP2007533719A (ja) | 2007-11-22 |
| AU2005235345B2 (en) | 2011-04-14 |
| IL178722A0 (en) | 2007-02-11 |
| PL2263680T3 (pl) | 2015-02-27 |
| AU2005235345A1 (en) | 2005-11-03 |
| AU2005235345B8 (en) | 2011-05-12 |
| US20070298100A1 (en) | 2007-12-27 |
| NO20064780L (no) | 2007-01-18 |
| EP1742645B1 (fr) | 2011-01-26 |
| DK1742645T3 (da) | 2011-05-09 |
| ES2519540T3 (es) | 2014-11-07 |
| CA2561649A1 (fr) | 2005-11-03 |
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