ZA200605307B - Polymorphic Forms of a Gabaa agonist - Google Patents
Polymorphic Forms of a Gabaa agonist Download PDFInfo
- Publication number
- ZA200605307B ZA200605307B ZA200605307A ZA200605307A ZA200605307B ZA 200605307 B ZA200605307 B ZA 200605307B ZA 200605307 A ZA200605307 A ZA 200605307A ZA 200605307 A ZA200605307 A ZA 200605307A ZA 200605307 B ZA200605307 B ZA 200605307B
- Authority
- ZA
- South Africa
- Prior art keywords
- gaboxadol
- crystalline
- peak
- monohydrate
- anhydrate
- Prior art date
Links
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Classifications
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Applications Claiming Priority (1)
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|---|---|---|---|
| GBGB0402118.4A GB0402118D0 (en) | 2004-01-30 | 2004-01-30 | Polymorphic forms of a GABAA agonist |
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| Publication Number | Publication Date |
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| ZA200605307B true ZA200605307B (en) | 2007-11-28 |
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| Application Number | Title | Priority Date | Filing Date |
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| ZA200605307A ZA200605307B (en) | 2004-01-30 | 2006-06-27 | Polymorphic Forms of a Gabaa agonist |
Country Status (34)
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| EP (2) | EP2042505A1 (https=) |
| JP (1) | JP4917440B2 (https=) |
| KR (1) | KR101210361B1 (https=) |
| CN (1) | CN1914212B (https=) |
| AR (1) | AR047511A1 (https=) |
| AT (1) | ATE414088T1 (https=) |
| AU (1) | AU2005209473B2 (https=) |
| BR (1) | BRPI0506858A (https=) |
| CA (1) | CA2554536C (https=) |
| CO (1) | CO5700743A2 (https=) |
| CY (1) | CY1108647T1 (https=) |
| DE (1) | DE602005010975D1 (https=) |
| DK (1) | DK1713813T3 (https=) |
| DO (1) | DOP2005000013A (https=) |
| EA (1) | EA009413B1 (https=) |
| EC (1) | ECSP066735A (https=) |
| ES (1) | ES2314613T3 (https=) |
| GB (2) | GB0402118D0 (https=) |
| HR (1) | HRP20080614T3 (https=) |
| IL (1) | IL176863A0 (https=) |
| MA (1) | MA28364A1 (https=) |
| MX (1) | MXPA06008595A (https=) |
| MY (1) | MY139525A (https=) |
| NO (1) | NO20063843L (https=) |
| NZ (1) | NZ548191A (https=) |
| PE (1) | PE20050769A1 (https=) |
| PL (1) | PL1713813T3 (https=) |
| PT (1) | PT1713813E (https=) |
| SI (1) | SI1713813T1 (https=) |
| TW (1) | TWI345972B (https=) |
| UA (1) | UA87487C2 (https=) |
| WO (1) | WO2005073237A2 (https=) |
| ZA (1) | ZA200605307B (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0402118D0 (en) | 2004-01-30 | 2004-03-03 | Merck Sharp & Dohme | Polymorphic forms of a GABAA agonist |
| US8268866B2 (en) | 2004-03-29 | 2012-09-18 | Matthieu Guitton | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
| US20060063802A1 (en) | 2004-03-29 | 2006-03-23 | Matthieu Guitton | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
| US9072662B2 (en) | 2004-03-29 | 2015-07-07 | Auris Medical Ag | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
| DE102005004343A1 (de) * | 2005-01-25 | 2006-08-10 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Behandlung von Phantomphänomenen |
| EP1848420A4 (en) | 2005-01-28 | 2008-01-23 | Merck & Co Inc | POLYMORPH SHAPES OF A GABAA AGONIST |
| KR101271263B1 (ko) | 2005-09-28 | 2013-06-07 | 아우리스 메디칼 아게 | 내이 장애 치료용 약학 조성물 |
| CN102093387B (zh) * | 2009-12-10 | 2012-07-25 | 天津泰普医药知识产权流转储备中心有限公司 | 4,5,6,7-四氢异噁唑并[5,4-c]吡啶-3-醇一水合物的晶型化合物 |
| WO2013087090A1 (en) | 2011-12-12 | 2013-06-20 | Auris Medical Ag | Treatment of tinnitus through modulation of chloride co-transporter nkcc1 in the auditory system |
| EP4541420A3 (en) | 2015-07-17 | 2025-06-25 | Ovid Therapeutics Inc. | Methods of treating developmental disorders with gaboxadol |
| EP3481387A4 (en) | 2016-08-11 | 2020-04-08 | Ovid Therapeutics Inc | METHOD AND COMPOSITIONS FOR TREATING EPILEPTIC DISEASES |
| CN110225754A (zh) * | 2016-11-22 | 2019-09-10 | 奥维德医疗公司 | 用氟吡汀治疗发育障碍和/或癫痫发作紊乱的方法 |
| US10071083B2 (en) | 2017-02-03 | 2018-09-11 | Ovid Therapeutics Inc | Use of gaboxadol in the treatment of tinnitus |
| JP2020529440A (ja) | 2017-08-04 | 2020-10-08 | オービッド・セラピューティクス・インコーポレイテッドＯｖｉｄ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． | 糖尿病および関連する状態の処置におけるガボキサドールの使用 |
| WO2020061410A1 (en) | 2018-09-20 | 2020-03-26 | Ovid Therapeutics Inc. | Use of gaboxadol for the treatment of tourette syndrome, tics and stuttering |
| JP2022514194A (ja) | 2018-11-21 | 2022-02-10 | セルテゴ セラピューティクス インコーポレイテッド | 自殺のリスクを低減し、うつ病を迅速に軽減するためのガボキサドール |
| WO2020131856A1 (en) | 2018-12-17 | 2020-06-25 | Ovid Therapeutics Inc. | Use of gaboxadol for the treatment of non-24 hour sleep-wake disorder |
| US11364228B2 (en) | 2019-12-18 | 2022-06-21 | Ovid Therapeutics Inc. | Gaboxadol for therapeutic treatment of 1p36 deletion syndrome |
| MX2022014599A (es) | 2020-05-20 | 2022-12-16 | Certego Therapeutics Inc | Gaboxadol deuterado en anillo y su uso para el tratamiento de trastornos psiquiatricos. |
Family Cites Families (22)
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| DK270378A (da) | 1977-06-20 | 1978-12-21 | Krogsgaard Larsen P | Isoxazolderivater |
| US4315934A (en) | 1979-09-24 | 1982-02-16 | Sandoz Ltd. | Organic compounds |
| US4362731A (en) | 1980-09-01 | 1982-12-07 | Sandoz Ltd. | Myotonolytic use of 4,5,6,7-tetrahydroisoxazolo [5,4-c] pyridin-3-ol and derivatives thereof |
| US4352731A (en) * | 1980-11-03 | 1982-10-05 | Occidental Research Corporation | Apparatus for selective wetting of particles |
| DE19525598C2 (de) | 1995-07-13 | 1997-09-25 | Max Planck Gesellschaft | Schlafmittel |
| UA52661C2 (uk) * | 1996-06-14 | 2003-01-15 | Ново Нордіск А/С | Безводна кристалічна форма гідрохлориду r(-)-n-(4,4-ди(3-метилтієн-2-іл)бут-3-еніл) ніпекотинової кислоти |
| EP1220658A1 (en) | 1999-09-28 | 2002-07-10 | H. Lundbeck A/S | Melt granulated composition and modified release dosage form prepared from said composition |
| AR031473A1 (es) | 2000-11-20 | 2003-09-24 | Lundbeck & Co As H | Intensificadores de gaba en el tratamiento de enfermedades relacionadas con una reducida actividad neuroesteroide |
| BR0209820A (pt) | 2001-05-18 | 2004-06-01 | Lonza Ag | Processo para a preparação de formulações sólidas de 3-hidróxi-3-metilbutirato de sódio |
| AU2002338855B2 (en) | 2001-05-21 | 2007-08-16 | H. Lundbeck A/S | Granular preparations of gaboxadol |
| WO2004022550A1 (en) * | 2002-09-03 | 2004-03-18 | Naturon Limited | Compound for treatment of anxiety and methods of preparation and use thereof |
| US20050234093A1 (en) * | 2003-06-25 | 2005-10-20 | H. Lundbeck A/S | Treatment of depression and other affective disorders |
| BRPI0410857A (pt) * | 2003-06-25 | 2006-07-04 | Lundbeck & Co As H | método para o tratamento de depressão, uso de gaboxadol, e, composição farmacêutica |
| AR045540A1 (es) * | 2003-09-05 | 2005-11-02 | Lundbeck & Co As H | Metodo de elaboracion de 4,5,6,7 tetrahidroisoxazol [5,4-c] piridin-3-ol (thip) |
| US20070032553A1 (en) | 2003-09-10 | 2007-02-08 | Mckernan Ruth | Use of gabaa receptor agonists for the treatment of hearing, vestibular and attention disorders, intention tremor and restless leg syndrome |
| TW200528098A (en) | 2003-12-18 | 2005-09-01 | Lundbeck & Co As H | Treatment of insomnia in human patients |
| GB0402118D0 (en) | 2004-01-30 | 2004-03-03 | Merck Sharp & Dohme | Polymorphic forms of a GABAA agonist |
| MXPA06015196A (es) | 2004-06-29 | 2007-03-15 | Lundbeck & Co As H | Tratamiento del dolor neuropatico, la fibromialgia o la artritis reumatoide. |
| GB0417558D0 (en) | 2004-08-06 | 2004-09-08 | Merck Sharp & Dohme | Novel combination therapy |
| EP1848420A4 (en) | 2005-01-28 | 2008-01-23 | Merck & Co Inc | POLYMORPH SHAPES OF A GABAA AGONIST |
| WO2006102093A1 (en) | 2005-03-18 | 2006-09-28 | Transform Pharmaceuticals, Inc. | Gaboxadol forms, compositions thereof, and related methods |
| US20080262029A1 (en) | 2005-04-29 | 2008-10-23 | H. Lundbeck A/S | Acid and Base Salt Forms of Gaboxadol |
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2004
- 2004-01-30 GB GBGB0402118.4A patent/GB0402118D0/en not_active Ceased
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2005
- 2005-01-20 AR ARP050100210A patent/AR047511A1/es not_active Application Discontinuation
- 2005-01-21 TW TW094101857A patent/TWI345972B/zh not_active IP Right Cessation
- 2005-01-24 MY MYPI20050253A patent/MY139525A/en unknown
- 2005-01-27 PE PE2005000102A patent/PE20050769A1/es not_active Application Discontinuation
- 2005-01-28 DO DO2005000013A patent/DOP2005000013A/es unknown
- 2005-01-28 PT PT05702040T patent/PT1713813E/pt unknown
- 2005-01-28 DE DE602005010975T patent/DE602005010975D1/de not_active Expired - Lifetime
- 2005-01-28 US US11/045,768 patent/US7262300B2/en not_active Expired - Lifetime
- 2005-01-28 NZ NZ548191A patent/NZ548191A/en not_active IP Right Cessation
- 2005-01-28 EP EP08019457A patent/EP2042505A1/en not_active Withdrawn
- 2005-01-28 ES ES05702040T patent/ES2314613T3/es not_active Expired - Lifetime
- 2005-01-28 JP JP2006550301A patent/JP4917440B2/ja not_active Expired - Lifetime
- 2005-01-28 PL PL05702040T patent/PL1713813T3/pl unknown
- 2005-01-28 UA UAA200609410A patent/UA87487C2/ru unknown
- 2005-01-28 MX MXPA06008595A patent/MXPA06008595A/es active IP Right Grant
- 2005-01-28 EA EA200601404A patent/EA009413B1/ru not_active IP Right Cessation
- 2005-01-28 DK DK05702040T patent/DK1713813T3/da active
- 2005-01-28 GB GB0501847A patent/GB2410434A/en not_active Withdrawn
- 2005-01-28 CA CA2554536A patent/CA2554536C/en not_active Expired - Fee Related
- 2005-01-28 AT AT05702040T patent/ATE414088T1/de active
- 2005-01-28 SI SI200530521T patent/SI1713813T1/sl unknown
- 2005-01-28 CN CN2005800031615A patent/CN1914212B/zh not_active Expired - Lifetime
- 2005-01-28 HR HR20080614T patent/HRP20080614T3/xx unknown
- 2005-01-28 AU AU2005209473A patent/AU2005209473B2/en not_active Ceased
- 2005-01-28 BR BRPI0506858-4A patent/BRPI0506858A/pt not_active IP Right Cessation
- 2005-01-28 EP EP05702040A patent/EP1713813B1/en not_active Expired - Lifetime
- 2005-01-28 WO PCT/GB2005/000288 patent/WO2005073237A2/en not_active Ceased
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2006
- 2006-06-27 ZA ZA200605307A patent/ZA200605307B/en unknown
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- 2006-07-26 CO CO06073254A patent/CO5700743A2/es not_active Application Discontinuation
- 2006-07-28 KR KR1020067015417A patent/KR101210361B1/ko not_active Expired - Fee Related
- 2006-07-28 EC EC2006006735A patent/ECSP066735A/es unknown
- 2006-08-22 MA MA29278A patent/MA28364A1/fr unknown
- 2006-08-29 NO NO20063843A patent/NO20063843L/no not_active Application Discontinuation
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2007
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