ZA200603887B - Novewl imaging agents comprising caspase-3 inhibitors - Google Patents

Novewl imaging agents comprising caspase-3 inhibitors Download PDF

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Publication number
ZA200603887B
ZA200603887B ZA200603887A ZA200603887A ZA200603887B ZA 200603887 B ZA200603887 B ZA 200603887B ZA 200603887 A ZA200603887 A ZA 200603887A ZA 200603887 A ZA200603887 A ZA 200603887A ZA 200603887 B ZA200603887 B ZA 200603887B
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South Africa
Prior art keywords
caspase
formula
alkyl
radioactive
inhibitor
Prior art date
Application number
ZA200603887A
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English (en)
Inventor
Hiscock Duncan
Guilbert Benedicte
Newton Ben
Original Assignee
Ge Healthcare Ltd
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Publication of ZA200603887B publication Critical patent/ZA200603887B/en

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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/0429Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K51/0431Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0446Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • AHUMAN NECESSITIES
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    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
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    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
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  • Health & Medical Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Optics & Photonics (AREA)
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ZA200603887A 2003-11-26 2006-05-15 Novewl imaging agents comprising caspase-3 inhibitors ZA200603887B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0327494.1A GB0327494D0 (en) 2003-11-26 2003-11-26 Novel imaging agents

Publications (1)

Publication Number Publication Date
ZA200603887B true ZA200603887B (en) 2008-02-27

Family

ID=29797853

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200603887A ZA200603887B (en) 2003-11-26 2006-05-15 Novewl imaging agents comprising caspase-3 inhibitors

Country Status (15)

Country Link
US (1) US20060275215A1 (ja)
EP (1) EP1763371A2 (ja)
JP (1) JP2007512302A (ja)
KR (1) KR101236124B1 (ja)
CN (1) CN1905904B (ja)
AU (1) AU2004294784B2 (ja)
BR (1) BRPI0416938A (ja)
CA (1) CA2547236A1 (ja)
GB (1) GB0327494D0 (ja)
IL (1) IL175667A (ja)
MX (1) MXPA06006045A (ja)
NO (1) NO20062387L (ja)
RU (1) RU2006117819A (ja)
WO (1) WO2005053752A2 (ja)
ZA (1) ZA200603887B (ja)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE487692T1 (de) 2004-07-08 2010-11-15 Aposense Ltd Verfahren und verbindungen zum nachweis von medizinischen erkrankungen
WO2006074799A2 (en) * 2005-01-17 2006-07-20 Universitätsklinikum Münster 5-pyrrolidinylsulfonyl isatin derivatives
GB0502277D0 (en) * 2005-02-04 2005-03-09 Amersham Plc Novel imaging agents
KR101449507B1 (ko) * 2005-10-21 2014-10-13 씨드 리써치 앤드 디벨롭먼트, 엘엘씨 아팝토시스의 생체내 검출
GB0610395D0 (en) * 2006-05-25 2006-07-05 Ge Healthcare Ltd Novel imaging agents
GB0612333D0 (en) * 2006-06-21 2006-08-02 Ge Healthcare Ltd Radiopharmaceutical products
PL2029178T3 (pl) * 2006-06-21 2012-08-31 Ge Healthcare Ltd Produkty radiofarmaceutyczne
GB0718957D0 (en) * 2007-09-28 2007-11-07 Ge Healthcare Ltd Optical imaging agents
KR100845010B1 (ko) * 2007-08-29 2008-07-08 한국생명공학연구원 Nir/mr 이중모드 분자영상용 고분자 입자 및 그제조방법
JP5627569B2 (ja) * 2008-04-30 2014-11-19 シーメンス メディカル ソリューションズ ユーエスエー インコーポレイテッドSiemens Medical Solutions USA,Inc. 新規基質に基づくpet造影剤
US20110165611A1 (en) * 2008-09-04 2011-07-07 Chun Li Dual modality detection of apoptosis
KR20110066927A (ko) 2008-09-05 2011-06-17 임페리얼 이노베이션스 리미티드 생체 내 영상화제로서 사용하기 위한 이사틴 유도체
GB0818738D0 (en) * 2008-10-13 2008-11-19 Ge Healthcare Ltd Imaging neuroflammation
WO2014186737A1 (en) * 2013-05-16 2014-11-20 The Johns Hopkins University Compositions and methods for chemical exchange saturation transfer (cest) based magnetic resonance imaging (mri)
WO2017053864A1 (en) * 2015-09-23 2017-03-30 Intracellular Technologies, Llc Cysteine protease inhibitors
CN107655871A (zh) * 2017-09-12 2018-02-02 重庆医科大学 一种阿仑膦酸钠的高灵敏宽检测范围荧光检测新方法
WO2023108009A1 (en) * 2021-12-08 2023-06-15 Cytosite Biopharma Inc. Compounds specific to granzyme b and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5601801A (en) * 1994-08-02 1997-02-11 Merck Frosst Canada, Inc. Radiolabelled angiotensin converting enzyme inhibitors
AR016384A1 (es) * 1997-07-30 2001-07-04 Smithkline Beecham Corp Inhibidores de caspasas, composiciones farmaceuticas que comprenden dichos inhibidores de caspasas y uso de los inhibidores de caspasas para prepararun medicamento util para el tratamiento de apoptosis y desordenes asociados con excesiva actividad de la convertosa il-1 beta.
US6589503B1 (en) * 1998-06-20 2003-07-08 Washington University Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy
EP1283728A2 (en) * 2000-05-23 2003-02-19 Amersham Health AS Contrast agents
NO20002644D0 (no) * 2000-05-23 2000-05-23 Nycomed Imaging As Kontrastmiddel
CA2709871C (en) * 2001-03-02 2013-08-13 University Of Western Ontario Polymer precursors of radiolabeled compounds, and methods of making and using the same
AU2003275055A1 (en) * 2002-09-24 2004-04-19 The General Hospital Corporation Azulene dimer-quenched, near-infrared fluorescent probes
EP1594819A1 (en) * 2003-02-07 2005-11-16 Merck Frosst Canada & Co. Irreversible caspase-3 inhibitors as active site probes
PE20050159A1 (es) * 2003-05-27 2005-04-19 Vertex Pharma Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa

Also Published As

Publication number Publication date
CN1905904A (zh) 2007-01-31
EP1763371A2 (en) 2007-03-21
CA2547236A1 (en) 2005-06-16
IL175667A0 (en) 2006-09-05
CN1905904B (zh) 2011-12-21
AU2004294784B2 (en) 2008-04-24
WO2005053752A3 (en) 2005-10-06
MXPA06006045A (es) 2006-08-23
NO20062387L (no) 2006-05-31
KR101236124B1 (ko) 2013-02-21
AU2004294784A1 (en) 2005-06-16
RU2006117819A (ru) 2008-01-10
US20060275215A1 (en) 2006-12-07
JP2007512302A (ja) 2007-05-17
IL175667A (en) 2013-09-30
KR20060123196A (ko) 2006-12-01
GB0327494D0 (en) 2003-12-31
WO2005053752A2 (en) 2005-06-16
BRPI0416938A (pt) 2007-02-13

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