ZA200600761B - Oral delivery system comprising a biliquid foam - Google Patents

Info

Publication number

ZA200600761B

ZA200600761B ZA200600761A ZA200600761A ZA200600761B ZA 200600761 B ZA200600761 B ZA 200600761B ZA 200600761 A ZA200600761 A ZA 200600761A ZA 200600761 A ZA200600761 A ZA 200600761A ZA 200600761 B ZA200600761 B ZA 200600761B

Authority

ZA

South Africa

Prior art keywords

delivery system

drug delivery

oral drug

agent

weight

Prior art date

2003-07-30

Links

• Espacenet
• Global Dossier
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• 239000006260 foam Substances 0.000 title claims description 18
• 229940079593 drug Drugs 0.000 claims description 36
• 239000003814 drug Substances 0.000 claims description 36
• 238000012377 drug delivery Methods 0.000 claims description 30
• 239000000203 mixture Substances 0.000 claims description 28
• 229940126701 oral medication Drugs 0.000 claims description 24
• 239000012071 phase Substances 0.000 claims description 20
• 239000004094 surface-active agent Substances 0.000 claims description 17
• -1 fatty acid ester Chemical class 0.000 claims description 16
• DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 15
• 239000003921 oil Substances 0.000 claims description 13
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
• 235000014113 dietary fatty acids Nutrition 0.000 claims description 8
• 239000000194 fatty acid Substances 0.000 claims description 8
• 229930195729 fatty acid Natural products 0.000 claims description 8
• 238000009472 formulation Methods 0.000 claims description 8
• 150000003626 triacylglycerols Chemical class 0.000 claims description 8
• 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 7
• 150000003839 salts Chemical class 0.000 claims description 7
• LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 6
• 239000002775 capsule Substances 0.000 claims description 6
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• 239000002552 dosage form Substances 0.000 claims description 6
• ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 6
• 239000002202 Polyethylene glycol Substances 0.000 claims description 5
• 239000008346 aqueous phase Substances 0.000 claims description 5
• 239000003795 chemical substances by application Substances 0.000 claims description 5
• 239000006184 cosolvent Substances 0.000 claims description 5
• 229920001223 polyethylene glycol Polymers 0.000 claims description 5
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 4
• NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 claims description 4
• 125000000217 alkyl group Chemical group 0.000 claims description 4
• 230000015572 biosynthetic process Effects 0.000 claims description 4
• 239000007957 coemulsifier Substances 0.000 claims description 4
• 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 4
• 150000003904 phospholipids Chemical class 0.000 claims description 4
• DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical group C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims description 3
• 125000004432 carbon atom Chemical group C* 0.000 claims description 3
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• 230000000078 anti-malarial effect Effects 0.000 claims description 2
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• 239000003416 antiarrhythmic agent Substances 0.000 claims description 2
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• 229940127219 anticoagulant drug Drugs 0.000 claims description 2
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• 239000000935 antidepressant agent Substances 0.000 claims description 2
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• 239000002934 diuretic Substances 0.000 claims description 2
• 150000002314 glycerols Chemical class 0.000 claims description 2
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• 229960001340 histamine Drugs 0.000 claims description 2
• 239000003326 hypnotic agent Substances 0.000 claims description 2
• 230000000147 hypnotic effect Effects 0.000 claims description 2
• 239000002563 ionic surfactant Substances 0.000 claims description 2
• 239000003149 muscarinic antagonist Substances 0.000 claims description 2
• 239000002736 nonionic surfactant Substances 0.000 claims description 2
• 235000016709 nutrition Nutrition 0.000 claims description 2
• 229920000151 polyglycol Polymers 0.000 claims description 2
• 239000010695 polyglycol Substances 0.000 claims description 2
• 229920001522 polyglycol ester Polymers 0.000 claims description 2
• 229940044551 receptor antagonist Drugs 0.000 claims description 2
• 239000002464 receptor antagonist Substances 0.000 claims description 2
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• 239000003904 antiprotozoal agent Substances 0.000 claims 1
• 235000008504 concentrate Nutrition 0.000 claims 1
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• VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 description 6
• 239000003981 vehicle Substances 0.000 description 6
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• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
• 108010010803 Gelatin Proteins 0.000 description 3
• 150000001768 cations Chemical class 0.000 description 3
• 235000019864 coconut oil Nutrition 0.000 description 3
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• 125000005456 glyceride group Chemical group 0.000 description 3
• GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
• XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 2
• XMIIGOLPHOKFCH-UHFFFAOYSA-N 3-phenylpropionic acid Chemical compound OC(=O)CCC1=CC=CC=C1 XMIIGOLPHOKFCH-UHFFFAOYSA-N 0.000 description 2
• 229930000680 A04AD01 - Scopolamine Natural products 0.000 description 2
• ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
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