ZA200506204B - 2-propylidene-19-nor-vitamin D compounds - Google Patents
2-propylidene-19-nor-vitamin D compounds Download PDFInfo
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- ZA200506204B ZA200506204B ZA200506204A ZA200506204A ZA200506204B ZA 200506204 B ZA200506204 B ZA 200506204B ZA 200506204 A ZA200506204 A ZA 200506204A ZA 200506204 A ZA200506204 A ZA 200506204A ZA 200506204 B ZA200506204 B ZA 200506204B
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- ZA
- South Africa
- Prior art keywords
- compound
- hydroxy
- group
- hydrogen
- isomer
- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims description 251
- 229910052739 hydrogen Inorganic materials 0.000 claims description 103
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 103
- 239000001257 hydrogen Substances 0.000 claims description 99
- 150000002431 hydrogen Chemical class 0.000 claims description 77
- 239000000203 mixture Substances 0.000 claims description 67
- 125000000217 alkyl group Chemical group 0.000 claims description 54
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- 201000010099 disease Diseases 0.000 claims description 32
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- 238000000034 method Methods 0.000 claims description 29
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 28
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- 229910052799 carbon Inorganic materials 0.000 claims description 27
- 125000004043 oxo group Chemical group O=* 0.000 claims description 26
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 24
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- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Engineering & Computer Science (AREA)
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- Rheumatology (AREA)
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- Hematology (AREA)
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- Emergency Medicine (AREA)
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- Cardiology (AREA)
- Transplantation (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (1)
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| US46195803P | 2003-04-10 | 2003-04-10 |
Publications (1)
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| ZA200506204B true ZA200506204B (en) | 2006-10-25 |
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| ZA200506204A ZA200506204B (en) | 2003-04-10 | 2004-04-09 | 2-propylidene-19-nor-vitamin D compounds |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| KR20050120787A (ko) * | 2003-04-10 | 2005-12-23 | 위스콘신 얼럼나이 리서어치 화운데이션 | 2-프로필리덴-19-노르-비타민 ｄ 화합물 |
| US7713951B2 (en) * | 2004-04-09 | 2010-05-11 | Wisconsin Alumni Research Foundation | 2-alkylidene-18,19-dinor-vitamin D compounds |
| CA2597624C (en) * | 2005-02-11 | 2012-08-14 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-(20s-24s)-1.alpha.,25-dihydroxyvitamin-d2 |
| EP1848442B1 (en) * | 2005-02-11 | 2012-04-25 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-(20s-24epi)-1alpha,25-dihydroxyvitamine-d2 |
| US8114393B2 (en) | 2005-09-14 | 2012-02-14 | Wisconsin Alumni Research Foundation | Methods and compositions for phosphate binding |
| EP2010483A2 (en) * | 2006-04-05 | 2009-01-07 | Wisconsin Alumni Research Foundation | 1.alpha.-hydroxy-2-(3'-hydroxypropylidene)-19-nor-vitamin d compounds and methods of making and use thereof |
| US20090281340A1 (en) * | 2006-04-05 | 2009-11-12 | Deluca Hector F | 1alpha-hydroxy-2-(3'-hydroxypropylidene)-19-nor-vitamin d compounds and methods of making and treatment thereof |
| MX2008012913A (es) * | 2006-04-06 | 2009-03-06 | Wisconsin Alumni Res Found | 2-metilen-1a,25-dihidroxi-18,19,21-trinorvitamina d3 y sus usos. |
| AU2007234717B2 (en) * | 2006-04-06 | 2012-04-19 | Wisconsin Alumni Research Foundation | 2-methylene-1alpha,25-dihydroxy-19,21-dinorvitamin D3 analogs and uses thereof |
| US8575136B2 (en) * | 2006-04-06 | 2013-11-05 | Wisconsin Alumni Research Foundation | 2-methylene-1α-hydroxy-18,19,21-trinorvitamin D3 analogs and uses thereof |
| EP2021320A2 (en) | 2006-04-06 | 2009-02-11 | Wisconsin Alumni Research Foundation | 2-substituted-1alpha, 25-dihydroxy-19,26,27-trinor vitamin d analogs and uses thereof |
| MX2008012673A (es) * | 2006-04-06 | 2008-10-15 | Wisconsin Alumni Res Found | Analogos de 2-metilen-1a-hidroxi-19, 21-dinorvitamina d3 y sus usos. |
| AU2007291005A1 (en) * | 2006-04-06 | 2008-03-06 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D analogs with 1,2,or 3,2 heterocyclic ring |
| ATE496885T1 (de) * | 2006-04-10 | 2011-02-15 | Wisconsin Alumni Res Found | 1-alpha-hydroxy-2-(3'-hydroxypropyliden)-19-nor vitamin-d-verbindungen mit einer 1,1- dimethylpropyl-seitenkette |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
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| IL67153A (en) | 1981-11-02 | 1986-12-31 | Res Inst Medicine Chem | Intermediates in the production of vitamin d analogues and method for their production |
| US4666634A (en) | 1984-12-05 | 1987-05-19 | Chugai Seiyaku Kabushiki Kaisha | vitamin D3 derivatives having a substituent at 2-position |
| GB8904154D0 (en) | 1989-02-23 | 1989-04-05 | Leo Pharm Prod Ltd | Chemical compounds |
| US5246925A (en) * | 1989-03-09 | 1993-09-21 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D compounds for use in treating hyperparathyroidism |
| NZ232734A (en) | 1989-03-09 | 1991-11-26 | Wisconsin Alumni Res Found | 19-nor vitamin d derivatives and pharmaceutical compositions |
| CA1333616C (en) * | 1989-03-09 | 1994-12-20 | Hector F. Deluca | 19-nor-vitamin d compounds |
| AU649057B2 (en) | 1990-08-24 | 1994-05-12 | Wisconsin Alumni Research Foundation | Methods and compositions containing vitamin D compounds for improvement of skin conditions |
| ATE173401T1 (de) | 1990-09-07 | 1998-12-15 | Wisconsin Alumni Res Found | Neue verwendung von 1-alpha-hydroxylierten-19-nor-vitamin-d-verbind ngen zur behandlung von psoriasis |
| US5086191A (en) * | 1991-05-28 | 1992-02-04 | Wisconsin Alumni Research Foundation | Intermediates for the synthesis of 19-nor vitamin D compounds |
| AU650751B2 (en) | 1991-05-28 | 1994-06-30 | Wisconsin Alumni Research Foundation | Novel synthesis of 19-nor vitamin D compounds |
| JP3213092B2 (ja) * | 1991-11-01 | 2001-09-25 | 中外製薬株式会社 | ２β位に置換基を有するビタミンＤ誘導体 |
| JP2898882B2 (ja) * | 1993-04-05 | 1999-06-02 | ウイスコンシン アラムナイ リサーチ フオンデーシヨン | ２−位に置換基を有する１９−ノル−ビタミンｄ３ 化合物 |
| US5565589A (en) * | 1993-11-03 | 1996-10-15 | Wisconsin Alumni Research Foundation | 17-formyl-5,6-trans-vitamin D compounds |
| US5428029A (en) * | 1993-11-24 | 1995-06-27 | Hoffmann-La Roche Inc. | Vitamin D3 fluorinated analogs |
| WO1996001811A1 (en) * | 1994-07-11 | 1996-01-25 | The Johns-Hopkins University | 2-substituted 1,25-dihydroxyvitamin d3 derivatives |
| JPH10509715A (ja) * | 1994-11-21 | 1998-09-22 | ウィスコンシン・アルムニ・リサーチ・ファウンデーション | １８，１９−ジノル−ビタミンｄ 化合物 |
| US5877168A (en) * | 1995-02-10 | 1999-03-02 | Chugai Seiyaku Kabushiki Kaisha | Vitamin D derivative with substituent at the 2β-position |
| IL118156A (en) * | 1995-05-09 | 2001-08-26 | Duphar Int Res | Vitamin d compounds, their preparation and pharmaceutical compositions containing them |
| US5945410A (en) * | 1997-03-17 | 1999-08-31 | Wisconsin Alumni Research Foundation | 2-alkyl-19-nor-vitamin D compounds |
| US6392071B1 (en) * | 1997-03-17 | 2002-05-21 | Wisconsin Alumni: Research Foundation | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds |
| US5843928A (en) * | 1997-03-17 | 1998-12-01 | Wisconsin Alumni Research Foundation | 2-alkylidene-19-nor-vitamin D compounds |
| GB9915839D0 (en) * | 1999-07-06 | 1999-09-08 | Textron Automotive U K | Valve assembly for vehicle washing system |
| EP1524264A3 (en) * | 2000-05-31 | 2010-01-20 | Wisconsin Alumni Research Foundation | 2-ethylidene-19-nor-vitamin D compounds |
| ES2309069T3 (es) * | 2000-05-31 | 2008-12-16 | Wisconsin Alumni Research Foundation | Compuestos de 2-etil y 2-etiliden-19-nor-vitamina d. |
| US6846811B2 (en) * | 2002-04-22 | 2005-01-25 | Wisconsin Alumni Research Foundation | (20S) 1α-hydroxy-2α-methyl and 2β-methyl-19-nor-vitamin D3 and their uses |
| KR20050120787A (ko) * | 2003-04-10 | 2005-12-23 | 위스콘신 얼럼나이 리서어치 화운데이션 | 2-프로필리덴-19-노르-비타민 ｄ 화합물 |
| WO2005051396A2 (en) * | 2003-11-25 | 2005-06-09 | Deltanoid Pharmaceuticals, Inc. | Methods for reducing body fat using vitamin d compounds |
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2004
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- 2004-04-09 WO PCT/US2004/011059 patent/WO2004092118A2/en not_active Ceased
- 2004-04-09 CN CN2008101302056A patent/CN101293894B/zh not_active Expired - Fee Related
- 2004-04-09 US US10/544,163 patent/US20060293291A1/en not_active Abandoned
- 2004-04-09 JP JP2006509883A patent/JP5005340B2/ja not_active Expired - Fee Related
- 2004-04-09 AT AT04749961T patent/ATE556999T1/de active
- 2004-04-09 MX MXPA05009336A patent/MXPA05009336A/es active IP Right Grant
- 2004-04-09 NZ NZ542674A patent/NZ542674A/en not_active IP Right Cessation
- 2004-04-09 BR BRPI0409194-9A patent/BRPI0409194A/pt not_active Application Discontinuation
- 2004-04-09 CN CNB2004800096206A patent/CN100534981C/zh not_active Expired - Fee Related
- 2004-04-09 EP EP04749961A patent/EP1613588B1/en not_active Expired - Lifetime
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2007
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| CN1771226A (zh) | 2006-05-10 |
| US20070213546A1 (en) | 2007-09-13 |
| WO2004092118A2 (en) | 2004-10-28 |
| US7241747B2 (en) | 2007-07-10 |
| EP1613588B1 (en) | 2012-05-09 |
| US7531527B2 (en) | 2009-05-12 |
| JP5005340B2 (ja) | 2012-08-22 |
| ATE556999T1 (de) | 2012-05-15 |
| MXPA05009336A (es) | 2005-11-04 |
| MY146504A (en) | 2012-08-15 |
| CA2516233A1 (en) | 2004-10-28 |
| BRPI0409194A (pt) | 2006-04-11 |
| CN101293894B (zh) | 2011-04-06 |
| CN100534981C (zh) | 2009-09-02 |
| CA2516233C (en) | 2011-09-20 |
| US20040229851A1 (en) | 2004-11-18 |
| AU2004230948A1 (en) | 2004-10-28 |
| JP2006523239A (ja) | 2006-10-12 |
| EP1613588A2 (en) | 2006-01-11 |
| US20060293291A1 (en) | 2006-12-28 |
| KR20050120787A (ko) | 2005-12-23 |
| HK1086817A1 (zh) | 2006-09-29 |
| WO2004092118A3 (en) | 2005-01-27 |
| CN101293894A (zh) | 2008-10-29 |
| NZ542674A (en) | 2009-03-31 |
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