ZA200503752B - Method of stimulating hair growth using benzopyrans - Google Patents
Method of stimulating hair growth using benzopyrans Download PDFInfo
- Publication number
- ZA200503752B ZA200503752B ZA200503752A ZA200503752A ZA200503752B ZA 200503752 B ZA200503752 B ZA 200503752B ZA 200503752 A ZA200503752 A ZA 200503752A ZA 200503752 A ZA200503752 A ZA 200503752A ZA 200503752 B ZA200503752 B ZA 200503752B
- Authority
- ZA
- South Africa
- Prior art keywords
- hair
- alopecia
- compound
- alkyl
- formula
- Prior art date
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- 230000003779 hair growth Effects 0.000 title claims abstract description 43
- 238000000034 method Methods 0.000 title abstract description 38
- 230000004936 stimulating effect Effects 0.000 title abstract description 10
- 150000001562 benzopyrans Chemical class 0.000 title abstract description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 33
- 210000004209 hair Anatomy 0.000 claims description 20
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 claims description 13
- 241000699670 Mus sp. Species 0.000 claims description 11
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- 230000012010 growth Effects 0.000 claims description 2
- SAHIZENKTPRYSN-UHFFFAOYSA-N [2-[3-(phenoxymethyl)phenoxy]-6-(trifluoromethyl)pyridin-4-yl]methanamine Chemical compound O(C1=CC=CC=C1)CC=1C=C(OC2=NC(=CC(=C2)CN)C(F)(F)F)C=CC=1 SAHIZENKTPRYSN-UHFFFAOYSA-N 0.000 claims 1
- ABRVLXLNVJHDRQ-UHFFFAOYSA-N [2-pyridin-3-yl-6-(trifluoromethyl)pyridin-4-yl]methanamine Chemical compound FC(C1=CC(=CC(=N1)C=1C=NC=CC=1)CN)(F)F ABRVLXLNVJHDRQ-UHFFFAOYSA-N 0.000 claims 1
- 201000004384 Alopecia Diseases 0.000 description 101
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- AICOOMRHRUFYCM-ZRRPKQBOSA-N oxazine, 1 Chemical compound C([C@@H]1[C@H](C(C[C@]2(C)[C@@H]([C@H](C)N(C)C)[C@H](O)C[C@]21C)=O)CC1=CC2)C[C@H]1[C@@]1(C)[C@H]2N=C(C(C)C)OC1 AICOOMRHRUFYCM-ZRRPKQBOSA-N 0.000 description 1
- MPQXHAGKBWFSNV-UHFFFAOYSA-N oxidophosphanium Chemical class [PH3]=O MPQXHAGKBWFSNV-UHFFFAOYSA-N 0.000 description 1
- 229940101267 panthenol Drugs 0.000 description 1
- 235000020957 pantothenol Nutrition 0.000 description 1
- 239000011619 pantothenol Substances 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 235000019477 peppermint oil Nutrition 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 229960003742 phenol Drugs 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 229920000056 polyoxyethylene ether Polymers 0.000 description 1
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 1
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229940113124 polysorbate 60 Drugs 0.000 description 1
- 239000003450 potassium channel blocker Substances 0.000 description 1
- 239000004036 potassium channel stimulating agent Substances 0.000 description 1
- 239000001508 potassium citrate Substances 0.000 description 1
- 229960002635 potassium citrate Drugs 0.000 description 1
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 1
- 235000011082 potassium citrates Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
- 229960005205 prednisolone Drugs 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- NEOZOXKVMDBOSG-UHFFFAOYSA-N propan-2-yl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OC(C)C NEOZOXKVMDBOSG-UHFFFAOYSA-N 0.000 description 1
- 229940117382 propecia Drugs 0.000 description 1
- 230000004800 psychological effect Effects 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 229940116351 sebacate Drugs 0.000 description 1
- CXMXRPHRNRROMY-UHFFFAOYSA-L sebacate(2-) Chemical compound [O-]C(=O)CCCCCCCCC([O-])=O CXMXRPHRNRROMY-UHFFFAOYSA-L 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000003352 sequestering agent Substances 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- FBWNMEQMRUMQSO-UHFFFAOYSA-N tergitol NP-9 Chemical compound CCCCCCCCCC1=CC=C(OCCOCCOCCOCCOCCOCCOCCOCCOCCO)C=C1 FBWNMEQMRUMQSO-UHFFFAOYSA-N 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 229940098465 tincture Drugs 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical class CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 229930007845 β-thujaplicin Natural products 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42568602P | 2002-11-12 | 2002-11-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200503752B true ZA200503752B (en) | 2006-12-27 |
Family
ID=32313039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200503752A ZA200503752B (en) | 2002-11-12 | 2005-05-10 | Method of stimulating hair growth using benzopyrans |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7306789B2 (ja) |
| EP (1) | EP1562547B1 (ja) |
| JP (1) | JP2006507317A (ja) |
| KR (1) | KR20050074592A (ja) |
| CN (1) | CN100337624C (ja) |
| AT (1) | ATE407724T1 (ja) |
| AU (1) | AU2003274569B2 (ja) |
| BR (1) | BR0316132A (ja) |
| CA (1) | CA2505500C (ja) |
| DE (1) | DE60323533D1 (ja) |
| DK (1) | DK1562547T3 (ja) |
| ES (1) | ES2311727T3 (ja) |
| HK (1) | HK1085122A1 (ja) |
| IL (1) | IL168345A (ja) |
| MX (1) | MXPA05004668A (ja) |
| MY (1) | MY135460A (ja) |
| NZ (1) | NZ539903A (ja) |
| PL (1) | PL376835A1 (ja) |
| TW (1) | TW200425890A (ja) |
| WO (1) | WO2004043424A1 (ja) |
| ZA (1) | ZA200503752B (ja) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2505500C (en) | 2002-11-12 | 2009-08-18 | Warner-Lambert Company Llc | Method of stimulating hair growth using benzopyrans |
| AU2005215258A1 (en) * | 2004-02-12 | 2005-09-01 | Warner-Lambert Company Llc | Method of stimulating hair growth |
| WO2006008641A1 (en) * | 2004-07-16 | 2006-01-26 | Warner-Lambert Company Llc | Hair growth promoting agents |
| MXPA06014390A (es) * | 2004-07-19 | 2007-10-02 | Warner Lambert Co | Formulacion para estimular el crecimiento del pelo. |
| WO2011034940A1 (en) | 2009-09-15 | 2011-03-24 | Five Prime Therapeutics, Inc. | Hair growth methods using fgfr4 extracellular domains |
| US8685931B2 (en) | 2009-12-17 | 2014-04-01 | Five Prime Therapeutics, Inc. | Hair growth methods using FGFR3 extracellular domains |
| US9897569B2 (en) * | 2010-07-08 | 2018-02-20 | The Johns Hopkins University | Circuits, devices and sensors for fluid detection |
| US8481038B2 (en) | 2010-11-15 | 2013-07-09 | Five Prime Therapeutics, Inc. | Treatment of cancer with elevated dosages of soluble FGFR1 fusion proteins |
| BR112019000706A8 (pt) | 2016-07-15 | 2022-12-06 | Pasteur Institut | Agente de estímulo do receptor 1b de 5-hidroxitriptamina para reparo de pele e/ou cabelo |
| JP2021042161A (ja) * | 2019-09-11 | 2021-03-18 | 国立大学法人東海国立大学機構 | 脱毛剤、脱毛モデル動物及び白髪モデル動物 |
| CN113713083A (zh) * | 2020-05-25 | 2021-11-30 | 南京帝昌医药科技有限公司 | 一种用于治疗脱发的药物组合 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3824446A1 (de) | 1988-07-19 | 1990-01-25 | Hoechst Ag, 6230 Frankfurt | Verwendung substituierter 3,4-dihydro-2h-benzopyrane als heilmittel gegen obstruktive funktionsstoerungen der lunge und/oder stoerungen der ableitenden harnwege |
| DE3918041A1 (de) | 1989-06-02 | 1990-12-06 | Merck Patent Gmbh | Chromanderivate |
| US5061813A (en) | 1990-04-02 | 1991-10-29 | E. R. Squibb & Sons, Inc. | Substituted cyanoimino benzopyranes |
| TW244350B (ja) | 1991-12-14 | 1995-04-01 | Hoechst Ag | |
| JPH0673061A (ja) | 1992-01-18 | 1994-03-15 | Hoechst Ag | ６−置換クロメン類のエナンチオ選択的エポキシ化方法 |
| GB9316111D0 (en) * | 1993-08-04 | 1993-09-22 | Pfizer Ltd | Benzopyrans |
| GB9822024D0 (en) * | 1998-10-09 | 1998-12-02 | Novartis Ag | Organic compounds |
| CA2505500C (en) | 2002-11-12 | 2009-08-18 | Warner-Lambert Company Llc | Method of stimulating hair growth using benzopyrans |
| AU2005215258A1 (en) * | 2004-02-12 | 2005-09-01 | Warner-Lambert Company Llc | Method of stimulating hair growth |
-
2003
- 2003-11-03 CA CA002505500A patent/CA2505500C/en not_active Expired - Fee Related
- 2003-11-03 WO PCT/IB2003/004926 patent/WO2004043424A1/en active IP Right Grant
- 2003-11-03 DK DK03758544T patent/DK1562547T3/da active
- 2003-11-03 CN CNB2003801086832A patent/CN100337624C/zh not_active Expired - Fee Related
- 2003-11-03 DE DE60323533T patent/DE60323533D1/de not_active Expired - Lifetime
- 2003-11-03 AT AT03758544T patent/ATE407724T1/de not_active IP Right Cessation
- 2003-11-03 NZ NZ539903A patent/NZ539903A/en unknown
- 2003-11-03 MX MXPA05004668A patent/MXPA05004668A/es active IP Right Grant
- 2003-11-03 US US10/699,895 patent/US7306789B2/en not_active Expired - Fee Related
- 2003-11-03 EP EP03758544A patent/EP1562547B1/en not_active Expired - Lifetime
- 2003-11-03 ES ES03758544T patent/ES2311727T3/es not_active Expired - Lifetime
- 2003-11-03 KR KR1020057008391A patent/KR20050074592A/ko not_active Application Discontinuation
- 2003-11-03 BR BR0316132-3A patent/BR0316132A/pt not_active IP Right Cessation
- 2003-11-03 JP JP2004550894A patent/JP2006507317A/ja active Pending
- 2003-11-03 PL PL376835A patent/PL376835A1/pl not_active Application Discontinuation
- 2003-11-03 AU AU2003274569A patent/AU2003274569B2/en not_active Ceased
- 2003-11-07 MY MYPI20034270A patent/MY135460A/en unknown
- 2003-11-11 TW TW092131553A patent/TW200425890A/zh unknown
-
2005
- 2005-05-02 IL IL168345A patent/IL168345A/en not_active IP Right Cessation
- 2005-05-10 ZA ZA200503752A patent/ZA200503752B/en unknown
-
2006
- 2006-05-03 HK HK06105221A patent/HK1085122A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003274569B2 (en) | 2008-07-31 |
| CN1738591A (zh) | 2006-02-22 |
| ES2311727T3 (es) | 2009-02-16 |
| DK1562547T3 (da) | 2008-11-17 |
| WO2004043424A1 (en) | 2004-05-27 |
| CA2505500C (en) | 2009-08-18 |
| HK1085122A1 (en) | 2006-08-18 |
| AU2003274569A1 (en) | 2004-06-03 |
| IL168345A (en) | 2009-09-22 |
| MXPA05004668A (es) | 2005-06-08 |
| JP2006507317A (ja) | 2006-03-02 |
| PL376835A1 (pl) | 2006-01-09 |
| US7306789B2 (en) | 2007-12-11 |
| EP1562547B1 (en) | 2008-09-10 |
| BR0316132A (pt) | 2005-09-27 |
| CN100337624C (zh) | 2007-09-19 |
| DE60323533D1 (de) | 2008-10-23 |
| MY135460A (en) | 2008-04-30 |
| WO2004043424A8 (en) | 2004-07-08 |
| EP1562547A1 (en) | 2005-08-17 |
| NZ539903A (en) | 2008-02-29 |
| TW200425890A (en) | 2004-12-01 |
| KR20050074592A (ko) | 2005-07-18 |
| CA2505500A1 (en) | 2004-05-27 |
| US20040157856A1 (en) | 2004-08-12 |
| ATE407724T1 (de) | 2008-09-15 |
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