ZA200502874B - Therapeutic treatment. - Google Patents
Therapeutic treatment. Download PDFInfo
- Publication number
- ZA200502874B ZA200502874B ZA200502874A ZA200502874A ZA200502874B ZA 200502874 B ZA200502874 B ZA 200502874B ZA 200502874 A ZA200502874 A ZA 200502874A ZA 200502874 A ZA200502874 A ZA 200502874A ZA 200502874 B ZA200502874 B ZA 200502874B
- Authority
- ZA
- South Africa
- Prior art keywords
- acceptable salt
- pharmaceutically acceptable
- cancer
- substance
- composition
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
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| AU (1) | AU2003269259B2 (is) |
| BR (1) | BR0315140A (is) |
| CA (1) | CA2501959A1 (is) |
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| HK (1) | HK1078784A1 (is) |
| IS (1) | IS2473B (is) |
| MX (1) | MXPA05003808A (is) |
| MY (1) | MY135441A (is) |
| NO (1) | NO20051658L (is) |
| NZ (1) | NZ539137A (is) |
| PL (1) | PL375584A1 (is) |
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| UY (1) | UY28017A1 (is) |
| WO (1) | WO2004035057A1 (is) |
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| GB0218526D0 (en) * | 2002-08-09 | 2002-09-18 | Astrazeneca Ab | Combination therapy |
| GB0219660D0 (en) | 2002-08-23 | 2002-10-02 | Astrazeneca Ab | Therapeutic use |
| WO2004100991A1 (en) * | 2003-05-15 | 2004-11-25 | Universite Catholique De Louvain | Use of endothelin-1 antagonists for improving cancer therapy |
| GB0320806D0 (en) * | 2003-09-05 | 2003-10-08 | Astrazeneca Ab | Therapeutic treatment |
| GB0403744D0 (en) | 2004-02-20 | 2004-03-24 | Astrazeneca Ab | Chemical process |
| GB0425854D0 (en) * | 2004-11-25 | 2004-12-29 | Astrazeneca Ab | Therapeutic treatment |
| WO2009047565A2 (en) * | 2007-10-12 | 2009-04-16 | Astrazeneca Ab | Composition 064 |
| HUE026005T2 (en) * | 2009-08-10 | 2016-04-28 | Univ Texas | Treatment of brain metastases with a combination of endothelin receptor inhibitors and cytotoxic chemotherapeutic agents |
| KR20200119246A (ko) | 2018-01-12 | 2020-10-19 | 이엔비 테라퓨틱스, 인크. | Etbr 활성화와 관련된 암을 치료하기 위한 중수소화 화합물, 조성물, 및 방법 |
| CN114423425A (zh) * | 2019-07-17 | 2022-04-29 | Enb治疗公司 | 通过使用内皮素b受体拮抗剂治疗尿路上皮癌和肾癌 |
| KR20240022646A (ko) | 2021-06-22 | 2024-02-20 | 앨커메디신, 인크. | 화합물, 엔도텔린 a 수용체 길항제 및 의약 조성물 |
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| US5464853A (en) * | 1993-05-20 | 1995-11-07 | Immunopharmaceutics, Inc. | N-(5-isoxazolyl)biphenylsulfonamides, N-(3-isoxazolyl)biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin |
| US5514691A (en) * | 1993-05-20 | 1996-05-07 | Immunopharmaceutics, Inc. | N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin |
| GB9300059D0 (en) * | 1992-01-20 | 1993-03-03 | Zeneca Ltd | Quinazoline derivatives |
| US6063911A (en) * | 1993-12-01 | 2000-05-16 | Marine Polymer Technologies, Inc. | Methods and compositions for treatment of cell proliferative disorders |
| GB9508538D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| UA58494C2 (uk) * | 1995-06-07 | 2003-08-15 | Зенека Лімітед | Похідні n-гетероарилпіридинсульфонаміду, фармацевтична композиція, спосіб одержання та спосіб протидії впливам ендотеліну |
| US5780435A (en) * | 1995-12-15 | 1998-07-14 | Praecis Pharmaceuticals Incorporated | Methods for treating prostate cancer with LHRH-R antagonists |
| AU759691C (en) * | 1998-04-29 | 2004-04-29 | Osi Pharmaceuticals, Inc. | N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4- quinazolinamine mesylate anhydrate and monohydrate |
| US6355678B1 (en) * | 1998-06-29 | 2002-03-12 | Parker Hughes Institute | Inhibitors of the EGF-receptor tyrosine kinase and methods for their use |
| GB0008368D0 (en) * | 2000-04-06 | 2000-05-24 | Astrazeneca Ab | Combination product |
| US20020055457A1 (en) * | 2000-08-07 | 2002-05-09 | Janus Todd J. | Methods of treating cancer and the pain associated therewith using endothelin antagonists |
| US20030092757A1 (en) * | 2001-04-11 | 2003-05-15 | Amitabh Singh | Favorable modulation of health-related quality of life and health-related quality-adjusted time-to-progression of disease in patients with prostate cancer |
| DE10155076A1 (de) * | 2001-11-09 | 2003-05-22 | Merck Patent Gmbh | Verwendung von Endothelin-Rezeptor-Antagonisten zur Behandlung von Tumorerkrankungen |
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2007
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Also Published As
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| NZ539137A (en) | 2008-01-31 |
| CN1703224A (zh) | 2005-11-30 |
| CY1107605T1 (el) | 2013-03-13 |
| ES2289316T3 (es) | 2008-02-01 |
| EP1553950A1 (en) | 2005-07-20 |
| KR20050056238A (ko) | 2005-06-14 |
| TW200412971A (en) | 2004-08-01 |
| IS7825A (is) | 2005-04-26 |
| BR0315140A (pt) | 2005-08-16 |
| US20060122180A1 (en) | 2006-06-08 |
| DE60315490D1 (de) | 2007-09-20 |
| UY28017A1 (es) | 2004-04-30 |
| UA82492C2 (uk) | 2008-04-25 |
| WO2004035057A1 (en) | 2004-04-29 |
| EP1553950B1 (en) | 2007-08-08 |
| GB0223854D0 (en) | 2002-11-20 |
| MXPA05003808A (es) | 2005-06-08 |
| AU2003269259B2 (en) | 2007-03-15 |
| AU2003269259A1 (en) | 2004-05-04 |
| PT1553950E (pt) | 2007-09-26 |
| AR041595A1 (es) | 2005-05-26 |
| IS2473B (is) | 2008-12-15 |
| NO20051658L (no) | 2005-05-06 |
| CA2501959A1 (en) | 2004-04-29 |
| DK1553950T3 (da) | 2007-10-15 |
| HK1078784A1 (en) | 2006-03-24 |
| DE60315490T2 (de) | 2008-05-08 |
| MY135441A (en) | 2008-04-30 |
| RU2005114487A (ru) | 2006-02-10 |
| CN100342853C (zh) | 2007-10-17 |
| JP2006510605A (ja) | 2006-03-30 |
| PL375584A1 (en) | 2005-11-28 |
| SA04240502B1 (ar) | 2008-09-14 |
| ATE369136T1 (de) | 2007-08-15 |
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