ZA200501724B - Method of producing hydroxyalkyl starch derivatives - Google Patents

Method of producing hydroxyalkyl starch derivatives

Info

Publication number
ZA200501724B
ZA200501724B ZA200501724A ZA200501724A ZA200501724B ZA 200501724 B ZA200501724 B ZA 200501724B ZA 200501724 A ZA200501724 A ZA 200501724A ZA 200501724 A ZA200501724 A ZA 200501724A ZA 200501724 B ZA200501724 B ZA 200501724B
Authority
ZA
South Africa
Prior art keywords
starch derivatives
hydroxyalkyl starch
producing hydroxyalkyl
producing
derivatives
Prior art date
Application number
ZA200501724A
Other languages
English (en)
Inventor
Norbert Zander
Harald S Conradt
Wolfram Eichner
Original Assignee
Fresenius Kabi De Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fresenius Kabi De Gmbh filed Critical Fresenius Kabi De Gmbh
Publication of ZA200501724B publication Critical patent/ZA200501724B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5412—IL-6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C07K17/10—Peptides being immobilised on, or in, an organic carrier the carrier being a carbohydrate
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B31/00—Preparation of derivatives of starch
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B31/00—Preparation of derivatives of starch
    • C08B31/003—Crosslinking of starch
    • C08B31/006—Crosslinking of derivatives of starch
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B31/00—Preparation of derivatives of starch
    • C08B31/08—Ethers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B31/00—Preparation of derivatives of starch
    • C08B31/08—Ethers
    • C08B31/12—Ethers having alkyl or cycloalkyl radicals substituted by heteroatoms, e.g. hydroxyalkyl or carboxyalkyl starch
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B31/00—Preparation of derivatives of starch
    • C08B31/18—Oxidised starch
    • C08B31/185—Derivatives of oxidised starch, e.g. crosslinked oxidised starch
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
    • C08H1/00—Macromolecular products derived from proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ZA200501724A 2002-09-11 2005-02-28 Method of producing hydroxyalkyl starch derivatives ZA200501724B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02020425A EP1400533A1 (de) 2002-09-11 2002-09-11 Hasylierte Polypeptide, besonders hasyliertes Erythropoietin

Publications (1)

Publication Number Publication Date
ZA200501724B true ZA200501724B (en) 2006-05-31

Family

ID=31896851

Family Applications (3)

Application Number Title Priority Date Filing Date
ZA200501724A ZA200501724B (en) 2002-09-11 2005-02-28 Method of producing hydroxyalkyl starch derivatives
ZA200501725A ZA200501725B (en) 2002-09-11 2005-02-28 Hydroxyalkyl starch derivatives
ZA200501729A ZA200501729B (en) 2002-09-11 2005-02-28 Hasylated polypeptides especially hasylated erythropoietin

Family Applications After (2)

Application Number Title Priority Date Filing Date
ZA200501725A ZA200501725B (en) 2002-09-11 2005-02-28 Hydroxyalkyl starch derivatives
ZA200501729A ZA200501729B (en) 2002-09-11 2005-02-28 Hasylated polypeptides especially hasylated erythropoietin

Country Status (9)

Country Link
EP (1) EP1400533A1 (de)
JP (2) JP4688494B2 (de)
CN (3) CN100480274C (de)
CA (2) CA2496318A1 (de)
DE (1) DE02020425T1 (de)
ES (1) ES2214166T1 (de)
NO (1) NO20051418L (de)
PL (1) PL217251B1 (de)
ZA (3) ZA200501724B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10112825A1 (de) 2001-03-16 2002-10-02 Fresenius Kabi De Gmbh HESylierung von Wirkstoffen in wässriger Lösung
DE10209822A1 (de) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung niedermolekularer Substanzen an ein modifiziertes Polysaccharid
DE10209821A1 (de) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung von Proteinen an ein modifiziertes Polysaccharid
BR0314107A (pt) 2002-09-11 2005-07-19 Fresenius Kabi De Gmbh Método de produção de derivados de hidroxialquil amido
DE02020425T1 (de) * 2002-09-11 2004-07-15 Fresenius Kabi Deutschland Gmbh Hasylierte Polypeptide, besonders hasyliertes Erythropoietin
EP1549350B1 (de) 2002-10-08 2008-09-24 Fresenius Kabi Deutschland GmbH Pharmazeutisch aktive oligosaccharid-conjugate
WO2005014655A2 (en) 2003-08-08 2005-02-17 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein
CA2558738C (en) 2004-03-11 2013-02-05 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination
WO2005095331A1 (ja) * 2004-03-31 2005-10-13 Shionogi & Co., Ltd. 糖鎖－ペプチド結合剤
EP1861124A2 (de) * 2005-03-11 2007-12-05 Fresenius Kabi Deutschland GmbH Herstellung von bioaktiven glykoproteinen aus inaktiven ausgangsmaterialien durch konjugation mit hydroxyalkylstärke
US8299015B2 (en) * 2006-07-25 2012-10-30 Lipoxen Technologies Limited Derivatisation of granulocyte colony-stimulating factor
PT2457919T (pt) 2007-01-18 2019-09-20 Genzyme Corp Oligossacáridos compreendendo um grupo amino-oxi e os seus conjugados
EP2070950A1 (de) * 2007-12-14 2009-06-17 Fresenius Kabi Deutschland GmbH Hydroxyalkylstärkederivate und deren Herstellungsverfahren
WO2009134344A1 (en) * 2008-04-28 2009-11-05 Surmodics, Inc. POLY-α(1→4)GLUCOPYRANOSE-BASED MATRICES WITH HYDRAZIDE CROSSLINKING
CN101407553B (zh) * 2008-11-20 2010-09-22 广西大学 一种歧化松香胺基季铵型阳离子木薯淀粉的微波合成方法
PT2459224T (pt) * 2009-07-27 2016-09-05 Baxalta Inc Conjugados proteicos para coagulação sanguínea
WO2011012850A2 (en) * 2009-07-27 2011-02-03 Lipoxen Technologies Limited Glycopolysialylation of non-blood coagulation proteins
MX345608B (es) 2010-12-22 2017-02-07 Baxalta Inc Materiales y metodos para conjugar un derivado de acido graso soluble en agua a una proteina.
MY163078A (en) * 2011-07-14 2017-08-15 Grifols Sa Rapid and accurate analysis of protein sialylation
US10202469B2 (en) * 2012-11-30 2019-02-12 Glytech, Inc. Sugar chain-attached linker, compound containing sugar chain-attached linker and physiologically active substance or salt thereof, and method for producing same
US20160311933A1 (en) * 2013-03-20 2016-10-27 Fresenius Kabi Deutschland Gmbh Process for the preparation of thiol functionalized hydroxyalkyl starch derivatives
CN105418754A (zh) * 2015-09-30 2016-03-23 天津药物研究院有限公司 羟乙基淀粉修饰的促红细胞生成素模拟肽及其制备和应用
JP2019510042A (ja) * 2016-03-28 2019-04-11 クック・ジェネラル・バイオテクノロジー・エルエルシー 生細胞組成物及び生細胞組成物に関連する方法
CN108219019B (zh) * 2018-02-08 2020-03-20 华中科技大学 一种巯基化羟乙基淀粉及其修饰的纳米材料和制备方法
CN113336823A (zh) * 2021-05-28 2021-09-03 联宁（苏州）生物制药有限公司 一种用于抗体偶联药物连接子lnd1067的合成方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0019403B1 (de) * 1979-05-10 1985-07-31 American Hospital Supply Corporation Arzneimittelträger auf der Basis von Hydroxyalkyl-Stärke
DE3029307A1 (de) * 1980-08-01 1982-03-04 Dr. Eduard Fresenius, Chemisch-pharmazeutische Industrie KG, 6380 Bad Homburg Haemoglobin enthaltendes blutersatzmittel
US4847325A (en) * 1988-01-20 1989-07-11 Cetus Corporation Conjugation of polymer to colony stimulating factor-1
YU134490A (sh) * 1989-07-18 1992-09-07 Warner-Labmert Company Preparati polimernih smeša koji sadrže destrukturisani skrob
US5281698A (en) * 1991-07-23 1994-01-25 Cetus Oncology Corporation Preparation of an activated polymer ester for protein conjugation
FI935485A (fi) * 1992-12-09 1994-06-10 Ortho Pharma Corp PEG-hydratsoni- ja PEG-oksiimisidoksen muodostavat reagenssit ja niiden proteiinijohdannaiset
AU7097094A (en) * 1993-06-01 1994-12-20 Enzon, Inc. Carbohydrate-modified polymer conjugates with erythropoietic activity
TW517067B (en) * 1996-05-31 2003-01-11 Hoffmann La Roche Interferon conjugates
DE19628705A1 (de) * 1996-07-08 1998-01-15 Fresenius Ag Neue Sauerstoff-Transport-Mittel, diese enthaltende Hämoglobin-Hydroxyethylstärke-Konjugate, Verfahren zu deren Herstellung, sowie deren Verwendung als Blutersatzstoffe
DE10112825A1 (de) * 2001-03-16 2002-10-02 Fresenius Kabi De Gmbh HESylierung von Wirkstoffen in wässriger Lösung
DE02020425T1 (de) * 2002-09-11 2004-07-15 Fresenius Kabi Deutschland Gmbh Hasylierte Polypeptide, besonders hasyliertes Erythropoietin
BR0314107A (pt) * 2002-09-11 2005-07-19 Fresenius Kabi De Gmbh Método de produção de derivados de hidroxialquil amido

Also Published As

Publication number Publication date
CN100480274C (zh) 2009-04-22
CA2799437C (en) 2014-06-03
DE02020425T1 (de) 2004-07-15
CN101580547B (zh) 2014-01-15
CN101497671A (zh) 2009-08-05
CA2496318A1 (en) 2004-03-25
EP1400533A1 (de) 2004-03-24
NO20051418L (no) 2005-05-31
ZA200501725B (en) 2006-05-31
PL217251B1 (pl) 2014-06-30
PL398391A1 (pl) 2012-05-21
JP4688494B2 (ja) 2011-05-25
CN101497671B (zh) 2013-01-16
CN101580547A (zh) 2009-11-18
JP2006505635A (ja) 2006-02-16
JP4692958B2 (ja) 2011-06-01
CN1708514A (zh) 2005-12-14
CA2799437A1 (en) 2004-03-25
JP2006511635A (ja) 2006-04-06
ES2214166T1 (es) 2004-09-16
ZA200501729B (en) 2006-05-31

Similar Documents

Publication Publication Date Title
PL374969A1 (en) Method of producing hydroxyalkyl starch derivatives
ZA200501724B (en) Method of producing hydroxyalkyl starch derivatives
AU2003303239A8 (en) Process of making chalcone derivatives
IL215617A0 (en) Substituted pyrrolo-pyrazole derivatives and process for their preparation
EP1539692A4 (de) Furanonderivate und verfahren zu deren herstellung
ZA200604586B (en) Method for modifying starch or starch derivatives
EP1577280A4 (de) Deuterisierungsverfahren
IL146580A0 (en) Method of producing nitroguanidine-and nitroenamine derivatives
AU2003233820A1 (en) Method for the treatment of starch
IL148825A0 (en) Derivatives of isoflavones
PT1594901T (pt) Um método para produzir amido resistente
IL165137A0 (en) Process for the preparation of thioalkylamine derivatives
PL354668A1 (en) Method of manufacture of starch acrylate derivatives
PL352959A1 (en) Method of obtaining derivatives of taxane
PL357914A1 (en) Method of manufacture of carboxy-methyl starch
AU2003222584A1 (en) Method of producing organoacyloxysilanes
PL357429A1 (en) Method of manufacture of 4-aminocynnoline and its derivatives
PL346356A1 (en) Method of obtaining n-urethane derivatives of l-ornitin
IL164126A0 (en) Derivatives of isoflavones
PL331785A1 (en) Method of obtaining starch derivatives
AU5534000A (en) Method of producing compounded starch derivatives
GB0204377D0 (en) Method of curcadian adjustment
SI1480963T1 (sl) Postopek za pripravo derivatov 3-amidinofenilalanina
PL332055A1 (en) Method of obtaining modified starch
PL355043A1 (en) Method of production of p-octylohenol