ZA200410061B - Phenylalkanoic acid and phenyloxyalkanoic acid derivatives as hPPAR acivators - Google Patents
Phenylalkanoic acid and phenyloxyalkanoic acid derivatives as hPPAR acivators Download PDFInfo
- Publication number
- ZA200410061B ZA200410061B ZA200410061A ZA200410061A ZA200410061B ZA 200410061 B ZA200410061 B ZA 200410061B ZA 200410061 A ZA200410061 A ZA 200410061A ZA 200410061 A ZA200410061 A ZA 200410061A ZA 200410061 B ZA200410061 B ZA 200410061B
- Authority
- ZA
- South Africa
- Prior art keywords
- pyridinyl
- oxy
- phenyl
- acid
- acetic acid
- Prior art date
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Classifications
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- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
- C07D213/34—Sulfur atoms to which a second hetero atom is attached
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0214149.7A GB0214149D0 (en) | 2002-06-19 | 2002-06-19 | Chemical compounds |
Publications (1)
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|---|---|
| ZA200410061B true ZA200410061B (en) | 2006-07-26 |
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| ZA200410061A ZA200410061B (en) | 2002-06-19 | 2004-12-13 | Phenylalkanoic acid and phenyloxyalkanoic acid derivatives as hPPAR acivators |
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| ES (1) | ES2295601T3 (enExample) |
| GB (1) | GB0214149D0 (enExample) |
| IL (1) | IL165476A0 (enExample) |
| IS (1) | IS7574A (enExample) |
| MX (1) | MXPA04012857A (enExample) |
| NO (1) | NO20045328L (enExample) |
| NZ (1) | NZ537210A (enExample) |
| PL (1) | PL375148A1 (enExample) |
| PT (1) | PT1513526E (enExample) |
| RU (1) | RU2323929C2 (enExample) |
| SI (1) | SI1513526T1 (enExample) |
| WO (1) | WO2004000315A1 (enExample) |
| ZA (1) | ZA200410061B (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US7244763B2 (en) | 2003-04-17 | 2007-07-17 | Warner Lambert Company Llc | Compounds that modulate PPAR activity and methods of preparation |
| CA2539446C (en) | 2003-09-19 | 2013-12-03 | Janssen Pharmaceutica, N.V. | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
| JP4745244B2 (ja) | 2003-11-05 | 2011-08-10 | エフ．ホフマン−ラ ロシュ アーゲー | Ｐｐａｒアゴニストとしてのフェニル誘導体 |
| WO2005063729A1 (en) * | 2003-12-25 | 2005-07-14 | Takeda Pharmaceutical Company Limited | 3-(4-benzyloxyphenyl)propanoic acid derivatives |
| BRPI0508098A (pt) | 2004-02-27 | 2007-07-17 | Amgen Inc | compostos, composições farmacêuticas e métodos para uso no tratamento de distúrbios metabólicos |
| AR048523A1 (es) * | 2004-04-07 | 2006-05-03 | Kalypsys Inc | Compuestos con estructura de aril sulfonamida y sulfonilo como moduladores de ppar y metodos para tratar trastornos metabolicos |
| EP1745014B1 (en) | 2004-05-05 | 2011-07-06 | High Point Pharmaceuticals, LLC | Novel compounds, their preparation and use |
| WO2005105726A1 (en) | 2004-05-05 | 2005-11-10 | Novo Nordisk A/S | Novel compounds, their preparation and use |
| MY147518A (en) * | 2004-09-15 | 2012-12-31 | Janssen Pharmaceutica Nv | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
| US7465804B2 (en) | 2005-05-20 | 2008-12-16 | Amgen Inc. | Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders |
| EP2298742B1 (en) | 2005-06-30 | 2014-01-08 | High Point Pharmaceuticals, LLC | phenoxy acetic acids as PPAR delta activators |
| CA2621949A1 (en) * | 2005-09-14 | 2007-03-22 | Amgen Inc. | Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders |
| JO3006B1 (ar) | 2005-09-14 | 2016-09-05 | Janssen Pharmaceutica Nv | املاح ليسين مبتكرة من مشتقات حامض 4-((فينوكسي الكيل)ثيو) فينوكسي الخليك |
| EP2386540A1 (en) | 2005-12-22 | 2011-11-16 | High Point Pharmaceuticals, LLC | Novel compounds, their preparation and use |
| CA2645719A1 (en) | 2006-03-09 | 2007-09-13 | High Point Pharmaceuticals, Llc | Compounds that modulate ppar activity, their preparation and use |
| WO2007106469A2 (en) * | 2006-03-14 | 2007-09-20 | Amgen Inc. | Bicyclic carboxylic acid derivatives useful for treating metabolic disorders |
| UY30288A1 (es) | 2006-04-18 | 2007-08-31 | Janssen Pharmaceutica Nv | Derivados del ácido benzoazepin-oxi-acético como agonistas de ppar-delta usados para aumentar hdl-c. reducir ldl-c y reducir colesterol |
| CN101591227B (zh) * | 2006-06-23 | 2012-09-05 | 赵昱 | 一类肉桂醇类衍生物及其制备方法和药物用途 |
| US7687526B2 (en) * | 2006-09-07 | 2010-03-30 | Amgen Inc. | Benzo-fused compounds for use in treating metabolic disorders |
| US7714008B2 (en) | 2006-09-07 | 2010-05-11 | Amgen Inc. | Heterocyclic GPR40 modulators |
| WO2008066356A1 (en) | 2006-12-02 | 2008-06-05 | Seoul National University Industry Foundation | Aryl compounds as ppar ligands and their use |
| EP2139843B1 (en) | 2007-04-16 | 2013-12-25 | Amgen, Inc | Substituted biphenyl phenoxy-, thiophenyl- and aminophenylpropanoic acid gpr40 modulators |
| EP2184277B1 (en) * | 2007-07-25 | 2015-07-01 | Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China | Aryl pyrimidine derivatives, preparation methods and pharmaceutical uses thereof |
| EP2205548A1 (en) | 2007-10-10 | 2010-07-14 | Amgen, Inc | Substituted biphenyl gpr40 modulators |
| CA2716352C (en) | 2008-03-06 | 2013-05-28 | Amgen Inc. | Conformationally constrained carboxylic acid derivatives useful for treating metabolic disorders |
| EP2358656B1 (en) * | 2008-10-15 | 2014-01-01 | Amgen, Inc | Spirocyclic gpr40 modulators |
| AU2012245344B2 (en) * | 2011-04-22 | 2017-11-09 | Jasco Pharmaceuticals, LLC | Aminopyrimidine kinase inhibitors |
| NZ631569A (en) | 2012-02-28 | 2016-10-28 | Piramal Entpr Ltd | Phenyl alkanoic acid derivatives as gpr agonists |
| KR101569522B1 (ko) | 2013-04-18 | 2015-11-17 | 현대약품 주식회사 | 신규한 3-(4-(벤질옥시)페닐)헥스-4-이노익 산 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 대사성 질환의 예방 또는 치료용 약학적 조성물 |
| WO2015035171A1 (en) | 2013-09-09 | 2015-03-12 | High Point Pharmaceuticals, Llc | Use of a ppar-delta agonist for treating muscle atrophy |
| CN108503581A (zh) * | 2018-04-12 | 2018-09-07 | 苏州康润医药有限公司 | 一种3-溴-6-氟-2-吡啶乙酮的合成方法 |
| WO2023147309A1 (en) | 2022-01-25 | 2023-08-03 | Reneo Pharmaceuticals, Inc. | Use of ppar-delta agonists in the treatment of disease |
Family Cites Families (11)
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| CS175831B1 (enExample) * | 1974-12-17 | 1977-05-31 | ||
| FR2401459A1 (fr) * | 1977-08-26 | 1979-03-23 | Cii Honeywell Bull | Support d'information portatif muni d'un microprocesseur et d'une memoire morte programmable |
| DE4038335A1 (de) * | 1990-12-01 | 1992-06-04 | Boehringer Mannheim Gmbh | Neue pyridinderivate, verfahren zu ihrer herstellung und verwendung als arzneimittel |
| GB9604242D0 (en) * | 1996-02-28 | 1996-05-01 | Glaxo Wellcome Inc | Chemical compounds |
| KR20000068151A (ko) * | 1996-08-19 | 2000-11-25 | 미즈노 마사루 | 프로피온산 유도체 및 그의 용도 |
| WO1999011255A1 (en) * | 1997-08-28 | 1999-03-11 | Ono Pharmaceutical Co., Ltd. | Peroxisome proliferator-activated receptor controllers |
| AU3275999A (en) * | 1998-03-10 | 1999-09-27 | Ono Pharmaceutical Co. Ltd. | Carboxylic acid derivatives and drugs containing the same as the active ingredient |
| US6586475B1 (en) * | 1998-11-20 | 2003-07-01 | Takeda Chemical Industries, Ltd. | β-amyloid protein production/secretion inhibitors |
| NZ515087A (en) * | 1999-04-28 | 2003-11-28 | Aventis Pharma Gmbh | Tri-aryl acid derivatives as PPAR receptor ligands |
| US6677473B1 (en) * | 1999-11-19 | 2004-01-13 | Corvas International Inc | Plasminogen activator inhibitor antagonists |
| US20040110743A1 (en) * | 2000-05-19 | 2004-06-10 | Masaomi Miyamato | -Secretase inhibitors |
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2002
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2003
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- 2003-06-18 US US10/518,679 patent/US7338960B2/en not_active Expired - Fee Related
- 2003-06-18 MX MXPA04012857A patent/MXPA04012857A/es active IP Right Grant
- 2003-06-18 PT PT03738056T patent/PT1513526E/pt unknown
- 2003-06-18 ES ES03738056T patent/ES2295601T3/es not_active Expired - Lifetime
- 2003-06-18 WO PCT/EP2003/006415 patent/WO2004000315A1/en not_active Ceased
- 2003-06-18 BR BR0311931-9A patent/BR0311931A/pt not_active IP Right Cessation
- 2003-06-18 EP EP03738056A patent/EP1513526B1/en not_active Expired - Lifetime
- 2003-06-18 RU RU2004135539/04A patent/RU2323929C2/ru not_active IP Right Cessation
- 2003-06-18 JP JP2004514761A patent/JP2005534672A/ja active Pending
- 2003-06-18 PL PL03375148A patent/PL375148A1/xx not_active Application Discontinuation
- 2003-06-18 DK DK03738056T patent/DK1513526T3/da active
- 2003-06-18 AT AT03738056T patent/ATE377420T1/de not_active IP Right Cessation
- 2003-06-18 AU AU2003245962A patent/AU2003245962B2/en not_active Ceased
- 2003-06-18 NZ NZ537210A patent/NZ537210A/en unknown
- 2003-06-18 CA CA002487909A patent/CA2487909A1/en not_active Abandoned
- 2003-06-18 CN CNA03819290XA patent/CN1674897A/zh active Pending
- 2003-06-18 IL IL16547603A patent/IL165476A0/xx unknown
- 2003-06-18 SI SI200331089T patent/SI1513526T1/sl unknown
- 2003-06-18 KR KR1020047020583A patent/KR20050030624A/ko not_active Ceased
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2004
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- 2004-12-03 NO NO20045328A patent/NO20045328L/no not_active Application Discontinuation
- 2004-12-13 ZA ZA200410061A patent/ZA200410061B/en unknown
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2008
- 2008-01-31 CY CY20081100116T patent/CY1107168T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1076712A1 (en) | 2006-01-27 |
| SI1513526T1 (sl) | 2008-04-30 |
| KR20050030624A (ko) | 2005-03-30 |
| DE60317326T2 (de) | 2008-08-28 |
| BR0311931A (pt) | 2005-04-05 |
| NZ537210A (en) | 2006-09-29 |
| RU2004135539A (ru) | 2005-08-10 |
| AU2003245962A1 (en) | 2004-01-06 |
| EP1513526A1 (en) | 2005-03-16 |
| CY1107168T1 (el) | 2012-10-24 |
| ATE377420T1 (de) | 2007-11-15 |
| NO20045328L (no) | 2005-03-09 |
| RU2323929C2 (ru) | 2008-05-10 |
| DK1513526T3 (da) | 2008-03-17 |
| MXPA04012857A (es) | 2005-02-24 |
| CN1674897A (zh) | 2005-09-28 |
| CA2487909A1 (en) | 2003-12-31 |
| ES2295601T3 (es) | 2008-04-16 |
| US20060089394A1 (en) | 2006-04-27 |
| JP2005534672A (ja) | 2005-11-17 |
| GB0214149D0 (en) | 2002-07-31 |
| PT1513526E (pt) | 2008-02-12 |
| US7338960B2 (en) | 2008-03-04 |
| EP1513526B1 (en) | 2007-11-07 |
| IS7574A (is) | 2004-11-30 |
| WO2004000315A1 (en) | 2003-12-31 |
| IL165476A0 (en) | 2006-01-15 |
| DE60317326D1 (de) | 2007-12-20 |
| PL375148A1 (en) | 2005-11-28 |
| AU2003245962B2 (en) | 2008-07-03 |
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