ZA200408411B - Method of treating arrhythmias comprising administration of an A1 adenosine agonist with a beta blocker, calcium channel blocker or a cardiac glycoside. - Google Patents
Method of treating arrhythmias comprising administration of an A1 adenosine agonist with a beta blocker, calcium channel blocker or a cardiac glycoside. Download PDFInfo
- Publication number
- ZA200408411B ZA200408411B ZA200408411A ZA200408411A ZA200408411B ZA 200408411 B ZA200408411 B ZA 200408411B ZA 200408411 A ZA200408411 A ZA 200408411A ZA 200408411 A ZA200408411 A ZA 200408411A ZA 200408411 B ZA200408411 B ZA 200408411B
- Authority
- ZA
- South Africa
- Prior art keywords
- optionally substituted
- cvt
- formula
- beta blocker
- pharmaceutical composition
- Prior art date
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- 239000002876 beta blocker Substances 0.000 title claims abstract description 51
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- 230000006793 arrhythmia Effects 0.000 title claims abstract description 26
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- OESBDSFYJMDRJY-BAYCTPFLSA-N (2r,3s,4r,5r)-2-(hydroxymethyl)-5-[6-[[(3r)-oxolan-3-yl]amino]purin-9-yl]oxolane-3,4-diol Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(N[C@H]3COCC3)=C2N=C1 OESBDSFYJMDRJY-BAYCTPFLSA-N 0.000 claims description 52
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Classifications
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
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- A—HUMAN NECESSITIES
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- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
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CN (2) | CN1646142A (ru) |
AT (1) | ATE418991T1 (ru) |
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CA (1) | CA2482928A1 (ru) |
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RU (1) | RU2332220C2 (ru) |
WO (1) | WO2003088978A1 (ru) |
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EP2359688B1 (en) | 1999-03-23 | 2015-05-27 | Hibernation Therapeutics, a KF LLC | Organ arrest, protection and preservation |
US6403567B1 (en) | 1999-06-22 | 2002-06-11 | Cv Therapeutics, Inc. | N-pyrazole A2A adenosine receptor agonists |
USRE47351E1 (en) | 1999-06-22 | 2019-04-16 | Gilead Sciences, Inc. | 2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists |
AU2001238665A1 (en) | 2000-02-23 | 2001-09-03 | Cv Therapeutics, Inc. | Method of identifying partial agonists of the a2a receptor |
US7713946B2 (en) * | 2002-07-11 | 2010-05-11 | Cv Therapeutics, Inc. | Partial and full agonists A1 adenosine receptors |
US7157440B2 (en) * | 2001-07-13 | 2007-01-02 | Cv Therapeutics, Inc. | Partial and full agonists of A1 adenosine receptors |
DE60325572D1 (de) * | 2002-04-18 | 2009-02-12 | Cv Therapeutics Inc | Methode zur behandlung von herzrhythmusstörungen mit einem a1 adenosin agonist zusammen mit einem beta blocker |
US8470801B2 (en) | 2002-07-29 | 2013-06-25 | Gilead Sciences, Inc. | Myocardial perfusion imaging methods and compositions |
GB2436255B (en) * | 2002-12-23 | 2007-11-28 | Global Cardiac Solutions Pty L | Organ preconditioning, arrest, protection, preservation and recovery |
JP2008505967A (ja) * | 2004-07-12 | 2008-02-28 | シーブイ・セラピューティクス・インコーポレイテッド | A1アデノシンレセプターアゴニストの製造方法 |
US20060019954A1 (en) * | 2004-07-20 | 2006-01-26 | Cedars-Sinai Medical Center | Method for reducing the likelihood of the occurrence of cardiac arrhythmias |
US7300923B2 (en) * | 2004-08-30 | 2007-11-27 | Cv Therapeutics, Inc. | Partial and full agonists of A1 adenosine receptors |
EP1802775B1 (en) | 2004-09-14 | 2010-05-26 | The Regents of the University of Colorado | Method for treatment with bucindolol based on genetic targeting |
US7822474B2 (en) * | 2005-11-30 | 2010-10-26 | Cedars-Sinai Medical Center | Methods for the prediction of arrhythmias and prevention of sudden cardiac death |
KR101494125B1 (ko) | 2006-02-03 | 2015-02-16 | 길리애드 사이언시즈, 인코포레이티드 | A2a-아데노신 수용체 효능제 및 이의 다형체의 제조 방법 |
JP2009538834A (ja) | 2006-05-29 | 2009-11-12 | ハイバーネイション セラピューティクス リミテッド | 組織維持の改善 |
KR20140108346A (ko) | 2006-07-25 | 2014-09-05 | 하이버네이션 테라퓨틱스 리미티드 | 외상 치료법 |
CA2717162A1 (en) | 2007-03-02 | 2008-09-12 | Hibernation Therapeutics Limited | Transplants |
SI2234614T1 (sl) * | 2007-12-21 | 2013-01-31 | Aop Orphan Pharmaceuticals Ag | Farmacevtska zmes za parenteralno administracijo ultra-kratko delujočega blokatorja beta-adrenoreceptorja |
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GB0903299D0 (en) | 2009-02-26 | 2009-04-08 | Guys And St Thomas Nhs Foundat | Composition and methods |
CA2835771C (en) * | 2009-03-18 | 2017-01-24 | Incarda Therapeutics, Inc. | Unit doses, aerosols, kits, and methods for treating heart conditions by pulmonary administration |
US20110039799A1 (en) | 2009-08-14 | 2011-02-17 | Gilead Palo Alto, Inc. | A1 adenosine receptor agonist polymorphs |
EA025415B1 (ru) | 2010-01-11 | 2016-12-30 | Инотек Фармасьютикалз Корпорейшн | Комбинация, набор и способ снижения внутриглазного давления |
PL2555776T3 (pl) * | 2010-03-19 | 2017-08-31 | Inotek Pharmaceuticals Corporation | Kompozycje połączenia agonistów receptora adenozyny A<sub>1</sub> i nieselektywnego blokera receptora beta-adrenergicznego do obniżania ciśnienia wewnątrzgałkowego |
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AU2014239222A1 (en) | 2013-03-15 | 2015-10-01 | Inotek Pharmaceuticals Corporation | Ophthalmic formulations |
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CN106370754B (zh) * | 2016-11-07 | 2019-03-08 | 西安科技大学 | 基于手性高效液相色谱-质谱/质谱技术定量检测布新洛尔光学异构体含量的方法 |
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JP7156154B2 (ja) * | 2019-04-18 | 2022-10-19 | 株式会社島津製作所 | 培地処理システム及び培地処理方法 |
US11007185B2 (en) | 2019-08-01 | 2021-05-18 | Incarda Therapeutics, Inc. | Antiarrhythmic formulation |
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US5108363A (en) * | 1988-02-19 | 1992-04-28 | Gensia Pharmaceuticals, Inc. | Diagnosis, evaluation and treatment of coronary artery disease by exercise simulation using closed loop drug delivery of an exercise simulating agent beta agonist |
US5736528A (en) * | 1993-10-28 | 1998-04-07 | University Of Florida Research Foundation, Inc. | N6 -(epoxynorborn-2-yl) adenosines as A1 adenosine receptor agonists |
AU722110B2 (en) * | 1996-06-28 | 2000-07-20 | Merck & Co., Inc. | Pharmaceutical preparation |
US5789416B1 (en) | 1996-08-27 | 1999-10-05 | Cv Therapeutics Inc | N6 mono heterocyclic substituted adenosine derivatives |
EP0966274B1 (en) * | 1997-01-31 | 2002-06-12 | The Board Of Trustees Of The Leland Stanford Junior University | Treatment of arrhythmias via inhibition of a multifunctional calcium/calmodulin-dependent protein kinase |
CO5180581A1 (es) * | 1999-09-30 | 2002-07-30 | Pfizer Prod Inc | Compuestos para el tratamiento de la isquemia ciones farmaceuticas que los contienen para el tratamiento de la isquemia |
US6605597B1 (en) * | 1999-12-03 | 2003-08-12 | Cv Therapeutics, Inc. | Partial or full A1agonists-N-6 heterocyclic 5′-thio substituted adenosine derivatives |
US6576620B2 (en) | 1999-12-03 | 2003-06-10 | Cv Therapeutics, Inc. | Method of identifying partial adenosine A1 receptor agonists |
IL154652A0 (en) * | 2000-09-08 | 2003-09-17 | Cv Therapeutics Inc | Purine ribosides as antiarrhythmics |
US6946449B2 (en) | 2001-07-13 | 2005-09-20 | Cv Therapeutics, Inc. | Partial and full agonists of A1 adenosine receptors |
DE60325572D1 (de) * | 2002-04-18 | 2009-02-12 | Cv Therapeutics Inc | Methode zur behandlung von herzrhythmusstörungen mit einem a1 adenosin agonist zusammen mit einem beta blocker |
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2003
- 2003-04-18 DE DE60325572T patent/DE60325572D1/de not_active Expired - Lifetime
- 2003-04-18 US US10/418,654 patent/US7005425B2/en not_active Expired - Fee Related
- 2003-04-18 KR KR10-2004-7016764A patent/KR20040106354A/ko active IP Right Grant
- 2003-04-18 EP EP03724098A patent/EP1494685B1/en not_active Expired - Lifetime
- 2003-04-18 WO PCT/US2003/012043 patent/WO2003088978A1/en active Application Filing
- 2003-04-18 AU AU2003235466A patent/AU2003235466C1/en not_active Ceased
- 2003-04-18 CN CNA038086999A patent/CN1646142A/zh active Pending
- 2003-04-18 RU RU2004130826/14A patent/RU2332220C2/ru not_active IP Right Cessation
- 2003-04-18 AT AT03724098T patent/ATE418991T1/de not_active IP Right Cessation
- 2003-04-18 CN CNA2008101711378A patent/CN101385738A/zh active Pending
- 2003-04-18 MX MXPA04010285A patent/MXPA04010285A/es active IP Right Grant
- 2003-04-18 JP JP2003585730A patent/JP2005530736A/ja active Pending
- 2003-04-18 NZ NZ536001A patent/NZ536001A/en not_active IP Right Cessation
- 2003-04-18 CA CA002482928A patent/CA2482928A1/en not_active Abandoned
- 2003-04-18 ES ES03724098T patent/ES2318129T3/es not_active Expired - Lifetime
-
2004
- 2004-10-18 IL IL16465204A patent/IL164652A0/xx unknown
- 2004-10-18 ZA ZA200408411A patent/ZA200408411B/en unknown
- 2004-11-17 NO NO20045005A patent/NO20045005L/no not_active Application Discontinuation
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2005
- 2005-10-28 US US11/262,025 patent/US7479485B2/en not_active Expired - Fee Related
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CN1646142A (zh) | 2005-07-27 |
WO2003088978A1 (en) | 2003-10-30 |
JP2005530736A (ja) | 2005-10-13 |
AU2003235466C1 (en) | 2008-03-20 |
KR20040106354A (ko) | 2004-12-17 |
US20030216349A1 (en) | 2003-11-20 |
ATE418991T1 (de) | 2009-01-15 |
US20090118221A1 (en) | 2009-05-07 |
ES2318129T3 (es) | 2009-05-01 |
AU2003235466A1 (en) | 2003-11-03 |
CA2482928A1 (en) | 2003-10-30 |
US7479485B2 (en) | 2009-01-20 |
RU2332220C2 (ru) | 2008-08-27 |
NZ536001A (en) | 2006-05-26 |
CN101385738A (zh) | 2009-03-18 |
US7005425B2 (en) | 2006-02-28 |
IL164652A0 (en) | 2005-12-18 |
DE60325572D1 (de) | 2009-02-12 |
RU2004130826A (ru) | 2005-05-10 |
EP1494685A1 (en) | 2005-01-12 |
NO20045005L (no) | 2004-11-17 |
EP1494685B1 (en) | 2008-12-31 |
MXPA04010285A (es) | 2005-02-03 |
US20060052333A1 (en) | 2006-03-09 |
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