ZA200407948B - Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and radiotherapy - Google Patents
Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and radiotherapy Download PDFInfo
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- ZA200407948B ZA200407948B ZA200407948A ZA200407948A ZA200407948B ZA 200407948 B ZA200407948 B ZA 200407948B ZA 200407948 A ZA200407948 A ZA 200407948A ZA 200407948 A ZA200407948 A ZA 200407948A ZA 200407948 B ZA200407948 B ZA 200407948B
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- South Africa
- Prior art keywords
- acryloyl
- bromo
- methyl
- amino
- chloro
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02076240 | 2002-04-02 |
Publications (1)
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|---|---|
| ZA200407948B true ZA200407948B (en) | 2006-08-30 |
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| ZA200407948A ZA200407948B (en) | 2002-04-02 | 2004-10-01 | Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and radiotherapy |
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| Country | Link |
|---|---|
| US (1) | US20110166077A9 (es) |
| EP (1) | EP1490053B1 (es) |
| JP (1) | JP2005527552A (es) |
| KR (1) | KR100968657B1 (es) |
| CN (1) | CN1302777C (es) |
| AT (1) | ATE383154T1 (es) |
| AU (1) | AU2003219102B2 (es) |
| BR (1) | BR0308976A (es) |
| CA (1) | CA2481005C (es) |
| DE (1) | DE60318561T2 (es) |
| ES (1) | ES2299692T3 (es) |
| HK (1) | HK1079116A1 (es) |
| IL (2) | IL164356A0 (es) |
| MX (1) | MXPA04009542A (es) |
| NO (1) | NO20044709L (es) |
| NZ (1) | NZ535700A (es) |
| PL (1) | PL373998A1 (es) |
| RU (1) | RU2314807C2 (es) |
| WO (1) | WO2003082267A1 (es) |
| ZA (1) | ZA200407948B (es) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0015446D0 (en) * | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites |
| EP1603575A2 (en) * | 2003-03-18 | 2005-12-14 | Pharmacia Italia S.p.A. | Nemorubicin as radiosensitizer in combination with radiation therapy against tumors |
| CN101141955A (zh) * | 2005-04-08 | 2008-03-12 | 内尔维阿诺医学科学有限公司 | 包含被取代的丙烯酰基偏端霉素衍生物以及抑制生长因子或其受体的抗体的抗肿瘤组合 |
| RU2478374C1 (ru) * | 2012-02-06 | 2013-04-10 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Минздравсоцразвития России | Способ внутриполостной терапии при лечении больных с метастазами рака во влагалище |
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| WO1990012321A1 (en) * | 1989-03-31 | 1990-10-18 | The Cancer Institute Board | Halogenated dna ligand radiosensitisers for cancer therapy |
| JPH0925268A (ja) * | 1995-07-12 | 1997-01-28 | Taiho Yakuhin Kogyo Kk | ２−ニトロイミダゾール誘導体 |
| GB9615692D0 (en) * | 1996-07-25 | 1996-09-04 | Pharmacia Spa | Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents |
| US6331286B1 (en) * | 1998-12-21 | 2001-12-18 | Photogen, Inc. | Methods for high energy phototherapeutics |
| KR20010071271A (ko) * | 1998-05-15 | 2001-07-28 | 존 비. 랜디스 | 방사선 및 성장 인자 수용체 티로신 키나아제 억제제에의한 사람 종양의 치료법 |
| US6498181B1 (en) * | 1999-01-06 | 2002-12-24 | Maxim Pharmaceuticals | Synergistic tumorcidal response induced by histamine |
| US6576759B2 (en) * | 1999-02-10 | 2003-06-10 | Pangene Corporation | Antisense inhibition of RAD51 |
| GB0011059D0 (en) * | 2000-05-08 | 2000-06-28 | Pharmacia & Upjohn Spa | Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione |
| GB0015447D0 (en) * | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents |
| US6576612B1 (en) * | 2000-10-02 | 2003-06-10 | Pharmacia Italia S.P.A. | Antitumor therapy comprising distamycin derivatives |
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2003
- 2003-03-17 DE DE60318561T patent/DE60318561T2/de not_active Expired - Lifetime
- 2003-03-17 KR KR1020047015602A patent/KR100968657B1/ko not_active IP Right Cessation
- 2003-03-17 EP EP03714888A patent/EP1490053B1/en not_active Expired - Lifetime
- 2003-03-17 BR BR0308976-2A patent/BR0308976A/pt not_active IP Right Cessation
- 2003-03-17 JP JP2003579805A patent/JP2005527552A/ja not_active Ceased
- 2003-03-17 ES ES03714888T patent/ES2299692T3/es not_active Expired - Lifetime
- 2003-03-17 CN CNB038099837A patent/CN1302777C/zh not_active Expired - Fee Related
- 2003-03-17 WO PCT/EP2003/003192 patent/WO2003082267A1/en active IP Right Grant
- 2003-03-17 AU AU2003219102A patent/AU2003219102B2/en not_active Ceased
- 2003-03-17 IL IL16435603A patent/IL164356A0/xx unknown
- 2003-03-17 PL PL03373998A patent/PL373998A1/xx not_active Application Discontinuation
- 2003-03-17 MX MXPA04009542A patent/MXPA04009542A/es active IP Right Grant
- 2003-03-17 CA CA002481005A patent/CA2481005C/en not_active Expired - Fee Related
- 2003-03-17 AT AT03714888T patent/ATE383154T1/de not_active IP Right Cessation
- 2003-03-17 RU RU2004131860/15A patent/RU2314807C2/ru not_active IP Right Cessation
- 2003-03-17 NZ NZ535700A patent/NZ535700A/en not_active IP Right Cessation
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2004
- 2004-09-28 IL IL164356A patent/IL164356A/en not_active IP Right Cessation
- 2004-10-01 US US10/957,507 patent/US20110166077A9/en not_active Abandoned
- 2004-10-01 ZA ZA200407948A patent/ZA200407948B/en unknown
- 2004-11-01 NO NO20044709A patent/NO20044709L/no not_active Application Discontinuation
-
2005
- 2005-12-12 HK HK05111365A patent/HK1079116A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IL164356A0 (en) | 2005-12-18 |
| US20110166077A9 (en) | 2011-07-07 |
| CN1302777C (zh) | 2007-03-07 |
| CA2481005C (en) | 2009-06-09 |
| KR20040101379A (ko) | 2004-12-02 |
| BR0308976A (pt) | 2005-01-11 |
| ES2299692T3 (es) | 2008-06-01 |
| WO2003082267A1 (en) | 2003-10-09 |
| US20050143315A1 (en) | 2005-06-30 |
| CN1649583A (zh) | 2005-08-03 |
| ATE383154T1 (de) | 2008-01-15 |
| KR100968657B1 (ko) | 2010-07-06 |
| RU2004131860A (ru) | 2005-04-10 |
| PL373998A1 (en) | 2005-09-19 |
| NZ535700A (en) | 2007-06-29 |
| RU2314807C2 (ru) | 2008-01-20 |
| EP1490053B1 (en) | 2008-01-09 |
| DE60318561T2 (de) | 2009-01-08 |
| CA2481005A1 (en) | 2003-10-09 |
| IL164356A (en) | 2010-11-30 |
| EP1490053A1 (en) | 2004-12-29 |
| JP2005527552A (ja) | 2005-09-15 |
| AU2003219102B2 (en) | 2008-05-08 |
| MXPA04009542A (es) | 2005-01-25 |
| NO20044709L (no) | 2004-12-30 |
| AU2003219102A1 (en) | 2003-10-13 |
| HK1079116A1 (en) | 2006-03-31 |
| DE60318561D1 (de) | 2008-02-21 |
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