ZA200405774B - Therapeutic acridone and acridine compounds. - Google Patents

Info

Publication number

ZA200405774B

ZA200405774B ZA200405774A ZA200405774A ZA200405774B ZA 200405774 B ZA200405774 B ZA 200405774B ZA 200405774 A ZA200405774 A ZA 200405774A ZA 200405774 A ZA200405774 A ZA 200405774A ZA 200405774 B ZA200405774 B ZA 200405774B

Authority

ZA

South Africa

Prior art keywords

independently

group

compound according

substituent

compound

Prior art date

2002-01-15

Links

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• FZEYVTFCMJSGMP-UHFFFAOYSA-N acridone Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3NC2=C1 FZEYVTFCMJSGMP-UHFFFAOYSA-N 0.000 title claims description 17
• GDALETGZDYOOGB-UHFFFAOYSA-N Acridone Natural products C1=C(O)C=C2N(C)C3=CC=CC=C3C(=O)C2=C1O GDALETGZDYOOGB-UHFFFAOYSA-N 0.000 title claims description 9
• 150000001251 acridines Chemical class 0.000 title description 41
• 230000001225 therapeutic effect Effects 0.000 title description 7
• 150000001875 compounds Chemical class 0.000 claims description 257
• -1 acridone compound Chemical class 0.000 claims description 137
• 238000000034 method Methods 0.000 claims description 91
• 125000003277 amino group Chemical group 0.000 claims description 72
• 229910052739 hydrogen Inorganic materials 0.000 claims description 64
• 150000003839 salts Chemical class 0.000 claims description 55
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• 239000000203 mixture Substances 0.000 claims description 46
• 125000001424 substituent group Chemical group 0.000 claims description 45
• 238000011282 treatment Methods 0.000 claims description 45
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 42
• 125000006413 ring segment Chemical group 0.000 claims description 41
• DZBUGLKDJFMEHC-UHFFFAOYSA-N acridine Chemical compound C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 claims description 39
• 229920006395 saturated elastomer Polymers 0.000 claims description 39
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• 125000000623 heterocyclic group Chemical group 0.000 claims description 34
• 125000000217 alkyl group Chemical group 0.000 claims description 33
• 239000001257 hydrogen Substances 0.000 claims description 30
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 28
• 125000004122 cyclic group Chemical group 0.000 claims description 27
• 229910052757 nitrogen Inorganic materials 0.000 claims description 27
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