ZA200403460B - Cell culture process - Google Patents
Cell culture process Download PDFInfo
- Publication number
- ZA200403460B ZA200403460B ZA200403460A ZA200403460A ZA200403460B ZA 200403460 B ZA200403460 B ZA 200403460B ZA 200403460 A ZA200403460 A ZA 200403460A ZA 200403460 A ZA200403460 A ZA 200403460A ZA 200403460 B ZA200403460 B ZA 200403460B
- Authority
- ZA
- South Africa
- Prior art keywords
- rotor
- blades
- turbine engine
- engine according
- stator
- Prior art date
Links
- 238000004113 cell culture Methods 0.000 title 1
- 239000013598 vector Substances 0.000 claims description 14
- 230000008859 change Effects 0.000 claims description 6
- 238000011144 upstream manufacturing Methods 0.000 claims description 5
- 239000012208 gear oil Substances 0.000 claims description 4
- 230000007246 mechanism Effects 0.000 claims description 4
- 239000012530 fluid Substances 0.000 claims description 3
- 230000008878 coupling Effects 0.000 claims description 2
- 238000010168 coupling process Methods 0.000 claims description 2
- 238000005859 coupling reaction Methods 0.000 claims description 2
- 230000009467 reduction Effects 0.000 claims description 2
- 230000000717 retained effect Effects 0.000 claims description 2
- 238000004148 unit process Methods 0.000 claims description 2
- 230000003213 activating effect Effects 0.000 claims 1
- 238000010586 diagram Methods 0.000 description 14
- 238000000034 method Methods 0.000 description 5
- 230000008901 benefit Effects 0.000 description 3
- 101100221616 Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1) cosB gene Proteins 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- RLQJEEJISHYWON-UHFFFAOYSA-N flonicamid Chemical compound FC(F)(F)C1=CC=NC=C1C(=O)NCC#N RLQJEEJISHYWON-UHFFFAOYSA-N 0.000 description 1
- 238000013178 mathematical model Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000021715 photosynthesis, light harvesting Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/34—Sugars
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/70—Undefined extracts
- C12N2500/76—Undefined extracts from plants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
- C12N2500/92—Medium free of human- or animal-derived components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Structures Of Non-Positive Displacement Pumps (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33386701P | 2001-11-28 | 2001-11-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200403460B true ZA200403460B (en) | 2006-05-31 |
Family
ID=23304592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200403460A ZA200403460B (en) | 2001-11-28 | 2004-05-06 | Cell culture process |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20050069979A1 (xx) |
| EP (1) | EP1453948A2 (xx) |
| JP (1) | JP2005517391A (xx) |
| KR (1) | KR20040065231A (xx) |
| CN (1) | CN1596302A (xx) |
| AU (1) | AU2002342922A1 (xx) |
| BR (1) | BR0214483A (xx) |
| CA (1) | CA2466881A1 (xx) |
| HR (1) | HRP20040475A2 (xx) |
| HU (1) | HUP0402226A2 (xx) |
| IL (1) | IL161858A0 (xx) |
| MX (1) | MXPA04005190A (xx) |
| NO (1) | NO20042159L (xx) |
| NZ (1) | NZ533084A (xx) |
| PL (1) | PL368749A1 (xx) |
| RU (1) | RU2004119816A (xx) |
| WO (1) | WO2003045995A2 (xx) |
| ZA (1) | ZA200403460B (xx) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7157276B2 (en) * | 2003-06-20 | 2007-01-02 | Biogen Idec Inc. | Use of depth filtration in series with continuous centrifugation to clarify mammalian cell cultures |
| GB2404665B (en) * | 2003-08-08 | 2005-07-06 | Cambridge Antibody Tech | Cell culture |
| FR2879214A1 (fr) * | 2004-12-14 | 2006-06-16 | Pierre Fabre Medicament Sa | Fractions peptidiques favorisant la croissance et la synthese de produit(s) d'interet en culture de cellules et/ou de tissus |
| US20070190057A1 (en) | 2006-01-23 | 2007-08-16 | Jian Wu | Methods for modulating mannose content of recombinant proteins |
| US8911964B2 (en) | 2006-09-13 | 2014-12-16 | Abbvie Inc. | Fed-batch method of making human anti-TNF-alpha antibody |
| SG174804A1 (xx) | 2006-09-13 | 2011-10-28 | Abbott Lab | |
| EP2152856B1 (en) | 2007-05-11 | 2012-08-29 | Amgen Inc. | Improved feed media |
| AU2009347206C1 (en) | 2008-10-20 | 2016-12-08 | Abbvie Inc. | Isolation and purification of antibodies using Protein A affinity chromatography |
| SG10201702951RA (en) | 2008-10-20 | 2017-06-29 | Abbvie Inc | Viral inactivation during purification of antibodies |
| BRPI1008762B8 (pt) | 2009-02-27 | 2021-05-25 | Novartis Ag | métodos para seleção de células de mamífero expressando uma proteína heteróloga, para produzir um produto de interesse e uso de um meio de cultura seletivo |
| WO2011011674A2 (en) * | 2009-07-24 | 2011-01-27 | Dr. Reddy's Laboratories Ltd. | Production of erythropoiesis stimulating protein using metal ions |
| US8580554B2 (en) * | 2009-07-31 | 2013-11-12 | Baxter International Inc. | Method of producing a polypeptide or virus of interest in a continuous cell culture |
| AU2011246502B2 (en) * | 2010-04-26 | 2014-08-28 | Novartis Ag | Improved cell cultivation process |
| TWI670073B (zh) * | 2010-07-08 | 2019-09-01 | 美商巴克斯歐塔公司 | 在細胞培養物中生產重組高分子量ｖＷＦ的方法 |
| MX2013009741A (es) * | 2011-02-23 | 2014-01-17 | Amgen Inc | Medio de cultivo celular para exposicion a uvc y metodos relacionados al mismo. |
| WO2012149197A2 (en) | 2011-04-27 | 2012-11-01 | Abbott Laboratories | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| DK2732027T3 (en) * | 2011-07-12 | 2017-05-22 | Foodchek Systems Inc | CULTIVATION MEDIUM, METHOD OF CULTIVATING SALMONELLA AND E. COLI AND METHOD OF DETERMINING SALMONELLA AND E. COLI |
| CN102634476A (zh) * | 2012-03-01 | 2012-08-15 | 江苏太平洋美诺克生物药业有限公司 | 高耐受细胞株的筛选方法 |
| US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
| WO2013158279A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Protein purification methods to reduce acidic species |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| US9249182B2 (en) | 2012-05-24 | 2016-02-02 | Abbvie, Inc. | Purification of antibodies using hydrophobic interaction chromatography |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| WO2014035475A1 (en) | 2012-09-02 | 2014-03-06 | Abbvie Inc. | Methods to control protein heterogeneity |
| EP2830651A4 (en) | 2013-03-12 | 2015-09-02 | Abbvie Inc | HUMAN ANTIBODIES THAT BIND TNF-ALPHA AND PREPARATION METHODS |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| US8921526B2 (en) | 2013-03-14 | 2014-12-30 | Abbvie, Inc. | Mutated anti-TNFα antibodies and methods of their use |
| US9499614B2 (en) | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
| US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| WO2015073884A2 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| CN105777897A (zh) * | 2015-03-20 | 2016-07-20 | 广东东阳光药业有限公司 | 一种cho细胞收获液的前处理方法 |
| JP7271175B2 (ja) * | 2015-05-08 | 2023-05-11 | ウィルソン ウォルフ マニュファクチャリング | 試験のための改良された培養方法と装置 |
| CN111781042B (zh) * | 2020-07-08 | 2023-07-07 | 青海省畜牧兽医科学院 | 一种附红细胞体检测试剂盒及样品处理方法 |
| EP4043551A1 (en) | 2021-02-12 | 2022-08-17 | Bühler AG | Nutrient media for cell culture containing plant protein hydrolysates |
| CN116024278B (zh) * | 2022-12-16 | 2024-05-07 | 黑龙江新和成生物科技有限公司 | 一种发酵法制备d-泛酸的方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ210501A (en) * | 1983-12-13 | 1991-08-27 | Kirin Amgen Inc | Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence |
| JP2859679B2 (ja) * | 1990-03-01 | 1999-02-17 | 協和醗酵工業株式会社 | 新規細胞株 |
| US5122469A (en) * | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
| GB9022545D0 (en) * | 1990-10-17 | 1990-11-28 | Wellcome Found | Culture medium |
| EP0653487A1 (de) * | 1993-11-07 | 1995-05-17 | Ferruccio Dr. Messi | Serum- und proteinfrei wachsende Zellen |
| JP2000517188A (ja) * | 1996-08-30 | 2000-12-26 | ライフ テクノロジーズ，インコーポレイテッド | 無血清哺乳動物細胞培養培地およびその使用 |
| DE69738806D1 (de) * | 1996-10-10 | 2008-08-14 | Invitrogen Corp | Tierzellkulturmedium mit pflanzlichen nährstoffen |
| EP0984062A1 (en) * | 1998-09-04 | 2000-03-08 | Cytos Biotechnology AG | Production of human erythropoietin |
| AT409379B (de) * | 1999-06-02 | 2002-07-25 | Baxter Ag | Medium zur protein- und serumfreien kultivierung von zellen |
| DK1200561T3 (da) * | 1999-08-05 | 2006-10-16 | Baxter Ag | Rekombinant stabil celleklon, dens fremstilling og anvendelse |
-
2002
- 2002-11-26 CA CA002466881A patent/CA2466881A1/en not_active Abandoned
- 2002-11-26 US US10/497,123 patent/US20050069979A1/en not_active Abandoned
- 2002-11-26 PL PL02368749A patent/PL368749A1/xx not_active Application Discontinuation
- 2002-11-26 NZ NZ533084A patent/NZ533084A/en unknown
- 2002-11-26 IL IL16185802A patent/IL161858A0/xx unknown
- 2002-11-26 MX MXPA04005190A patent/MXPA04005190A/es unknown
- 2002-11-26 EP EP02779572A patent/EP1453948A2/en not_active Ceased
- 2002-11-26 CN CNA028236998A patent/CN1596302A/zh active Pending
- 2002-11-26 KR KR10-2004-7008093A patent/KR20040065231A/ko not_active Application Discontinuation
- 2002-11-26 RU RU2004119816/13A patent/RU2004119816A/ru not_active Application Discontinuation
- 2002-11-26 JP JP2003547444A patent/JP2005517391A/ja active Pending
- 2002-11-26 HU HU0402226A patent/HUP0402226A2/hu unknown
- 2002-11-26 BR BR0214483-2A patent/BR0214483A/pt not_active IP Right Cessation
- 2002-11-26 AU AU2002342922A patent/AU2002342922A1/en not_active Abandoned
- 2002-11-26 WO PCT/EP2002/013298 patent/WO2003045995A2/en active Application Filing
-
2004
- 2004-05-06 ZA ZA200403460A patent/ZA200403460B/en unknown
- 2004-05-25 NO NO20042159A patent/NO20042159L/no not_active Application Discontinuation
- 2004-05-27 HR HR20040475A patent/HRP20040475A2/hr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002342922A1 (en) | 2003-06-10 |
| MXPA04005190A (es) | 2005-02-17 |
| JP2005517391A (ja) | 2005-06-16 |
| NO20042159L (no) | 2004-07-28 |
| KR20040065231A (ko) | 2004-07-21 |
| NZ533084A (en) | 2006-02-24 |
| RU2004119816A (ru) | 2006-01-10 |
| BR0214483A (pt) | 2005-07-19 |
| HUP0402226A2 (hu) | 2005-02-28 |
| US20050069979A1 (en) | 2005-03-31 |
| IL161858A0 (en) | 2005-11-20 |
| PL368749A1 (en) | 2005-04-04 |
| WO2003045995A2 (en) | 2003-06-05 |
| CA2466881A1 (en) | 2003-06-05 |
| CN1596302A (zh) | 2005-03-16 |
| WO2003045995A3 (en) | 2004-01-15 |
| EP1453948A2 (en) | 2004-09-08 |
| HRP20040475A2 (en) | 2005-06-30 |
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