ZA200402720B - Succinic acid salts of 5,8,14-triazatetracyclo'10.3.10<2,11>.0<4,9>-hexadeca-2(11),3,5,7,9-pentaene and pharmaceutical compositions thereof. - Google Patents
Succinic acid salts of 5,8,14-triazatetracyclo'10.3.10<2,11>.0<4,9>-hexadeca-2(11),3,5,7,9-pentaene and pharmaceutical compositions thereof. Download PDFInfo
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- ZA200402720B ZA200402720B ZA200402720A ZA200402720A ZA200402720B ZA 200402720 B ZA200402720 B ZA 200402720B ZA 200402720 A ZA200402720 A ZA 200402720A ZA 200402720 A ZA200402720 A ZA 200402720A ZA 200402720 B ZA200402720 B ZA 200402720B
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- South Africa
- Prior art keywords
- compound according
- ray diffraction
- diffraction pattern
- hexadeca
- pentaene
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
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US33424501P | 2001-11-29 | 2001-11-29 |
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ZA200402720B true ZA200402720B (en) | 2005-05-18 |
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ZA200402720A ZA200402720B (en) | 2001-11-29 | 2004-04-07 | Succinic acid salts of 5,8,14-triazatetracyclo'10.3.10<2,11>.0<4,9>-hexadeca-2(11),3,5,7,9-pentaene and pharmaceutical compositions thereof. |
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EP (1) | EP1461040B1 (zh) |
JP (1) | JP4196829B2 (zh) |
KR (1) | KR20040066140A (zh) |
CN (1) | CN1589148A (zh) |
AR (1) | AR037677A1 (zh) |
AT (1) | ATE320256T1 (zh) |
AU (1) | AU2002341327A1 (zh) |
BR (1) | BR0214559A (zh) |
CA (1) | CA2468705A1 (zh) |
DE (1) | DE60209929T2 (zh) |
DO (1) | DOP2002000512A (zh) |
ES (1) | ES2258652T3 (zh) |
GT (1) | GT200200236A (zh) |
HN (1) | HN2002000332A (zh) |
IL (1) | IL161326A0 (zh) |
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PA (1) | PA8559401A1 (zh) |
PE (1) | PE20030738A1 (zh) |
PL (1) | PL374325A1 (zh) |
RU (1) | RU2004116311A (zh) |
SV (1) | SV2004001413A (zh) |
TW (1) | TW200300345A (zh) |
UY (1) | UY27548A1 (zh) |
WO (1) | WO2003045394A1 (zh) |
ZA (1) | ZA200402720B (zh) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR9814592B1 (pt) * | 1997-12-31 | 2010-06-01 | composto azapolicìclico condensado com arila, composição farmacêutica contendo o mesmo e seu uso na fabricação de um medicamento. | |
ATE490788T1 (de) | 2003-04-25 | 2010-12-15 | Gilead Sciences Inc | Antivirale phosphonate analoge |
BRPI0410219A (pt) * | 2003-05-20 | 2006-05-09 | Pfizer Prod Inc | composições farmacêuticas de vareniclina |
KR20060101476A (ko) * | 2003-10-27 | 2006-09-25 | 머크 앤드 캄파니 인코포레이티드 | Ccr-2 길항제 염 |
EP1778251B1 (en) | 2004-07-27 | 2011-04-13 | Gilead Sciences, Inc. | Nucleoside phosphonate conjugates as anti hiv agents |
US20110086086A1 (en) * | 2005-07-26 | 2011-04-14 | Pfizer Inc | Transdermal system for varenicline |
KR100734147B1 (ko) * | 2005-07-29 | 2007-07-02 | 주식회사 엘지데이콤 | 호 알림 지연을 통한 멀티미디어 통화연결음 서비스 시스템및 방법 |
WO2007136650A2 (en) * | 2006-05-16 | 2007-11-29 | Gilead Sciences, Inc. | Method and compositions for treating hematological malignancies |
JP2010527907A (ja) * | 2006-11-09 | 2010-08-19 | ファイザー・プロダクツ・インク | ニコチン様中間体の多形体 |
ES2360014T3 (es) * | 2006-12-21 | 2011-05-31 | Pfizer Products Inc. | Sal succinato de 2-((4-(1-metil-4-(piridin-4-il)-1h-pirazol-3-il)-fenoxi)metil)quinolina. |
WO2009109651A1 (en) * | 2008-03-06 | 2009-09-11 | Medichem, S.A. | SALTS OF A PYRAZINO[2,3-h][3]BENZAZEPINE DERIVATIVE |
US8039620B2 (en) | 2008-05-22 | 2011-10-18 | Teva Pharmaceutical Industries Ltd. | Varenicline tosylate, an intermediate in the preparation process of varenicline L-tartrate |
US20090318460A1 (en) * | 2008-05-26 | 2009-12-24 | Glenmark | Amorphous varenicline tartrate and process for the preparation thereof |
AU2009268681B2 (en) | 2008-07-08 | 2014-10-02 | Gilead Sciences, Inc. | Salts of HIV inhibitor compounds |
US20100010221A1 (en) * | 2008-07-10 | 2010-01-14 | Revital Lifshitz-Liron | Processes for purifying varenicline l-tartrate salt and preparing crystalline forms of varenicline l-tartrate salt |
WO2010033045A1 (en) * | 2008-09-16 | 2010-03-25 | Igor Anatolievich Pomytkin | Compositions and methods for prevention or treatment of beta amyloid deposition |
US8980873B2 (en) * | 2008-12-11 | 2015-03-17 | Cti Biopharma Corp. | 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene citrate salt |
US20120093887A1 (en) | 2009-06-10 | 2012-04-19 | Actavis Group Ptc Ehf | Amorphous varenicline tartrate co-precipitates |
RU2012102052A (ru) | 2009-06-22 | 2013-11-20 | Тева Фармасьютикал Индастриз Лтд. | Твердые формы солей варениклина и способы их получения |
WO2011140431A1 (en) | 2010-05-06 | 2011-11-10 | Teva Pharmaceutical Industries Ltd. | Varenicline salts and crystal forms thereof |
CN104334561B (zh) | 2012-04-13 | 2016-06-22 | 连云港金康和信药业有限公司 | 化合物jk12a及其制备 |
SG10202011669PA (en) | 2014-10-20 | 2020-12-30 | Oyster Point Pharma Inc | Methods of treating ocular conditions |
KR102485299B1 (ko) | 2016-04-07 | 2023-01-06 | 오이스터 포인트 파마 인코포레이티드 | 안구 장애의 치료 방법 |
EP3960740B1 (en) | 2017-08-01 | 2023-11-15 | Gilead Sciences, Inc. | Crystalline forms of ethyl ((s)-((((2r,5r)-5-(6-amino-9h-purin-9-yl)-4-fluoro-2,5-dihydrofuran-2-yl)oxy)methyl)(phenoxy)phosphoryl)-l-alaninate (gs-9131) vanillate for treating viral infections |
WO2018154395A2 (en) | 2018-06-11 | 2018-08-30 | Alvogen Malta Operations (Row) Ltd | Controlled release pharmaceutical composition of varenicline |
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BR9814592B1 (pt) * | 1997-12-31 | 2010-06-01 | composto azapolicìclico condensado com arila, composição farmacêutica contendo o mesmo e seu uso na fabricação de um medicamento. | |
KR100737980B1 (ko) | 1999-08-27 | 2007-07-12 | 아이넥스 파머슈티컬스 코포레이션 | 사이토카인 분비 자극용 및 면역반응 유도용 조성물 |
CZ20011726A3 (cs) * | 2000-05-26 | 2002-02-13 | Pfizer Products Inc. | Způsob reakční krystalizace, který umoľňuje řídit velikost částic |
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PA8559401A1 (es) | 2004-02-07 |
BR0214559A (pt) | 2007-03-13 |
HN2002000332A (es) | 2003-12-11 |
CA2468705A1 (en) | 2003-06-05 |
IL161326A0 (en) | 2004-09-27 |
UY27548A1 (es) | 2003-06-30 |
DOP2002000512A (es) | 2003-05-31 |
RU2004116311A (ru) | 2005-03-27 |
ES2258652T3 (es) | 2006-09-01 |
KR20040066140A (ko) | 2004-07-23 |
EP1461040A1 (en) | 2004-09-29 |
DE60209929D1 (de) | 2006-05-11 |
EP1461040B1 (en) | 2006-03-15 |
AR037677A1 (es) | 2004-12-01 |
TW200300345A (en) | 2003-06-01 |
GT200200236A (es) | 2003-06-25 |
PE20030738A1 (es) | 2003-08-28 |
DE60209929T2 (de) | 2006-11-16 |
US6794388B2 (en) | 2004-09-21 |
AU2002341327A1 (en) | 2003-06-10 |
WO2003045394A1 (en) | 2003-06-05 |
CN1589148A (zh) | 2005-03-02 |
PL374325A1 (en) | 2005-10-17 |
JP4196829B2 (ja) | 2008-12-17 |
MXPA04003192A (es) | 2004-07-27 |
US20030149044A1 (en) | 2003-08-07 |
ATE320256T1 (de) | 2006-04-15 |
SV2004001413A (es) | 2004-05-07 |
JP2005513032A (ja) | 2005-05-12 |
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