RU2004116311A - Сукцинатные соли 5,8,14-триазатетрацикло [10.3.1.02,11(04,9]гексадека- 2(11),3,5,7,9-пентаена и их фармацевтические композиции - Google Patents

Сукцинатные соли 5,8,14-триазатетрацикло [10.3.1.02,11(04,9]гексадека- 2(11),3,5,7,9-пентаена и их фармацевтические композиции Download PDF

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RU2004116311A
RU2004116311A RU2004116311/04A RU2004116311A RU2004116311A RU 2004116311 A RU2004116311 A RU 2004116311A RU 2004116311/04 A RU2004116311/04 A RU 2004116311/04A RU 2004116311 A RU2004116311 A RU 2004116311A RU 2004116311 A RU2004116311 A RU 2004116311A
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compound according
ray diffraction
diffraction pattern
addiction
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Джордж Джозеф КВОЛЛИЧ (US)
Джордж Джозеф Кволлич
Льюин Теофилус УИНТ (US)
Льюин Теофилус УИНТ
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Пфайзер Продактс Инк. (Us)
Пфайзер Продактс Инк.
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Claims (11)

1. Сукцинатная соль 5,8,14-триазатетрацикло-[10.3.1.02,11.04,9]-гексадека-2(11),3,5,7,9-пентаена.
2. Соединение по п.1, где соль является безводной.
3. Соединение по п.2, имеющее рентгеновскую дифрактограмму, характеризуемую, главным образом, наличием пиков на рентгеновской дифрактограмме, как измерено с медным излучателем, при 2θ примерно 13,3 и 17,2.
4. Соединение по п.2, имеющее рентгеновскую дифрактограмму, характеризуемую, главным образом, следующими главными пиками на рентгеновской дифрактограмме, выраженными в терминах 2θ и D-интервалов, как измерено с медным излучателем:
Угол 2θ d-величина (Е) 13,1 6,7 17,0 5,2 22,2 4,0 23,8 3,7
5. Соединение по п.2, отличающееся остановкой перехода плавление/разложение при примерно 198оС.
6. Фармацевтическая композиция, включающая соединение по п.2 и фармацевтически приемлемый носитель.
7. Соединение по п.1, где соль представляет собой гидрат.
8. Соединение по п.7, имеющее рентгеновскую дифрактограмму, характеризуемую, главным образом, наличием пиков на рентгеновской дифрактограмме, как измерено с медным излучателем, при 2θ примерно 13,0, 16,5 и 19,0.
9. Соединение по п.7, имеющее рентгеновскую дифрактограмму, характеризуемую, главным образом, следующими главными пиками на рентгеновской дифрактограмме, выраженными в терминах 2θ и D-интервалов, как измерено с медным излучателем:
Угол 2θ d-величина (Е) 13,0 6,8 16,5 5,4 19,4 4,6
10. Способ лечения воспалительных заболеваний кишечника (включая, но не ограничиваясь этим, язвенный колит, гангренозную пиодермию и болезнь Крона), синдрома раздраженной толстой кишки, спастической дистонии, хронических болей, острых болей, нетропической спру (болезнью глютеновой недостаточности), воспаления брюшины, сужения сосудов, беспокойства, панического состояния, депрессии, биполярного расстройства, аутизма, расстройств сна, нарушения суточного ритма организма при перелете через несколько часовых поясов, бокового амиотрофического склероза (БАС), дисфункции познавательной способности, гипертонии, булимии, анорексии, тучности, сердечной аритмии, повышенной кислотности желудка, язвенных болезней, феохромоцитомы, прогрессивной надмышечной атрофии, зависимостей от химических веществ и пристрастия к ним (например, зависимости от или пристрастия к никотину (и/или табачным продуктам), алкоголю, бензодиазепинам, барбитуратам, опиоидам или кокаину), головной боли, мигрени, удара, травматического поражения мозга (ТПМ), обсессивно-компульсивного расстройства (ОКР), психоза, хореи Хантингтона, поздней дискинезии, гиперкинезии, дислексии, шизофрении, мультиинфарктного слабоумия, возрастного ухудшения познавательной способности, эпилепсии, включая эпилепсию кратковременной потери сознания, старческого слабоумия альцгеймеровского типа (болезнь Альцгеймера, БА), болезни Паркинсона (БП), расстройства дефицита внимания - гиперактивности (ADHD), и синдрома Туррета, включающий введение нуждающемуся в лечении субъекту терапевтически эффективного количества соединения по п.1.
11. Способ лечения никотиновой зависимости, пристрастия к никотину и синдрома абстиненции в отношении никотина у млекопитающих, включающий введение нуждающемуся в этом субъекту соединения по п.1.
RU2004116311/04A 2001-11-29 2002-10-21 Сукцинатные соли 5,8,14-триазатетрацикло [10.3.1.02,11(04,9]гексадека- 2(11),3,5,7,9-пентаена и их фармацевтические композиции RU2004116311A (ru)

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