ZA200402594B - Ibuprofen salt emulsifiers and cream formulations containing the same - Google Patents
Ibuprofen salt emulsifiers and cream formulations containing the same Download PDFInfo
- Publication number
- ZA200402594B ZA200402594B ZA200402594A ZA200402594A ZA200402594B ZA 200402594 B ZA200402594 B ZA 200402594B ZA 200402594 A ZA200402594 A ZA 200402594A ZA 200402594 A ZA200402594 A ZA 200402594A ZA 200402594 B ZA200402594 B ZA 200402594B
- Authority
- ZA
- South Africa
- Prior art keywords
- ibuprofen
- weight
- group
- composition
- effective
- Prior art date
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- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical class CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 title claims description 74
- 239000000203 mixture Substances 0.000 title claims description 55
- 239000003995 emulsifying agent Substances 0.000 title claims description 39
- 239000006071 cream Substances 0.000 title claims description 36
- 238000009472 formulation Methods 0.000 title claims description 13
- -1 fatty acid esters Chemical class 0.000 claims description 77
- 229960001680 ibuprofen Drugs 0.000 claims description 64
- 239000000839 emulsion Substances 0.000 claims description 43
- 150000001875 compounds Chemical class 0.000 claims description 28
- 239000000194 fatty acid Substances 0.000 claims description 25
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 24
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- 239000002562 thickening agent Substances 0.000 claims description 17
- 239000000126 substance Substances 0.000 claims description 16
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 15
- 230000002708 enhancing effect Effects 0.000 claims description 13
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
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- A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32671801P | 2001-10-04 | 2001-10-04 |
Publications (1)
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|---|---|
| ZA200402594B true ZA200402594B (en) | 2006-05-31 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200402594A ZA200402594B (en) | 2001-10-04 | 2004-04-01 | Ibuprofen salt emulsifiers and cream formulations containing the same |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20050032900A1 (ja) |
| EP (1) | EP1432405A1 (ja) |
| JP (1) | JP2005506333A (ja) |
| KR (1) | KR20040066096A (ja) |
| CN (1) | CN1582142A (ja) |
| AU (1) | AU2002341984B2 (ja) |
| BR (1) | BR0213128A (ja) |
| CA (1) | CA2461618A1 (ja) |
| IL (1) | IL161103A0 (ja) |
| MX (1) | MXPA04003179A (ja) |
| RU (1) | RU2004113433A (ja) |
| WO (1) | WO2003028702A1 (ja) |
| ZA (1) | ZA200402594B (ja) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003000158A1 (en) * | 2001-06-22 | 2003-01-03 | Bentley Pharmaceuticals, Inc. | Pharmaceutical composition |
| US7244703B2 (en) | 2001-06-22 | 2007-07-17 | Bentley Pharmaceuticals, Inc. | Pharmaceutical compositions and methods for peptide treatment |
| DE10314976A1 (de) | 2003-04-02 | 2004-10-14 | Bayer Healthcare Ag | Verbesserte Penetration von Wirkstoffen in Zellen und Organe |
| NZ544851A (en) * | 2003-06-23 | 2008-03-28 | Macrochem Corp | A vanishing cream base composition suitable for topical administration of an active agent to an animal or plant |
| US20070065494A1 (en) * | 2005-08-03 | 2007-03-22 | Watson Laboratories, Inc. | Formulations and Methods for Enhancing the Transdermal Penetration of a Drug |
| ES2289897B1 (es) * | 2005-11-08 | 2008-12-16 | Laboratorios Belmac, S.A. | Composicion para administracion transdermica de agentes fisiologicamente activos. |
| US7595348B2 (en) * | 2006-05-24 | 2009-09-29 | Ferro Corporation | Butyl lactate emulsions for the precipitation of water-insoluble drug nanoparticles |
| KR20110017365A (ko) * | 2008-05-30 | 2011-02-21 | 페어필드 클리니컬 트라이얼즈 엘엘씨 | 피부 염증 및 변색을 위한 방법 및 조성물 |
| EP3560485A1 (en) | 2011-05-03 | 2019-10-30 | Aponia Laboratories, Inc. | Transdermal compositions of ibuprofen and methods of use thereof |
| US9023399B2 (en) | 2012-11-16 | 2015-05-05 | NU Technology, LLC | Water-soluble anti-inflammatory cream with natural ingredients base |
| US8613961B1 (en) * | 2013-01-09 | 2013-12-24 | NU Technology, LLC | Dermatological cream with natural ingredients base |
| US20160184431A1 (en) * | 2014-03-11 | 2016-06-30 | Promius Pharma Llc | Topical compositions comprising a corticosteroid |
| US20160120797A1 (en) * | 2014-10-31 | 2016-05-05 | Sreedhar Rao Rayudu | Anti-acne composition and methods of use thereof |
| US10596117B1 (en) | 2014-12-31 | 2020-03-24 | Eric Morrison | Lipoleosomes as carriers for aromatic amide anesthetic compounds |
| US10561627B2 (en) * | 2014-12-31 | 2020-02-18 | Eric Morrison | Ibuprofen nanoparticle carriers encapsulated with hermetic surfactant films |
| US11007161B1 (en) | 2014-12-31 | 2021-05-18 | Eric Morrison | Ibuprofen nanoparticle carriers encapsulated with hermatic surfactant films |
| GB201706969D0 (en) * | 2017-05-02 | 2017-06-14 | Medherant Ltd | Formulation |
| WO2019112848A1 (en) | 2017-12-04 | 2019-06-13 | Johnson & Johnson Consumer Inc. | Topical emulsion composition containing nonsteroidal anti-inflammatory drug |
| CN112206222A (zh) * | 2018-11-09 | 2021-01-12 | 北京德默高科医药技术有限公司 | 含有布洛芬结构类似物的多层经皮给药系统 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3205504C2 (de) * | 1982-02-16 | 1983-12-01 | Dolorgiet Gmbh & Co Kg, 5300 Bonn | Äußerlich anwendbares, Ibuprofen enthaltendes Arzneimittel |
| US5104656A (en) * | 1989-06-16 | 1992-04-14 | Seth Pyare L | Percutaneous treatment with a high potency non-steroidal anti-inflammatory agent |
| US5210099A (en) * | 1991-02-11 | 1993-05-11 | American Home Products Corporation | Analgesic compositions |
| US6525214B1 (en) * | 1991-05-13 | 2003-02-25 | Bernard John Armitage | Therapeutic agent |
| AT408067B (de) * | 1995-03-17 | 2001-08-27 | Gebro Pharma Gmbh | Pharmazeutische zusammensetzung zur topischen applizierung und verfahren zu ihrer herstellung |
| US5976566A (en) * | 1997-08-29 | 1999-11-02 | Macrochem Corporation | Non-steroidal antiinflammtory drug formulations for topical application to the skin |
-
2002
- 2002-10-04 EP EP02776146A patent/EP1432405A1/en not_active Withdrawn
- 2002-10-04 US US10/491,493 patent/US20050032900A1/en not_active Abandoned
- 2002-10-04 BR BR0213128-5A patent/BR0213128A/pt not_active Application Discontinuation
- 2002-10-04 RU RU2004113433/15A patent/RU2004113433A/ru not_active Application Discontinuation
- 2002-10-04 CA CA002461618A patent/CA2461618A1/en not_active Abandoned
- 2002-10-04 WO PCT/US2002/031798 patent/WO2003028702A1/en active Application Filing
- 2002-10-04 KR KR10-2004-7004826A patent/KR20040066096A/ko not_active Application Discontinuation
- 2002-10-04 IL IL16110302A patent/IL161103A0/xx unknown
- 2002-10-04 MX MXPA04003179A patent/MXPA04003179A/es active IP Right Grant
- 2002-10-04 AU AU2002341984A patent/AU2002341984B2/en not_active Ceased
- 2002-10-04 JP JP2003532035A patent/JP2005506333A/ja active Pending
- 2002-10-04 CN CNA028215028A patent/CN1582142A/zh active Pending
-
2004
- 2004-04-01 ZA ZA200402594A patent/ZA200402594B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA04003179A (es) | 2005-01-25 |
| WO2003028702A1 (en) | 2003-04-10 |
| CA2461618A1 (en) | 2003-04-10 |
| IL161103A0 (en) | 2004-08-31 |
| US20050032900A1 (en) | 2005-02-10 |
| BR0213128A (pt) | 2004-09-21 |
| RU2004113433A (ru) | 2005-03-20 |
| KR20040066096A (ko) | 2004-07-23 |
| EP1432405A1 (en) | 2004-06-30 |
| CN1582142A (zh) | 2005-02-16 |
| AU2002341984B2 (en) | 2008-01-03 |
| JP2005506333A (ja) | 2005-03-03 |
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