ZA200402532B - Extended release pharmaceutical composition containing metformin. - Google Patents
Extended release pharmaceutical composition containing metformin. Download PDFInfo
- Publication number
- ZA200402532B ZA200402532B ZA200402532A ZA200402532A ZA200402532B ZA 200402532 B ZA200402532 B ZA 200402532B ZA 200402532 A ZA200402532 A ZA 200402532A ZA 200402532 A ZA200402532 A ZA 200402532A ZA 200402532 B ZA200402532 B ZA 200402532B
- Authority
- ZA
- South Africa
- Prior art keywords
- pharmaceutical composition
- composition according
- metformin
- process according
- water content
- Prior art date
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- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 title claims description 36
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 32
- 229960003105 metformin Drugs 0.000 title claims description 27
- 238000013265 extended release Methods 0.000 title claims description 14
- 238000000034 method Methods 0.000 claims description 52
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1002DE2001 IN192180B (de) | 2001-09-28 | 2001-09-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200402532B true ZA200402532B (en) | 2005-01-04 |
Family
ID=11097117
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200402532A ZA200402532B (en) | 2001-09-28 | 2004-03-31 | Extended release pharmaceutical composition containing metformin. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20040059001A1 (de) |
| EP (1) | EP1434568A1 (de) |
| JP (1) | JP2005507896A (de) |
| KR (1) | KR20040063900A (de) |
| CN (1) | CN1582145A (de) |
| AR (1) | AR037326A1 (de) |
| BR (1) | BR0212931A (de) |
| EA (1) | EA200400487A1 (de) |
| IN (1) | IN192180B (de) |
| MX (1) | MXPA04002910A (de) |
| WO (1) | WO2003028704A1 (de) |
| ZA (1) | ZA200402532B (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100897890B1 (ko) | 2002-06-17 | 2009-05-18 | 인벤티아 헬스케어 피브이티. 엘티디. | 티아졸리딘디온 및 바이구아나이드를 함유하는 다층 정제및 그의 제조 방법 |
| EP1646374A1 (de) * | 2003-06-16 | 2006-04-19 | Ranbaxy Laboratories, Ltd. | Metformin enthaltende tabletten mit verlängerter freisetzung |
| WO2005092293A1 (en) * | 2004-03-22 | 2005-10-06 | Ranbaxy Laboratories Limited | Formulations of metformin |
| EP1814528A2 (de) * | 2004-10-08 | 2007-08-08 | Rubicon Research Private Limited | Verfahren zur herstellung einer stark komprimierbaren metforminzusammensetzung mit kontrollierter freisetzung |
| EA012220B1 (ru) * | 2004-10-19 | 2009-08-28 | Крка, Товарна Здравил, Д. Д., Ново Место | Твёрдая фармацевтическая композиция, содержащая донепезила гидрохлорид |
| WO2006082523A2 (en) * | 2005-01-25 | 2006-08-10 | Aurobindo Pharma Limited | Pharmaceutical sustained release composition of metformin |
| US20060252830A1 (en) * | 2005-05-06 | 2006-11-09 | Brandon Stephen F | Method for the treatment of magnesium and potassium deficiencies |
| US20060252831A1 (en) * | 2005-05-06 | 2006-11-09 | Christopher Offen | Method for the treatment of magnesium and potassium deficiencies |
| AU2006244213B2 (en) * | 2005-05-10 | 2010-05-13 | Novartis Ag | Extrusion process for making compositions with poorly compressible therapeutic compounds |
| KR100780553B1 (ko) * | 2005-08-18 | 2007-11-29 | 한올제약주식회사 | 메트포르민 서방정 및 그의 제조방법 |
| JP2009514884A (ja) * | 2005-11-04 | 2009-04-09 | イーストマン ケミカル カンパニー | 難溶性医薬活性剤の投与のためのカルボキシアルキルセルロースエステル |
| BRPI0605967A (pt) * | 2006-12-20 | 2008-08-12 | Medley S A Ind Farmaceutica | composição farmacêutica de liberação controlada, forma farmacêutica de liberação controlada e processo para obtenção de forma farmacêutica |
| CN105152983A (zh) * | 2007-01-29 | 2015-12-16 | 韩诺生物制药株式会社 | N,n-二甲基亚氨基二碳亚氨酸二酰胺乙酸盐、其制备方法和包含其的药物组合物 |
| KR101597004B1 (ko) | 2013-07-25 | 2016-02-23 | 씨제이헬스케어 주식회사 | 서방형 메트포르민과 속방형 HMG-CoA 환원효소 억제제를 포함하는 복합제제 |
| CN106138020A (zh) * | 2015-04-03 | 2016-11-23 | 中国人民解放军第三军医大学第三附属医院 | 双胍类药物在制备预防或减弱肺纤维化的药物中的应用 |
| CN107049980A (zh) * | 2017-04-01 | 2017-08-18 | 重庆康刻尔制药有限公司 | 一种盐酸二甲双胍缓释片及其制备方法 |
| WO2021133046A1 (ko) * | 2019-12-23 | 2021-07-01 | 주식회사 대웅제약 | 메트포르민 서방성 제제 및 이의 제조 방법 |
| CN111588701B (zh) * | 2020-05-25 | 2021-04-23 | 上海普康药业有限公司 | 一种盐酸二甲双胍缓释片及其制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8813064D0 (en) * | 1988-06-02 | 1988-07-06 | Euro Celtique Sa | Controlled release dosage forms having defined water content |
| US5451409A (en) * | 1993-11-22 | 1995-09-19 | Rencher; William F. | Sustained release matrix system using hydroxyethyl cellulose and hydroxypropyl cellulose polymer blends |
| DE4432757A1 (de) * | 1994-09-14 | 1996-03-21 | Boehringer Mannheim Gmbh | Pharmazeutische Zubereitung enthaltend Metformin und Verfahren zu deren Herstellung |
| AU738804B2 (en) * | 1997-12-08 | 2001-09-27 | Bristol-Myers Squibb Company | Novel salts of metformin and method |
| CN1203846C (zh) * | 1998-03-19 | 2005-06-01 | 布里斯托尔-迈尔斯斯奎布公司 | 高溶解性药物的双相控释递送系统和方法 |
| US6117451A (en) * | 1998-08-25 | 2000-09-12 | Pharmalogix, Inc. | Direct compression metformin hydrochloride tablets |
-
2001
- 2001-09-28 IN IN1002DE2001 patent/IN192180B/en unknown
-
2002
- 2002-09-27 EP EP02800214A patent/EP1434568A1/de not_active Withdrawn
- 2002-09-27 WO PCT/IB2002/003997 patent/WO2003028704A1/en not_active Application Discontinuation
- 2002-09-27 KR KR10-2004-7004586A patent/KR20040063900A/ko not_active Application Discontinuation
- 2002-09-27 JP JP2003532037A patent/JP2005507896A/ja active Pending
- 2002-09-27 MX MXPA04002910A patent/MXPA04002910A/es unknown
- 2002-09-27 US US10/432,654 patent/US20040059001A1/en not_active Abandoned
- 2002-09-27 BR BR0212931-0A patent/BR0212931A/pt not_active Application Discontinuation
- 2002-09-27 CN CNA02822180XA patent/CN1582145A/zh active Pending
- 2002-09-27 EA EA200400487A patent/EA200400487A1/ru unknown
- 2002-09-30 AR ARP020103687A patent/AR037326A1/es unknown
-
2004
- 2004-03-31 ZA ZA200402532A patent/ZA200402532B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20040063900A (ko) | 2004-07-14 |
| IN192180B (de) | 2004-03-06 |
| AR037326A1 (es) | 2004-11-03 |
| WO2003028704A1 (en) | 2003-04-10 |
| CN1582145A (zh) | 2005-02-16 |
| EA200400487A1 (ru) | 2004-10-28 |
| MXPA04002910A (es) | 2004-07-05 |
| US20040059001A1 (en) | 2004-03-25 |
| EP1434568A1 (de) | 2004-07-07 |
| BR0212931A (pt) | 2004-10-13 |
| JP2005507896A (ja) | 2005-03-24 |
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