ZA200401711B - Macrolides containing pharmaceutical compositions. - Google Patents
Macrolides containing pharmaceutical compositions. Download PDFInfo
- Publication number
- ZA200401711B ZA200401711B ZA200401711A ZA200401711A ZA200401711B ZA 200401711 B ZA200401711 B ZA 200401711B ZA 200401711 A ZA200401711 A ZA 200401711A ZA 200401711 A ZA200401711 A ZA 200401711A ZA 200401711 B ZA200401711 B ZA 200401711B
- Authority
- ZA
- South Africa
- Prior art keywords
- compound
- formula
- amino
- propanediol
- pharmaceutical composition
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 24
- 239000003120 macrolide antibiotic agent Substances 0.000 title description 2
- 229940041033 macrolides Drugs 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims description 104
- KJJPLEZQSCZCKE-UHFFFAOYSA-N 2-aminopropane-1,3-diol Chemical compound OCC(N)CO KJJPLEZQSCZCKE-UHFFFAOYSA-N 0.000 claims description 40
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 16
- 201000010099 disease Diseases 0.000 claims description 12
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 12
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 4
- 241001465754 Metazoa Species 0.000 description 17
- 230000000694 effects Effects 0.000 description 11
- 150000003839 salts Chemical class 0.000 description 11
- 125000000217 alkyl group Chemical group 0.000 description 10
- 241000700159 Rattus Species 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 230000001363 autoimmune Effects 0.000 description 6
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- ZMKGDQSIRSGUDJ-VSROPUKISA-N (3s,6s,9s,12r,15s,18s,21s,24s,30s,33s)-33-[(e,1r,2r)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-30-propyl-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,1 Chemical compound CCC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O ZMKGDQSIRSGUDJ-VSROPUKISA-N 0.000 description 1
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- CKOZVEHVVHCMGD-UHFFFAOYSA-N 5-[(4-fluorophenyl)methyl]-n,n-dimethyltetrazole-1-carboxamide Chemical compound CN(C)C(=O)N1N=NN=C1CC1=CC=C(F)C=C1 CKOZVEHVVHCMGD-UHFFFAOYSA-N 0.000 description 1
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- 229930105110 Cyclosporin A Natural products 0.000 description 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 1
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- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 description 1
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- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
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- SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 description 1
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- PHEZJEYUWHETKO-UHFFFAOYSA-N brequinar Chemical compound N1=C2C=CC(F)=CC2=C(C(O)=O)C(C)=C1C(C=C1)=CC=C1C1=CC=CC=C1F PHEZJEYUWHETKO-UHFFFAOYSA-N 0.000 description 1
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- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
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- 229910052751 metal Inorganic materials 0.000 description 1
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- HPNSFSBZBAHARI-UHFFFAOYSA-N micophenolic acid Natural products OC1=C(CC=C(C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-UHFFFAOYSA-N 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
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- RTGDFNSFWBGLEC-SYZQJQIISA-N mycophenolate mofetil Chemical compound COC1=C(C)C=2COC(=O)C=2C(O)=C1C\C=C(/C)CCC(=O)OCCN1CCOCC1 RTGDFNSFWBGLEC-SYZQJQIISA-N 0.000 description 1
- 229960004866 mycophenolate mofetil Drugs 0.000 description 1
- 229960000951 mycophenolic acid Drugs 0.000 description 1
- HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 description 1
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- 108020003175 receptors Proteins 0.000 description 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/133—Amines having hydroxy groups, e.g. sphingosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
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- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Dermatology (AREA)
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- Pain & Pain Management (AREA)
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- Biomedical Technology (AREA)
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- Neurosurgery (AREA)
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- Urology & Nephrology (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| GBGB0125443.2A GB0125443D0 (en) | 2001-10-23 | 2001-10-23 | Organic Compounds |
| GB0127341A GB0127341D0 (en) | 2001-11-14 | 2001-11-14 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200401711B true ZA200401711B (en) | 2004-10-21 |
Family
ID=26246689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200401711A ZA200401711B (en) | 2001-10-23 | 2004-03-02 | Macrolides containing pharmaceutical compositions. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7259170B2 (https=) |
| EP (1) | EP1439838A1 (https=) |
| JP (1) | JP2005509634A (https=) |
| KR (2) | KR100978971B1 (https=) |
| CN (1) | CN1307993C (https=) |
| AU (1) | AU2002346859C1 (https=) |
| BR (1) | BR0213463A (https=) |
| CA (1) | CA2458690C (https=) |
| EC (1) | ECSP045086A (https=) |
| GB (1) | GB0125443D0 (https=) |
| HU (1) | HUP0402108A3 (https=) |
| IL (1) | IL160973A0 (https=) |
| MX (1) | MXPA04003738A (https=) |
| NO (1) | NO20042074L (https=) |
| NZ (1) | NZ532412A (https=) |
| PL (1) | PL368533A1 (https=) |
| RU (1) | RU2321402C2 (https=) |
| WO (1) | WO2003035068A1 (https=) |
| ZA (1) | ZA200401711B (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2005512946A (ja) * | 2001-05-09 | 2005-05-12 | ノバルティス アクチエンゲゼルシャフト | 選択的免疫調節法 |
| BR0306811A (pt) | 2002-01-11 | 2004-10-26 | Sankyo Co | Composto, éster farmacologicamente aceitável do mesmo, composição farmacêutica e métodos para prevenção ou tratamento de doenças autoimunes, da artrite reumatóide e da rejeição causada pelo transplante de vários órgãos em um mamìfero |
| GB0307867D0 (en) * | 2003-04-04 | 2003-05-14 | Novartis Ag | Pharmaceutical composition |
| JP2005272453A (ja) | 2004-02-24 | 2005-10-06 | Sankyo Co Ltd | アミノアルコール化合物 |
Family Cites Families (19)
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| DE68921934T2 (de) | 1988-06-29 | 1995-10-19 | Merck & Co Inc | Immunsuppressives Agens. |
| DK0427680T3 (da) * | 1989-11-09 | 1995-12-18 | Sandoz Ltd | Heteroatom-holdige cykliske forbindelser |
| US5352671A (en) * | 1989-11-09 | 1994-10-04 | Sandoz Ltd. | Heteroatoms-containing tricyclic compounds |
| GB2252041A (en) * | 1991-01-23 | 1992-07-29 | Fujisawa Pharmaceutical Co | Use of macrolide compounds in treatment of autoimmune myocarditis |
| CA2106483A1 (en) * | 1991-03-19 | 1992-09-20 | Vithal J. Rajadhyaksha | Compositions and method comprising aminoalcohol derivatives as membrane penetration enhancers |
| US5247076A (en) * | 1991-09-09 | 1993-09-21 | Merck & Co., Inc. | Imidazolidyl macrolides having immunosuppressive activity |
| GB9203636D0 (en) * | 1992-02-19 | 1992-04-08 | Lucas Ind Plc | Fuel pumping apparatus |
| US5604229A (en) * | 1992-10-21 | 1997-02-18 | Yoshitomi Pharmaceutical Industries, Ltd. | 2-amino-1,3-propanediol compound and immunosuppressant |
| JPH08507789A (ja) | 1993-03-17 | 1996-08-20 | アボツト・ラボラトリーズ | 大環状アミド及び尿素免疫調節剤 |
| US5590460A (en) * | 1994-07-19 | 1997-01-07 | Tessera, Inc. | Method of making multilayer circuit |
| DE69524962D1 (de) * | 1994-08-22 | 2002-02-14 | Welfide Corp | Benzolderivate und deren medizinische verwendung |
| GB9521322D0 (en) | 1995-10-17 | 1995-12-20 | Sandoz Ltd | Organic compounds |
| JPH11209277A (ja) | 1998-01-19 | 1999-08-03 | Yoshitomi Pharmaceut Ind Ltd | 医薬組成物 |
| GB9624038D0 (en) | 1996-11-19 | 1997-01-08 | Sandoz Ltd | Organic compounds |
| ATE298740T1 (de) * | 1997-04-04 | 2005-07-15 | Mitsubishi Pharma Corp | 2-aminopropan-1,3-diol-verbindungen, ihre medizinische anwendung und zwischenprodukte zu ihrer synthese |
| GB9713730D0 (en) * | 1997-06-30 | 1997-09-03 | Ciba Geigy Ag | Organic compounds |
| JP4627356B2 (ja) * | 1999-06-30 | 2011-02-09 | 昭 松森 | ウイルス性心筋炎の予防または治療薬剤 |
| GB0003932D0 (en) | 2000-02-18 | 2000-04-12 | Novartis Ag | Pharmaceutical compositions |
| EP1355588B1 (en) | 2000-12-22 | 2007-08-15 | Avantec Vascular Corporation | Device for delivery of therepeutic agents |
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2001
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2002
- 2002-10-22 NZ NZ532412A patent/NZ532412A/en unknown
- 2002-10-22 RU RU2004116067/15A patent/RU2321402C2/ru not_active IP Right Cessation
- 2002-10-22 KR KR1020047005958A patent/KR100978971B1/ko not_active Expired - Fee Related
- 2002-10-22 EP EP02782975A patent/EP1439838A1/en not_active Withdrawn
- 2002-10-22 WO PCT/EP2002/011799 patent/WO2003035068A1/en not_active Ceased
- 2002-10-22 MX MXPA04003738A patent/MXPA04003738A/es active IP Right Grant
- 2002-10-22 CA CA2458690A patent/CA2458690C/en not_active Expired - Fee Related
- 2002-10-22 CN CNB028211588A patent/CN1307993C/zh not_active Expired - Fee Related
- 2002-10-22 JP JP2003537635A patent/JP2005509634A/ja active Pending
- 2002-10-22 IL IL16097302A patent/IL160973A0/xx unknown
- 2002-10-22 AU AU2002346859A patent/AU2002346859C1/en not_active Ceased
- 2002-10-22 HU HU0402108A patent/HUP0402108A3/hu unknown
- 2002-10-22 BR BR0213463-2A patent/BR0213463A/pt not_active IP Right Cessation
- 2002-10-22 PL PL02368533A patent/PL368533A1/xx not_active Application Discontinuation
- 2002-10-22 US US10/492,439 patent/US7259170B2/en not_active Expired - Fee Related
- 2002-10-22 KR KR1020097021354A patent/KR20090114483A/ko not_active Ceased
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2004
- 2004-03-02 ZA ZA200401711A patent/ZA200401711B/en unknown
- 2004-04-23 EC EC2004005086A patent/ECSP045086A/es unknown
- 2004-05-19 NO NO20042074A patent/NO20042074L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US20040192716A1 (en) | 2004-09-30 |
| CA2458690A1 (en) | 2003-05-01 |
| CA2458690C (en) | 2011-01-25 |
| ECSP045086A (es) | 2004-06-28 |
| PL368533A1 (en) | 2005-04-04 |
| KR20090114483A (ko) | 2009-11-03 |
| KR100978971B1 (ko) | 2010-08-30 |
| JP2005509634A (ja) | 2005-04-14 |
| WO2003035068A1 (en) | 2003-05-01 |
| BR0213463A (pt) | 2004-11-09 |
| HUP0402108A3 (en) | 2008-02-28 |
| IL160973A0 (en) | 2004-08-31 |
| AU2002346859C1 (en) | 2008-07-10 |
| NO20042074L (no) | 2004-05-19 |
| MXPA04003738A (es) | 2004-07-23 |
| CN1307993C (zh) | 2007-04-04 |
| AU2002346859B2 (en) | 2006-03-02 |
| RU2321402C2 (ru) | 2008-04-10 |
| CN1575173A (zh) | 2005-02-02 |
| US7259170B2 (en) | 2007-08-21 |
| KR20040052250A (ko) | 2004-06-22 |
| EP1439838A1 (en) | 2004-07-28 |
| RU2004116067A (ru) | 2005-04-20 |
| NZ532412A (en) | 2006-01-27 |
| HUP0402108A2 (hu) | 2005-02-28 |
| GB0125443D0 (en) | 2001-12-12 |
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