ZA200309288B - Process for the isolation of crystalline imipenem. - Google Patents

Process for the isolation of crystalline imipenem.

Info

Publication number
ZA200309288B
ZA200309288B ZA200309288A ZA200309288A ZA200309288B ZA 200309288 B ZA200309288 B ZA 200309288B ZA 200309288 A ZA200309288 A ZA 200309288A ZA 200309288 A ZA200309288 A ZA 200309288A ZA 200309288 B ZA200309288 B ZA 200309288B
Authority
ZA
South Africa
Prior art keywords
isolation
crystalline imipenem
imipenem
crystalline
Prior art date
Application number
ZA200309288A
Other languages
English (en)
Inventor
Yatendra Kumar
Neera Tewari
Ram Chander Aryan
Bishwa Prakash Rai
Original Assignee
Ranbaxy Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd filed Critical Ranbaxy Lab Ltd
Publication of ZA200309288B publication Critical patent/ZA200309288B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
ZA200309288A 2001-05-18 2003-11-28 Process for the isolation of crystalline imipenem. ZA200309288B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN595DE2001 2001-05-18

Publications (1)

Publication Number Publication Date
ZA200309288B true ZA200309288B (en) 2005-02-28

Family

ID=11097062

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200309288A ZA200309288B (en) 2001-05-18 2003-11-28 Process for the isolation of crystalline imipenem.

Country Status (17)

Country Link
US (1) US7241885B2 (sk)
EP (1) EP1395588A4 (sk)
JP (1) JP2005514323A (sk)
KR (1) KR20040010649A (sk)
CN (1) CN1522255A (sk)
AR (1) AR036018A1 (sk)
BR (1) BR0209844A (sk)
CA (1) CA2447673A1 (sk)
CZ (1) CZ20033351A3 (sk)
HU (1) HUP0501093A2 (sk)
MX (1) MXPA03010548A (sk)
NO (1) NO20035137D0 (sk)
OA (1) OA12608A (sk)
PL (1) PL373527A1 (sk)
SK (1) SK15092003A3 (sk)
WO (1) WO2002094773A2 (sk)
ZA (1) ZA200309288B (sk)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0209842A (pt) * 2001-05-18 2005-01-04 Ranbaxy Lab Ltd Processo para a preparação de imipenem
US20040198973A1 (en) * 2001-08-13 2004-10-07 Tsujii Masahiko Process for preparation of carbapenem antibiotics
CN1608066A (zh) * 2001-11-16 2005-04-20 兰贝克赛实验室有限公司 结晶亚胺培南的制备方法
US8293924B2 (en) 2007-10-08 2012-10-23 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of carbapenem antibiotic
CN103524508B (zh) * 2013-09-02 2016-03-30 上海龙翔生物医药开发有限公司 一种亚胺培南一水合物的结晶方法
CN108623598A (zh) * 2018-05-21 2018-10-09 重庆天地药业有限责任公司 一种亚胺培南中间体及亚胺培南的制备方法
CN113135916A (zh) * 2020-01-20 2021-07-20 鲁南制药集团股份有限公司 一种亚胺培南制备工艺的除钯方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4138433A (en) * 1975-06-26 1979-02-06 Hoechst Aktiengesellschaft Process for preparing 1,2-oxa-phospholanes
US4194047A (en) 1975-11-21 1980-03-18 Merck & Co., Inc. Substituted N-methylene derivatives of thienamycin
US4081455A (en) * 1976-06-02 1978-03-28 Pfizer Inc. 6-Amino-2,2-dimethyl-3-cyanopenams
US4260543A (en) 1978-07-03 1981-04-07 Merck & Co., Inc. Crystalline N-formimidoyl thienamycin
US4292436A (en) * 1980-06-25 1981-09-29 Merck & Co., Inc. Process for the preparation of N-protected N-formimidoyl 2-aminoethanethiol
US4374772A (en) 1981-03-19 1983-02-22 Merck & Co., Inc. Process for the preparation of N-formimidoyl thienamycin and reagents therefor
US4894450A (en) 1987-05-11 1990-01-16 Merck & Co., Inc. Process for 2-(aminoalkylthio) carbapenems
US5245069A (en) * 1992-10-27 1993-09-14 Merck & Co., Inc. Process for the preparation of bis(aryl)-phosphorohalidates
IN191798B (sk) 2000-11-03 2004-01-03 Ranbaxy Lab Ltd
CN1608066A (zh) * 2001-11-16 2005-04-20 兰贝克赛实验室有限公司 结晶亚胺培南的制备方法

Also Published As

Publication number Publication date
CA2447673A1 (en) 2002-11-28
CZ20033351A3 (cs) 2007-12-27
EP1395588A2 (en) 2004-03-10
OA12608A (en) 2006-06-08
AR036018A1 (es) 2004-08-04
WO2002094773A2 (en) 2002-11-28
KR20040010649A (ko) 2004-01-31
EP1395588A4 (en) 2004-09-15
JP2005514323A (ja) 2005-05-19
WO2002094773A3 (en) 2003-10-16
SK15092003A3 (sk) 2004-09-08
NO20035137D0 (no) 2003-11-18
CN1522255A (zh) 2004-08-18
MXPA03010548A (es) 2004-05-27
US20040242865A1 (en) 2004-12-02
BR0209844A (pt) 2005-04-05
HUP0501093A2 (en) 2006-03-28
US7241885B2 (en) 2007-07-10
PL373527A1 (en) 2005-09-05

Similar Documents

Publication Publication Date Title
EP1425279A4 (en) PROCESS FOR THE PREPARATION OF CRYSTALLINE TETRAHYDROBENZOTHIEPINES
PL368984A1 (en) Process for the preparation of crystalline imipenem
MXPA03010020A (es) PROCEDIMIETO PARA LA PREPARACIoN DE UREA.
IL143106A (en) Process for the preparation of diphenylmethylthioacetamide
MXPA03008205A (es) Procedimiento para la preparacion de compuestos de imidazol.
AU2001273762A1 (en) Process for the preparation of (r)-2-alkyl-3-phenyl-1-propanols
SI1423360T1 (sl) Postopek za izdelavo cilastatina
MXPA02006102A (es) Metodo para preparar compuestos bormodifluoroaceticos.
ZA200309288B (en) Process for the isolation of crystalline imipenem.
HK1040984A1 (zh) 製備d，l-薄荷醇的方法
PL370705A1 (en) Process for the preparation of imipenem
AU2002367890A1 (en) Process for the preparation of 4-methyl-thiazole-5-carbaldehyde intermediate
AU2001232158A1 (en) Crystallizing process
AP2003002913A0 (en) Process for the isolation of crystalline imipenem.
AU2002329441A1 (en) Process for the preparation of 3 - isochromanone
HUP0303025A3 (en) Process for the preparation of arylethanoldiamines
MXPA03009210A (es) PROCEDIMIENTO PARA LA PREPARACIoN DE OXABISPIDINAS.
AU2002358085A1 (en) Process for the preparation of 4-methyl-7-aminoquinolones
PL371583A1 (en) Process for the preparation of 7alpha-methylsteroids
SG111997A1 (en) Improved process for the preparation of polyalkylphenoxyaminoalkanes
IL164788A0 (en) Process for the preparation of 3-isochromanone
AU2002257307A1 (en) Process for isolation of monophenolic-bisaryl triazines
AU2002324291A1 (en) Process for the preparation of beta-ionylideneacetaldehyde
HK1051190A1 (en) Process for the preparation of 2-(4-alkyl-1-piperazinyl-benzaldehyde and -benzylidenyl compounds.
AU2002231651A1 (en) Process for the preparation of morpholinones