ZA200309288B - Process for the isolation of crystalline imipenem. - Google Patents

Process for the isolation of crystalline imipenem.

Info

Publication number
ZA200309288B
ZA200309288B ZA200309288A ZA200309288A ZA200309288B ZA 200309288 B ZA200309288 B ZA 200309288B ZA 200309288 A ZA200309288 A ZA 200309288A ZA 200309288 A ZA200309288 A ZA 200309288A ZA 200309288 B ZA200309288 B ZA 200309288B
Authority
ZA
South Africa
Prior art keywords
isolation
crystalline imipenem
imipenem
crystalline
Prior art date
Application number
ZA200309288A
Other languages
English (en)
Inventor
Yatendra Kumar
Neera Tewari
Ram Chander Aryan
Bishwa Prakash Rai
Original Assignee
Ranbaxy Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd filed Critical Ranbaxy Lab Ltd
Publication of ZA200309288B publication Critical patent/ZA200309288B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
ZA200309288A 2001-05-18 2003-11-28 Process for the isolation of crystalline imipenem. ZA200309288B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN595DE2001 2001-05-18

Publications (1)

Publication Number Publication Date
ZA200309288B true ZA200309288B (en) 2005-02-28

Family

ID=11097062

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200309288A ZA200309288B (en) 2001-05-18 2003-11-28 Process for the isolation of crystalline imipenem.

Country Status (17)

Country Link
US (1) US7241885B2 (cs)
EP (1) EP1395588A4 (cs)
JP (1) JP2005514323A (cs)
KR (1) KR20040010649A (cs)
CN (1) CN1522255A (cs)
AR (1) AR036018A1 (cs)
BR (1) BR0209844A (cs)
CA (1) CA2447673A1 (cs)
CZ (1) CZ20033351A3 (cs)
HU (1) HUP0501093A2 (cs)
MX (1) MXPA03010548A (cs)
NO (1) NO20035137D0 (cs)
OA (1) OA12608A (cs)
PL (1) PL373527A1 (cs)
SK (1) SK15092003A3 (cs)
WO (1) WO2002094773A2 (cs)
ZA (1) ZA200309288B (cs)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7462712B2 (en) * 2001-05-18 2008-12-09 Ranbaxy Laboratories Limited Process for the preparation of imipenem
WO2003016312A1 (fr) * 2001-08-13 2003-02-27 Eisai Co., Ltd. Procede de preparation d'antibiotiques a base de carbapenem
EA200400682A1 (ru) * 2001-11-16 2004-10-28 Рэнбакси Лабораториз Лимитед Способ получения кристаллического имипенема
WO2009047604A1 (en) * 2007-10-08 2009-04-16 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of carbapenem antibiotic
CN103524508B (zh) * 2013-09-02 2016-03-30 上海龙翔生物医药开发有限公司 一种亚胺培南一水合物的结晶方法
CN108623598A (zh) * 2018-05-21 2018-10-09 重庆天地药业有限责任公司 一种亚胺培南中间体及亚胺培南的制备方法
CN113135916A (zh) * 2020-01-20 2021-07-20 鲁南制药集团股份有限公司 一种亚胺培南制备工艺的除钯方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4138433A (en) * 1975-06-26 1979-02-06 Hoechst Aktiengesellschaft Process for preparing 1,2-oxa-phospholanes
US4194047A (en) * 1975-11-21 1980-03-18 Merck & Co., Inc. Substituted N-methylene derivatives of thienamycin
US4081455A (en) * 1976-06-02 1978-03-28 Pfizer Inc. 6-Amino-2,2-dimethyl-3-cyanopenams
US4260543A (en) * 1978-07-03 1981-04-07 Merck & Co., Inc. Crystalline N-formimidoyl thienamycin
US4292436A (en) * 1980-06-25 1981-09-29 Merck & Co., Inc. Process for the preparation of N-protected N-formimidoyl 2-aminoethanethiol
US4374772A (en) * 1981-03-19 1983-02-22 Merck & Co., Inc. Process for the preparation of N-formimidoyl thienamycin and reagents therefor
US4894450A (en) * 1987-05-11 1990-01-16 Merck & Co., Inc. Process for 2-(aminoalkylthio) carbapenems
US5245069A (en) * 1992-10-27 1993-09-14 Merck & Co., Inc. Process for the preparation of bis(aryl)-phosphorohalidates
IN191798B (cs) * 2000-11-03 2004-01-03 Ranbaxy Lab Ltd
EA200400682A1 (ru) * 2001-11-16 2004-10-28 Рэнбакси Лабораториз Лимитед Способ получения кристаллического имипенема

Also Published As

Publication number Publication date
SK15092003A3 (sk) 2004-09-08
CN1522255A (zh) 2004-08-18
WO2002094773A3 (en) 2003-10-16
WO2002094773A2 (en) 2002-11-28
CZ20033351A3 (cs) 2007-12-27
EP1395588A4 (en) 2004-09-15
US7241885B2 (en) 2007-07-10
PL373527A1 (en) 2005-09-05
JP2005514323A (ja) 2005-05-19
AR036018A1 (es) 2004-08-04
CA2447673A1 (en) 2002-11-28
EP1395588A2 (en) 2004-03-10
KR20040010649A (ko) 2004-01-31
US20040242865A1 (en) 2004-12-02
MXPA03010548A (es) 2004-05-27
OA12608A (en) 2006-06-08
HUP0501093A2 (en) 2006-03-28
BR0209844A (pt) 2005-04-05
NO20035137D0 (no) 2003-11-18

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