ZA200309263B - A pharmaceutical combination comprising either (S)-2-ethoxy-3- [4-(2-{4-methane sulfonyl oxyphenyl} ethoxy) phenyl) propanoic acid or 3-{4-[2-(4-tert- butoxy carbonyl aminophenyl) ethoxyl phenyl} -(S)-2-ethoxy propanoic acid and a sulfonylurea. - Google Patents
A pharmaceutical combination comprising either (S)-2-ethoxy-3- [4-(2-{4-methane sulfonyl oxyphenyl} ethoxy) phenyl) propanoic acid or 3-{4-[2-(4-tert- butoxy carbonyl aminophenyl) ethoxyl phenyl} -(S)-2-ethoxy propanoic acid and a sulfonylurea. Download PDFInfo
- Publication number
- ZA200309263B ZA200309263B ZA200309263A ZA200309263A ZA200309263B ZA 200309263 B ZA200309263 B ZA 200309263B ZA 200309263 A ZA200309263 A ZA 200309263A ZA 200309263 A ZA200309263 A ZA 200309263A ZA 200309263 B ZA200309263 B ZA 200309263B
- Authority
- ZA
- South Africa
- Prior art keywords
- ethoxy
- propanoic acid
- phenyl
- sulfonylurea
- composition
- Prior art date
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- 229940100389 Sulfonylurea Drugs 0.000 title claims description 68
- YROXIXLRRCOBKF-UHFFFAOYSA-N sulfonylurea Chemical class OC(=N)N=S(=O)=O YROXIXLRRCOBKF-UHFFFAOYSA-N 0.000 title claims description 66
- CXGTZJYQWSUFET-IBGZPJMESA-N tesaglitazar Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OCCC1=CC=C(OS(C)(=O)=O)C=C1 CXGTZJYQWSUFET-IBGZPJMESA-N 0.000 title claims description 20
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 title claims description 16
- 239000000203 mixture Substances 0.000 claims description 56
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- DUWWHGPELOTTOE-UHFFFAOYSA-N n-(5-chloro-2,4-dimethoxyphenyl)-3-oxobutanamide Chemical compound COC1=CC(OC)=C(NC(=O)CC(C)=O)C=C1Cl DUWWHGPELOTTOE-UHFFFAOYSA-N 0.000 claims description 15
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- RKWGIWYCVPQPMF-UHFFFAOYSA-N Chloropropamide Chemical compound CCCNC(=O)NS(=O)(=O)C1=CC=C(Cl)C=C1 RKWGIWYCVPQPMF-UHFFFAOYSA-N 0.000 claims description 4
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- LLJFMFZYVVLQKT-UHFFFAOYSA-N 1-cyclohexyl-3-[4-[2-(7-methoxy-4,4-dimethyl-1,3-dioxo-2-isoquinolinyl)ethyl]phenyl]sulfonylurea Chemical compound C=1C(OC)=CC=C(C(C2=O)(C)C)C=1C(=O)N2CCC(C=C1)=CC=C1S(=O)(=O)NC(=O)NC1CCCCC1 LLJFMFZYVVLQKT-UHFFFAOYSA-N 0.000 claims description 3
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- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 231100000489 sensitizer Toxicity 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 208000020352 skin basal cell carcinoma Diseases 0.000 description 1
- 201000010106 skin squamous cell carcinoma Diseases 0.000 description 1
- 108091008012 small dense LDL Proteins 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 229910001467 sodium calcium phosphate Inorganic materials 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000035488 systolic blood pressure Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000003451 thiazide diuretic agent Substances 0.000 description 1
- 150000001467 thiazolidinediones Chemical class 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 239000012049 topical pharmaceutical composition Substances 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 229960001729 voglibose Drugs 0.000 description 1
- 238000011680 zucker rat Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0101982A SE0101982D0 (sv) | 2001-06-01 | 2001-06-01 | Pharmaceutical combination |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200309263B true ZA200309263B (en) | 2005-03-11 |
Family
ID=20284364
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200309263A ZA200309263B (en) | 2001-06-01 | 2003-11-27 | A pharmaceutical combination comprising either (S)-2-ethoxy-3- [4-(2-{4-methane sulfonyl oxyphenyl} ethoxy) phenyl) propanoic acid or 3-{4-[2-(4-tert- butoxy carbonyl aminophenyl) ethoxyl phenyl} -(S)-2-ethoxy propanoic acid and a sulfonylurea. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20040157927A1 (ru) |
| EP (1) | EP1399166A1 (ru) |
| JP (1) | JP2004532891A (ru) |
| KR (1) | KR20040007624A (ru) |
| CN (1) | CN1250226C (ru) |
| BR (1) | BR0210127A (ru) |
| CA (1) | CA2448763A1 (ru) |
| CO (1) | CO5540382A2 (ru) |
| CZ (1) | CZ20033235A3 (ru) |
| EE (1) | EE200300583A (ru) |
| HU (1) | HUP0401613A3 (ru) |
| IL (1) | IL159035A0 (ru) |
| IS (1) | IS7057A (ru) |
| MX (1) | MXPA03011010A (ru) |
| NO (1) | NO20035235D0 (ru) |
| PL (1) | PL367890A1 (ru) |
| RU (1) | RU2003136157A (ru) |
| SE (1) | SE0101982D0 (ru) |
| SK (1) | SK14722003A3 (ru) |
| WO (1) | WO2002100413A1 (ru) |
| ZA (1) | ZA200309263B (ru) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008019169A (ja) * | 2004-10-25 | 2008-01-31 | Osaka Univ | 新規ｐｐａｒ調節剤およびそのスクリーニング方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW438587B (en) * | 1995-06-20 | 2001-06-07 | Takeda Chemical Industries Ltd | A pharmaceutical composition for prophylaxis and treatment of diabetes |
| US5783556A (en) * | 1996-08-13 | 1998-07-21 | Genentech, Inc. | Formulated insulin-containing composition |
| US6552055B2 (en) * | 1996-12-11 | 2003-04-22 | Dana-Farber Cancer Institute | Methods and pharmaceutical compositions for inhibiting tumor cell growth |
| US6011049A (en) * | 1997-02-19 | 2000-01-04 | Warner-Lambert Company | Combinations for diabetes |
| US5859037A (en) * | 1997-02-19 | 1999-01-12 | Warner-Lambert Company | Sulfonylurea-glitazone combinations for diabetes |
| SE9801992D0 (sv) * | 1998-06-04 | 1998-06-04 | Astra Ab | New 3-aryl-2-hydroxypropionic acid derivative I |
| SE9801990D0 (sv) * | 1998-06-04 | 1998-06-04 | Astra Ab | New 3-aryl propionic acid derivatives and analogs |
-
2001
- 2001-06-01 SE SE0101982A patent/SE0101982D0/xx unknown
-
2002
- 2002-05-30 CA CA002448763A patent/CA2448763A1/en not_active Abandoned
- 2002-05-30 RU RU2003136157/15A patent/RU2003136157A/ru not_active Application Discontinuation
- 2002-05-30 MX MXPA03011010A patent/MXPA03011010A/es unknown
- 2002-05-30 US US10/479,205 patent/US20040157927A1/en not_active Abandoned
- 2002-05-30 JP JP2003503234A patent/JP2004532891A/ja not_active Withdrawn
- 2002-05-30 KR KR10-2003-7015644A patent/KR20040007624A/ko not_active Application Discontinuation
- 2002-05-30 IL IL15903502A patent/IL159035A0/xx unknown
- 2002-05-30 BR BR0210127-0A patent/BR0210127A/pt not_active IP Right Cessation
- 2002-05-30 CZ CZ20033235A patent/CZ20033235A3/cs unknown
- 2002-05-30 PL PL02367890A patent/PL367890A1/xx not_active Application Discontinuation
- 2002-05-30 HU HU0401613A patent/HUP0401613A3/hu unknown
- 2002-05-30 EP EP02736370A patent/EP1399166A1/en not_active Withdrawn
- 2002-05-30 WO PCT/SE2002/001036 patent/WO2002100413A1/en not_active Application Discontinuation
- 2002-05-30 SK SK1472-2003A patent/SK14722003A3/sk not_active Application Discontinuation
- 2002-05-30 EE EEP200300583A patent/EE200300583A/xx unknown
- 2002-05-30 CN CNB028149882A patent/CN1250226C/zh not_active Expired - Fee Related
-
2003
- 2003-11-25 NO NO20035235A patent/NO20035235D0/no not_active Application Discontinuation
- 2003-11-27 ZA ZA200309263A patent/ZA200309263B/en unknown
- 2003-11-28 IS IS7057A patent/IS7057A/is unknown
- 2003-12-23 CO CO03112113A patent/CO5540382A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PL367890A1 (en) | 2005-03-07 |
| SE0101982D0 (sv) | 2001-06-01 |
| NO20035235D0 (no) | 2003-11-25 |
| HUP0401613A3 (en) | 2007-11-28 |
| EP1399166A1 (en) | 2004-03-24 |
| BR0210127A (pt) | 2004-06-08 |
| IS7057A (is) | 2003-11-28 |
| RU2003136157A (ru) | 2005-05-20 |
| CZ20033235A3 (cs) | 2004-12-15 |
| JP2004532891A (ja) | 2004-10-28 |
| WO2002100413A1 (en) | 2002-12-19 |
| CN1537008A (zh) | 2004-10-13 |
| IL159035A0 (en) | 2004-05-12 |
| US20040157927A1 (en) | 2004-08-12 |
| MXPA03011010A (es) | 2004-02-27 |
| SK14722003A3 (sk) | 2004-08-03 |
| KR20040007624A (ko) | 2004-01-24 |
| EE200300583A (et) | 2004-02-16 |
| CN1250226C (zh) | 2006-04-12 |
| HUP0401613A2 (hu) | 2004-11-29 |
| CO5540382A2 (es) | 2005-07-29 |
| CA2448763A1 (en) | 2002-12-19 |
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