ZA200308570B - Process for preparing a thiazole PPAR-ligand and polymorphs thereof. - Google Patents

Process for preparing a thiazole PPAR-ligand and polymorphs thereof. Download PDF

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Publication number
ZA200308570B
ZA200308570B ZA200308570A ZA200308570A ZA200308570B ZA 200308570 B ZA200308570 B ZA 200308570B ZA 200308570 A ZA200308570 A ZA 200308570A ZA 200308570 A ZA200308570 A ZA 200308570A ZA 200308570 B ZA200308570 B ZA 200308570B
Authority
ZA
South Africa
Prior art keywords
compound
methyl
formula
composition
compounds
Prior art date
Application number
ZA200308570A
Other languages
English (en)
Inventor
Thierry Boyer
Andrew Jonathan Whitehead
Caroline Jane Day
Richard Anthony Henson
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ZA200308570B publication Critical patent/ZA200308570B/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Nutrition Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
ZA200308570A 2001-05-31 2003-11-03 Process for preparing a thiazole PPAR-ligand and polymorphs thereof. ZA200308570B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0113232.3A GB0113232D0 (en) 2001-05-31 2001-05-31 Chemical process

Publications (1)

Publication Number Publication Date
ZA200308570B true ZA200308570B (en) 2005-02-03

Family

ID=9915637

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200308570A ZA200308570B (en) 2001-05-31 2003-11-03 Process for preparing a thiazole PPAR-ligand and polymorphs thereof.

Country Status (22)

Country Link
US (1) US7244849B2 (https=)
EP (1) EP1395572B1 (https=)
JP (1) JP2004532265A (https=)
KR (1) KR20040007631A (https=)
CN (1) CN1551871A (https=)
AT (1) ATE315556T1 (https=)
AU (1) AU2002317764B2 (https=)
BR (1) BR0209892A (https=)
CA (1) CA2448101A1 (https=)
CO (1) CO5540298A2 (https=)
CZ (1) CZ20033256A3 (https=)
DE (1) DE60208682T2 (https=)
ES (1) ES2256493T3 (https=)
GB (1) GB0113232D0 (https=)
HU (1) HUP0400117A3 (https=)
IL (1) IL158641A0 (https=)
MX (1) MXPA03010943A (https=)
NO (1) NO20035313L (https=)
NZ (1) NZ529486A (https=)
PL (1) PL367114A1 (https=)
WO (1) WO2002096893A1 (https=)
ZA (1) ZA200308570B (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7105551B2 (en) * 2000-12-20 2006-09-12 Smithkline Beecham Corporation Thiazole derivatives for treating PPAR related disorders
EP1517882A1 (en) 2002-06-19 2005-03-30 Eli Lilly And Company Amide linker peroxisome proliferator activated receptor modulators
TW200400816A (en) 2002-06-26 2004-01-16 Lilly Co Eli Tricyclic steroid hormone nuclear receptor modulators
AU2003261935A1 (en) 2002-09-06 2004-03-29 Takeda Pharmaceutical Company Limited Furan or thiophene derivative and medicinal use thereof
EA010422B1 (ru) 2003-08-01 2008-08-29 Янссен Фармацевтика Н.В. Замещённые индол-о-глюкозиды
WO2005097076A2 (en) * 2004-04-09 2005-10-20 Smithkline Beecham Corporation Low dose pharmaceutical products
EP2044042A2 (en) * 2006-01-10 2009-04-08 SmithKline Beecham Corporation Polymorphic forms of { 2-methyl-4- [4-methyl-2- (trifluoromethylphenyl) thiazol-5-methylthiol phenoxy}-acetic acid
WO2012168948A2 (en) * 2011-06-06 2012-12-13 Hetero Research Foundation Process for febuxostat

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE451346T1 (de) * 1998-03-10 2009-12-15 Ono Pharmaceutical Co Carbonsäurederivate und medikamente die diese als aktiven wirkstoff enthalten
PE20011010A1 (es) * 1999-12-02 2001-10-18 Glaxo Group Ltd Oxazoles y tiazoles sustituidos como agonista del receptor activado por el proliferador de peroxisomas humano
US7091225B2 (en) * 2000-12-20 2006-08-15 Smithkline Beecham Corporation Substituted oxazoles and thiazoles as hPPAR alpha agonists
GB0111523D0 (en) * 2001-05-11 2001-07-04 Glaxo Group Ltd Chemical compounds
GB0113233D0 (en) * 2001-05-31 2001-07-25 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
EP1395572B1 (en) 2006-01-11
AU2002317764B2 (en) 2005-01-06
JP2004532265A (ja) 2004-10-21
BR0209892A (pt) 2004-06-08
US7244849B2 (en) 2007-07-17
MXPA03010943A (es) 2004-02-27
NZ529486A (en) 2005-12-23
ES2256493T3 (es) 2006-07-16
PL367114A1 (en) 2005-02-21
CZ20033256A3 (en) 2004-04-14
WO2002096893A1 (en) 2002-12-05
CN1551871A (zh) 2004-12-01
DE60208682D1 (de) 2006-04-06
CA2448101A1 (en) 2002-12-05
NO20035313L (no) 2003-12-09
HUP0400117A3 (en) 2005-09-28
HUP0400117A2 (hu) 2005-03-29
EP1395572A1 (en) 2004-03-10
DE60208682T2 (de) 2006-08-24
IL158641A0 (en) 2004-05-12
NO20035313D0 (no) 2003-11-28
CO5540298A2 (es) 2005-07-29
KR20040007631A (ko) 2004-01-24
ATE315556T1 (de) 2006-02-15
US20040242657A1 (en) 2004-12-02
GB0113232D0 (en) 2001-07-25

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