ZA200308112B - Use of rare earth compounds for the prevention of kidney stone disease. - Google Patents
Use of rare earth compounds for the prevention of kidney stone disease. Download PDFInfo
- Publication number
- ZA200308112B ZA200308112B ZA200308112A ZA200308112A ZA200308112B ZA 200308112 B ZA200308112 B ZA 200308112B ZA 200308112 A ZA200308112 A ZA 200308112A ZA 200308112 A ZA200308112 A ZA 200308112A ZA 200308112 B ZA200308112 B ZA 200308112B
- Authority
- ZA
- South Africa
- Prior art keywords
- oxalate
- rare earth
- earth metal
- lanthanum
- salt
- Prior art date
Links
- 229910052761 rare earth metal Inorganic materials 0.000 title claims description 24
- 206010029148 Nephrolithiasis Diseases 0.000 title claims description 18
- 208000000913 Kidney Calculi Diseases 0.000 title claims description 17
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims description 8
- -1 rare earth compounds Chemical class 0.000 title description 19
- 230000002265 prevention Effects 0.000 title description 2
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 89
- 229910017569 La2(CO3)3 Inorganic materials 0.000 claims description 25
- 229960001633 lanthanum carbonate Drugs 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 24
- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 17
- 150000003839 salts Chemical class 0.000 claims description 15
- 238000010521 absorption reaction Methods 0.000 claims description 13
- 229910052746 lanthanum Inorganic materials 0.000 claims description 10
- 229910052684 Cerium Inorganic materials 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- 229910052727 yttrium Inorganic materials 0.000 claims description 9
- 231100000252 nontoxic Toxicity 0.000 claims description 8
- 230000003000 nontoxic effect Effects 0.000 claims description 8
- FZLIPJUXYLNCLC-UHFFFAOYSA-N lanthanum atom Chemical compound [La] FZLIPJUXYLNCLC-UHFFFAOYSA-N 0.000 claims description 7
- VWQVUPCCIRVNHF-UHFFFAOYSA-N yttrium atom Chemical compound [Y] VWQVUPCCIRVNHF-UHFFFAOYSA-N 0.000 claims description 6
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 5
- GWXLDORMOJMVQZ-UHFFFAOYSA-N cerium Chemical compound [Ce] GWXLDORMOJMVQZ-UHFFFAOYSA-N 0.000 claims description 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 4
- 230000007935 neutral effect Effects 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 3
- 229910052747 lanthanoid Inorganic materials 0.000 claims description 3
- 229910052692 Dysprosium Inorganic materials 0.000 claims description 2
- 229910052691 Erbium Inorganic materials 0.000 claims description 2
- 229910052693 Europium Inorganic materials 0.000 claims description 2
- 229910052688 Gadolinium Inorganic materials 0.000 claims description 2
- 229910052689 Holmium Inorganic materials 0.000 claims description 2
- 229910052765 Lutetium Inorganic materials 0.000 claims description 2
- 229910052779 Neodymium Inorganic materials 0.000 claims description 2
- 229910052777 Praseodymium Inorganic materials 0.000 claims description 2
- 229910052772 Samarium Inorganic materials 0.000 claims description 2
- 229910052771 Terbium Inorganic materials 0.000 claims description 2
- 229910052775 Thulium Inorganic materials 0.000 claims description 2
- 229910052769 Ytterbium Inorganic materials 0.000 claims description 2
- 150000002602 lanthanoids Chemical class 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 229910052706 scandium Inorganic materials 0.000 claims description 2
- 150000002910 rare earth metals Chemical class 0.000 claims 7
- NZPIUJUFIFZSPW-UHFFFAOYSA-H lanthanum carbonate Chemical group [La+3].[La+3].[O-]C([O-])=O.[O-]C([O-])=O.[O-]C([O-])=O NZPIUJUFIFZSPW-UHFFFAOYSA-H 0.000 claims 2
- 150000002500 ions Chemical class 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 229910021645 metal ion Inorganic materials 0.000 claims 1
- 229940039748 oxalate Drugs 0.000 description 85
- PKOQIYFBOVTYOH-UHFFFAOYSA-H lanthanum(3+);tricarbonate;tetrahydrate Chemical compound O.O.O.O.[La+3].[La+3].[O-]C([O-])=O.[O-]C([O-])=O.[O-]C([O-])=O PKOQIYFBOVTYOH-UHFFFAOYSA-H 0.000 description 27
- 229910019142 PO4 Inorganic materials 0.000 description 26
- 235000021317 phosphate Nutrition 0.000 description 26
- 239000010452 phosphate Substances 0.000 description 25
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 24
- 230000027455 binding Effects 0.000 description 14
- 239000000243 solution Substances 0.000 description 10
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- 239000000872 buffer Substances 0.000 description 8
- 238000003556 assay Methods 0.000 description 7
- 235000005911 diet Nutrition 0.000 description 7
- 230000000378 dietary effect Effects 0.000 description 5
- 239000011550 stock solution Substances 0.000 description 5
- 210000002784 stomach Anatomy 0.000 description 5
- 206010007027 Calculus urinary Diseases 0.000 description 4
- QXDMQSPYEZFLGF-UHFFFAOYSA-L calcium oxalate Chemical compound [Ca+2].[O-]C(=O)C([O-])=O QXDMQSPYEZFLGF-UHFFFAOYSA-L 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 230000036571 hydration Effects 0.000 description 4
- 238000006703 hydration reaction Methods 0.000 description 4
- 210000003734 kidney Anatomy 0.000 description 4
- 238000000159 protein binding assay Methods 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- ZNCPFRVNHGOPAG-UHFFFAOYSA-L sodium oxalate Chemical compound [Na+].[Na+].[O-]C(=O)C([O-])=O ZNCPFRVNHGOPAG-UHFFFAOYSA-L 0.000 description 4
- 229940039790 sodium oxalate Drugs 0.000 description 4
- 208000008281 urolithiasis Diseases 0.000 description 4
- 239000003643 water by type Substances 0.000 description 4
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 150000001242 acetic acid derivatives Chemical class 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- GHLITDDQOMIBFS-UHFFFAOYSA-H cerium(3+);tricarbonate Chemical compound [Ce+3].[Ce+3].[O-]C([O-])=O.[O-]C([O-])=O.[O-]C([O-])=O GHLITDDQOMIBFS-UHFFFAOYSA-H 0.000 description 3
- 230000009137 competitive binding Effects 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 239000011574 phosphorus Substances 0.000 description 3
- 229910052698 phosphorus Inorganic materials 0.000 description 3
- 229920000768 polyamine Polymers 0.000 description 3
- 210000000813 small intestine Anatomy 0.000 description 3
- 239000003826 tablet Substances 0.000 description 3
- 230000007704 transition Effects 0.000 description 3
- QVOIJBIQBYRBCF-UHFFFAOYSA-H yttrium(3+);tricarbonate Chemical compound [Y+3].[Y+3].[O-]C([O-])=O.[O-]C([O-])=O.[O-]C([O-])=O QVOIJBIQBYRBCF-UHFFFAOYSA-H 0.000 description 3
- 102000006335 Phosphate-Binding Proteins Human genes 0.000 description 2
- 108010058514 Phosphate-Binding Proteins Proteins 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 125000001931 aliphatic group Chemical group 0.000 description 2
- 150000001450 anions Chemical class 0.000 description 2
- 206010003246 arthritis Diseases 0.000 description 2
- 238000003149 assay kit Methods 0.000 description 2
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 150000001805 chlorine compounds Chemical class 0.000 description 2
- 238000012875 competitive assay Methods 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 150000004677 hydrates Chemical class 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 150000002603 lanthanum Chemical class 0.000 description 2
- ICAKDTKJOYSXGC-UHFFFAOYSA-K lanthanum(iii) chloride Chemical compound Cl[La](Cl)Cl ICAKDTKJOYSXGC-UHFFFAOYSA-K 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000004575 stone Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- OBOSXEWFRARQPU-UHFFFAOYSA-N 2-n,2-n-dimethylpyridine-2,5-diamine Chemical compound CN(C)C1=CC=C(N)C=N1 OBOSXEWFRARQPU-UHFFFAOYSA-N 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- ROYHLTACAPCFNX-UHFFFAOYSA-N O.O.O.O.O.[La] Chemical compound O.O.O.O.O.[La] ROYHLTACAPCFNX-UHFFFAOYSA-N 0.000 description 1
- NFJVLTHWUUZXDP-UHFFFAOYSA-N O.O.O.O.[La] Chemical compound O.O.O.O.[La] NFJVLTHWUUZXDP-UHFFFAOYSA-N 0.000 description 1
- 108010068005 Oxalate decarboxylase Proteins 0.000 description 1
- 108010063734 Oxalate oxidase Proteins 0.000 description 1
- 241000219061 Rheum Species 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- ICGOZJYHBAHKNX-UHFFFAOYSA-N carbonic acid pentahydrate Chemical compound C(O)(O)=O.O.O.O.O.O ICGOZJYHBAHKNX-UHFFFAOYSA-N 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- VYLVYHXQOHJDJL-UHFFFAOYSA-K cerium trichloride Chemical compound Cl[Ce](Cl)Cl VYLVYHXQOHJDJL-UHFFFAOYSA-K 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000007910 chewable tablet Substances 0.000 description 1
- 229940068682 chewable tablet Drugs 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- RYCXCWMKVIFLTC-UHFFFAOYSA-K dihydrogen phosphate;lanthanum(3+);carbonate Chemical compound [La+3].[O-]C([O-])=O.OP(O)([O-])=O RYCXCWMKVIFLTC-UHFFFAOYSA-K 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 235000019800 disodium phosphate Nutrition 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000002702 enteric coating Substances 0.000 description 1
- 238000009505 enteric coating Methods 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 235000012041 food component Nutrition 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000002198 insoluble material Substances 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- OXHNIMPTBAKYRS-UHFFFAOYSA-H lanthanum(3+);oxalate Chemical compound [La+3].[La+3].[O-]C(=O)C([O-])=O.[O-]C(=O)C([O-])=O.[O-]C(=O)C([O-])=O OXHNIMPTBAKYRS-UHFFFAOYSA-H 0.000 description 1
- LQFNMFDUAPEJRY-UHFFFAOYSA-K lanthanum(3+);phosphate Chemical compound [La+3].[O-]P([O-])([O-])=O LQFNMFDUAPEJRY-UHFFFAOYSA-K 0.000 description 1
- AFCUGQOTNCVYSW-UHFFFAOYSA-H lanthanum(3+);tricarbonate;hydrate Chemical class O.[La+3].[La+3].[O-]C([O-])=O.[O-]C([O-])=O.[O-]C([O-])=O AFCUGQOTNCVYSW-UHFFFAOYSA-H 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000003891 oxalate salts Chemical class 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 239000001508 potassium citrate Substances 0.000 description 1
- 229960002635 potassium citrate Drugs 0.000 description 1
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 1
- 235000011082 potassium citrates Nutrition 0.000 description 1
- 230000002250 progressing effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000005067 remediation Methods 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 210000001635 urinary tract Anatomy 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/04—Drugs for disorders of the urinary system for urolithiasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- External Artificial Organs (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28590101P | 2001-04-23 | 2001-04-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200308112B true ZA200308112B (en) | 2005-01-17 |
Family
ID=23096166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200308112A ZA200308112B (en) | 2001-04-23 | 2003-10-17 | Use of rare earth compounds for the prevention of kidney stone disease. |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US7192609B2 (cs) |
| EP (1) | EP1389102B1 (cs) |
| JP (2) | JP4515030B2 (cs) |
| KR (1) | KR100956013B1 (cs) |
| CN (1) | CN100438866C (cs) |
| AT (1) | ATE499943T1 (cs) |
| AU (2) | AU2002307543B2 (cs) |
| BR (1) | BR0209072A (cs) |
| CA (1) | CA2442414C (cs) |
| CY (1) | CY1112049T1 (cs) |
| CZ (2) | CZ298280B6 (cs) |
| DE (2) | DE60239329D1 (cs) |
| DK (2) | DK1389102T3 (cs) |
| ES (1) | ES2362271T3 (cs) |
| FI (1) | FIU20060390U0 (cs) |
| HU (1) | HUP0303938A3 (cs) |
| MX (1) | MXPA03009668A (cs) |
| NO (1) | NO20034704L (cs) |
| NZ (1) | NZ528818A (cs) |
| PL (1) | PL370642A1 (cs) |
| PT (1) | PT1389102E (cs) |
| RU (1) | RU2296584C2 (cs) |
| SI (1) | SI1389102T1 (cs) |
| WO (1) | WO2002085348A1 (cs) |
| ZA (1) | ZA200308112B (cs) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7381428B2 (en) | 2003-08-26 | 2008-06-03 | Shire International Licensing B.V. | Stabilized lanthanum carbonate compositions |
| EA012798B1 (ru) * | 2003-08-26 | 2009-12-30 | Шир Холдингз Аг | Фармацевтический состав, содержащий карбонат лантана (варианты) |
| US20060153932A1 (en) * | 2004-07-27 | 2006-07-13 | Shire Pharmaceuticals, Inc. | Method of treating hyperphosphataemia using lanthanum hydroxycarbonate |
| US20070104799A1 (en) * | 2005-11-09 | 2007-05-10 | Shire International Licensing B.V. | Treatment of chronic kidney disease (CKD) subjects using lanthanum compounds |
| US8974824B2 (en) * | 2008-03-26 | 2015-03-10 | Mylan Laboratories Ltd. | Lanthanum composition |
| KR101940207B1 (ko) | 2010-05-12 | 2019-01-18 | 스펙트럼 파마슈티컬즈 인크 | 란탄 카보네이트 하이드록사이드, 란탄 옥시카보네이트 및 이들의 제조 및 사용 방법 |
| RU2657755C1 (ru) * | 2017-07-10 | 2018-06-15 | Александр Александрович Кролевец | Способ получения нанокапсул солей лантаноидов в каррагинане |
| WO2021101461A1 (en) | 2019-11-21 | 2021-05-27 | Santa Farma İlaç Sanayi̇ A.Ş. | Oral solid pharmaceutical compositions comprising lanthanum carbonate octahydrate |
| WO2021163574A1 (en) * | 2020-02-13 | 2021-08-19 | Lawrence Livermore National Security, Llc | Methods of sequestering target elements |
| JP2025521859A (ja) * | 2022-07-01 | 2025-07-10 | エイエムジーエムティー | 経口投与可能な医薬剤形および高シュウ酸尿症の治療方法におけるその使用 |
| AU2023424695A1 (en) * | 2023-01-18 | 2025-08-28 | Applause Pharma Co., Ltd. | Pharmaceutical composition having, as active ingredient, cerium compound that contains trivalent cerium |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1668562C3 (de) * | 1967-12-08 | 1975-01-30 | Pharmazeutische Fabrik Evers & Co, 2080 Pinneberg | Cergluconat, Verfahren zu seiner Herstellung und dieses enthaltende pharmazeutische Präparate |
| DE3046580A1 (de) * | 1980-12-11 | 1982-07-01 | Leskovar, Peter, Dr.-Ing., 8000 München | Harnsteinaufloesende mittel |
| DE3213139A1 (de) * | 1980-12-11 | 1983-10-20 | Leskovar, Peter, Dr.-Ing., 8000 München | Harnsteinaufloesende mittel |
| JPS614529A (ja) * | 1984-06-15 | 1986-01-10 | Asahi Chem Ind Co Ltd | リン酸イオンの吸着剤 |
| JPS614528A (ja) | 1984-06-15 | 1986-01-10 | Arubatsuku Service Kk | 水溶性ガスの高純度溶液の製造装置 |
| JPH06705B2 (ja) * | 1985-12-19 | 1994-01-05 | 旭化成工業株式会社 | リン酸イオンの固定化剤 |
| US5171583A (en) * | 1988-10-21 | 1992-12-15 | The Regents Of The University Of California | Treatment of osteoporosis using potassium bicarbonate |
| US5696239A (en) * | 1988-10-31 | 1997-12-09 | The Dow Chemical Company | Conjugates possessing ortho ligating functionality and complexes thereof |
| US5342604A (en) * | 1988-10-31 | 1994-08-30 | The Dow Chemical Company | Complexes possessing ortho ligating functionality |
| JP2640570B2 (ja) * | 1992-01-13 | 1997-08-13 | ファイザー インク． | 強度が増加した錠剤の製造 |
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