ZA200307829B - Modified human granulocyte macrophage colony stimulating factor (GM-CSF) with reduced immunogenicity. - Google Patents

Modified human granulocyte macrophage colony stimulating factor (GM-CSF) with reduced immunogenicity. Download PDF

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Publication number
ZA200307829B
ZA200307829B ZA200307829A ZA200307829A ZA200307829B ZA 200307829 B ZA200307829 B ZA 200307829B ZA 200307829 A ZA200307829 A ZA 200307829A ZA 200307829 A ZA200307829 A ZA 200307829A ZA 200307829 B ZA200307829 B ZA 200307829B
Authority
ZA
South Africa
Prior art keywords
amino acid
molecule
peptide
binding
csf
Prior art date
Application number
ZA200307829A
Other languages
English (en)
Inventor
Francis J Carr
Graham Carter
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of ZA200307829B publication Critical patent/ZA200307829B/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/53Colony-stimulating factor [CSF]
    • C07K14/535Granulocyte CSF; Granulocyte-macrophage CSF
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ZA200307829A 2001-03-08 2003-10-07 Modified human granulocyte macrophage colony stimulating factor (GM-CSF) with reduced immunogenicity. ZA200307829B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01105775 2001-03-08

Publications (1)

Publication Number Publication Date
ZA200307829B true ZA200307829B (en) 2004-07-21

Family

ID=8176721

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200307829A ZA200307829B (en) 2001-03-08 2003-10-07 Modified human granulocyte macrophage colony stimulating factor (GM-CSF) with reduced immunogenicity.

Country Status (15)

Country Link
US (1) US7208147B2 (fr)
EP (1) EP1366074B1 (fr)
JP (1) JP2004535777A (fr)
KR (1) KR20030082962A (fr)
CN (1) CN1494551A (fr)
AT (1) ATE339446T1 (fr)
BR (1) BR0207945A (fr)
CA (1) CA2439926A1 (fr)
DE (1) DE60214682T2 (fr)
HU (1) HUP0303429A3 (fr)
MX (1) MXPA03008032A (fr)
PL (1) PL362986A1 (fr)
RU (1) RU2003129058A (fr)
WO (1) WO2002070548A2 (fr)
ZA (1) ZA200307829B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60332358D1 (de) * 2002-09-09 2010-06-10 Hanall Pharmaceutical Co Ltd Protease-resistente modifizierte interferon alpha polypeptide
US7741450B2 (en) 2006-02-08 2010-06-22 Morphotek Inc. Antibodies to GM-CSF
AU2013201228B2 (en) * 2006-02-08 2016-01-21 Eisai, Inc. Antigenic gm-csf peptides and antibodies to gm-csf
US8252897B2 (en) * 2007-06-21 2012-08-28 Angelica Therapeutics, Inc. Modified toxins
US8470314B2 (en) * 2008-02-29 2013-06-25 Angelica Therapeutics, Inc. Modified toxins
CN104093414A (zh) 2011-11-29 2014-10-08 神经噬菌体制药股份有限公司 噬菌体的p3作为淀粉样蛋白结合剂的用途
DK2906235T3 (en) 2012-10-02 2017-09-25 Proclara Biosciences Inc USE OF P3 OF BACTERIOPHAGIC FUSION PROTEINS AS AMYLOID BINDING AGENTS
CA2902905A1 (fr) 2013-03-15 2014-09-25 Claude Geoffrey Davis Toxines modifiees
EA030389B1 (ru) 2013-05-28 2018-07-31 Проклара Байосайенсиз, Инк. ПОЛИПЕПТИДЫ, СОДЕРЖАЩИЕ ИЗМЕНЕННУЮ АМИНОКИСЛОТНУЮ ПОСЛЕДОВАТЕЛЬНОСТЬ g3p БАКТЕРИОФАГА С ПОНИЖЕННОЙ ИММУНОГЕННОСТЬЮ
EP3227313B1 (fr) 2014-12-03 2022-02-09 Proclara Biosciences, Inc. Polypeptides comportant une séquence d'acides aminés modifiée de la protéine g3p d'un bactériophage, dépourvue de signal de glycosylation
TW201808987A (zh) 2016-06-08 2018-03-16 健生生物科技公司 Gm-csf變體及使用方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5349052A (en) * 1988-10-20 1994-09-20 Royal Free Hospital School Of Medicine Process for fractionating polyethylene glycol (PEG)-protein adducts and an adduct for PEG and granulocyte-macrophage colony stimulating factor
DE69833755T2 (de) * 1997-05-21 2006-12-28 Biovation Ltd. Verfahren zur herstellung von nicht-immunogenen proteinen
GB9712892D0 (en) 1997-06-20 1997-08-20 Eclagen Ltd Identification of mhc binding peptides
CN1202128C (zh) 1998-12-08 2005-05-18 拜奥威神有限公司 修饰蛋白的免疫原性

Also Published As

Publication number Publication date
EP1366074B1 (fr) 2006-09-13
KR20030082962A (ko) 2003-10-23
BR0207945A (pt) 2004-07-27
US7208147B2 (en) 2007-04-24
DE60214682T2 (de) 2007-09-13
WO2002070548A3 (fr) 2003-05-01
CN1494551A (zh) 2004-05-05
JP2004535777A (ja) 2004-12-02
PL362986A1 (en) 2004-11-15
DE60214682D1 (de) 2006-10-26
HUP0303429A2 (hu) 2004-01-28
MXPA03008032A (es) 2003-12-04
HUP0303429A3 (en) 2005-12-28
ATE339446T1 (de) 2006-10-15
US20040092717A1 (en) 2004-05-13
RU2003129058A (ru) 2005-04-20
CA2439926A1 (fr) 2002-09-12
EP1366074A2 (fr) 2003-12-03
WO2002070548A2 (fr) 2002-09-12

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