ZA200307672B - 8-heteroaryl xanthine adenosine A2B receptor antagonists. - Google Patents
8-heteroaryl xanthine adenosine A2B receptor antagonists. Download PDFInfo
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- ZA200307672B ZA200307672B ZA200307672A ZA200307672A ZA200307672B ZA 200307672 B ZA200307672 B ZA 200307672B ZA 200307672 A ZA200307672 A ZA 200307672A ZA 200307672 A ZA200307672 A ZA 200307672A ZA 200307672 B ZA200307672 B ZA 200307672B
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- ZA
- South Africa
- Prior art keywords
- methyl
- pyrazol
- compound
- tetrahydro
- purin
- Prior art date
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- 229940123053 Adenosine A2b receptor antagonist Drugs 0.000 title 1
- 239000003449 adenosine A2 receptor antagonist Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 323
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 140
- 239000002126 C01EB10 - Adenosine Substances 0.000 claims description 112
- 229960005305 adenosine Drugs 0.000 claims description 112
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- -1 aralkoxyalkylthio Chemical group 0.000 claims description 96
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/804—Radioisotope, e.g. radioimmunoassay
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- Organic Chemistry (AREA)
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- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Dermatology (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
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US35331702P | 2002-02-01 | 2002-02-01 |
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US (2) | US7205403B2 (fr) |
EP (1) | EP1469856A4 (fr) |
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BR (1) | BR0302965A (fr) |
CA (1) | CA2443023A1 (fr) |
IL (1) | IL158214A0 (fr) |
MX (1) | MXPA03008967A (fr) |
NZ (1) | NZ528591A (fr) |
WO (1) | WO2003063800A2 (fr) |
ZA (1) | ZA200307672B (fr) |
Families Citing this family (34)
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US7317017B2 (en) | 2002-11-08 | 2008-01-08 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
US20080318983A1 (en) * | 2001-11-09 | 2008-12-25 | Rao Kalla | A2b adenosine receptor antagonists |
US20080194593A1 (en) * | 2001-11-09 | 2008-08-14 | Rao Kalla | A2b adenosine receptor antagonists |
US7304070B2 (en) * | 2001-11-09 | 2007-12-04 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
AU2011224104B2 (en) * | 2003-05-06 | 2012-06-28 | Gilead Sciences, Inc. | A2B adenosine receptor antagonists |
ES2311759T3 (es) * | 2003-05-06 | 2009-02-16 | Cv Therapeutics, Inc. | Derivados de xantina como antagonistas del receptor a2b de adenosina. |
CN1894250B (zh) * | 2003-08-25 | 2010-06-09 | PGx健康有限责任公司 | 取代的8-杂芳基黄嘌呤 |
KR100722049B1 (ko) * | 2005-01-14 | 2007-05-25 | 엘지전자 주식회사 | 인터레이스 주사 방식 구현 tv 및 구현 방법 |
US7618962B2 (en) | 2005-02-25 | 2009-11-17 | Pgx Health, Llc | Pyrazolyl substituted xanthines |
US7579348B2 (en) * | 2005-02-25 | 2009-08-25 | Pgxhealth, Llc | Derivatives of 8-substituted xanthines |
WO2006091936A2 (fr) * | 2005-02-25 | 2006-08-31 | Adenosine Therapeutics, Llc | Procedes permettant d'effectuer la synthese de xanthines a substitution cycloalkyle dissymetrique |
ES2270715B1 (es) | 2005-07-29 | 2008-04-01 | Laboratorios Almirall S.A. | Nuevos derivados de pirazina. |
ES2274712B1 (es) | 2005-10-06 | 2008-03-01 | Laboratorios Almirall S.A. | Nuevos derivados imidazopiridina. |
TWI649092B (zh) * | 2005-12-22 | 2019-02-01 | 海卓勒生物科學公司 | 用於調節trpa1功能之化合物 |
EP1829867A1 (fr) * | 2006-03-03 | 2007-09-05 | Laboratorios Del Dr. Esteve, S.A. | Composés d'imidazole ayant une acitivité pharmaceutique vis-à-vis le recepteur sigma |
US7884100B2 (en) * | 2006-06-16 | 2011-02-08 | Pgxhealth, Llc | Substituted 8-[6-amino-3-pyridyl]xanthines |
US7767685B2 (en) * | 2006-06-29 | 2010-08-03 | King Pharmaceuticals Research And Development, Inc. | Adenosine A2B receptor antagonists |
US8163761B2 (en) * | 2007-06-22 | 2012-04-24 | Hydra Biosciences, Inc. | Methods and compositions for treating disorders |
GB0718434D0 (en) | 2007-09-21 | 2007-10-31 | Vernalis R&D Ltd | New chemical compounds |
WO2009088518A1 (fr) * | 2008-01-11 | 2009-07-16 | Cv Therapeutics, Inc. | Antagonistes du récepteur d'adénosine a2b pour le traitement du cancer |
CA2718983C (fr) * | 2008-03-26 | 2015-12-08 | Advinus Therapeutics Pvt. Ltd. | Composes heterocycliques utiles comme antagonistes des recepteurs adenosiniques |
EP2274449B1 (fr) * | 2008-03-28 | 2015-12-23 | Pacific Biosciences of California, Inc. | Procédés pour le séquençage d acide nucléique |
US8318728B2 (en) | 2008-05-14 | 2012-11-27 | Hydra Biosciences, Inc. | Compounds and compositions for treating chemical warfare agent-induced injuries |
WO2009140517A1 (fr) | 2008-05-14 | 2009-11-19 | Hydra Biosciences, Inc. | Composés et compositions pour le traitement de lésions induites par des agents de guerre chimique |
JP2011528364A (ja) * | 2008-07-16 | 2011-11-17 | キング・ファーマシューティカルズ・リサーチ・アンド・デベロプメント・インコーポレイティッド | アテローム性動脈硬化症の治療 |
JP5765239B2 (ja) | 2009-03-13 | 2015-08-19 | アドヴィナス・セラピューティックス・リミテッド | 置換縮合ピリミジン化合物 |
WO2011005871A1 (fr) | 2009-07-07 | 2011-01-13 | Pgxhealth, Llc | 8-[6-carbonylamino-3-pyridyle] xanthines substituées en tant quantagonistes de ladénosine a2b |
EP2499142B1 (fr) | 2009-11-09 | 2016-09-21 | Advinus Therapeutics Limited | Composés pyrimidine fusionnés substitués, leur préparation et leurs utilisations |
CN103261200B (zh) | 2010-09-13 | 2016-03-30 | 阿迪维纳斯疗法有限公司 | 作为a2b腺苷受体拮抗剂的前药的嘌呤化合物、它们的制备方法及医药用途 |
CN102772800A (zh) * | 2011-12-20 | 2012-11-14 | 同济大学 | 靶向腺苷受体a2bar的药物在制备用于预防或治疗自身免疫性疾病的药物中的用途 |
WO2014015523A1 (fr) * | 2012-07-27 | 2014-01-30 | Hutchison Medipharma Limited | Nouveaux composés hétéroaryliques et hétérocycliques et compositions et procédés s'y rapportant |
AU2020205753A1 (en) | 2019-01-11 | 2021-08-05 | Omeros Corporation | Methods and compositions for treating cancer |
WO2022050230A1 (fr) * | 2020-09-03 | 2022-03-10 | 学校法人埼玉医科大学 | Composition inhibant l'activation d'un récepteur de l'adénosine |
AU2021342568A1 (en) | 2020-09-21 | 2023-04-20 | Landos Biopharma, Inc. | Nlrx1 ligands |
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Publication number | Priority date | Publication date | Assignee | Title |
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US4593095A (en) * | 1983-02-18 | 1986-06-03 | The Johns Hopkins University | Xanthine derivatives |
US4567183A (en) * | 1983-03-11 | 1986-01-28 | Analgesic Associates | Analgesic and anti-inflammatory compositions comprising xanthines and methods of using same |
US4772607A (en) * | 1986-05-20 | 1988-09-20 | Warner-Lambert Company | Dialkenyl derivatives of xanthine, pharmaceutical compositions and methods of use therefor |
US4783530A (en) | 1986-11-13 | 1988-11-08 | Marion Laboratories, Inc. | 8-arylxanthines |
US5424297A (en) * | 1992-04-27 | 1995-06-13 | University Of Virginia Alumni Patents Foundation | Adenosine dextran conjugates |
IT1277392B1 (it) | 1995-07-28 | 1997-11-10 | Schering Plough S P A | Analoghi eterociclici di 1,2,4-triazolo(1,5-c]pirimidine ad attivita' antagonista per il recettore a2a dell'adenosina |
US6117878A (en) | 1998-02-24 | 2000-09-12 | University Of Virginia | 8-phenyl- or 8-cycloalkyl xanthine antagonists of A2B human adenosine receptors |
ATE234099T1 (de) * | 1998-04-24 | 2003-03-15 | Leuven K U Res & Dev | Immununterdrückende effekte von 8 substituierten xanthinderivaten |
US7125993B2 (en) * | 2001-11-09 | 2006-10-24 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
US7317017B2 (en) * | 2002-11-08 | 2008-01-08 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
PL370207A1 (en) * | 2001-11-09 | 2005-05-16 | Cv Therapeutics, Inc. | A2b adenosine receptor antagonists |
US7304070B2 (en) * | 2001-11-09 | 2007-12-04 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
US6977300B2 (en) * | 2001-11-09 | 2005-12-20 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
CN1894250B (zh) * | 2003-08-25 | 2010-06-09 | PGx健康有限责任公司 | 取代的8-杂芳基黄嘌呤 |
US7601723B2 (en) * | 2005-02-25 | 2009-10-13 | Pgx Health, Llc | Pyridyl substituted xanthines |
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CA2443023A1 (fr) | 2003-08-07 |
WO2003063800A8 (fr) | 2004-06-03 |
IL158214A0 (en) | 2004-05-12 |
WO2003063800A3 (fr) | 2003-12-24 |
US7205403B2 (en) | 2007-04-17 |
NZ528591A (en) | 2006-11-30 |
JP2005516975A (ja) | 2005-06-09 |
MXPA03008967A (es) | 2004-02-12 |
US7335655B2 (en) | 2008-02-26 |
WO2003063800A2 (fr) | 2003-08-07 |
EP1469856A4 (fr) | 2005-06-22 |
BR0302965A (pt) | 2005-02-09 |
US20060142309A1 (en) | 2006-06-29 |
KR20040080939A (ko) | 2004-09-20 |
US20030207879A1 (en) | 2003-11-06 |
EP1469856A2 (fr) | 2004-10-27 |
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