ZA200303357B - LFA-1 antagonist compounds. - Google Patents
LFA-1 antagonist compounds. Download PDFInfo
- Publication number
- ZA200303357B ZA200303357B ZA200303357A ZA200303357A ZA200303357B ZA 200303357 B ZA200303357 B ZA 200303357B ZA 200303357 A ZA200303357 A ZA 200303357A ZA 200303357 A ZA200303357 A ZA 200303357A ZA 200303357 B ZA200303357 B ZA 200303357B
- Authority
- ZA
- South Africa
- Prior art keywords
- compound according
- optionally substituted
- hydroxyl
- amino
- halogen
- Prior art date
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Classifications
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
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- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Furan Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25368200P | 2000-11-28 | 2000-11-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200303357B true ZA200303357B (en) | 2004-04-30 |
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| ZA200303357A ZA200303357B (en) | 2000-11-28 | 2003-04-30 | LFA-1 antagonist compounds. |
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| EP (1) | EP1347968A1 (fr) |
| JP (1) | JP2004517928A (fr) |
| KR (1) | KR20030051882A (fr) |
| CN (1) | CN1592746A (fr) |
| AU (1) | AU2002248142B2 (fr) |
| CA (1) | CA2429353A1 (fr) |
| CZ (1) | CZ20031380A3 (fr) |
| HU (1) | HUP0402305A2 (fr) |
| IL (1) | IL155683A0 (fr) |
| MX (1) | MXPA03004527A (fr) |
| NO (1) | NO20032382L (fr) |
| NZ (1) | NZ525573A (fr) |
| PL (1) | PL363962A1 (fr) |
| RU (1) | RU2003114422A (fr) |
| WO (1) | WO2002059114A1 (fr) |
| ZA (1) | ZA200303357B (fr) |
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| KR20030051882A (ko) * | 2000-11-28 | 2003-06-25 | 제넨테크, 인크. | Ｌｆａ-1 대항제 화합물 |
| WO2004032861A2 (fr) | 2002-10-11 | 2004-04-22 | Bristol-Myers Squibb Company | Composes hexahydro-benzimidazolones utiles en tant qu'agents anti-inflammatoires |
| TWI311557B (en) | 2003-01-23 | 2009-07-01 | Novartis A | Pharmaceutically active diazepanes |
| EP1682537B1 (fr) * | 2003-11-05 | 2012-03-28 | SARcode Bioscience Inc. | Modulateurs de l'adhesion cellulaire |
| KR20070012408A (ko) * | 2004-04-16 | 2007-01-25 | 제넨테크, 인크. | Ｂ 세포 고갈을 증대시키는 방법 |
| AU2005277547B2 (en) * | 2004-08-16 | 2011-08-25 | Immune Disease Institute, Inc. | Method of delivering RNA interference and uses thereof |
| JP2008512490A (ja) * | 2004-09-08 | 2008-04-24 | チェルシー・セラピューティクス，インコーポレイテッド | 異常細胞増殖および炎症の障害を治療するための代謝的に不活性な葉酸拮抗剤 |
| TW200616634A (en) | 2004-10-01 | 2006-06-01 | Bristol Myers Squibb Co | Crystalline forms and process for preparing spiro-hydantoin compounds |
| US7186727B2 (en) | 2004-12-14 | 2007-03-06 | Bristol-Myers Squibb Company | Pyridyl-substituted spiro-hydantoin compounds and use thereof |
| ES2614080T3 (es) | 2005-05-17 | 2017-05-29 | Sarcode Bioscience Inc. | Composiciones y métodos para el tratamiento de trastornos oculares |
| AU2007243370A1 (en) * | 2006-04-24 | 2007-11-08 | The Cbr Institute For Biomedical Research, Inc. | Method of producing immunoliposomes and compositions thereof |
| EP2018436A2 (fr) * | 2006-04-25 | 2009-01-28 | Immune Disease Institute Inc. | Administration ciblée vers des leucocytes au moyen de supports non protéiniques |
| WO2008089390A1 (fr) * | 2007-01-19 | 2008-07-24 | Chelsea Therapeutics, Inc. | Nouveaux antifolates classiques |
| EP3797775A1 (fr) | 2007-10-19 | 2021-03-31 | Novartis AG | Compositions et procédés pour le traitement de la rétinopathie diabétique |
| MX2010010998A (es) * | 2008-04-07 | 2011-01-25 | Chelsea Therapeutics Inc | Composiciones de antifolato. |
| CN102056485A (zh) * | 2008-04-15 | 2011-05-11 | 萨可德公司 | 用于局部治疗免疫相关疾病的局部lfa-1拮抗剂 |
| EP2265124A4 (fr) * | 2008-04-15 | 2011-12-28 | Sarcode Bioscience Inc | Antagonistes de lfa-1 sous forme d'aérosol utilisés en traitement localisé de troubles de nature immunitaire |
| WO2009139817A2 (fr) | 2008-04-15 | 2009-11-19 | Sarcode Corporation | Produit pharmaceutique cristallin et ses procédés de préparation et d'utilisation |
| JP2011516607A (ja) * | 2008-04-15 | 2011-05-26 | サーコード コーポレイション | 胃腸系へのｌｆａ−１アンタゴニストの送達 |
| CN105943534A (zh) * | 2008-04-15 | 2016-09-21 | 萨可德生物科学公司 | 用于局部治疗免疫相关疾病的局部lfa-1拮抗剂 |
| WO2011005832A1 (fr) * | 2009-07-08 | 2011-01-13 | Chelsea Therapeutics, Inc. | Polymorphes cristallins stables du sel de dipotassium de lacide (s) -2- {4- [2- (2, 4-diamino-quinazolin-6-yle) -éthyle] -benzoylamino} -4-méthylène-pentane dioïque |
| WO2011050175A1 (fr) | 2009-10-21 | 2011-04-28 | Sarcode Corporation | Agent pharmaceutique cristallin et procédés de préparation et utilisation de celui-ci |
| EP2496237A2 (fr) * | 2009-11-06 | 2012-09-12 | Chelsea Therapeutics, Inc. | Composés d'inhibition d'une enzyme |
| US20110237609A1 (en) * | 2010-03-29 | 2011-09-29 | Chelsea Therapeutics, Inc. | Antifolate compositions |
| WO2012078708A1 (fr) | 2010-12-07 | 2012-06-14 | Chelsea Therapeutics, Inc. | Combinaison comprenant du méthotrexate et un composé d'antifolate |
| EP2721147B1 (fr) * | 2011-06-17 | 2018-04-25 | CytoDyn, Inc. | Méthodes de traitement d'infections rétrovirales chez des félins |
| CN104797574B (zh) | 2012-07-25 | 2019-11-22 | 原生质生物科学股份有限公司 | Lfa-1抑制剂及其多晶型物 |
| CA2944989A1 (fr) | 2013-04-08 | 2014-10-16 | Cytodyn Inc. | Anticorps felinises et methodes de traitement d'infections retrovirales chez les felins |
| EP3810085A1 (fr) | 2018-06-20 | 2021-04-28 | Progenity, Inc. | Traitement d'une maladie du tractus gastro-intestinal par un inhibiteur de l'intégrine |
| WO2021174024A1 (fr) | 2020-02-28 | 2021-09-02 | First Wave Bio, Inc. | Méthodes de traitement de la colite auto-immune iatrogène |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL47062A (en) * | 1975-04-10 | 1979-07-25 | Yeda Res & Dev | Process for diminishing antigenicity of tissues to be usedas transplants by treatment with glutaraldehyde |
| US4665077A (en) | 1979-03-19 | 1987-05-12 | The Upjohn Company | Method for treating rejection of organ or skin grafts with 6-aryl pyrimidine compounds |
| US5424399A (en) * | 1988-06-28 | 1995-06-13 | The Children's Medical Center Corporation | Human CR3α/β heterodimers |
| US5149780A (en) * | 1988-10-03 | 1992-09-22 | The Scripps Research Institute | Peptides and antibodies that inhibit integrin-ligand binding |
| AU8631991A (en) * | 1990-08-27 | 1992-03-17 | Cetus Corporation | Cd18 peptide medicaments for the treatment of disease |
| US5288854A (en) * | 1990-11-28 | 1994-02-22 | Center For Blood Research, Inc. | Functional derivatives of ICAM-1 which are substantially capable of binding to LFA-1 but are substantially incapable of binding to MAC-1 |
| US5472973A (en) * | 1991-12-12 | 1995-12-05 | Scios Nova Inc. | Fluorenyl derivatives as anti-inflammatory agents |
| US5470953A (en) * | 1993-12-23 | 1995-11-28 | Icos Corporation | Human β2 integrin α subunit |
| WO1997008133A1 (fr) | 1995-08-22 | 1997-03-06 | Japan Tobacco Inc. | Composes amide et leur utilisation |
| NZ333904A (en) * | 1996-07-25 | 2000-06-23 | Biogen Inc | VLA-4 and IIb/IIIa cell adhesion inhibitors |
| EP1063982B1 (fr) | 1998-03-27 | 2007-02-14 | Genentech, Inc. | Antagonistes destines au traitement de troubles induits par le recepteur d'adhesion de cd11/cd18 |
| US6331640B1 (en) * | 1998-10-13 | 2001-12-18 | Hoffmann-La Roche Inc. | Diaminopropionic acid derivatives |
| US6110922A (en) * | 1998-12-29 | 2000-08-29 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds |
| KR20030051882A (ko) * | 2000-11-28 | 2003-06-25 | 제넨테크, 인크. | Ｌｆａ-1 대항제 화합물 |
-
2001
- 2001-11-26 KR KR10-2003-7007132A patent/KR20030051882A/ko not_active Application Discontinuation
- 2001-11-26 JP JP2002559416A patent/JP2004517928A/ja active Pending
- 2001-11-26 RU RU2003114422/04A patent/RU2003114422A/ru not_active Application Discontinuation
- 2001-11-26 NZ NZ525573A patent/NZ525573A/en unknown
- 2001-11-26 EP EP01997016A patent/EP1347968A1/fr not_active Withdrawn
- 2001-11-26 PL PL01363962A patent/PL363962A1/xx not_active Application Discontinuation
- 2001-11-26 WO PCT/US2001/044203 patent/WO2002059114A1/fr active IP Right Grant
- 2001-11-26 CN CNA018217974A patent/CN1592746A/zh active Pending
- 2001-11-26 CA CA002429353A patent/CA2429353A1/fr not_active Abandoned
- 2001-11-26 HU HU0402305A patent/HUP0402305A2/hu unknown
- 2001-11-26 CZ CZ20031380A patent/CZ20031380A3/cs unknown
- 2001-11-26 US US09/994,546 patent/US6667318B2/en not_active Expired - Fee Related
- 2001-11-26 IL IL15568301A patent/IL155683A0/xx unknown
- 2001-11-26 AU AU2002248142A patent/AU2002248142B2/en not_active Ceased
- 2001-11-26 MX MXPA03004527A patent/MXPA03004527A/es not_active Application Discontinuation
-
2003
- 2003-04-30 ZA ZA200303357A patent/ZA200303357B/en unknown
- 2003-05-27 NO NO20032382A patent/NO20032382L/no not_active Application Discontinuation
- 2003-07-11 US US10/618,178 patent/US6872735B2/en not_active Expired - Fee Related
-
2005
- 2005-01-21 US US11/040,639 patent/US20050148588A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| RU2003114422A (ru) | 2004-11-20 |
| WO2002059114A9 (fr) | 2002-10-17 |
| MXPA03004527A (es) | 2003-09-10 |
| AU2002248142B8 (en) | 2002-08-06 |
| WO2002059114A1 (fr) | 2002-08-01 |
| CZ20031380A3 (cs) | 2003-10-15 |
| US20040058968A1 (en) | 2004-03-25 |
| JP2004517928A (ja) | 2004-06-17 |
| CN1592746A (zh) | 2005-03-09 |
| US20020119994A1 (en) | 2002-08-29 |
| IL155683A0 (en) | 2003-11-23 |
| US6667318B2 (en) | 2003-12-23 |
| KR20030051882A (ko) | 2003-06-25 |
| NO20032382L (no) | 2003-07-09 |
| NZ525573A (en) | 2005-08-26 |
| PL363962A1 (en) | 2004-11-29 |
| HUP0402305A2 (hu) | 2005-02-28 |
| NO20032382D0 (no) | 2003-05-27 |
| EP1347968A1 (fr) | 2003-10-01 |
| US20050148588A1 (en) | 2005-07-07 |
| US6872735B2 (en) | 2005-03-29 |
| CA2429353A1 (fr) | 2002-08-01 |
| AU2002248142B2 (en) | 2007-11-01 |
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