ZA200303214B - O-substituated 6-methyl-tramadol derivatives. - Google Patents
O-substituated 6-methyl-tramadol derivatives. Download PDFInfo
- Publication number
- ZA200303214B ZA200303214B ZA200303214A ZA200303214A ZA200303214B ZA 200303214 B ZA200303214 B ZA 200303214B ZA 200303214 A ZA200303214 A ZA 200303214A ZA 200303214 A ZA200303214 A ZA 200303214A ZA 200303214 B ZA200303214 B ZA 200303214B
- Authority
- ZA
- South Africa
- Prior art keywords
- dimethylaminomethyl
- substituted
- methyltramadol
- methylcyclohexanol
- derivatives
- Prior art date
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- 150000003839 salts Chemical class 0.000 claims description 26
- 208000004454 Hyperalgesia Diseases 0.000 claims description 24
- 208000002193 Pain Diseases 0.000 claims description 21
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- 239000003814 drug Substances 0.000 claims description 16
- DMVJUXLKJXRMSV-UHFFFAOYSA-N 3-[2-[(dimethylamino)methyl]-1-hydroxy-6-methylcyclohexyl]phenol Chemical compound CC1CCCC(CN(C)C)C1(O)C1=CC=CC(O)=C1 DMVJUXLKJXRMSV-UHFFFAOYSA-N 0.000 claims description 15
- -1 3-cyclopentyloxyphenyl Chemical group 0.000 claims description 13
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- 238000000034 method Methods 0.000 claims description 12
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- ZDAVLYNMOVBPQN-UHFFFAOYSA-N 2-[(dimethylamino)methyl]-6-methylcyclohexan-1-one Chemical compound CC1CCCC(CN(C)C)C1=O ZDAVLYNMOVBPQN-UHFFFAOYSA-N 0.000 claims description 7
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- 125000001544 thienyl group Chemical group 0.000 claims description 6
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- AZFWCGWLDUTDPS-UHFFFAOYSA-N 1-[3-(cyclobutylmethoxy)phenyl]-2-(dimethylamino)-2,6-dimethylcyclohexan-1-ol Chemical compound CC1CCCC(C)(N(C)C)C1(O)C1=CC=CC(OCC2CCC2)=C1 AZFWCGWLDUTDPS-UHFFFAOYSA-N 0.000 claims description 2
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Classifications
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- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
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- C—CHEMISTRY; METALLURGY
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
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- Reproductive Health (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10049483A DE10049483A1 (de) | 2000-09-29 | 2000-09-29 | Substituierte 1-Aminobutan-3-ol-Derivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200303214B true ZA200303214B (en) | 2004-08-31 |
Family
ID=7658871
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200303214A ZA200303214B (en) | 2000-09-29 | 2003-04-24 | O-substituated 6-methyl-tramadol derivatives. |
| ZA200303220A ZA200303220B (en) | 2000-09-29 | 2003-04-24 | Substituted 1-aminobutan-3-ol-derivatives. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200303220A ZA200303220B (en) | 2000-09-29 | 2003-04-24 | Substituted 1-aminobutan-3-ol-derivatives. |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US7022739B2 (hu) |
| EP (2) | EP1322592B2 (hu) |
| JP (2) | JP2004510755A (hu) |
| KR (2) | KR100835549B1 (hu) |
| CN (2) | CN1478067A (hu) |
| AR (1) | AR034158A1 (hu) |
| AT (2) | ATE272045T1 (hu) |
| AU (4) | AU2002220578B2 (hu) |
| BR (2) | BR0114380A (hu) |
| CA (2) | CA2423903A1 (hu) |
| DE (3) | DE10049483A1 (hu) |
| DK (2) | DK1322592T4 (hu) |
| EC (2) | ECSP034532A (hu) |
| ES (2) | ES2225605T5 (hu) |
| HK (2) | HK1052924B (hu) |
| HU (2) | HUP0303361A3 (hu) |
| IL (2) | IL155105A0 (hu) |
| MX (2) | MXPA03002737A (hu) |
| NO (2) | NO20031382L (hu) |
| NZ (2) | NZ525171A (hu) |
| PE (1) | PE20020413A1 (hu) |
| PL (2) | PL361632A1 (hu) |
| PT (2) | PT1322592E (hu) |
| RU (2) | RU2286334C2 (hu) |
| SI (2) | SI1322592T1 (hu) |
| SK (2) | SK286727B6 (hu) |
| TR (2) | TR200402030T4 (hu) |
| WO (2) | WO2002028817A1 (hu) |
| ZA (2) | ZA200303214B (hu) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10049483A1 (de) * | 2000-09-29 | 2002-05-02 | Gruenenthal Gmbh | Substituierte 1-Aminobutan-3-ol-Derivate |
| US6825217B2 (en) | 2001-10-16 | 2004-11-30 | Endo Pharmaceuticals, Inc. | Carbinols for the treatment of neuropathic dysfunction |
| PL211954B1 (pl) * | 2002-01-11 | 2012-07-31 | Sankyo Co | Związek, kompozycja farmaceutyczna oraz zastosowanie kompozycji farmaceutycznej |
| US8128957B1 (en) | 2002-02-21 | 2012-03-06 | Valeant International (Barbados) Srl | Modified release compositions of at least one form of tramadol |
| US20050182056A9 (en) * | 2002-02-21 | 2005-08-18 | Seth Pawan | Modified release formulations of at least one form of tramadol |
| SI1839654T1 (sl) | 2002-11-22 | 2010-08-31 | Gruenenthal Gmbh | Uporaba (1R, 2R)-3-(3-dimetilamino-1-etil-2-metil- propil)-fenola za zdravljenje vnetne bolečine |
| EP1733724A4 (en) | 2004-02-24 | 2010-07-07 | Sankyo Co | Aminoalcohol compound |
| MX2009012685A (es) * | 2007-05-31 | 2009-12-14 | Sepracor Inc | Cicloalquilaminas sustituidas con fenilo como inhibidores de la reabsorcion de monoamina. |
| US20100183600A1 (en) * | 2008-12-05 | 2010-07-22 | Arqule, Inc. | RAF Inhibitors and Their Uses |
| ES2343050B1 (es) * | 2008-12-16 | 2011-06-14 | Chemo Iberica, S.A. | Procedimiento para la preparacion de desvenlafaxina y sus sales de adicion de acido farmaceuticamente aceptables. |
| WO2012100423A1 (en) * | 2011-01-27 | 2012-08-02 | Eli Lilly And Company | Analgesic compounds, methods, and formulations |
| WO2017125351A1 (en) * | 2016-01-21 | 2017-07-27 | Laboratorios Lesvi Sl | Process for preparing (( r)-3-[(-1-methylpyrrolidin-2-yl)methyl]-5-(2-phenylsulfonylethyl)-1h-indole |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3652589A (en) * | 1967-07-27 | 1972-03-28 | Gruenenthal Chemie | 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols |
| ZA732238B (en) * | 1972-04-06 | 1974-01-30 | American Home Prod | Benzylamine analgesics |
| US4155935A (en) * | 1973-03-26 | 1979-05-22 | American Home Products Corporation | Benzylamine analgesics |
| DE19525137C2 (de) * | 1995-07-11 | 2003-02-27 | Gruenenthal Gmbh | 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe |
| US6017963A (en) * | 1995-11-14 | 2000-01-25 | Euro-Celtique, S.A. | Formulation for intranasal administration |
| DE19547766A1 (de) | 1995-12-20 | 1997-06-26 | Gruenenthal Gmbh | 1-Phenyl-2-dimethylaminomethyl-cyclohexan-1-ol-verbindungen als pharmazeutische Wirkstoffe |
| DE19601744C2 (de) | 1996-01-19 | 1998-04-16 | Gruenenthal Gmbh | Verfahren zur Herstellung der Enantiomeren von O-Demethyltramadol |
| DE19609847A1 (de) * | 1996-03-13 | 1997-09-18 | Gruenenthal Gmbh | Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe |
| US5919826A (en) * | 1996-10-24 | 1999-07-06 | Algos Pharmaceutical Corporation | Method of alleviating pain |
| US6245804B1 (en) * | 1997-05-30 | 2001-06-12 | Schering Aktiengesellschaft | Nonsteroidal gestagens |
| DE69809055T2 (de) * | 1997-07-15 | 2003-06-05 | Russinsky Ltd | Verfahren zur herstellung von reinem cis-tramadol |
| ES2212849T3 (es) * | 1998-05-22 | 2004-08-01 | Mallinckrodt Inc. | Sintesis y purificacion mejoradas de hidrocloruro de (r*,r*)-2-((dimetilamino)metil)-1-(3-metoxifenil)ciclohexanol. |
| ES2141688B1 (es) * | 1998-11-06 | 2001-02-01 | Vita Invest Sa | Nuevos esteres derivados de compuestos fenil-ciclohexil sustituidos. |
| DE19915601A1 (de) * | 1999-04-07 | 2000-10-19 | Gruenenthal Gmbh | 3-Amino-3-arylpropan-1-ol-Derivate, deren Herstellung und Verwendung |
| ATE284223T1 (de) * | 1999-08-20 | 2004-12-15 | Ortho Mcneil Pharm Inc | Zusammensetzung enthaltend ein tramadol und ein antikonvulsives arzneimittel |
| PE20010623A1 (es) * | 1999-10-05 | 2001-07-07 | Gruenenthal Chemie | Uso de (+)-tramadol y/o o-demetiltramadol para tratamiento de urgencia urinaria incrementada y/o incontinencia urinaria |
| US6339105B1 (en) * | 1999-10-12 | 2002-01-15 | Ortho-Mcneil Pharmaceutical, Inc. | Analgesic regimen |
| DE10000312A1 (de) * | 2000-01-05 | 2001-07-12 | Gruenenthal Gmbh | Substituierte Aminomethyl-Phenyl-Cyclohexanderivate |
| DE10049483A1 (de) * | 2000-09-29 | 2002-05-02 | Gruenenthal Gmbh | Substituierte 1-Aminobutan-3-ol-Derivate |
| DE10048714A1 (de) * | 2000-09-30 | 2002-04-11 | Gruenenthal Gmbh | 5-Amino-1-penlen-3-ol-Derivate |
| US6649783B2 (en) * | 2001-10-03 | 2003-11-18 | Euro-Celtique, S.A. | Synthesis of (+/-)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols |
| WO2003048113A1 (en) * | 2001-11-30 | 2003-06-12 | Sepracor Inc. | Tramadol analogs and uses thereof |
-
2000
- 2000-09-29 DE DE10049483A patent/DE10049483A1/de not_active Withdrawn
-
2001
- 2001-09-28 JP JP2002532404A patent/JP2004510755A/ja active Pending
- 2001-09-28 WO PCT/EP2001/011231 patent/WO2002028817A1/de active IP Right Grant
- 2001-09-28 SI SI200130184T patent/SI1322592T1/xx unknown
- 2001-09-28 CA CA002423903A patent/CA2423903A1/en not_active Abandoned
- 2001-09-28 DK DK01969791T patent/DK1322592T4/da active
- 2001-09-28 KR KR1020037004490A patent/KR100835549B1/ko not_active IP Right Cessation
- 2001-09-28 SK SK340-2003A patent/SK286727B6/sk not_active IP Right Cessation
- 2001-09-28 WO PCT/EP2001/011276 patent/WO2002026694A1/de active IP Right Grant
- 2001-09-28 PE PE2001000968A patent/PE20020413A1/es not_active Application Discontinuation
- 2001-09-28 EP EP01969791A patent/EP1322592B2/de not_active Expired - Lifetime
- 2001-09-28 CN CNA018196454A patent/CN1478067A/zh active Pending
- 2001-09-28 AU AU2002220578A patent/AU2002220578B2/en not_active Ceased
- 2001-09-28 PL PL01361632A patent/PL361632A1/xx not_active Application Discontinuation
- 2001-09-28 DE DE50103035T patent/DE50103035D1/de not_active Expired - Lifetime
- 2001-09-28 NZ NZ525171A patent/NZ525171A/en unknown
- 2001-09-28 DK DK01985699T patent/DK1322593T3/da active
- 2001-09-28 DE DE50103036T patent/DE50103036D1/de not_active Expired - Lifetime
- 2001-09-28 EP EP01985699A patent/EP1322593B1/de not_active Expired - Lifetime
- 2001-09-28 NZ NZ524976A patent/NZ524976A/en unknown
- 2001-09-28 IL IL15510501A patent/IL155105A0/xx unknown
- 2001-09-28 RU RU2003111756/04A patent/RU2286334C2/ru not_active IP Right Cessation
- 2001-09-28 BR BR0114380-8A patent/BR0114380A/pt not_active IP Right Cessation
- 2001-09-28 PL PL01361382A patent/PL361382A1/xx unknown
- 2001-09-28 TR TR2004/02030T patent/TR200402030T4/xx unknown
- 2001-09-28 ES ES01969791T patent/ES2225605T5/es not_active Expired - Lifetime
- 2001-09-28 AT AT01969791T patent/ATE272045T1/de active
- 2001-09-28 AR ARP010104583A patent/AR034158A1/es unknown
- 2001-09-28 KR KR1020037004521A patent/KR100864796B1/ko not_active IP Right Cessation
- 2001-09-28 MX MXPA03002737A patent/MXPA03002737A/es active IP Right Grant
- 2001-09-28 HU HU0303361A patent/HUP0303361A3/hu unknown
- 2001-09-28 AT AT01985699T patent/ATE272046T1/de not_active IP Right Cessation
- 2001-09-28 ES ES01985699T patent/ES2225628T3/es not_active Expired - Lifetime
- 2001-09-28 AU AU2057802A patent/AU2057802A/xx active Pending
- 2001-09-28 HU HU0303195A patent/HUP0303195A3/hu unknown
- 2001-09-28 SI SI200130189T patent/SI1322593T1/xx unknown
- 2001-09-28 CN CNB018166067A patent/CN100391933C/zh not_active Expired - Fee Related
- 2001-09-28 PT PT01969791T patent/PT1322592E/pt unknown
- 2001-09-28 SK SK338-2003A patent/SK3382003A3/sk not_active Application Discontinuation
- 2001-09-28 MX MXPA03002738A patent/MXPA03002738A/es active IP Right Grant
- 2001-09-28 CA CA002423860A patent/CA2423860A1/en not_active Abandoned
- 2001-09-28 JP JP2002531080A patent/JP2004509939A/ja active Pending
- 2001-09-28 TR TR2004/02230T patent/TR200402230T4/xx unknown
- 2001-09-28 RU RU2003111753/04A patent/RU2288219C2/ru not_active IP Right Cessation
- 2001-09-28 IL IL15510601A patent/IL155106A0/xx unknown
- 2001-09-28 PT PT01985699T patent/PT1322593E/pt unknown
- 2001-09-28 BR BR0114381-6A patent/BR0114381A/pt not_active IP Right Cessation
- 2001-09-28 AU AU2001289937A patent/AU2001289937B2/en not_active Ceased
- 2001-09-28 AU AU8993701A patent/AU8993701A/xx active Pending
-
2003
- 2003-03-26 NO NO20031382A patent/NO20031382L/no not_active Application Discontinuation
- 2003-03-26 NO NO20031387A patent/NO20031387L/no not_active Application Discontinuation
- 2003-03-28 EC EC2003004532A patent/ECSP034532A/es unknown
- 2003-03-28 EC EC2003004530A patent/ECSP034530A/es unknown
- 2003-03-28 US US10/401,020 patent/US7022739B2/en not_active Expired - Fee Related
- 2003-03-31 US US10/402,147 patent/US6828345B2/en not_active Expired - Fee Related
- 2003-04-24 ZA ZA200303214A patent/ZA200303214B/en unknown
- 2003-04-24 ZA ZA200303220A patent/ZA200303220B/en unknown
- 2003-07-16 HK HK03105140.5A patent/HK1052924B/zh not_active IP Right Cessation
- 2003-07-17 HK HK03105163.7A patent/HK1052925B/zh not_active IP Right Cessation
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