ZA200303203B - Antiinflammation agents. - Google Patents
Antiinflammation agents. Download PDFInfo
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- ZA200303203B ZA200303203B ZA200303203A ZA200303203A ZA200303203B ZA 200303203 B ZA200303203 B ZA 200303203B ZA 200303203 A ZA200303203 A ZA 200303203A ZA 200303203 A ZA200303203 A ZA 200303203A ZA 200303203 B ZA200303203 B ZA 200303203B
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- 230000034512 ubiquitination Effects 0.000 description 1
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- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
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Classifications
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- C07—ORGANIC CHEMISTRY
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
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- Chemical & Material Sciences (AREA)
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Applications Claiming Priority (1)
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| US24358100P | 2000-10-26 | 2000-10-26 |
Publications (1)
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| CA2307278A1 (en) * | 2000-04-28 | 2001-10-28 | University Of British Columbia | Use of n-heterocyclic substituted salicylic acids for inhibition of cellular uptake of cystine |
| EA200300508A1 (ru) | 2000-10-26 | 2004-06-24 | Туларик Инк. | Противовоспалительные агенты |
| JP2005511608A (ja) * | 2001-11-07 | 2005-04-28 | エフ．ホフマン−ラ ロシュ アーゲー | アミノピリミジン類及び−ピリジン類 |
| US7176314B2 (en) | 2001-12-05 | 2007-02-13 | Amgen, Inc. | Inflammation modulators |
| EA008706B1 (ru) | 2002-06-06 | 2007-06-29 | Бёрингер Ингельхайм Фармасьютиклз, Инк. | АМИДЫ ЗАМЕЩЕННЫХ 3-АМИНОТИЕНО[2,3-b]ПИРИДИН-2-КАРБОНОВЫХ КИСЛОТ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ |
| US7199119B2 (en) | 2002-10-31 | 2007-04-03 | Amgen Inc. | Antiinflammation agents |
| WO2004060308A2 (en) | 2002-12-27 | 2004-07-22 | Chiron Corporation | Thiosemicarbazones as anti-virals and immunopotentiators |
| US7329764B2 (en) | 2003-07-31 | 2008-02-12 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substitute benzothiophene compounds |
| GB0400895D0 (en) * | 2004-01-15 | 2004-02-18 | Smithkline Beecham Corp | Chemical compounds |
| PE20060373A1 (es) | 2004-06-24 | 2006-04-29 | Smithkline Beecham Corp | Derivados 3-piperidinil-7-carboxamida-indazol como inhibidores de la actividad cinasa de ikk2 |
| TW200626142A (en) * | 2004-09-21 | 2006-08-01 | Glaxo Group Ltd | Chemical compounds |
| EP2664340B1 (en) | 2005-06-24 | 2020-02-12 | Duke University | A direct drug delivery system based on thermally responsive biopolymers |
| US8063071B2 (en) | 2007-10-31 | 2011-11-22 | GlaxoSmithKline, LLC | Chemical compounds |
| TWI380973B (zh) | 2005-06-30 | 2013-01-01 | Smithkline Beecham Corp | 化合物 |
| GB0523576D0 (en) * | 2005-11-18 | 2005-12-28 | Theradeas Ltd | Drug composition and its use in therapy |
| US20080269291A1 (en) * | 2005-11-18 | 2008-10-30 | Kerns Jeffrey K | Chemical Compounds |
| EP2029608A1 (en) | 2006-06-06 | 2009-03-04 | Boehringer Ingelheim International GmbH | Substituted 3-amino-thieno[2,3-b] pyridine-2-carboxamide compounds, their preparation and use |
| DE102007012794B3 (de) * | 2007-03-16 | 2008-06-19 | Novaled Ag | Pyrido[3,2-h]chinazoline und/oder deren 5,6-Dihydroderivate, deren Herstellungsverfahren und diese enthaltendes dotiertes organisches Halbleitermaterial |
| PE20081889A1 (es) | 2007-03-23 | 2009-03-05 | Smithkline Beecham Corp | Indol carboxamidas como inhibidores de ikk2 |
| WO2008150827A1 (en) * | 2007-05-29 | 2008-12-11 | Smithkline Beecham Corporation | Naphthyridine, derivatives as p13 kinase inhibitors |
| KR101449785B1 (ko) | 2008-04-21 | 2014-10-14 | 오토노미, 인코포레이티드 | 귀 질환 및 병태를 치료하기 위한 귀 조제물 |
| US11969501B2 (en) | 2008-04-21 | 2024-04-30 | Dompé Farmaceutici S.P.A. | Auris formulations for treating otic diseases and conditions |
| BRPI0919282A2 (pt) * | 2008-10-02 | 2017-03-28 | Asahi Kasei Pharma Corp | composto, composição farmacêutica, inibidor de ikkb, método para inibir ikkb, métodos para prevenir e/ou tratar uma doença ou sintoma associado com nf-kb, uma doença ou sintoma associado com ikkb, e uma doença ou sintoma associado com reação inflamatória aguda ou crônica em mamíferos |
| US8354539B2 (en) | 2009-03-10 | 2013-01-15 | Glaxo Group Limited | Indole derivatives as IKK2 inhibitors |
| ES2731773T3 (es) | 2013-03-14 | 2019-11-19 | Celgene Quanticel Res Inc | Inhibidores de la histona desmetilasa |
| US9896436B2 (en) | 2014-09-16 | 2018-02-20 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| SG11201702108PA (en) | 2014-09-16 | 2017-04-27 | Celgene Quanticel Res Inc | Histone demethylase inhibitors |
| EP3445170A4 (en) * | 2016-04-18 | 2019-11-20 | New York University | CHINOLINE COMPOUNDS AS RAGE ACTIVITY MODULATORS AND USES THEREOF |
| JP7033789B2 (ja) | 2016-06-29 | 2022-03-11 | オトノミー，インク． | トリグリセリド耳用製剤とその使用 |
| US20220274929A1 (en) * | 2019-02-25 | 2022-09-01 | The Regents Of The University Of California | Thiosemicarbazone compounds and uses thereof |
| WO2024072870A1 (en) * | 2022-09-28 | 2024-04-04 | New York University | Quinoline compounds as modulators of rage activity and uses thereof |
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| KR20010020201A (ko) * | 1997-04-22 | 2001-03-15 | 코센시스 인크 | 탄소고리 및 헤테로고리 치환된 세미카르바존 및 티오세미카르바존과 그들의 사용 방법 |
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| US5843721A (en) * | 1997-07-03 | 1998-12-01 | Tularik Inc. | Nucleic acids encoding human NIK protein |
| US6258822B1 (en) * | 1997-08-06 | 2001-07-10 | Abbott Laboratories | Urokinase inhibitors |
| MXPA01012283A (es) | 1999-06-23 | 2002-07-30 | Aventis Pharma Gmbh | Bencimidazoles sustituidos. |
| DE19951360A1 (de) | 1999-10-26 | 2001-05-03 | Aventis Pharma Gmbh | Substituierte Indole |
| GB0003154D0 (en) | 2000-02-12 | 2000-04-05 | Astrazeneca Uk Ltd | Novel compounds |
| EP1268477B1 (en) | 2000-03-15 | 2010-04-21 | Sanofi-Aventis Deutschland GmbH | Substituted beta-carbolines with ikb-kinase inhibiting activity |
| JP4272338B2 (ja) | 2000-09-22 | 2009-06-03 | バイエル アクチェンゲゼルシャフト | ピリジン誘導体 |
| US6960585B2 (en) | 2000-10-03 | 2005-11-01 | Bristol-Myers Squibb Company | Amino-substituted tetracyclic compounds useful as anti-inflammatory agents and pharmaceutical compositions comprising same |
| EP1328272A1 (en) | 2000-10-12 | 2003-07-23 | SmithKline Beecham Corporation | Nf-kappa-b inhibitors |
| EP1324759A4 (en) | 2000-10-12 | 2004-05-12 | Smithkline Beecham Corp | NF - G (K) B INHIBITORS |
| EA200300508A1 (ru) | 2000-10-26 | 2004-06-24 | Туларик Инк. | Противовоспалительные агенты |
| JP2002193938A (ja) | 2000-12-01 | 2002-07-10 | Bayer Ag | ４−アリールピリジン誘導体 |
| US7122544B2 (en) | 2000-12-06 | 2006-10-17 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto |
| AU2002247059B2 (en) | 2001-02-01 | 2006-11-16 | Bristol-Myers Squibb Company | Method of treating inflammatory and immune diseases using inhibitors of IkappaB kinase (IKK) |
| WO2002076985A1 (en) | 2001-03-23 | 2002-10-03 | Smithkline Beecham Corporation | Compounds useful as kinase inhibitors for the treatment of hyperproliferative diseases |
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- 2001-10-23 ES ES01987605T patent/ES2305125T3/es not_active Expired - Lifetime
- 2001-10-23 CN CN01821344.8A patent/CN1503673A/zh active Pending
- 2001-10-23 CA CA002427284A patent/CA2427284A1/en not_active Abandoned
- 2001-10-23 IL IL15551901A patent/IL155519A0/xx unknown
- 2001-10-23 DE DE60133758T patent/DE60133758T2/de not_active Expired - Fee Related
- 2001-10-23 BR BR0114978-4A patent/BR0114978A/pt not_active IP Right Cessation
- 2001-10-23 AU AU2002239806A patent/AU2002239806B2/en not_active Ceased
- 2001-10-23 WO PCT/US2001/051403 patent/WO2002041843A2/en active IP Right Grant
- 2001-10-23 AT AT01987605T patent/ATE392898T1/de not_active IP Right Cessation
- 2001-10-23 US US10/004,287 patent/US6846834B2/en not_active Expired - Fee Related
- 2001-10-23 AU AU3980602A patent/AU3980602A/xx active Pending
- 2001-10-23 PL PL01366114A patent/PL366114A1/xx unknown
- 2001-10-23 JP JP2002544024A patent/JP4285602B2/ja not_active Expired - Fee Related
- 2001-10-23 NZ NZ525474A patent/NZ525474A/en unknown
- 2001-10-23 MX MXPA03003599A patent/MXPA03003599A/es active IP Right Grant
- 2001-10-23 KR KR10-2003-7005797A patent/KR20030064773A/ko not_active Application Discontinuation
- 2001-10-29 AR ARP010105038A patent/AR035499A1/es not_active Application Discontinuation
-
2003
- 2003-04-24 ZA ZA200303203A patent/ZA200303203B/en unknown
- 2003-04-25 NO NO20031869A patent/NO20031869L/no not_active Application Discontinuation
-
2004
- 2004-08-26 US US10/928,784 patent/US7186841B2/en not_active Expired - Fee Related
-
2007
- 2007-01-05 US US11/650,268 patent/US20070135464A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| NO20031869D0 (no) | 2003-04-25 |
| EP1333834A2 (en) | 2003-08-13 |
| AU2002239806B8 (en) | 2002-06-03 |
| ES2305125T3 (es) | 2008-11-01 |
| JP2004516252A (ja) | 2004-06-03 |
| ATE392898T1 (de) | 2008-05-15 |
| EA200300508A1 (ru) | 2004-06-24 |
| NZ525474A (en) | 2005-10-28 |
| AU3980602A (en) | 2002-06-03 |
| DE60133758T2 (de) | 2009-07-02 |
| DE60133758D1 (de) | 2008-06-05 |
| US20050043330A1 (en) | 2005-02-24 |
| KR20030064773A (ko) | 2003-08-02 |
| CN1503673A (zh) | 2004-06-09 |
| MXPA03003599A (es) | 2003-08-01 |
| BR0114978A (pt) | 2004-04-20 |
| US20020161004A1 (en) | 2002-10-31 |
| PL366114A1 (en) | 2005-01-24 |
| NO20031869L (no) | 2003-06-26 |
| WO2002041843A2 (en) | 2002-05-30 |
| EP1333834B1 (en) | 2008-04-23 |
| AR035499A1 (es) | 2004-06-02 |
| WO2002041843A3 (en) | 2003-02-06 |
| JP4285602B2 (ja) | 2009-06-24 |
| US6846834B2 (en) | 2005-01-25 |
| CA2427284A1 (en) | 2002-05-30 |
| AU2002239806B2 (en) | 2007-01-18 |
| US20070135464A1 (en) | 2007-06-14 |
| US7186841B2 (en) | 2007-03-06 |
| IL155519A0 (en) | 2003-11-23 |
| EP1333834A4 (en) | 2007-01-17 |
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