ZA200301869B - Novel crystals of N-hydroxy-2 (S)-methyl-5-ethoxymethoxy-4 (S)-[N-(4-phenoxyphenylcarbonyl)amino]pentanamide, process for their production and medicines containing the crystals as the active ingredient. - Google Patents
Novel crystals of N-hydroxy-2 (S)-methyl-5-ethoxymethoxy-4 (S)-[N-(4-phenoxyphenylcarbonyl)amino]pentanamide, process for their production and medicines containing the crystals as the active ingredient. Download PDFInfo
- Publication number
- ZA200301869B ZA200301869B ZA200301869A ZA200301869A ZA200301869B ZA 200301869 B ZA200301869 B ZA 200301869B ZA 200301869 A ZA200301869 A ZA 200301869A ZA 200301869 A ZA200301869 A ZA 200301869A ZA 200301869 B ZA200301869 B ZA 200301869B
- Authority
- ZA
- South Africa
- Prior art keywords
- type
- crystal
- ethoxymethoxy
- phenoxyphenylcarbonyl
- pentanamide
- Prior art date
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- 239000013078 crystal Substances 0.000 title claims description 127
- HDWWQELUBWGQGA-WMZOPIPTSA-N n-[(2s,4s)-1-(ethoxymethoxy)-5-(hydroxyamino)-4-methyl-5-oxopentan-2-yl]-4-phenoxybenzamide Chemical compound C1=CC(C(=O)N[C@@H](C[C@H](C)C(=O)NO)COCOCC)=CC=C1OC1=CC=CC=C1 HDWWQELUBWGQGA-WMZOPIPTSA-N 0.000 title claims description 19
- 238000000034 method Methods 0.000 title claims description 16
- 239000004480 active ingredient Substances 0.000 title claims description 8
- 239000003814 drug Substances 0.000 title description 3
- 238000004519 manufacturing process Methods 0.000 title description 3
- 229940079593 drug Drugs 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims description 41
- 238000001228 spectrum Methods 0.000 claims description 36
- 239000000203 mixture Substances 0.000 claims description 28
- 238000000634 powder X-ray diffraction Methods 0.000 claims description 19
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 11
- 238000002360 preparation method Methods 0.000 claims description 11
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims description 9
- 210000004027 cell Anatomy 0.000 claims description 9
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 9
- 201000010099 disease Diseases 0.000 claims description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 8
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- 239000007787 solid Substances 0.000 claims 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 18
- 238000000113 differential scanning calorimetry Methods 0.000 description 18
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 16
- 238000010521 absorption reaction Methods 0.000 description 15
- 239000012046 mixed solvent Substances 0.000 description 10
- 239000000243 solution Substances 0.000 description 10
- 239000003795 chemical substances by application Substances 0.000 description 7
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- 238000004090 dissolution Methods 0.000 description 6
- 238000010438 heat treatment Methods 0.000 description 6
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 6
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- IPWFJLQDVFKJDU-UHFFFAOYSA-N pentanamide Chemical compound CCCCC(N)=O IPWFJLQDVFKJDU-UHFFFAOYSA-N 0.000 description 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
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- 238000002441 X-ray diffraction Methods 0.000 description 3
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- KKJUPNGICOCCDW-UHFFFAOYSA-N 7-N,N-Dimethylamino-1,2,3,4,5-pentathiocyclooctane Chemical compound CN(C)C1CSSSSSC1 KKJUPNGICOCCDW-UHFFFAOYSA-N 0.000 description 2
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- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 2
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- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
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- CHRHZFQUDFAQEQ-UHFFFAOYSA-L calcium;2-hydroxyacetate Chemical compound [Ca+2].OCC([O-])=O.OCC([O-])=O CHRHZFQUDFAQEQ-UHFFFAOYSA-L 0.000 description 1
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- YQBDFGQBMNKUAM-FPOVZHCZSA-N n-[(2s,4s)-1-(ethoxymethoxy)-5-(2-methoxypropan-2-yloxyamino)-4-methyl-5-oxopentan-2-yl]-4-phenoxybenzamide Chemical compound C1=CC(C(=O)N[C@@H](C[C@H](C)C(=O)NOC(C)(C)OC)COCOCC)=CC=C1OC1=CC=CC=C1 YQBDFGQBMNKUAM-FPOVZHCZSA-N 0.000 description 1
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- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/50—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
-
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Transplantation (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000273445 | 2000-09-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200301869B true ZA200301869B (en) | 2004-06-25 |
Family
ID=18759384
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200301869A ZA200301869B (en) | 2000-09-08 | 2003-03-06 | Novel crystals of N-hydroxy-2 (S)-methyl-5-ethoxymethoxy-4 (S)-[N-(4-phenoxyphenylcarbonyl)amino]pentanamide, process for their production and medicines containing the crystals as the active ingredient. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20040152785A1 (ru) |
| EP (1) | EP1316547A4 (ru) |
| KR (1) | KR20030059125A (ru) |
| CN (1) | CN1473148A (ru) |
| AU (1) | AU2001284477A1 (ru) |
| BR (1) | BR0113760A (ru) |
| CA (1) | CA2419744A1 (ru) |
| CZ (1) | CZ2003636A3 (ru) |
| HU (1) | HUP0302928A3 (ru) |
| IL (1) | IL154625A0 (ru) |
| MX (1) | MXPA03001985A (ru) |
| NO (1) | NO20031030L (ru) |
| PL (1) | PL361702A1 (ru) |
| RU (1) | RU2003106391A (ru) |
| WO (1) | WO2002020467A1 (ru) |
| ZA (1) | ZA200301869B (ru) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0100761D0 (en) | 2001-01-11 | 2001-02-21 | Biocompatibles Ltd | Drug delivery from stents |
| KR101013932B1 (ko) * | 2003-10-21 | 2011-02-14 | 워너-램버트 캄파니 엘엘씨 | Ｎ-[(ｒ)-2,3-디히드록시-프로폭시]-3,4-디플루오로-2-(2-플루오로-4-요오도페닐아미노)-벤자미드 다형체 형태 |
| US7713541B1 (en) | 2006-11-21 | 2010-05-11 | Abbott Cardiovascular Systems Inc. | Zwitterionic terpolymers, method of making and use on medical devices |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1282319A (zh) * | 1997-10-09 | 2001-01-31 | 小野药品工业株式会社 | 氨基丁酸衍生物 |
-
2001
- 2001-09-07 PL PL01361702A patent/PL361702A1/xx unknown
- 2001-09-07 WO PCT/JP2001/007775 patent/WO2002020467A1/ja not_active Application Discontinuation
- 2001-09-07 RU RU2003106391/04A patent/RU2003106391A/ru not_active Application Discontinuation
- 2001-09-07 KR KR10-2003-7003266A patent/KR20030059125A/ko not_active Application Discontinuation
- 2001-09-07 CZ CZ2003636A patent/CZ2003636A3/cs unknown
- 2001-09-07 CA CA002419744A patent/CA2419744A1/en not_active Abandoned
- 2001-09-07 HU HU0302928A patent/HUP0302928A3/hu unknown
- 2001-09-07 EP EP01963509A patent/EP1316547A4/en not_active Withdrawn
- 2001-09-07 IL IL15462501A patent/IL154625A0/xx unknown
- 2001-09-07 CN CNA018185525A patent/CN1473148A/zh active Pending
- 2001-09-07 US US10/362,290 patent/US20040152785A1/en not_active Abandoned
- 2001-09-07 MX MXPA03001985A patent/MXPA03001985A/es not_active Application Discontinuation
- 2001-09-07 AU AU2001284477A patent/AU2001284477A1/en not_active Abandoned
- 2001-09-07 BR BR0113760-3A patent/BR0113760A/pt not_active Application Discontinuation
-
2003
- 2003-03-05 NO NO20031030A patent/NO20031030L/no not_active Application Discontinuation
- 2003-03-06 ZA ZA200301869A patent/ZA200301869B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0302928A3 (en) | 2005-03-29 |
| HUP0302928A2 (hu) | 2003-12-29 |
| PL361702A1 (en) | 2004-10-04 |
| CZ2003636A3 (cs) | 2003-08-13 |
| NO20031030L (no) | 2003-05-08 |
| MXPA03001985A (es) | 2003-09-05 |
| NO20031030D0 (no) | 2003-03-05 |
| KR20030059125A (ko) | 2003-07-07 |
| CA2419744A1 (en) | 2003-02-26 |
| CN1473148A (zh) | 2004-02-04 |
| US20040152785A1 (en) | 2004-08-05 |
| EP1316547A1 (en) | 2003-06-04 |
| RU2003106391A (ru) | 2004-07-27 |
| WO2002020467A1 (fr) | 2002-03-14 |
| EP1316547A4 (en) | 2005-10-12 |
| IL154625A0 (en) | 2003-09-17 |
| BR0113760A (pt) | 2003-07-15 |
| AU2001284477A1 (en) | 2002-03-22 |
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