ZA200301757B - New process for the production of oxabispidines. - Google Patents

New process for the production of oxabispidines. Download PDF

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Publication number
ZA200301757B
ZA200301757B ZA200301757A ZA200301757A ZA200301757B ZA 200301757 B ZA200301757 B ZA 200301757B ZA 200301757 A ZA200301757 A ZA 200301757A ZA 200301757 A ZA200301757 A ZA 200301757A ZA 200301757 B ZA200301757 B ZA 200301757B
Authority
ZA
South Africa
Prior art keywords
alkyl
compound
formula
aryl
alkylene
Prior art date
Application number
ZA200301757A
Other languages
English (en)
Inventor
John Pavey
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of ZA200301757B publication Critical patent/ZA200301757B/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08Bridged systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
ZA200301757A 2000-10-02 2003-03-03 New process for the production of oxabispidines. ZA200301757B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PH12000002701 2000-10-02

Publications (1)

Publication Number Publication Date
ZA200301757B true ZA200301757B (en) 2004-02-05

Family

ID=52573779

Family Applications (2)

Application Number Title Priority Date Filing Date
ZA200301757A ZA200301757B (en) 2000-10-02 2003-03-03 New process for the production of oxabispidines.
ZA200302202A ZA200302202B (en) 2000-10-02 2003-03-18 New oxabispidine compound useful in the treatment of cardiac arrhythmias.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ZA200302202A ZA200302202B (en) 2000-10-02 2003-03-18 New oxabispidine compound useful in the treatment of cardiac arrhythmias.

Country Status (22)

Country Link
US (5) US6936712B1 (ko)
EP (3) EP1330461A1 (ko)
JP (2) JP2004510775A (ko)
KR (2) KR100812920B1 (ko)
CN (3) CN1793146A (ko)
AR (1) AR030756A1 (ko)
AU (3) AU2001292504B2 (ko)
BR (2) BR0114367A (ko)
CA (2) CA2422810A1 (ko)
CZ (1) CZ294217B6 (ko)
EE (1) EE200300131A (ko)
HU (1) HUP0302288A3 (ko)
IL (3) IL154803A0 (ko)
IS (1) IS6744A (ko)
MX (2) MXPA03002759A (ko)
NO (2) NO20031413L (ko)
NZ (2) NZ524573A (ko)
PL (1) PL364047A1 (ko)
RU (1) RU2003107668A (ko)
SK (1) SK3862003A3 (ko)
WO (2) WO2002028864A1 (ko)
ZA (2) ZA200301757B (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9903759D0 (sv) * 1999-10-18 1999-10-18 Astra Ab Pharmaceutically active compounds
GB0223712D0 (en) * 2002-10-14 2002-11-20 Astrazeneca Ab Chemical intermediate
SE0401539D0 (sv) * 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
SE0401540D0 (sv) * 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
CN101243093A (zh) 2005-06-13 2008-08-13 阿斯利康(瑞典)有限公司 用于治疗心律不齐的新型氧杂双哌啶化合物
WO2006137772A1 (en) * 2005-06-20 2006-12-28 Astrazeneca Ab New physical form of n,n´- disubstituted oxabispidines
MX2007016496A (es) * 2005-06-20 2008-03-06 Astrazeneca Ab Proceso para la preparacion de oxabispidinas n-n' -disustituidas.
US20080200673A1 (en) * 2005-06-20 2008-08-21 Astrazeneca Ab Process for The Preparation of Sulfonic Acid Salts of Oxabispidines
BRPI0611842A2 (pt) * 2005-06-20 2016-08-30 Astrazeneca Ab "processo para a preparação de um composto"
CN103319423B (zh) * 2013-06-28 2015-10-28 江苏师范大学 一种3,7-双芳基-1,5-二氧-3,7-二氮杂环辛烷的合成方法
KR20150082070A (ko) 2014-01-06 2015-07-15 (주)신비넷 위치 인식 시스템 및 그 시스템에서의 위치 인식을 위한 장치 및 방법
EP3059229A1 (en) 2015-02-17 2016-08-24 Evonik Degussa GmbH Method for the epoxidation of an olefin with hydrogen peroxide
CN115054728B (zh) * 2022-07-18 2023-11-07 中国科学院大学宁波华美医院 一种仿生骨组织工程支架材料及其制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3503939A (en) * 1967-03-29 1970-03-31 Du Pont Polyamides from heterocyclic diamines
DE2428792A1 (de) * 1974-06-14 1976-01-02 Knoll Ag Neue antiarrhythmika
DE3112055A1 (de) * 1981-03-27 1982-10-07 Basf Ag, 6700 Ludwigshafen Bispidinderivate, ihre herstellung und diese enthaltende arzneimittel
DE3234697A1 (de) * 1982-09-18 1984-03-22 Kali-Chemie Pharma Gmbh, 3000 Hannover Neue diazabicyclo-(3,3,1)-nonane
DE3732094A1 (de) * 1987-09-24 1989-04-06 Basf Ag Bispidinderivate als klasse iii-antiarrhythmika
DE3902357A1 (de) 1989-01-27 1990-08-02 Hoechst Ag Verwendung von rheniumorganischen verbindungen zur oxidation von c-c-mehrfachbindungen, darauf basierende oxidationsverfahren und neue rheniumorganische verbindungen
US5140033A (en) * 1989-04-03 1992-08-18 Bayer Aktiengesellschaft Antibacterial 5-alkylquinolonecarboxylic acids
US5110933A (en) 1989-11-13 1992-05-05 Board Of Regents Of Oklahoma State University Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof
US5468858A (en) * 1993-10-28 1995-11-21 The Board Of Regents Of Oklahoma State University Physical Sciences N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents
US5831099A (en) * 1995-03-10 1998-11-03 The United States Of America As Represented By The Secretary Of The Army Compounds of 1,5-disubstituted-3,7 diaza bicyclo 3.3.0! octanes and products containing the same
US5939568A (en) 1997-01-31 1999-08-17 The Scripps Research Institute Accelerated catalysis of olefinic epoxidations
SE9704709D0 (sv) * 1997-12-17 1997-12-17 Astra Ab Pharmaceutically active compounds
BR0009651A (pt) * 1999-04-09 2002-01-08 Astrazeneca Ab Composto, processo para a preparação de um composto, composição farmacêutica, uso de um composto, e, método para tratar artrite reumatóide e uma doença obstrutiva das vias aéreas
AUPQ274199A0 (en) 1999-09-09 1999-09-30 Ericsson Australia Pty Ltd Information transmission rate control across a core network
SE9903759D0 (sv) * 1999-10-18 1999-10-18 Astra Ab Pharmaceutically active compounds
GB0223712D0 (en) * 2002-10-14 2002-11-20 Astrazeneca Ab Chemical intermediate

Also Published As

Publication number Publication date
JP2004510776A (ja) 2004-04-08
US20090036675A1 (en) 2009-02-05
KR100812920B1 (ko) 2008-03-11
NO20031413L (no) 2003-05-22
IL154803A (en) 2008-03-20
NZ524573A (en) 2004-11-26
US7439355B2 (en) 2008-10-21
CA2421776A1 (en) 2002-04-11
MXPA03002759A (es) 2003-07-28
NO20031413D0 (no) 2003-03-27
CN1468244A (zh) 2004-01-14
RU2003107668A (ru) 2004-11-27
EP1330462A1 (en) 2003-07-30
EP1900741A8 (en) 2010-08-04
WO2002028863A8 (en) 2003-06-05
IL154803A0 (en) 2003-10-31
AU9250401A (en) 2002-04-15
US6936712B1 (en) 2005-08-30
HUP0302288A3 (en) 2004-11-29
NZ524574A (en) 2004-11-26
NO20031414D0 (no) 2003-03-27
IL154802A0 (en) 2003-10-31
AR030756A1 (es) 2003-09-03
BR0114366A (pt) 2003-08-12
CZ2003923A3 (cs) 2003-08-13
PL364047A1 (en) 2004-12-13
WO2002028864A1 (en) 2002-04-11
CZ294217B6 (cs) 2004-10-13
CN1468245A (zh) 2004-01-14
CN1243754C (zh) 2006-03-01
JP4248873B2 (ja) 2009-04-02
AU2001292503A1 (en) 2002-04-15
IS6744A (is) 2003-03-13
SK3862003A3 (en) 2003-10-07
EP1330461A1 (en) 2003-07-30
EP1900741A1 (en) 2008-03-19
WO2002028863A1 (en) 2002-04-11
US20090240051A1 (en) 2009-09-24
US20040039199A1 (en) 2004-02-26
MXPA03002679A (es) 2003-06-24
JP2004510775A (ja) 2004-04-08
HUP0302288A2 (hu) 2003-10-28
ZA200302202B (en) 2004-06-28
KR20030032061A (ko) 2003-04-23
NO20031414L (no) 2003-05-26
US20050171100A1 (en) 2005-08-04
CN1793146A (zh) 2006-06-28
CA2422810A1 (en) 2002-04-11
KR20030032060A (ko) 2003-04-23
AU2001292504B2 (en) 2006-09-07
EE200300131A (et) 2003-06-16
BR0114367A (pt) 2003-12-09

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