ZA200300170B - Pyrrolidine derivatives as metalloprotease inhibitors. - Google Patents
Pyrrolidine derivatives as metalloprotease inhibitors. Download PDFInfo
- Publication number
- ZA200300170B ZA200300170B ZA200300170A ZA200300170A ZA200300170B ZA 200300170 B ZA200300170 B ZA 200300170B ZA 200300170 A ZA200300170 A ZA 200300170A ZA 200300170 A ZA200300170 A ZA 200300170A ZA 200300170 B ZA200300170 B ZA 200300170B
- Authority
- ZA
- South Africa
- Prior art keywords
- pyrrolidine
- mercapto
- carboxylic acid
- alkyl
- compounds according
- Prior art date
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- 239000003475 metalloproteinase inhibitor Substances 0.000 title description 2
- 150000003235 pyrrolidines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 87
- 125000000217 alkyl group Chemical group 0.000 claims description 68
- -1 diarylalkyl Chemical group 0.000 claims description 63
- 125000003118 aryl group Chemical group 0.000 claims description 57
- 229910052739 hydrogen Inorganic materials 0.000 claims description 41
- 239000001257 hydrogen Substances 0.000 claims description 41
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 38
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 22
- 125000004181 carboxyalkyl group Chemical group 0.000 claims description 18
- 238000006243 chemical reaction Methods 0.000 claims description 17
- 201000010099 disease Diseases 0.000 claims description 17
- 125000001072 heteroaryl group Chemical group 0.000 claims description 17
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims description 17
- 150000002431 hydrogen Chemical group 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 17
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 15
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims description 14
- 125000005129 aryl carbonyl group Chemical group 0.000 claims description 14
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 14
- 125000001188 haloalkyl group Chemical group 0.000 claims description 14
- 125000000623 heterocyclic group Chemical group 0.000 claims description 14
- 238000011282 treatment Methods 0.000 claims description 14
- 125000003545 alkoxy group Chemical group 0.000 claims description 13
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D207/48—Sulfur atoms
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- C—CHEMISTRY; METALLURGY
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
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Applications Claiming Priority (1)
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| EP00114949 | 2000-07-19 |
Publications (1)
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| US7405234B2 (en) * | 2002-05-17 | 2008-07-29 | Bristol-Myers Squibb Company | Bicyclic modulators of androgen receptor function |
| MXPA05003715A (es) | 2002-10-07 | 2005-09-30 | Univ California | Modulacion de ansiedad a traves de bloqueo de hidrolisis de anandamida. |
| US7388027B2 (en) * | 2004-03-04 | 2008-06-17 | Bristol-Myers Squibb Company | Bicyclic compounds as modulators of androgen receptor function and method |
| CN101376656A (zh) * | 2007-08-30 | 2009-03-04 | 山东轩竹医药科技有限公司 | 培南衍生物 |
| EP2234608A2 (en) | 2007-12-11 | 2010-10-06 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitors using metal binding moieties in combination with targeting moieties |
| US8404866B2 (en) * | 2008-09-03 | 2013-03-26 | Florida State University Research Foundation | Substituted heterocyclic mercaptosulfonamide metalloprotease inhibitors |
| TWI759267B (zh) | 2015-07-02 | 2022-04-01 | 美商地平線罕見醫學製藥有限責任公司 | Ａｄｏ抗性半胱胺類似物及其用途 |
| EP3740466B1 (en) * | 2018-01-17 | 2024-03-06 | Migal Galilee Research Institute Ltd. | New methionine metabolic pathway inhibitors |
| CN111825582B (zh) * | 2020-08-12 | 2022-04-08 | 江西理工大学 | 一种以芳基磺酰氯为硫源合成β-硫代羰基化合物的方法 |
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| DE3579888D1 (de) * | 1984-11-08 | 1990-10-31 | Sumitomo Pharma | Carbapenemverbindungen und deren herstellung. |
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| HUP9902316A3 (en) * | 1996-02-13 | 2001-12-28 | Abbott Lab | 4-(benzo-1,3-dioxolyl)-pyrrolidine-3-carboxylic acid derivatives as endothelin antagonists and pharmaceutical compositions containing them |
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| KR20030024792A (ko) | 2003-03-26 |
| CA2415740A1 (en) | 2002-01-31 |
| US20030199569A1 (en) | 2003-10-23 |
| CN100406439C (zh) | 2008-07-30 |
| JP3983663B2 (ja) | 2007-09-26 |
| AU2001278479B2 (en) | 2007-06-21 |
| US20020040146A1 (en) | 2002-04-04 |
| MXPA03000368A (es) | 2004-09-13 |
| BR0112655A (pt) | 2003-06-24 |
| WO2002008185A1 (en) | 2002-01-31 |
| AR037990A1 (es) | 2004-12-22 |
| KR100613196B1 (ko) | 2006-08-18 |
| PE20020333A1 (es) | 2002-05-10 |
| EP1303486A1 (en) | 2003-04-23 |
| JP2004504379A (ja) | 2004-02-12 |
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