ZA200201760B - Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as D4 antagnosists. - Google Patents
Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as D4 antagnosists. Download PDFInfo
- Publication number
- ZA200201760B ZA200201760B ZA200201760A ZA200201760A ZA200201760B ZA 200201760 B ZA200201760 B ZA 200201760B ZA 200201760 A ZA200201760 A ZA 200201760A ZA 200201760 A ZA200201760 A ZA 200201760A ZA 200201760 B ZA200201760 B ZA 200201760B
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- South Africa
- Prior art keywords
- compound
- thieno
- phenoxy
- amine
- substance
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 title 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 154
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims description 70
- 239000000126 substance Substances 0.000 claims description 54
- -1 1,2,3,4-tetrahydronaphthyl Chemical group 0.000 claims description 45
- 238000000034 method Methods 0.000 claims description 41
- 229960003638 dopamine Drugs 0.000 claims description 35
- 125000000217 alkyl group Chemical group 0.000 claims description 26
- 239000003814 drug Substances 0.000 claims description 26
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 26
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- 125000003545 alkoxy group Chemical group 0.000 claims description 18
- 125000004076 pyridyl group Chemical group 0.000 claims description 18
- 229910052757 nitrogen Inorganic materials 0.000 claims description 15
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- 125000004604 benzisothiazolyl group Chemical group S1N=C(C2=C1C=CC=C2)* 0.000 claims description 6
- 125000004603 benzisoxazolyl group Chemical group O1N=C(C2=C1C=CC=C2)* 0.000 claims description 6
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- ZTDXYBZRQGLMPI-UHFFFAOYSA-N 3-[3-[3-(4-phenylpiperazin-1-yl)propoxy]phenyl]thieno[2,3-d][1,2]oxazole Chemical compound C=1C=CC(C=2C=3SC=CC=3ON=2)=CC=1OCCCN(CC1)CCN1C1=CC=CC=C1 ZTDXYBZRQGLMPI-UHFFFAOYSA-N 0.000 claims 1
- QZTPDKPNAHXFLH-UHFFFAOYSA-N 3-[3-[3-(4-pyrimidin-2-ylpiperazin-1-yl)propoxy]phenyl]thieno[2,3-d][1,2]oxazole Chemical compound C=1C=CC(C=2C=3SC=CC=3ON=2)=CC=1OCCCN(CC1)CCN1C1=NC=CC=N1 QZTPDKPNAHXFLH-UHFFFAOYSA-N 0.000 claims 1
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- QARVLSVVCXYDNA-UHFFFAOYSA-N bromobenzene Chemical group BrC1=CC=CC=C1 QARVLSVVCXYDNA-UHFFFAOYSA-N 0.000 description 1
- 125000003865 brosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1Br)S(*)(=O)=O 0.000 description 1
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- 201000011510 cancer Diseases 0.000 description 1
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- UWYVPFMHMJIBHE-OWOJBTEDSA-N hydroxymaleic acid group Chemical group O/C(/C(=O)O)=C/C(=O)O UWYVPFMHMJIBHE-OWOJBTEDSA-N 0.000 description 1
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- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
- 229960001252 methamphetamine Drugs 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 description 1
- 230000002969 morbid Effects 0.000 description 1
- 230000003551 muscarinic effect Effects 0.000 description 1
- PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical compound C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 description 1
- 208000015238 neurotic disease Diseases 0.000 description 1
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- 125000001736 nosyl group Chemical group S(=O)(=O)(C1=CC=C([N+](=O)[O-])C=C1)* 0.000 description 1
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- 230000001766 physiological effect Effects 0.000 description 1
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- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39615699A | 1999-09-14 | 1999-09-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200201760B true ZA200201760B (en) | 2003-08-27 |
Family
ID=23566087
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200201760A ZA200201760B (en) | 1999-09-14 | 2002-03-01 | Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as D4 antagnosists. |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP1216249B1 (xx) |
| JP (1) | JP4717306B2 (xx) |
| KR (1) | KR20020027644A (xx) |
| AR (1) | AR032135A1 (xx) |
| AT (1) | ATE254620T1 (xx) |
| AU (1) | AU7577200A (xx) |
| BR (1) | BR0014513A (xx) |
| CA (1) | CA2383327C (xx) |
| CZ (1) | CZ2002896A3 (xx) |
| DE (1) | DE60006698T2 (xx) |
| DK (1) | DK1216249T3 (xx) |
| EA (1) | EA004177B1 (xx) |
| EE (1) | EE200200133A (xx) |
| ES (1) | ES2206305T3 (xx) |
| HU (1) | HUP0202712A3 (xx) |
| IL (1) | IL148522A0 (xx) |
| MX (1) | MXPA02002690A (xx) |
| NO (1) | NO20021249L (xx) |
| PL (1) | PL354481A1 (xx) |
| PT (1) | PT1216249E (xx) |
| SK (1) | SK3502002A3 (xx) |
| WO (1) | WO2001019832A2 (xx) |
| ZA (1) | ZA200201760B (xx) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0207449D0 (en) * | 2002-03-28 | 2002-05-08 | Glaxo Group Ltd | Novel compounds |
| WO2018166855A1 (en) | 2017-03-16 | 2018-09-20 | Basf Se | Heterobicyclic substituted dihydroisoxazoles |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4728651A (en) * | 1985-10-24 | 1988-03-01 | Hoechst-Roussel Pharmaceuticals Inc. | Antihypertensive thieno-isoxazoles and -pyrazoles |
| US6187774B1 (en) * | 1996-03-04 | 2001-02-13 | Yoshitomi Pharmaceutical Industries, Ltd. | Fused heterocyclic compounds and pharmaceutical applications thereof |
| HUP9603001A3 (en) * | 1996-10-30 | 1999-07-28 | Richter Gedeon Vegyeszet | Heterocycle compounds comprising nitrogen, process for producing them and pharmaceutical compositions containing the same |
| US6335326B1 (en) * | 1998-02-09 | 2002-01-01 | Duphar International Research B.V. | Benzisoxazole derivatives having d4-antagonistic activity |
-
2000
- 2000-09-13 CA CA002383327A patent/CA2383327C/en not_active Expired - Fee Related
- 2000-09-13 CZ CZ2002896A patent/CZ2002896A3/cs unknown
- 2000-09-13 JP JP2001523409A patent/JP4717306B2/ja not_active Expired - Fee Related
- 2000-09-13 PT PT00964967T patent/PT1216249E/pt unknown
- 2000-09-13 BR BR0014513-0A patent/BR0014513A/pt not_active IP Right Cessation
- 2000-09-13 WO PCT/US2000/024949 patent/WO2001019832A2/en not_active Application Discontinuation
- 2000-09-13 KR KR1020027003354A patent/KR20020027644A/ko not_active Application Discontinuation
- 2000-09-13 IL IL14852200A patent/IL148522A0/xx unknown
- 2000-09-13 SK SK350-2002A patent/SK3502002A3/sk unknown
- 2000-09-13 EP EP00964967A patent/EP1216249B1/en not_active Expired - Lifetime
- 2000-09-13 DE DE60006698T patent/DE60006698T2/de not_active Expired - Lifetime
- 2000-09-13 HU HU0202712A patent/HUP0202712A3/hu unknown
- 2000-09-13 AT AT00964967T patent/ATE254620T1/de not_active IP Right Cessation
- 2000-09-13 EE EEP200200133A patent/EE200200133A/xx unknown
- 2000-09-13 EA EA200200357A patent/EA004177B1/ru not_active IP Right Cessation
- 2000-09-13 DK DK00964967T patent/DK1216249T3/da active
- 2000-09-13 PL PL00354481A patent/PL354481A1/xx unknown
- 2000-09-13 AR ARP000104794A patent/AR032135A1/es not_active Application Discontinuation
- 2000-09-13 MX MXPA02002690A patent/MXPA02002690A/es active IP Right Grant
- 2000-09-13 ES ES00964967T patent/ES2206305T3/es not_active Expired - Lifetime
- 2000-09-13 AU AU75772/00A patent/AU7577200A/en not_active Abandoned
-
2002
- 2002-03-01 ZA ZA200201760A patent/ZA200201760B/en unknown
- 2002-03-13 NO NO20021249A patent/NO20021249L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IL148522A0 (en) | 2002-09-12 |
| NO20021249L (no) | 2002-05-10 |
| EP1216249B1 (en) | 2003-11-19 |
| CZ2002896A3 (cs) | 2002-08-14 |
| PL354481A1 (en) | 2004-01-26 |
| EE200200133A (et) | 2003-04-15 |
| MXPA02002690A (es) | 2004-09-10 |
| HUP0202712A3 (en) | 2004-12-28 |
| PT1216249E (pt) | 2004-04-30 |
| DE60006698T2 (de) | 2004-09-23 |
| SK3502002A3 (en) | 2002-09-10 |
| ATE254620T1 (de) | 2003-12-15 |
| AR032135A1 (es) | 2003-10-29 |
| AU7577200A (en) | 2001-04-17 |
| EA200200357A1 (ru) | 2002-10-31 |
| NO20021249D0 (no) | 2002-03-13 |
| EP1216249A2 (en) | 2002-06-26 |
| DK1216249T3 (da) | 2004-03-15 |
| KR20020027644A (ko) | 2002-04-13 |
| BR0014513A (pt) | 2002-07-02 |
| DE60006698D1 (de) | 2003-12-24 |
| WO2001019832A2 (en) | 2001-03-22 |
| JP2003509431A (ja) | 2003-03-11 |
| ES2206305T3 (es) | 2004-05-16 |
| EA004177B1 (ru) | 2004-02-26 |
| CA2383327C (en) | 2009-11-03 |
| HUP0202712A2 (hu) | 2002-12-28 |
| WO2001019832A3 (en) | 2001-10-04 |
| JP4717306B2 (ja) | 2011-07-06 |
| CA2383327A1 (en) | 2001-03-22 |
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