ZA200108951B - Method for producing recombinant insulin from fusion proteins. - Google Patents
Method for producing recombinant insulin from fusion proteins. Download PDFInfo
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- ZA200108951B ZA200108951B ZA200108951A ZA200108951A ZA200108951B ZA 200108951 B ZA200108951 B ZA 200108951B ZA 200108951 A ZA200108951 A ZA 200108951A ZA 200108951 A ZA200108951 A ZA 200108951A ZA 200108951 B ZA200108951 B ZA 200108951B
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- South Africa
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- dna
- amino acid
- chain
- insulin
- acid sequence
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12487799A JP3406244B2 (ja) | 1999-04-30 | 1999-04-30 | 新規な融合蛋白質からの組み換えインスリンの製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200108951B true ZA200108951B (en) | 2002-10-30 |
Family
ID=14896314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200108951A ZA200108951B (en) | 1999-04-30 | 2001-10-30 | Method for producing recombinant insulin from fusion proteins. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6841361B1 (ru) |
| EP (1) | EP1179593B1 (ru) |
| JP (1) | JP3406244B2 (ru) |
| KR (1) | KR100659671B1 (ru) |
| CN (1) | CN1213146C (ru) |
| AT (1) | ATE381619T1 (ru) |
| AU (1) | AU775471B2 (ru) |
| CA (1) | CA2372221A1 (ru) |
| DE (1) | DE60037508T2 (ru) |
| DK (1) | DK1179593T3 (ru) |
| EA (1) | EA005586B1 (ru) |
| HK (1) | HK1042113A1 (ru) |
| WO (1) | WO2000066738A1 (ru) |
| ZA (1) | ZA200108951B (ru) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001068884A1 (fr) * | 2000-03-14 | 2001-09-20 | Itoham Foods Inc. | Procede de preparation d'un polypeptide comprenant une liaison disulfure |
| US7312192B2 (en) * | 2001-09-07 | 2007-12-25 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
| US7795384B2 (en) * | 2003-06-03 | 2010-09-14 | Shanghai Centre Of Research & Development Of New Drugs | Fusion protein suitable for high efficiency expression and the production method thereof |
| KR101269540B1 (ko) * | 2005-10-13 | 2013-05-30 | 바이오콘 리미티드 | 인슐린 접합체의 제조를 위한 방법 |
| WO2009101672A1 (ja) * | 2008-02-12 | 2009-08-20 | Itoham Foods Inc. | 高発現分泌インスリン前駆体を含む融合タンパク質、それをコードするｄｎａおよびインスリンの製造方法 |
| WO2013062029A1 (ja) | 2011-10-25 | 2013-05-02 | 味の素株式会社 | タンパク質の分泌生産法 |
| KR102646845B1 (ko) * | 2018-08-08 | 2024-03-14 | 주식회사 대웅제약 | 클로스트리파인을 이용한 지속형 인슐린 아날로그 복합체의 활성형 제조방법 |
| KR102666154B1 (ko) | 2018-08-08 | 2024-05-20 | 주식회사 대웅제약 | 지속형 인슐린 아날로그 및 그 복합체 |
| CN113773392B (zh) * | 2020-06-09 | 2023-04-07 | 宁波鲲鹏生物科技有限公司 | 一种甘精胰岛素的制备方法 |
| CN113773400B (zh) * | 2020-06-09 | 2023-08-18 | 宁波鲲鹏生物科技有限公司 | 一种门冬胰岛素衍生物及其应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4431740A (en) * | 1979-09-12 | 1984-02-14 | The Regents Of The University Of California | DNA Transfer vector and transformed microorganism containing human proinsulin and pre-proinsulin genes |
| PL128599B1 (en) | 1980-03-27 | 1984-02-29 | Lilly Co Eli | Insulin obtaining method |
| NZ199391A (en) | 1981-01-02 | 1985-12-13 | Genentech Inc | Chimeric polypeptides comprising a proinsulin sequence,and preparation by recombinant dna technique;production of human insulin |
| JPH07108224B2 (ja) | 1985-11-07 | 1995-11-22 | 重三 鵜高 | バチルス・ブレビスを用いる遺伝子の発現方法 |
| JPS6387980A (ja) * | 1986-09-30 | 1988-04-19 | Shikishima Boseki Kk | プラスミドベクタ−、菌株、及びそれを用いてペプシノ−ゲンを生産する方法 |
| US5426036A (en) * | 1987-05-05 | 1995-06-20 | Hoechst Aktiengesellschaft | Processes for the preparation of foreign proteins in streptomycetes |
| DE3936876A1 (de) | 1989-11-06 | 1991-05-23 | Hoechst Ag | Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
| JPH04126084A (ja) | 1990-05-11 | 1992-04-27 | Hoechst Japan Ltd | 蛋白質の製造法 |
| US5378613A (en) * | 1991-09-24 | 1995-01-03 | Eli Lilly And Company | Method for increased expression of low molecular weight recombinant polypeptides |
| ES2097426T3 (es) * | 1992-12-02 | 1997-04-01 | Hoechst Ag | Procedimiento para la obtencion de proinsulina con puentes de cistina correctamente unidos. |
| JP3164181B2 (ja) * | 1993-03-01 | 2001-05-08 | ヒゲタ醤油株式会社 | 新規発現ベクタ−、該発現ベクタ−を保有する微生物、該微生物を用いる有用物質の製造法 |
| US6001604A (en) * | 1993-12-29 | 1999-12-14 | Bio-Technology General Corp. | Refolding of proinsulins without addition of reducing agents |
| DE4405179A1 (de) | 1994-02-18 | 1995-08-24 | Hoechst Ag | Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken |
| HRP940432B1 (en) | 1994-08-05 | 2003-10-31 | Pliva Pharm & Chem Works | Dna sequences encoding biosynthetic insulin precursors and process for preparation of insulin |
| WO1996020724A1 (en) | 1994-12-29 | 1996-07-11 | Bio-Technology General Corp. | Generation of human insulin |
| KR0150565B1 (ko) * | 1995-02-15 | 1998-08-17 | 김정재 | 유전자 조환에 의한 사람 인슐린 전구체의 제조 및 이를 이용한 인슐린의 제조방법 |
| FR2732978B1 (fr) | 1995-04-14 | 1997-05-30 | Inst Nat Sante Rech Med | Vecteur viral recombinant, composition pharmaceutique le contenant et cellules transformees correspondantes |
| GB9513967D0 (en) * | 1995-07-08 | 1995-09-06 | Univ Leicester | Insulin |
| JP3313083B2 (ja) | 1998-03-31 | 2002-08-12 | 伊藤ハム株式会社 | 新規な融合蛋白質をコ―ドするｄｎａおよびその発現を介する有用ポリペプチドの製造方法 |
-
1999
- 1999-04-30 JP JP12487799A patent/JP3406244B2/ja not_active Expired - Fee Related
-
2000
- 2000-04-26 AU AU41425/00A patent/AU775471B2/en not_active Ceased
- 2000-04-26 CA CA002372221A patent/CA2372221A1/en not_active Abandoned
- 2000-04-26 EP EP00921035A patent/EP1179593B1/en not_active Expired - Lifetime
- 2000-04-26 CN CNB008069344A patent/CN1213146C/zh not_active Expired - Fee Related
- 2000-04-26 US US09/959,548 patent/US6841361B1/en not_active Expired - Fee Related
- 2000-04-26 EA EA200101161A patent/EA005586B1/ru not_active IP Right Cessation
- 2000-04-26 DE DE60037508T patent/DE60037508T2/de not_active Expired - Fee Related
- 2000-04-26 DK DK00921035T patent/DK1179593T3/da active
- 2000-04-26 WO PCT/JP2000/002736 patent/WO2000066738A1/ja active IP Right Grant
- 2000-04-26 KR KR1020017013921A patent/KR100659671B1/ko not_active IP Right Cessation
- 2000-04-26 AT AT00921035T patent/ATE381619T1/de not_active IP Right Cessation
-
2001
- 2001-10-30 ZA ZA200108951A patent/ZA200108951B/en unknown
-
2002
- 2002-04-27 HK HK02103154.4A patent/HK1042113A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP3406244B2 (ja) | 2003-05-12 |
| KR100659671B1 (ko) | 2006-12-21 |
| EP1179593A4 (en) | 2003-04-16 |
| US6841361B1 (en) | 2005-01-11 |
| JP2000316579A (ja) | 2000-11-21 |
| DK1179593T3 (da) | 2008-04-28 |
| AU4142500A (en) | 2000-11-17 |
| DE60037508D1 (de) | 2008-01-31 |
| EP1179593A1 (en) | 2002-02-13 |
| EA200101161A1 (ru) | 2002-06-27 |
| DE60037508T2 (de) | 2008-12-11 |
| EA005586B1 (ru) | 2005-04-28 |
| CN1213146C (zh) | 2005-08-03 |
| WO2000066738A1 (fr) | 2000-11-09 |
| AU775471B2 (en) | 2004-08-05 |
| EP1179593B1 (en) | 2007-12-19 |
| CA2372221A1 (en) | 2000-11-09 |
| ATE381619T1 (de) | 2008-01-15 |
| CN1350584A (zh) | 2002-05-22 |
| KR20020018192A (ko) | 2002-03-07 |
| HK1042113A1 (zh) | 2002-08-02 |
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