ZA200103485B - N-Arylsulfonyl amino acid omega amides. - Google Patents
N-Arylsulfonyl amino acid omega amides. Download PDFInfo
- Publication number
- ZA200103485B ZA200103485B ZA200103485A ZA200103485A ZA200103485B ZA 200103485 B ZA200103485 B ZA 200103485B ZA 200103485 A ZA200103485 A ZA 200103485A ZA 200103485 A ZA200103485 A ZA 200103485A ZA 200103485 B ZA200103485 B ZA 200103485B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- formula
- hydrogen atom
- compound
- sulfonylamino
- Prior art date
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- 150000001408 amides Chemical class 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims description 53
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 37
- 150000003254 radicals Chemical class 0.000 claims description 25
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 20
- -1 2-(4- chlorobiphenyl-4-sulfonylamino)-5-(2,3-dihydroindol-1-yl)-5- oxopentanoic acid Chemical compound 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 18
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims description 15
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims description 14
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 14
- 150000003839 salts Chemical class 0.000 claims description 14
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 12
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 11
- 239000002253 acid Substances 0.000 claims description 11
- 125000006239 protecting group Chemical group 0.000 claims description 11
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims description 10
- 238000006243 chemical reaction Methods 0.000 claims description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 10
- 208000035475 disorder Diseases 0.000 claims description 10
- 229910052757 nitrogen Inorganic materials 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 9
- 150000003458 sulfonic acid derivatives Chemical class 0.000 claims description 9
- 125000003277 amino group Chemical group 0.000 claims description 8
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical class CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims description 7
- 150000007513 acids Chemical class 0.000 claims description 7
- 125000004432 carbon atom Chemical group C* 0.000 claims description 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 7
- 229910052717 sulfur Inorganic materials 0.000 claims description 7
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims description 6
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 6
- 150000001413 amino acids Chemical class 0.000 claims description 6
- 230000015572 biosynthetic process Effects 0.000 claims description 6
- 229910052799 carbon Inorganic materials 0.000 claims description 6
- 125000004122 cyclic group Chemical group 0.000 claims description 6
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 6
- 125000004434 sulfur atom Chemical group 0.000 claims description 6
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 5
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- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 5
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 5
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- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 5
- 229910052794 bromium Inorganic materials 0.000 claims description 5
- 239000000460 chlorine Substances 0.000 claims description 5
- 229910052801 chlorine Inorganic materials 0.000 claims description 5
- 229910052731 fluorine Inorganic materials 0.000 claims description 5
- 239000011737 fluorine Substances 0.000 claims description 5
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- 150000002367 halogens Chemical class 0.000 claims description 5
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 5
- BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical compound C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 claims description 5
- 238000011282 treatment Methods 0.000 claims description 5
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical compound C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 claims description 4
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- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims description 4
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- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical compound NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 claims description 3
- WRYCSMQKUKOKBP-UHFFFAOYSA-N Imidazolidine Chemical compound C1CNCN1 WRYCSMQKUKOKBP-UHFFFAOYSA-N 0.000 claims description 3
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- XYOVOXDWRFGKEX-UHFFFAOYSA-N azepine Chemical compound N1C=CC=CC=C1 XYOVOXDWRFGKEX-UHFFFAOYSA-N 0.000 claims description 3
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- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 3
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- USPWKWBDZOARPV-UHFFFAOYSA-N pyrazolidine Chemical compound C1CNNC1 USPWKWBDZOARPV-UHFFFAOYSA-N 0.000 claims description 3
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- 239000000126 substance Substances 0.000 claims description 3
- 238000006277 sulfonation reaction Methods 0.000 claims description 3
- 238000002560 therapeutic procedure Methods 0.000 claims description 3
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical class CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 claims description 3
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical class OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims description 3
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 claims description 3
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
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- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
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- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyridine Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19851184A DE19851184A1 (de) | 1998-11-06 | 1998-11-06 | N-Arylsulfonyl-aminosäure-omega-amide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200103485B true ZA200103485B (en) | 2001-12-04 |
Family
ID=7886902
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200103485A ZA200103485B (en) | 1998-11-06 | 2001-04-30 | N-Arylsulfonyl amino acid omega amides. |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US6201130B1 (pt) |
| EP (1) | EP1124797B1 (pt) |
| JP (1) | JP4348014B2 (pt) |
| KR (1) | KR100655632B1 (pt) |
| CN (1) | CN1206213C (pt) |
| AR (1) | AR021086A1 (pt) |
| AT (1) | ATE260889T1 (pt) |
| AU (1) | AU757602B2 (pt) |
| BR (1) | BR9915729A (pt) |
| CA (1) | CA2350031C (pt) |
| CZ (1) | CZ302291B6 (pt) |
| DE (2) | DE19851184A1 (pt) |
| DK (1) | DK1124797T3 (pt) |
| ES (1) | ES2213405T3 (pt) |
| HK (1) | HK1041686B (pt) |
| HU (1) | HUP0104122A3 (pt) |
| ID (1) | ID28810A (pt) |
| PL (1) | PL198827B1 (pt) |
| PT (1) | PT1124797E (pt) |
| RU (1) | RU2228330C2 (pt) |
| TR (1) | TR200101245T2 (pt) |
| WO (1) | WO2000027808A1 (pt) |
| ZA (1) | ZA200103485B (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PA8557501A1 (es) | 2001-11-12 | 2003-06-30 | Pfizer Prod Inc | Benzamida, heteroarilamida y amidas inversas |
| WO2003042190A1 (en) | 2001-11-12 | 2003-05-22 | Pfizer Products Inc. | N-alkyl-adamantyl derivatives as p2x7-receptor antagonists |
| US7071223B1 (en) * | 2002-12-31 | 2006-07-04 | Pfizer, Inc. | Benzamide inhibitors of the P2X7 receptor |
| PA8591801A1 (es) | 2002-12-31 | 2004-07-26 | Pfizer Prod Inc | Inhibidores benzamidicos del receptor p2x7. |
| EP1615886A1 (en) * | 2003-04-15 | 2006-01-18 | Warner-Lambert Company LLC | [c]-fused bicyclic proline derivatives and their use for treating arthritic conditions |
| EP1626962B1 (en) * | 2003-05-12 | 2007-02-28 | Pfizer Products Inc. | Benzamide inhibitors of the p2x7 receptor |
| MXPA06014022A (es) * | 2004-06-29 | 2007-02-08 | Pfizer Prod Inc | Prcedimientos para preparar inhibidores de p2x7. |
| CA2572119A1 (en) * | 2004-06-29 | 2006-01-12 | Warner-Lambert Company Llc | Combination therapies utilizing benzamide inhibitors of the p2x7 receptor |
| MXPA06015273A (es) * | 2004-06-29 | 2007-03-15 | Pfizer Prod Inc | Procedimiento para preparar derivados de 5-[4-(2-hidroxi -etil)-3, 5-dioxo-4, 5-dihidro-3h-[1, 2, 4]-triazin -2-il]-benzamida con actividad inhibidora de p2x7 mediante reaccion del derivado no sustituido en posicion 4 de la triazina con un oxirano en |
| US7576222B2 (en) | 2004-12-28 | 2009-08-18 | Wyeth | Alkynyl-containing tryptophan derivative inhibitors of TACE/matrix metalloproteinase |
| PE20070505A1 (es) | 2005-07-11 | 2007-05-15 | Wyeth Corp | Inhibidores de glutamato de metaloproteinasas de matriz y agrecanasas |
| KR20080058436A (ko) | 2005-10-13 | 2008-06-25 | 와이어쓰 | 글루탐산 유도체의 제조 방법 |
| ES2533065T3 (es) | 2010-07-09 | 2015-04-07 | Pfizer Limited | Bencenosulfonamidas útiles como inhibidores de los canales de sodio |
| CA2900116C (en) * | 2013-02-06 | 2021-08-10 | Merck Patent Gmbh | Substituted carboxylic acid derivatives as aggrecanase inhibitors for the treatment of osteoarthritis |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1063026A1 (ru) * | 1982-05-19 | 1990-12-07 | Институт биохимии АН ЛитССР | N @ -Бензолсульфонильные производные трес-DL-фенилсерина, обладающие противовоспалительной активностью |
| JP2764262B2 (ja) | 1987-08-28 | 1998-06-11 | 持田製薬株式会社 | ヒダントイン誘導体及びそれを有効成分とする医薬組成物 |
| TW201303B (pt) | 1990-07-05 | 1993-03-01 | Hoffmann La Roche | |
| US5455258A (en) * | 1993-01-06 | 1995-10-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
| CN1151157A (zh) | 1994-06-22 | 1997-06-04 | 英国生物技术药物有限公司 | 金属蛋白酶抑制剂 |
| US5863949A (en) * | 1995-03-08 | 1999-01-26 | Pfizer Inc | Arylsulfonylamino hydroxamic acid derivatives |
| EP0837901A1 (en) * | 1995-06-28 | 1998-04-29 | E.I. Du Pont De Nemours And Company | Fluoropolymer nanocomposites |
| KR980009238A (ko) | 1995-07-28 | 1998-04-30 | 우에노 도시오 | 설포닐아미노산 유도체 |
| EP0901466B1 (en) * | 1996-05-17 | 2001-10-31 | Warner-Lambert Company | Biphenylsulfonamide matrix metalloproteinase inhibitors |
| DE19719621A1 (de) * | 1997-05-09 | 1998-11-12 | Hoechst Ag | Sulfonylaminocarbonsäuren |
-
1998
- 1998-11-06 DE DE19851184A patent/DE19851184A1/de not_active Withdrawn
-
1999
- 1999-10-21 JP JP2000580988A patent/JP4348014B2/ja not_active Expired - Fee Related
- 1999-10-21 ES ES99971799T patent/ES2213405T3/es not_active Expired - Lifetime
- 1999-10-21 ID IDW00200100995A patent/ID28810A/id unknown
- 1999-10-21 CA CA2350031A patent/CA2350031C/en not_active Expired - Fee Related
- 1999-10-21 TR TR2001/01245T patent/TR200101245T2/xx unknown
- 1999-10-21 CZ CZ20011506A patent/CZ302291B6/cs not_active IP Right Cessation
- 1999-10-21 WO PCT/EP1999/007979 patent/WO2000027808A1/de active IP Right Grant
- 1999-10-21 BR BR9915729-2A patent/BR9915729A/pt not_active Application Discontinuation
- 1999-10-21 AT AT99971799T patent/ATE260889T1/de active
- 1999-10-21 KR KR1020017005590A patent/KR100655632B1/ko not_active IP Right Cessation
- 1999-10-21 HU HU0104122A patent/HUP0104122A3/hu unknown
- 1999-10-21 EP EP99971799A patent/EP1124797B1/de not_active Expired - Lifetime
- 1999-10-21 CN CNB998129321A patent/CN1206213C/zh not_active Expired - Fee Related
- 1999-10-21 PL PL347574A patent/PL198827B1/pl not_active IP Right Cessation
- 1999-10-21 DE DE59908769T patent/DE59908769D1/de not_active Expired - Lifetime
- 1999-10-21 PT PT99971799T patent/PT1124797E/pt unknown
- 1999-10-21 DK DK99971799T patent/DK1124797T3/da active
- 1999-10-21 AU AU11530/00A patent/AU757602B2/en not_active Ceased
- 1999-10-21 RU RU2001115706/04A patent/RU2228330C2/ru not_active IP Right Cessation
- 1999-11-04 AR ARP990105584A patent/AR021086A1/es active IP Right Grant
- 1999-11-05 US US09/434,107 patent/US6201130B1/en not_active Expired - Lifetime
-
2000
- 2000-12-28 US US09/749,034 patent/US6335333B1/en not_active Expired - Lifetime
-
2001
- 2001-04-30 ZA ZA200103485A patent/ZA200103485B/en unknown
-
2002
- 2002-05-04 HK HK02103391.7A patent/HK1041686B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HK1041686B (zh) | 2005-09-23 |
| DK1124797T3 (da) | 2004-07-05 |
| CN1332724A (zh) | 2002-01-23 |
| KR20010080385A (ko) | 2001-08-22 |
| CA2350031C (en) | 2010-01-26 |
| CA2350031A1 (en) | 2000-05-18 |
| PT1124797E (pt) | 2004-07-30 |
| HK1041686A1 (en) | 2002-07-19 |
| ATE260889T1 (de) | 2004-03-15 |
| DE19851184A1 (de) | 2000-05-11 |
| EP1124797A1 (de) | 2001-08-22 |
| RU2228330C2 (ru) | 2004-05-10 |
| JP4348014B2 (ja) | 2009-10-21 |
| CZ302291B6 (cs) | 2011-02-09 |
| ID28810A (id) | 2001-07-05 |
| AR021086A1 (es) | 2002-06-12 |
| CN1206213C (zh) | 2005-06-15 |
| US6201130B1 (en) | 2001-03-13 |
| HUP0104122A3 (en) | 2002-04-29 |
| HUP0104122A2 (hu) | 2002-03-28 |
| CZ20011506A3 (cs) | 2001-08-15 |
| TR200101245T2 (tr) | 2001-10-22 |
| DE59908769D1 (de) | 2004-04-08 |
| US6335333B1 (en) | 2002-01-01 |
| BR9915729A (pt) | 2001-10-23 |
| KR100655632B1 (ko) | 2006-12-12 |
| JP2002529447A (ja) | 2002-09-10 |
| WO2000027808A1 (de) | 2000-05-18 |
| EP1124797B1 (de) | 2004-03-03 |
| AU1153000A (en) | 2000-05-29 |
| PL347574A1 (en) | 2002-04-08 |
| ES2213405T3 (es) | 2004-08-16 |
| AU757602B2 (en) | 2003-02-27 |
| PL198827B1 (pl) | 2008-07-31 |
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