YU97492A - Novi derivati lupana i postupak za njihovo dobijanje - Google Patents

Novi derivati lupana i postupak za njihovo dobijanje

Info

Publication number
YU97492A
YU97492A YU97492A YU97492A YU97492A YU 97492 A YU97492 A YU 97492A YU 97492 A YU97492 A YU 97492A YU 97492 A YU97492 A YU 97492A YU 97492 A YU97492 A YU 97492A
Authority
YU
Yugoslavia
Prior art keywords
denotes
alkyl
denote
bond
different
Prior art date
Application number
YU97492A
Other languages
English (en)
Inventor
R. Bouboutou
N. Dereu
M. Evers
J.C. Gueguen
C. James
C. Pousade
D. Reisdorf
I. Ribeill
F. Soler
Original Assignee
Rhone-Poulenc Rorer S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone-Poulenc Rorer S.A. filed Critical Rhone-Poulenc Rorer S.A.
Publication of YU97492A publication Critical patent/YU97492A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

novi derivati lupana opšte formule (I): u kojoj R označava: u kojoj su R' i R" identični ili različiti i označavaju H ili alkil, X je veza, karbamoil ili aminokarbonil koji su u datom slučaju supstituisani, Y je veza ili fenilen, RВ° i R°° su identični ili različiti i označavaju H ili alkil ili RВ° označava OH, hidroksialkil, fenil, benzil, karbamoilmetil, ili zajedno sa azotom iz X, kada X označava kar-bomoil, formira heterociklus i Y je veza, i n, m i p su celi brojevi od 0 do 16, pri čemu je 4 m+n+p 16, R1 je metil, R2 je hidroksi, metil, hidroksimetil, -CH2OR'2, -CH2SR'2 ili -CH2NHR'2 ili R2 označava supstituisan amino ili dialkilamino čiji alkil delovi mogu formirati heterociklus, R3 je H ili zajedno sa R1 ili R2 formira metilen ili okso, R4 i R5 su različiti i označavaju H ili hidroksi, ili zajedno formiraju okso, hidroksiimino ili alkiloksiimino koji može biti supstituisan, a R6 i R7 su H, ili R4 i R5, R6 i R7, zajedno formiraju radikale okso, pri čemu su radikali alkil (1 do 4 C-atoma) neračvasti ili račvasti, kao i njihove soli kada ove postoje i njihovo dobivanje. Ovi novi produkti prema pronalasku su naročito značajni u oblasti SIDE.
YU97492A 1991-11-13 1992-11-12 Novi derivati lupana i postupak za njihovo dobijanje YU97492A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9113907A FR2683531B1 (fr) 1991-11-13 1991-11-13 Nouveaux derives du lupane, leur preparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number Publication Date
YU97492A true YU97492A (sh) 1995-12-04

Family

ID=9418832

Family Applications (1)

Application Number Title Priority Date Filing Date
YU97492A YU97492A (sh) 1991-11-13 1992-11-12 Novi derivati lupana i postupak za njihovo dobijanje

Country Status (11)

Country Link
US (1) US5468888A (sh)
EP (2) EP0613483A1 (sh)
CA (1) CA2121692A1 (sh)
FI (1) FI942181A0 (sh)
FR (1) FR2683531B1 (sh)
HU (1) HUT66959A (sh)
IL (1) IL103731A0 (sh)
MX (1) MX9206503A (sh)
TW (1) TW224103B (sh)
WO (1) WO1993010142A1 (sh)
YU (1) YU97492A (sh)

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US5869535A (en) * 1995-03-21 1999-02-09 The Board Of Trustees Of The University Of Illinois Method and composition for selectively inhibiting melanoma
US5962527A (en) * 1995-03-21 1999-10-05 The Board Of Trustees Of The University Of Illinois Method and composition for treating cancers
US5679828A (en) * 1995-06-05 1997-10-21 Biotech Research Labs, Inc. Betulinic acid and dihydrobetulinic acid derivatives and uses therefor
EP0988311B9 (en) 1997-06-04 2004-12-15 Cornell Research Foundation, Inc. Betulinol derivatives
US6403816B1 (en) * 1997-09-30 2002-06-11 Dabur Research Foundation Betulinic acid derivatives having antiangiogenic activity, processes for producing such derivatives and their use for treating tumor associated angiogenesis
AU762404B2 (en) * 1998-03-02 2003-06-26 Panacos Pharmaceuticals, Inc. Acylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof
US6369101B1 (en) 1999-02-26 2002-04-09 Regents Of The University Of Minnesota Therapeutic method to treat herpes virus infection
US6392070B1 (en) * 1999-08-10 2002-05-21 Regents Of The University Of Minnesota Birch bark processing and the isolation of natural products from birch bark
DE69917684T2 (de) * 1999-09-09 2005-07-21 Dabur Research Foundation, Sahibabad Betulinsäure-derivate mit antiangiogener wirkung, verfahren zur herstellung solcher derivate und deren verwendung für die behandlung tumorassoziierter angiogenese
JP2004517045A (ja) * 2000-08-18 2004-06-10 ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ イリノイ 癌およびｈｉｖの治療用ベツリン酸誘導体のプロドラッグ
WO2002091858A1 (en) * 2001-05-11 2002-11-21 University Of Ottawa Anxiolytic marcgraviaceae compositions containing betulinic acid, betulinic acid derivatives, and methods
GB0128071D0 (en) * 2001-11-22 2002-01-16 Cyclacel Ltd Medicament
CA2514563A1 (en) * 2003-01-29 2004-08-19 Panacos Pharmaceuticals, Inc. Inhibition of hiv-1 replication by disruption of the processing of the viral capsid-spacer peptide 1 protein
US7537765B2 (en) * 2003-01-29 2009-05-26 Panacos Pharmaceuticals, Inc. Inhibition of HIV-1 replication by disruption of the processing of the viral capsid-spacer peptide 1 protein
US7026305B2 (en) * 2003-04-14 2006-04-11 Meharry Medical College Anti-HIV agents with dual sites of action
US7326717B2 (en) * 2003-05-06 2008-02-05 L'oreal Pyrimidine n-oxide compounds for stimulating the growth of keratin fibers and/or reducing loss thereof
EP1730163A4 (en) * 2004-03-17 2009-12-30 Panacos Pharmaceuticals Inc Pharmaceutical salts of 3-O- (3,3-dimethylsuccinyl) betulinic acid
US20060019934A1 (en) * 2004-05-20 2006-01-26 Saxena Brij B Anti-HIV-1 activity of betulinol derivatives
US7282521B2 (en) * 2004-05-24 2007-10-16 University Of North Carolina At Chapel Hill Anti-retroviral moronic acid derivatives
US20060154904A1 (en) * 2004-09-10 2006-07-13 Cornell Research Foundation, Inc. Betulinol derivatives as anti-HIV agents
TW200628161A (en) * 2004-11-12 2006-08-16 Panacos Pharmaceuticals Inc Novel betulin derivatives, preparation thereof and use thereof
US20060193804A1 (en) * 2005-02-24 2006-08-31 L'oreal Haircare use of cyclic amine derivatives
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US20070197646A1 (en) * 2006-02-21 2007-08-23 Achillion Pharmaceuticals, Inc. Substituted taraxastanes useful for treating viral infections
US20080039428A1 (en) * 2006-06-29 2008-02-14 Panacos Pharmaceuticals, Inc. Antiretroviral combination therapy
US20090105203A1 (en) * 2006-10-16 2009-04-23 Myriad Genetics, Incorporated Compounds for treating viral infections
RU2317996C1 (ru) * 2006-10-30 2008-02-27 Институт нефтехимии и катализа РАН N'-{n-[3-оксо-лупан-28-оил]-9-аминононаноил}-3-амино-3-фенил-пропионовая кислота и ее соли как противовирусные и иммуностимулирующие агенты
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FR2929117B1 (fr) 2008-03-28 2010-05-07 Oreal Utilisation de l'association du 2,4-diaminopyrimidine 3-n-oxyde et du madecassosside et/ou du terminoloside pour induire et/ou stimuler la croissance de ces fibres keratiniques humaines et/ou freiner leur chute
KR100941595B1 (ko) * 2008-06-05 2010-02-11 주식회사 알앤엘바이오 바이러스 억제제로서 유용한 트리테르페노이드계 화합물
FR2949052B1 (fr) 2009-08-13 2015-03-27 Oreal Procede de traitement cosmetique du cuir chevelu.
CN102558280B (zh) * 2011-11-18 2014-09-17 温州大学 一种30-卤代桦木酸的生产方法
EP2838533B1 (en) 2012-04-16 2017-10-04 Case Western Reserve University Compositions and methods of modulating 15-pgdh activity
CA2900124A1 (en) * 2013-02-06 2014-08-14 Bristol-Myers Squibb Company C-19 modified triterpenoids with hiv maturation inhibitory activity
CA2927730A1 (en) 2013-10-15 2015-05-07 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase activity
CN104045680B (zh) 2014-06-20 2016-09-14 东北林业大学 桦木醇的乙酰氨基酸酰类衍生物及其制备方法
WO2016090373A1 (en) 2014-12-05 2016-06-09 Case Western Reserve University Compositions and methods of modulating s-nitrosylation
PL227790B1 (pl) 2015-08-13 2018-01-31 Slaski Univ Medyczny W Katowicach Fosfoniany acetylenowych pochodnych betuliny o działaniu przeciwnowotworowym, sposób ich wytwarzania i zastosowanie.
WO2018102552A1 (en) 2016-11-30 2018-06-07 Case Western Reserve University Combinations of 15-pgdh inhibitors with corcosteroids and/or tnf inhibitors and uses thereof
CN118480009A (zh) 2017-02-06 2024-08-13 卡斯西部储备大学 调节短链脱氢酶活性的组合物和方法
PL237998B1 (pl) 2018-05-28 2021-06-28 Narodowy Inst Lekow Fosfonowe pochodne kwasu 3-karboksyacylobetulinowego, sposób ich otrzymywania oraz ich zastosowanie
CA3120858A1 (en) 2018-11-21 2020-05-28 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase activity
CN116507626A (zh) 2020-05-20 2023-07-28 罗迪奥治疗公司 调节短链脱氢酶活性的组合物和方法

Also Published As

Publication number Publication date
US5468888A (en) 1995-11-21
HU9401353D0 (en) 1994-08-29
HUT66959A (en) 1995-01-30
EP0613483A1 (fr) 1994-09-07
MX9206503A (es) 1993-05-01
EP0542622A1 (fr) 1993-05-19
TW224103B (sh) 1994-05-21
FI942181A (fi) 1994-05-11
CA2121692A1 (fr) 1993-05-27
FR2683531B1 (fr) 1993-12-31
FR2683531A1 (fr) 1993-05-14
FI942181A0 (fi) 1994-05-11
IL103731A0 (en) 1993-04-04
WO1993010142A1 (fr) 1993-05-27

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