YU68003A - Karbamatna jedinjenja za upotrebu u sprečavanju i lečenju bipolarnih poremećaja - Google Patents
Karbamatna jedinjenja za upotrebu u sprečavanju i lečenju bipolarnih poremećajaInfo
- Publication number
- YU68003A YU68003A YU68003A YUP68003A YU68003A YU 68003 A YU68003 A YU 68003A YU 68003 A YU68003 A YU 68003A YU P68003 A YUP68003 A YU P68003A YU 68003 A YU68003 A YU 68003A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- preventing
- bipolar disorder
- phenyl
- alkyl
- group
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Ovaj pronalazak se odnosi na postupak za sprečavanje ili lečenje bipolarnog poremećaja koji čini davanje subjektu kome je potrebno terapeutski efikasne količine enantiomera formule (I) ili enantiomerne smeše u kojoj jedan enantiomer formule (I) predominira, u kojoj fenil je supstituisan sa X sa jednim do pet atoma halogena izabranih iz grupe koju čine fluor, hlor, brom i jod; i R1, R2, R3 i R4 su nezavisno izabrani iz grupe koju čine vodonik i C1-C4 alkil; gde C1-C4 alkil je opciono supstituisan sa fenilom (gde je fenil opciono supstituisan sa supstituentima nezavisno izabranim iz grupe koju čine halogen, C1-C4 alkil, C1-C4 alkoksi, amino, nitro i cijano).[This invention is directed to a method for preventing or treating bipolar disorder comprising administering to a subject in need thereof a therapeutically effective amount of an enantiomer of formula (I) or enantiomeric mixture wherein one enantiomer of formula (I) predominates wherein phenyl is substituted at X with one to five halogen atoms selected from the group consisting of fluorine, chlorine, bromine and iodine; and, R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; wherein C1-C4 alkyl is optionally substituted with phenyl (wherein phenyl is optionally substituted with substituents independently selected from the group consisting of halogen, C1-C4 alkyl, C1-C4 alkoxy, amino, nitro and cyano).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27168001P | 2001-02-27 | 2001-02-27 | |
| US10/081,606 US7122576B2 (en) | 2001-02-27 | 2002-02-21 | Carbamate compounds for use in preventing or treating bipolar disorder |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU68003A true YU68003A (sh) | 2006-08-17 |
| RS50680B RS50680B (sr) | 2010-06-30 |
Family
ID=26765743
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7122576B2 (sh) |
| EP (1) | EP1368021B1 (sh) |
| JP (1) | JP4276839B2 (sh) |
| KR (1) | KR20030074849A (sh) |
| CN (1) | CN1250214C (sh) |
| AT (1) | ATE378046T1 (sh) |
| AU (1) | AU2002242226B2 (sh) |
| BR (1) | BR0207832A (sh) |
| CA (1) | CA2439292A1 (sh) |
| CY (1) | CY1107199T1 (sh) |
| CZ (1) | CZ296641B6 (sh) |
| DE (1) | DE60223506T2 (sh) |
| DK (1) | DK1368021T3 (sh) |
| ES (1) | ES2295320T3 (sh) |
| HK (1) | HK1058762A1 (sh) |
| HU (1) | HUP0303261A3 (sh) |
| IL (2) | IL157589A0 (sh) |
| MX (1) | MXPA03007716A (sh) |
| MY (1) | MY133370A (sh) |
| NO (1) | NO20033799L (sh) |
| NZ (1) | NZ527989A (sh) |
| PL (1) | PL364640A1 (sh) |
| PT (1) | PT1368021E (sh) |
| RS (1) | RS50680B (sh) |
| RU (1) | RU2286147C2 (sh) |
| WO (1) | WO2002067924A1 (sh) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20070057939A (ko) * | 2004-09-16 | 2007-06-07 | 얀센 파마슈티카 엔.브이. | 간질형성 및 간질을 치료하는 방법 |
| FR2884714B1 (fr) * | 2005-04-20 | 2011-05-06 | Servier Lab | Utilisation de l'agomelatine pour l'obtention de medicaments destines au traitement des troubles bipolaires |
| US20070021501A1 (en) * | 2005-07-12 | 2007-01-25 | Twyman Roy E | Methods of treating epileptogenesis |
| WO2007018496A1 (en) * | 2005-07-26 | 2007-02-15 | Janssen Pharmaceutica, N.V. | Methods for treating substance-related disorders |
| JP2010508355A (ja) * | 2006-10-30 | 2010-03-18 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 鬱病を処置する方法 |
| HUP0700353A2 (en) * | 2007-05-18 | 2008-12-29 | Richter Gedeon Nyrt | Metabolites of (thio)carbamoyl-cyclohexane derivatives |
| HUP0700370A2 (en) * | 2007-05-24 | 2009-04-28 | Richter Gedeon Nyrt | Use of (thio)-carbamoyl-cyclohexane derivatives in the manufacture of a medicament for the treatment of acute mania |
| US7875610B2 (en) * | 2007-12-03 | 2011-01-25 | Richter Gedeon Nyrt. | Pyrimidinyl-piperazines useful as D3/D2 receptor ligands |
| JP4409630B2 (ja) * | 2008-02-21 | 2010-02-03 | 田辺三菱製薬株式会社 | 経口投与用固形製剤 |
| ES2532636T3 (es) | 2008-07-16 | 2015-03-30 | Richter Gedeon Nyrt. | Formulaciones farmacéuticas que contienen ligandos de receptores de dopamina |
| HU230067B1 (hu) | 2008-12-17 | 2015-06-29 | Richter Gedeon Nyrt | Új piperazin só és eljárás előállítására |
| HUP0800766A2 (en) | 2008-12-18 | 2010-11-29 | Richter Gedeon Vegyeszet | Process for the preparation of piperazine derivatives |
| HUP0800765A2 (en) | 2008-12-18 | 2010-11-29 | Richter Gedeon Nyrt | A new process for the preparation of piperazine derivatives and their hydrochloric salts |
| US11274087B2 (en) | 2016-07-08 | 2022-03-15 | Richter Gedeon Nyrt. | Industrial process for the preparation of cariprazine |
| AU2017374458B2 (en) * | 2016-12-14 | 2023-03-02 | Sk Biopharmaceuticals Co., Ltd. | Use of carbamate compounds for prevention, alleviation or treatment of bipolar disorder |
| US11547707B2 (en) | 2019-04-10 | 2023-01-10 | Richter Gedeon Nyrt. | Carbamoyl cyclohexane derivatives for treating autism spectrum disorder |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3313692A (en) | 1958-04-21 | 1967-04-11 | Armour Pharma | Method of inducing calming and muscle relaxation with carbamates |
| US3278380A (en) | 1962-02-06 | 1966-10-11 | Armour Pharma | Methods of calming employing diphenyl hydroxy carbamate compounds |
| US3265728A (en) | 1962-07-18 | 1966-08-09 | Armour Pharma | Substituted phenethyl carbamates |
| US5698588A (en) * | 1996-01-16 | 1997-12-16 | Yukong Limited | Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol |
-
2002
- 2002-02-21 JP JP2002567291A patent/JP4276839B2/ja not_active Expired - Fee Related
- 2002-02-21 WO PCT/US2002/005425 patent/WO2002067924A1/en active IP Right Grant
- 2002-02-21 PL PL02364640A patent/PL364640A1/xx not_active Application Discontinuation
- 2002-02-21 US US10/081,606 patent/US7122576B2/en not_active Expired - Fee Related
- 2002-02-21 HU HU0303261A patent/HUP0303261A3/hu unknown
- 2002-02-21 DK DK02707850T patent/DK1368021T3/da active
- 2002-02-21 IL IL15758902A patent/IL157589A0/xx unknown
- 2002-02-21 DE DE60223506T patent/DE60223506T2/de not_active Expired - Lifetime
- 2002-02-21 NZ NZ527989A patent/NZ527989A/en not_active IP Right Cessation
- 2002-02-21 RU RU2003128996/14A patent/RU2286147C2/ru not_active IP Right Cessation
- 2002-02-21 AT AT02707850T patent/ATE378046T1/de active
- 2002-02-21 EP EP02707850A patent/EP1368021B1/en not_active Expired - Lifetime
- 2002-02-21 RS YUP-680/03A patent/RS50680B/sr unknown
- 2002-02-21 CN CNB02808716XA patent/CN1250214C/zh not_active Expired - Fee Related
- 2002-02-21 MX MXPA03007716A patent/MXPA03007716A/es active IP Right Grant
- 2002-02-21 CA CA002439292A patent/CA2439292A1/en not_active Abandoned
- 2002-02-21 AU AU2002242226A patent/AU2002242226B2/en not_active Ceased
- 2002-02-21 CZ CZ20032312A patent/CZ296641B6/cs not_active IP Right Cessation
- 2002-02-21 PT PT02707850T patent/PT1368021E/pt unknown
- 2002-02-21 KR KR10-2003-7011290A patent/KR20030074849A/ko not_active Application Discontinuation
- 2002-02-21 ES ES02707850T patent/ES2295320T3/es not_active Expired - Lifetime
- 2002-02-21 BR BR0207832-5A patent/BR0207832A/pt not_active Application Discontinuation
- 2002-02-27 MY MYPI20020694A patent/MY133370A/en unknown
-
2003
- 2003-08-26 NO NO20033799A patent/NO20033799L/no not_active Application Discontinuation
- 2003-08-26 IL IL157589A patent/IL157589A/en active IP Right Grant
-
2004
- 2004-03-01 HK HK04101490A patent/HK1058762A1/xx not_active IP Right Cessation
-
2008
- 2008-02-14 CY CY20081100183T patent/CY1107199T1/el unknown
Also Published As
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| MY138156A (en) | Carbamate compounds for use in preventing or treating neurodegenerative disorders | |
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