YU46201B - Postopek za pripravo novih analogov 13-aza-14-okso-txa2 - Google Patents

Postopek za pripravo novih analogov 13-aza-14-okso-txa2

Info

Publication number
YU46201B
YU46201B YU84087A YU84087A YU46201B YU 46201 B YU46201 B YU 46201B YU 84087 A YU84087 A YU 84087A YU 84087 A YU84087 A YU 84087A YU 46201 B YU46201 B YU 46201B
Authority
YU
Yugoslavia
Prior art keywords
group
unsubstituted
substituted
carbon atoms
straight
Prior art date
Application number
YU84087A
Other languages
English (en)
Other versions
YU84087A (en
Inventor
Miyake Hajimu
Oregawa Tadao
Kawasaki Akiyoshi
Original Assignee
Ono Pharmaceutical Co. Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co. Ltd. filed Critical Ono Pharmaceutical Co. Ltd.
Publication of YU84087A publication Critical patent/YU84087A/xx
Publication of YU46201B publication Critical patent/YU46201B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/05—Alcohols containing rings other than six-membered aromatic rings
    • C07C33/14—Alcohols containing rings other than six-membered aromatic rings containing six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0091—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is bridged condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
    • C07C59/11—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups containing rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Slide Fasteners, Snap Fasteners, And Hook Fasteners (AREA)
  • Interconnected Communication Systems, Intercoms, And Interphones (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Coupling Device And Connection With Printed Circuit (AREA)
  • Prostheses (AREA)

Abstract

ki je nesubstituirana ali substituirana z najmanj eno hidroksi skupino, amino skupino, atomom halogena ali feniltio skupino, R3 predstavlja (i) fenilno, fenoksi ali feniltio skupino, ki je nesubstituirana ali substituirana z najmanj eno ravno ali razvejeno alkilno ali alkoksi skupino z 1 do 6 atomi ogljika, atomom halogena ali hidroksi skupino, (ii) ravno ali razvejeno alkilno, alkenilno ali alkinilno skupino z 1 do 6 atomi ogljika, ki je nesubstituirana ali substituirana z najmanj enim atomom halogena ali hidroksi skupino, (iii) cikloalkilno, cikloalkiloksi ali cikloalkiltio skupino z 4 do 7 atomi ogljika, ki je nesubstiuirana ali substituirana najmanj z eno ravno ali razvejeno alkilno skupino z 1 do 6 atomi ogljika, atomom halogena ali hidroksi skupino, (iv) naftilno, indolilno ali indanilno skupino ali (v) amino skupino, ki je nesubstituirana ali substituirana z najmanj eno ravno ali razvejeno alkilno skupino z 1 do 6 atomi ogljika, in R4 predstavlja atom vodika ali metilno skupino, pri cemer velja, da atom ogljika, ki je najblizji R3 in R2, ne sme imeti substituentov, ce predstavlja R3 feniloksi, feniltio, cikloalkiloksi ali cikloalkiltio skupino, ki je nesubstituirana ali substituirana, oznacen s tem, da presnovimo aldehid s splosno formulo /kjer R2b predstavlja vez ali ravno ali razvejeno alkilensko ali alkenilensko skupino z 1 do 10 atomi ogljika, ki je nesubstituirana ali substituirana z najmanj eno hidroksi skupino, zasciteno amino skupino, atomom halogena ali feniltio skupino, in so drugi simboli definirani kot zgoraj/ in Wittigov reagent s splosno formulo (R7)3 P+-CH2 - D - COOH X1- /kjer R7 predstavlja fenilno skupino, ki je nesubstituirana ali substituirana z najmanj eno ravno ali razvejeno alkilno skupino z 1 do 4 atomi ogljika ali razvejeno alkilno ali alkoksi skupino z 1 do 6 atomi ogljika, D predstavlja skupino s splosno formulo -CH2)m-ali, in X1 predstavlja atom halogena/ in nato po zelji izvedemo reakcijo redukcije.
YU84087A 1984-06-12 1987-05-11 Postopek za pripravo novih analogov 13-aza-14-okso-txa2 YU46201B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59119000A JPS6149A (ja) 1984-06-12 1984-06-12 新規な１３―アザ―１４―オキソ―ＴｘＡ２類似化合物およびそれらを有効成分として含有するトロンボキサン起因疾患治療剤

Publications (2)

Publication Number Publication Date
YU84087A YU84087A (en) 1987-12-31
YU46201B true YU46201B (sh) 1993-05-28

Family

ID=14750515

Family Applications (2)

Application Number Title Priority Date Filing Date
YU00999/85A YU99985A (en) 1984-06-12 1985-06-13 Process for preparing new derivatives 13-aza-14-oxo-txa2
YU84087A YU46201B (sh) 1984-06-12 1987-05-11 Postopek za pripravo novih analogov 13-aza-14-okso-txa2

Family Applications Before (1)

Application Number Title Priority Date Filing Date
YU00999/85A YU99985A (en) 1984-06-12 1985-06-13 Process for preparing new derivatives 13-aza-14-oxo-txa2

Country Status (17)

Country Link
US (1) US4792550A (sh)
EP (1) EP0171146B1 (sh)
JP (1) JPS6149A (sh)
KR (1) KR860000256A (sh)
AT (1) ATE37535T1 (sh)
AU (1) AU575653B2 (sh)
CA (1) CA1261826A (sh)
DE (1) DE3565255D1 (sh)
DK (1) DK260085A (sh)
ES (2) ES8705370A1 (sh)
FI (1) FI852319L (sh)
GR (1) GR851412B (sh)
HU (1) HU196740B (sh)
NO (1) NO852319L (sh)
PT (1) PT80626B (sh)
YU (2) YU99985A (sh)
ZA (1) ZA854237B (sh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6395479U (sh) * 1986-12-09 1988-06-20
JPH0226306Y2 (sh) * 1986-12-31 1990-07-18
JPH02234630A (ja) * 1989-03-07 1990-09-17 Hideo Hayakawa 有害動物の威嚇装置
JPH039183U (sh) * 1989-06-08 1991-01-29
MX9710256A (es) 1995-06-21 1998-03-31 Shionogi & Co Derivados de amino biciclicos y antagonistas pgd2 que contienen los mismos.
US6069166A (en) * 1996-12-12 2000-05-30 Shionogi & Co., Ltd. Fused heterocyclic benzenecarboxamide derivatives and PGD2 antagonists comprising them
NZ336143A (en) * 1996-12-13 2002-05-31 Shionogi & Co Benzothiophenecarboxamide derivatives and pgd 2 antagonists comprising them
WO1999015502A1 (en) 1997-09-19 1999-04-01 Shionogi & Co., Ltd. Compounds having [2.2.1]bicyclo skeleton
US6506789B2 (en) 1998-06-03 2003-01-14 Shionogi & Co., Ltd. Methods for the treatment of itching comprising administering PGD2 receptor antagonist

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0044711B1 (en) * 1980-07-22 1984-03-14 Ono Pharmaceutical Co., Ltd. 9,11-methano-13-aza-11a-carbathrombanoic acid analogues and pharmaceutical use thereof
DE3280020D1 (en) * 1981-12-23 1989-12-21 Nat Res Dev Prostaglandins

Also Published As

Publication number Publication date
ES544054A0 (es) 1987-05-01
FI852319A0 (fi) 1985-06-11
JPS6149A (ja) 1986-01-06
YU99985A (en) 1987-12-31
GR851412B (sh) 1985-11-25
ES8704880A1 (es) 1987-04-16
ZA854237B (en) 1986-03-26
DE3565255D1 (en) 1988-11-03
ES552192A0 (es) 1987-04-16
CA1261826A (en) 1989-09-26
US4792550A (en) 1988-12-20
PT80626B (pt) 1994-11-30
KR860000256A (ko) 1986-01-27
HUT37914A (en) 1986-03-28
PT80626A (en) 1985-07-01
JPH0142938B2 (sh) 1989-09-18
AU575653B2 (en) 1988-08-04
HU196740B (en) 1989-01-30
AU4349585A (en) 1985-12-19
NO852319L (no) 1985-12-13
ATE37535T1 (de) 1988-10-15
FI852319A7 (fi) 1985-12-13
EP0171146B1 (en) 1988-09-28
YU84087A (en) 1987-12-31
FI852319L (fi) 1985-12-13
DK260085D0 (da) 1985-06-11
DK260085A (da) 1985-12-13
ES8705370A1 (es) 1987-05-01
EP0171146A1 (en) 1986-02-12

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