YU42468B - Process for obtaining compounds inhibiting the enzyme encephalinase - Google Patents
Process for obtaining compounds inhibiting the enzyme encephalinaseInfo
- Publication number
- YU42468B YU42468B YU1042/82A YU104282A YU42468B YU 42468 B YU42468 B YU 42468B YU 1042/82 A YU1042/82 A YU 1042/82A YU 104282 A YU104282 A YU 104282A YU 42468 B YU42468 B YU 42468B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- encephalinase
- enzyme
- obtaining compounds
- compounds inhibiting
- inhibiting
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
- C07C57/60—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/264,752 US4329495A (en) | 1981-05-18 | 1981-05-18 | Enkephalinase enzyme inhibiting compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU104282A YU104282A (en) | 1985-06-30 |
| YU42468B true YU42468B (en) | 1988-08-31 |
Family
ID=23007448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU1042/82A YU42468B (en) | 1981-05-18 | 1982-05-17 | Process for obtaining compounds inhibiting the enzyme encephalinase |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US4329495A (de) |
| EP (1) | EP0066956B1 (de) |
| JP (1) | JPS57193450A (de) |
| KR (1) | KR860001549B1 (de) |
| AR (1) | AR231279A1 (de) |
| AT (1) | ATE8881T1 (de) |
| AU (1) | AU529511B2 (de) |
| CA (1) | CA1179368A (de) |
| DE (1) | DE3260531D1 (de) |
| DK (1) | DK160711B (de) |
| ES (2) | ES8306719A1 (de) |
| FI (1) | FI76555C (de) |
| GR (1) | GR75496B (de) |
| HU (1) | HU188058B (de) |
| IE (1) | IE53226B1 (de) |
| IL (1) | IL65799A (de) |
| IN (1) | IN158365B (de) |
| NO (1) | NO153768C (de) |
| NZ (1) | NZ200639A (de) |
| PH (1) | PH18206A (de) |
| PL (1) | PL138043B1 (de) |
| PT (1) | PT74913B (de) |
| YU (1) | YU42468B (de) |
| ZA (1) | ZA823386B (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4432972A (en) * | 1981-08-03 | 1984-02-21 | E. R. Squibb & Sons, Inc. | Phosphonamidate compounds |
| US4474795A (en) * | 1981-10-09 | 1984-10-02 | E. R. Squibb & Sons, Inc. | Enkephalinase inhibitors |
| US4474799A (en) * | 1981-10-09 | 1984-10-02 | E. R. Squibb & Sons, Inc. | Enkephalinase inhibitors |
| US4401677A (en) * | 1981-10-09 | 1983-08-30 | E. R. Squibb & Sons, Inc. | Enkephalinase inhibitors |
| JPS58140065A (ja) * | 1982-02-10 | 1983-08-19 | Meito Sangyo Kk | メルカプトベンジル脂肪酸誘導体類及びその製法 |
| FR2540495B1 (fr) * | 1983-02-07 | 1986-02-14 | Roussel Uclaf | Nouveaux derives de o-mercaptopropanamide et de ses homologues, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus |
| FR2540498B1 (fr) * | 1983-02-07 | 1986-02-14 | Roussel Uclaf | Nouveaux medicaments derives d'amides d'acide mercaptoacetique et de l'acide 3-mercaptopropionique et les compositions pharmaceutiques les renfermant |
| FR2556721B1 (fr) * | 1983-12-14 | 1986-05-16 | Roussel Uclaf | Nouveaux derives de o-mercaptopropanamide d'o amino-acides, leur procede de preparation, leur application comme medicaments et les compositions les renfermant |
| FR2559770B1 (fr) * | 1984-02-20 | 1986-10-24 | Roussel Uclaf | Nouveaux derives de n-alkyl-o-mercaptopropanamide, leurs procedes de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus |
| US4929641B1 (en) * | 1988-05-11 | 1994-08-30 | Schering Corp | Mercapto-acylamino acid antihypertensives |
| EP0566157A1 (de) | 1986-06-20 | 1993-10-20 | Schering Corporation | Hemmer der neutralen Metalloendopeptidase zur Behandlung von Hypertension |
| US4801609B1 (en) * | 1987-03-27 | 1993-11-09 | Mercapto-acylamino acid antihypertensives | |
| EP0254032A3 (de) * | 1986-06-20 | 1990-09-05 | Schering Corporation | Hemmer der neutralen Metallendopeptidase zur Behandlung von Hypertension |
| US5262436A (en) * | 1987-03-27 | 1993-11-16 | Schering Corporation | Acylamino acid antihypertensives in the treatment of congestive heart failure |
| AU4056389A (en) * | 1988-08-24 | 1990-03-23 | Schering Corporation | Mercapto-acylamino acid antihypertensives |
| US4879309A (en) * | 1988-09-27 | 1989-11-07 | Schering Corporation | Mercapto-acylamino acids as antihypertensives |
| ZA902661B (en) * | 1989-04-10 | 1991-01-30 | Schering Corp | Mercapto-acyl amino acids |
| US5599951A (en) * | 1989-09-15 | 1997-02-04 | Societe Civile Bioprojet | Amino acid derivatives, the process for their preparation and their applications to therapy |
| FR2652087B1 (fr) * | 1989-09-15 | 1993-10-15 | Bioprojet Ste Civile | Derives d'amino-acides, leur procede de preparation et leurs applications therapeutiques. |
| AU7168091A (en) * | 1989-12-22 | 1991-07-24 | Schering Corporation | Mercaptocycloacyl aminoacid endopeptidase inhibitors |
| WO1991017980A1 (en) * | 1990-05-17 | 1991-11-28 | Schering Corporation | Disulfide derivatives of mercaptoacylamino acids |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4046889A (en) * | 1976-02-13 | 1977-09-06 | E. R. Squibb & Sons, Inc. | Azetidine-2-carboxylic acid derivatives |
| US4053651A (en) * | 1976-05-10 | 1977-10-11 | E. R. Squibb & Sons, Inc. | Compounds and method for alleviating angiotensin related hypertension |
| IT1148006B (it) * | 1980-04-11 | 1986-11-26 | Wellcome Found | Ammidi dotate di proprieta' farmaceutiche e loro preparazione |
| FR2480747A1 (fr) * | 1980-04-17 | 1981-10-23 | Roques Bernard | Derives d'acides amines et leur application therapeutique |
-
1981
- 1981-05-18 US US06/264,752 patent/US4329495A/en not_active Expired - Lifetime
-
1982
- 1982-03-30 IN IN263/DEL/82A patent/IN158365B/en unknown
- 1982-05-11 DE DE8282302387T patent/DE3260531D1/de not_active Expired
- 1982-05-11 EP EP82302387A patent/EP0066956B1/de not_active Expired
- 1982-05-11 AT AT82302387T patent/ATE8881T1/de active
- 1982-05-13 HU HU821506A patent/HU188058B/hu not_active IP Right Cessation
- 1982-05-13 GR GR68139A patent/GR75496B/el unknown
- 1982-05-13 NO NO821595A patent/NO153768C/no unknown
- 1982-05-14 CA CA000402956A patent/CA1179368A/en not_active Expired
- 1982-05-14 PL PL1982236425A patent/PL138043B1/pl unknown
- 1982-05-14 PH PH27313A patent/PH18206A/en unknown
- 1982-05-14 AR AR289397A patent/AR231279A1/es active
- 1982-05-17 YU YU1042/82A patent/YU42468B/xx unknown
- 1982-05-17 IL IL65799A patent/IL65799A/xx unknown
- 1982-05-17 FI FI821736A patent/FI76555C/fi not_active IP Right Cessation
- 1982-05-17 AU AU83759/82A patent/AU529511B2/en not_active Ceased
- 1982-05-17 PT PT74913A patent/PT74913B/pt unknown
- 1982-05-17 KR KR8202139A patent/KR860001549B1/ko active
- 1982-05-17 ES ES512278A patent/ES8306719A1/es not_active Expired
- 1982-05-17 NZ NZ200639A patent/NZ200639A/en unknown
- 1982-05-17 DK DK221182A patent/DK160711B/da not_active Application Discontinuation
- 1982-05-17 JP JP57082977A patent/JPS57193450A/ja active Granted
- 1982-05-17 ZA ZA823386A patent/ZA823386B/xx unknown
- 1982-05-17 IE IE1168/82A patent/IE53226B1/en unknown
-
1983
- 1983-02-09 ES ES519668A patent/ES8403107A1/es not_active Expired
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| YU44346B (en) | Process for preparing cepheme compounds | |
| YU42468B (en) | Process for obtaining compounds inhibiting the enzyme encephalinase | |
| GB2103647B (en) | Process for the preparation of organic compounds | |
| JPS57155290A (en) | Hydrogen-coal process | |
| DE3264982D1 (en) | Process for the purifacation of polytetramethylene-ether glycols | |
| IL65910A0 (en) | Co-nitrating process | |
| CU21425A3 (en) | Procedure for the dimethylathers production | |
| YU149482A (en) | Process for obtaining amido-benzamides | |
| DE3261521D1 (en) | An improved process for the manufacture of alkylaminoalkanol | |
| YU43084B (en) | Process for obtaining s-benzylthiocarbamates | |
| DE3261853D1 (en) | Process for the ortho-methylation of phenolic compounds | |
| YU105982A (en) | Process for foam-flotation | |
| DE3275536D1 (en) | Phosphoanhydrite process | |
| ZA823402B (en) | Comminnution process | |
| YU217582A (en) | Process for obtaining azolyl-pentene derivatives | |
| YU195484A (en) | Process for the manufacture of substituted trifluoromethylphenyl-tetrahydropyridines | |
| YU125882A (en) | Process for obtaining imidazolyl-propionitrile | |
| YU43789B (en) | Process for obtaining azaspiro-alcandione | |
| DE3273891D1 (en) | Process for making pyridyloxyphenol compounds | |
| GB2101120B (en) | 7a-methoxycephem compounds and process for preparing the same | |
| DE3260739D1 (en) | Process for making 2-carbalkoxy-5-carboxynitrobenzenes | |
| DE3265390D1 (en) | Process for the preparation of 4-thio-azetidinone compounds | |
| YU42908B (en) | Process for obtaining pyrbuterol | |
| GB2101997B (en) | Process for the preparation of gem-dihalogen compounds | |
| ZA822029B (en) | Resist-printing process |