YU40293A - Derivati hidroksamične kiseline - Google Patents

Derivati hidroksamične kiseline

Info

Publication number
YU40293A
YU40293A YU40293A YU40293A YU40293A YU 40293 A YU40293 A YU 40293A YU 40293 A YU40293 A YU 40293A YU 40293 A YU40293 A YU 40293A YU 40293 A YU40293 A YU 40293A
Authority
YU
Yugoslavia
Prior art keywords
alkyl
atoms
group
atom
amino acid
Prior art date
Application number
YU40293A
Other languages
English (en)
Inventor
J.M. Broadhurst
P.A. Brown
W.H. Jonson
G. Lawton
Original Assignee
F-Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F-Hoffmann La Roche filed Critical F-Hoffmann La Roche
Publication of YU40293A publication Critical patent/YU40293A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08—Hydroxylamino compounds or their ethers or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08—Hydroxylamino compounds or their ethers or esters
    • C07C239/22—Hydroxylamino compounds or their ethers or esters having oxygen atoms of hydroxylamino groups esterified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

DERIVATI HIDROKSAMIČNE KISELINE - Ovaj pronalazak daje derivate hidroksamične kiseline sa formulom u kojoj Rl predstavlja 1-7C alkil; R2 predstavlja vodonik, 1-6C alkil ili grupu formule -(CH2)n-aril ili -(CH2)n-het, u kojoj n ima vrednost 1-4 het predstavlja 5- ili 6-toclani N-heterocik-lični prsten, koji (a) je vezan preko N atoma, (b) po želji sadrži N, 0 i/ili S kao dodatne hetero atome u položaju koji nije susedan veznom N atomu, (c) je zamenjen sa okso na jednom ili oba C atoma, susedna veznom N atomu i (d) je po želji vezan benz-vezom ili po želji zamenjen na jednom ili vise C atoma sa 1-6C alkil ili okso i/ili na bilo kom dodatnom N atomu sa 1-6C alkil grupom; R3 predstavlja karakterističnu grupu prirodne ili veštačke alfa-amino kiseline, u kojoj se bilo koja prisutna funkcionalna grupa može zaštititi, pod uslovom da R3 ne predstavlja vodonik; R4 predstavlja karboksil, (1-6C alkoksi) karbonil, karbamojl ili (1-6C alkil)karbamojl; R5 predstavlja karakterističnu grupu prirodne alfa-amino kiseline u kojoj se svaka prisutna funkcionalna grupa može zaštititi; i R6 predstavlja vodonik; ili R4, R5 i R6 svaki pojedinačno predstavlja vodonik ili (l-6C)alkil i njihove farmaceutski prih-vadjive soli, koji su inhibitori matrične metaloproteinaze, korisni za kontrolu ili sprečavanje degenerativnih oboljenja zglobova kao Sto je reumatski artritis i osteoartritis Ui za tretman invazionih tumora, ateroskleroze ili multiple skleroze. Oni se mogu proizvoditi prema opSte poznatim postupcima skidanjem zaštite sa novog benziloksiamino jedinjenja ili hidrogenizovanjem odgovarajuće nove amino kiseline ili njenog aktiviranog derivata.
YU40293A 1992-06-25 1993-06-09 Derivati hidroksamične kiseline YU40293A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929213473A GB9213473D0 (en) 1992-06-25 1992-06-25 Hydroxamic acid derivatives

Publications (1)

Publication Number Publication Date
YU40293A true YU40293A (sh) 1997-07-31

Family

ID=10717706

Family Applications (1)

Application Number Title Priority Date Filing Date
YU40293A YU40293A (sh) 1992-06-25 1993-06-09 Derivati hidroksamične kiseline

Country Status (12)

Country Link
KR (1) KR100311556B1 (sh)
BR (1) BR9302642A (sh)
GB (2) GB9213473D0 (sh)
HR (1) HRP930980A2 (sh)
MX (1) MX9303672A (sh)
MY (1) MY134743A (sh)
PL (1) PL299465A1 (sh)
SI (1) SI9300313A (sh)
TW (1) TW279157B (sh)
UY (1) UY23606A1 (sh)
YU (1) YU40293A (sh)
ZA (1) ZA934398B (sh)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8601368D0 (en) * 1986-01-21 1986-02-26 Ici America Inc Hydroxamic acids
US5189178A (en) * 1990-11-21 1993-02-23 Galardy Richard E Matrix metalloprotease inhibitors

Also Published As

Publication number Publication date
ZA934398B (en) 1993-12-27
KR940005556A (ko) 1994-03-21
MY134743A (en) 2007-12-31
PL299465A1 (en) 1994-03-07
KR100311556B1 (ko) 2002-02-19
SI9300313A (sl) 1993-12-31
UY23606A1 (es) 1993-12-15
BR9302642A (pt) 1994-01-11
GB9213473D0 (en) 1992-08-12
MX9303672A (es) 1994-01-31
GB9307081D0 (en) 1993-05-26
HRP930980A2 (en) 1997-02-28
TW279157B (sh) 1996-06-21

Similar Documents

Publication Publication Date Title
ATE162514T1 (de) Hydroxamsäurederivate und deren pharmazeutische zusammensetzungen
AR036873A1 (es) Piridinas aril sustituidas a, composiciones farmaceuticas y el uso de las mismas para la preparacion de un medicamento
AR004495A1 (es) Compuestos derivados de acido amino sustituido arilo y heteroarilo carboxilico; composicion farmaceutica que los contiene; uso de los compuestos; proceso para preparar dichos compuestos y compuestos utiles como material de partida.
AR061273A1 (es) Terapia que utiliza inhibidores de citocina
AR037233A1 (es) Piridinas aril sustituidas, composiciones farmaceuticas y el uso de dichos compuestos para la elaboracion de un medicamento
HUP0401819A2 (hu) Proteinkináz inhibitorokként alkalmazható pirazolvegyületek és ezeket tartalmazó gyógyszerkészítmények
AR029489A1 (es) Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento
MY117557A (en) 1-(1,2-disubstituted piperidinyl)-4- substituted piperidine derivatives
AR058769A1 (es) Inhibidores de peptidil-deformilasa(pdf),utiles para el tratamiento de la tuberculosis y composiciones farmaceuticas que los contienen.
RS50577B (sr) Novi azabiciklični derivati, njihov postupak izrade i farmaceutske smeše koje ih sadrže
ATE114670T1 (de) Phenylamidinderivate als plättchenaggregationsinhibitoren.
TW375609B (en) 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
DK0753301T3 (da) Kombination af et benzimidazol med angiotensin-II-antagonistisk aktivitet med et diuretika
KR890002209A (ko) 메틸렌 포스포노알킬포스피네네이트, 이를 함유하는 약학적 조성물, 및 비정상적 칼슘 및 인산염 대사를 치료하는 방법
FR2673427B1 (fr) Derives heterocycliques diazotes n-substitues par un groupement biphenylmethyle, leur preparation, les compositions pharmaceutiques en contenant.
ATE450499T1 (de) Durch enzyme spaltbare prodrugs von substituierten stickstoff-lost-derivaten
ATE72431T1 (de) 5-gliedrige heterocyclische angiotensinumwandlungsenzym-inhibitoren.
FR2665441B1 (fr) Derives de la n-sulfonyl indoline, leur preparation, les compositions pharmaceutiques en contenant.
KR880007461A (ko) 헤테로 사이클-치환 디포스포네이트화합물 및 이의 약제학적 조성물
AR057461A1 (es) Derivados de pirazol, proceso de preparacion, composiciones farmaceuticas y usos
AR047486A1 (es) Derivados de indolizina1,2,3,6,7,8, substituida, inhibidores de los fgfs, su procedimiento de preparacion y composiciones farmaceuticas que los contienen
YU40293A (sh) Derivati hidroksamične kiseline
HUP0103113A2 (hu) NOS inhibitorokat tartalmazó gyógyászati készítmények
BR0307171A (pt) Método e composições para inibir a capacidade de seguimento de cheiro de mosquitos-pólvora mordedores
YU16196A (sh) Upotreba novih benzohinolin-3-ona i njihovih farmaceutski prihvatljivih soli za proizvodnju leka